![]() |
市場調查報告書
商品編碼
1656921
原位雜交市場:全球洞察、競爭格局與 2032 年預測In Situ Hybridization - Market Insights, Competitive Landscape, and Market Forecast - 2032 |
到 2024 年,原位雜交市場規模預計將達到 16.7355 億美元。預計預測期內(2025-2032 年),市場複合年增長率為 7.12%,到 2032 年將達到 28.8613 億美元。原位雜交的需求大幅增加,主要原因是癌症和遺傳疾病的發生率不斷上升。此外,神經疾病和傳染病的趨勢也進一步推動了這項需求。除此之外,研發活動和資金的增加是推動原位雜交市場成長軌跡的關鍵因素。預計這一成長趨勢將在 2025 年至 2032 年的整個預測期內持續並蓬勃發展。
ISH 用於診斷唐氏症和愛德華氏症等先天性疾病。研究可以分析特定基因在組織和器官中的表現方式,闡明它們在發育過程、疾病和生理功能中的作用。因此,患有遺傳疾病和一些罕見疾病的人數不斷增加,預計將促進市場的成長。例如,根據世界經濟論壇2023年2月發佈的報告,2019年約有4.75億人患有罕見疾病,佔世界人口的10%。未來五年內,預計約有 1,520 萬人將接受專為識別罕見疾病而設計的臨床基因組檢測。
根據強生公司2023年2月發表的文章估計,截至2023年,全球將有超過3億人患有罕見疾病。螢光原位雜交(FISH)是病理學家用來幫助診斷染色體異常引起的疾病的基因檢測技術。因此,遺傳疾病和罕見疾病的增加促進了原位雜交的廣泛應用,預計這將推動市場成長。
根據世界衛生組織(WHO)2022年發佈的數據,2020年全球報告乳癌約226萬例、肺癌221萬例、大腸直腸癌193萬例、攝護腺癌141萬例、胃癌109萬例。
根據全球癌症觀察站2021年發表的數據,2020年全球報告了約544,352例非何傑金氏淋巴瘤和83,087例霍奇金淋巴瘤。據同一消息來源稱,2020 年全球報告了約 474,519 例白血病病例和約 176,404 例多發性骨髓瘤病例。原位雜交是研究癌症相關基因表現變化和染色體異常的有價值的工具,有助於發現潛在的診斷指標和治療幹預目標,從而推動市場成長。
愛滋病毒和肝炎等傳染病的增加也是原位雜交 (ISH) 市場的主要驅動力。原位雜交 (ISH) 結合實驗室醫學和分子遺傳技術來檢測傳染性病原體。螢光原位雜交 (FISH) 特別適用於在保持細胞結構完整性的同時識別和定位不同樣本中的核甘酸序列。根據2022年世界衛生組織(WHO)的公告,預計2022年全球將有約3.54億人感染B型肝炎或C型肝炎。
政府的支持和資助旨在最大限度地發揮罕見疾病夥伴關係的價值,其總體目標是提高罕見疾病領域的研究和創新水平。例如,2023 年 9 月,英國研究和創新部門將總投資約 7.985 億美元(6.27 億英鎊),涵蓋一系列旨在推進罕見疾病研究的措施。值得注意的是,2016 年至 2021 年期間,MRC 獎學金和 NIHR 職業發展獎已獲得 1.269 億美元(9,970 萬英鎊)的撥款,展現了圍繞罕見疾病研究工作的全面支持網絡。
本報告概述了全球原位雜交市場,包括按產品類型、技術、應用、最終用戶、區域趨勢和公司概況劃分的市場概述。
In Situ Hybridization Market by Product Type (Instruments, Reagents & Kits, and Software), Technology (Fluorescence In Situ Hybridization (FISH), Chromogenic In Situ Hybridization (CISH), and Others), Application (Cancer Diagnosis, Genetic Diseases, Infectious Diseases, and Others), End-User (Hospitals and Clinics, Diagnostic Centers, Pharmaceutical and Biotechnology Companies, Academic and Research Institutes, and Others), and Geography (North America, Europe, Asia-Pacific, and Rest of the World) is expected to grow at a steady CAGR forecast till 2032 owing to the growing prevalence of cancer and genetic diseases and increasing incidences of neurological disorders and infectious disease
The in situ hybridization market was valued at USD 1,673.55 million in 2024, growing at a CAGR of 7.12% during the forecast period from 2025 to 2032 to reach USD 2,886.13 million by 2032. The demand for in situ hybridization is witnessing a notable surge, driven predominantly by the escalating prevalence of cancer and genetic diseases. Additionally, the upward trend in neurological disorders and infectious diseases further fuels this demand. Coupled with this, the intensifying R&D activities and funding are pivotal factors propelling the positive growth trajectory of the in situ hybridization market. This growth trend is expected to persist and flourish throughout the forecast period spanning from 2025 to 2032.
In Situ Hybridization Market Dynamics:
ISH is used to diagnose congenital diseases such as Down's syndrome and Edward's Syndrome. It enables researchers to analyze how certain genes are expressed in tissues or organs, shedding light on their involvement in developmental processes, diseases, and physiological functions. Therefore, the rising number of people affected by genetic or some kind of rare disease is expected to contribute to the growth of the market. For instance, a report by the World Economic Forum in February 2023, stated that approximately 475 million individuals were suffering from rare conditions in 2019 which comprised 10% of the global population. Within the upcoming five years, it was anticipated that around 15.2 million people were expected to undergo clinical genomic testing specifically aimed at identifying rare conditions.
According to an article shared by Johnson & Johnson in February 2023, the estimate suggests that over 300 million individuals were affected with rare diseases as of 2023 globally. Fluorescence in situ hybridization (FISH) is a genetic testing technique used by pathologists to aid in diagnosing diseases attributed to chromosomal abnormalities. Therefore, the growing genetic and rare diseases contribute to the extensive use of in situ hybridization which is expected to drive the market growth.
According to data cited by the World Health Organization in 2022, around 2.26 million cases of breast, 2.21 million cases of lung, 1.93 million cases of colon and rectum, 1.41 million cases of prostate, and 1.09 million cases of stomach cancer were reported in 2020 around the world.
As per data published by Global Cancer Observatory in 2021, around 544,352 cases of non-Hodgkin lymphoma and 83,087 cases of Hodgkin lymphoma were reported in 2020 worldwide. As per the same source, around 474,519 leukemia cases and nearly 176,404 cases of multiple myeloma were reported in 2020 across the globe. In situ hybridization serves as a valuable tool in examining changes in gene expression or chromosomal irregularities linked to cancer, aiding in the discovery of potential diagnostic indicators and targets for therapeutic intervention, thereby driving market growth.
The rising cases of infectious diseases such as HIV, hepatitis, and others is another key driver for the in situ hybridization (ISH) market. In situ hybridization (ISH) amalgamates laboratory medicine with molecular genetics technology to detect infectious pathogens. Fluorescence in situ hybridization (FISH) specifically aids in identifying and pinpointing nucleotide sequences within diverse samples, all while maintaining the integrity of cellular structures. According to the World Health Organization (WHO) 2022, it was estimated that around 354 million people were living with Hepatitis B or C infections in 2022 globally.
Government support and funding are directed towards maximizing the value derived from the Rare Diseases Partnership, with the overarching goal of fostering increased levels of research and innovation in the field of rare diseases. For instance, in September 2023, UK Research and Innovation, the investment, totaling nearly USD 798.5 million (GBP 627 million), encompasses various initiatives aimed at advancing rare disease research. Notably, USD 126.9 million (GBP 99.7 million) had been allocated to MRC fellowships and NIHR career development awards between 2016 and 2021, illustrating the comprehensive support network surrounding rare disease research efforts.
However, the in situ hybridization market may face growth constraints due to various factors, including the inefficiency of detecting DNA level rearrangements and chromosome pairs and concerns regarding potential exposure to radioactivity.
In Situ Hybridization Market Segment Analysis:
In Situ Hybridization Market by Product Type (Instruments, Reagents & Kits, and Software), Technology (Fluorescence In Situ Hybridization (FISH), Chromogenic In Situ Hybridization (CISH), and Others), Application (Cancer Diagnosis, Genetic Diseases, Infectious Diseases, and Others), End-User (Hospitals and Clinics, Diagnostic Centers, Pharmaceutical and Biotechnology Companies, Academic and Research Institutes, and Others), and Geography (North America, Europe, Asia-Pacific, and Rest of the World)
In the technology segment of the in situ hybridization market, the fluorescence in situ hybridization (FISH) category is estimated to account for a significant revenue share in the in situ hybridization market in 2024. This is attributed to the growing use of FISH in cancer diagnosis and research. In oncology, FISH is utilized to identify genetic changes linked with cancer, including gene amplifications, deletions, and rearrangements of chromosomes. Fluorescence in situ hybridization (FISH) is mainly used in the diagnosis, categorization, prognosis, and anticipation of treatment outcomes in cancer patients.
The application of FISH spans a broad spectrum of scientific disciplines, including genetic counseling, subcellular studies, detection and localization of chromosome mutations, species identification, biomedical research, clinical diagnosis, toxicology, chromosomal biology, and comparative genomics.
Key players in the market are developing innovative kits and reagents for fluorescence in situ hybridization (FISH) procedures. For instance, in December 2021, BioGenex, a US-based molecular pathology company launched NanoVIP. NanoVIP is a compact, fully automated bench-top system equipped with visualization kits designed for fluorescence in situ hybridization (FISH) and in-situ hybridization (ISH). Its 10-slide design ensures reliability through automation, featuring eXACT(TM) temperature control modules for individual slide positions, precise management of reaction times, and liquid level sensors for accurate liquid handling. This meticulous control ensures the delivery of clean, intense, reliable, and reproducible stains, minimizing the need for repeat procedures.
Further, in cellular biology and neuroscience, scientists utilize techniques such as fluorescence in situ hybridization (FISH) to investigate the expression, localization, and dynamics of genes within cells and tissues. This method allows for the visualization of specific genes or RNA molecules in various cell types including neuronal cells, glial cells, and others. By studying gene expression patterns and their spatial distribution, researchers gain valuable insights into brain function, development, and the underlying mechanisms of neurological disorders. Additionally, FISH can aid in the diagnosis of genetic disorders by enabling the visualization of specific chromosomal regions or genes associated with these conditions. Therefore, the wide applications of the fluorescence in situ hybridization (FISH) category is expected to contribute to the growth of the segment, thereby driving the growth of the in situ hybridization market during the forecast period.
North America is expected to dominate the Overall In-Situ Hybridization Market:
North America is estimated to dominate the in situ hybridization market in 2024. This is attributed to the growing prevalence of cancer and rare genetic diseases. In situ hybridization (ISH) stands as a pivotal tool in cancer research and diagnosis, facilitating the detection of gene expression and genetic abnormalities linked with cancer. These capabilities significantly contribute to the growth of the market in the region. Moreover, the escalating number of molecular diagnostics tests conducted in the region further propels the expansion of the North America in situ hybridization market.
Fluorescence in situ hybridization (FISH) is a diagnostic test that maps the genetic material within human cells, pinpointing specific genes or gene segments. Due to its capability to detect genetic abnormalities linked to cancer, FISH serves as a valuable tool in diagnosing certain types of the disease. For instance, according to the National Cancer Institute 2020, it was estimated that around 1,806,590 cancer cases were diagnosed in the year 2020 in the United States.
According to the Centers for Disease Control and Prevention (CDC) in May 2024, approximately 5,700 babies were born with Down syndrome each year in the United States. This equates to a prevalence of about 1 in every 640 babies. In situ hybridization is used to identify an extra chromosome or an extra piece of a chromosome for diagnosis of Down syndrome. Therefore, the growing prevalence of rare and genetic diseases is expected to drive the market growth in the region.
In Situ Hybridization Market Key Players:
Some of the key market players operating in the in situ hybridization market include Abbott Laboratories, Agilent Technologies, Inc., Thermo Fisher Scientific Inc., F. Hoffmann-La Roche Ltd, Merck & Co., Inc., PerkinElmer Inc., Sysmex Corporation, Biocare Medical, LLC, Genemed Biotechnologies, Inc., NeoGenomics Laboratories, Advanced Cell Diagnostics, Inc., BioView, Bio-Rad Laboratories, Inc., Bio-Techne, QIAGEN, BioGenex, ZYTOVISION GmbH, Promega Corporation, Illumina, Inc., Danaher Corporation, and others.
Recent Developmental Activities in the In-Situ Hybridization Market:
Key Takeaways from the In Situ Hybridization Market Report Study
TARGET AUDIENCE WHO CAN BE BENEFITED FROM THIS IN SITU HYBRIDIZATION MARKET REPORT STUDY
FREQUENTLY ASKED QUESTIONS FOR THE IN SITU HYBRIDIZATION MARKET: