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1588570

全球 3D 水凝膠培養市場 - 2024-2031

Global 3D Hydrogel Culture Market - 2024-2031

出版日期: 2024年11月08日 | 出版商:

DataM Intelligence | 英文 182 Pages | 商品交期: 最快1-2個工作天內

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簡介目錄

概述

2023年，全球3D水凝膠培養市場規模達15.8億美元，預估至2031年將達43.6億美元，2024-2031年預測期間複合年成長率為13.5%。

3D 水凝膠細胞培養是一種在模擬自然細胞外環境的3D (3D) 水凝膠基質中培養細胞的先進方法。水凝膠是交聯的親水性聚合物網路，能夠吸收大量的水，同時保持其結構完整性。

在這項技術中，細胞嵌入水凝膠基質中，使它們能夠在所有三個維度上與周圍環境相互作用，類似於它們在活組織中的行為。此設定提供了比傳統2D (2D) 細胞培養物更生理相關的模型，因為它更準確地反映了體內發生的細胞與其細胞外基質 (ECM) 之間的複雜相互作用。

用於 3D 細胞培養的水凝膠可以源自天然材料，例如膠原蛋白、纖維蛋白和藻酸鹽，也可以是合成材料，例如聚乙二醇 (PEG) 和聚丙烯醯胺。這些水凝膠可以透過改變其成分、硬度和孔隙率來客製化以複製特定的組織特徵。這種適應性對於研究和醫學的各種應用至關重要，包括癌症研究、幹細胞研究、組織工程和藥物發現。

市場動態：

司機

技術進步

全球3D水凝膠培養市場的需求是由多種因素所驅動的。主要因素之一是技術進步。水凝膠配方及其應用的創新，特別是 JellaGel Hydrogel 等產品的出現，在 3D 水凝膠培養市場的擴張中發揮關鍵作用。 JellaGel 由水母膠原蛋白製成，為研究人員提供了一種新穎的非哺乳動物替代品，可滿足細胞培養中對可靠且一致材料不斷成長的需求。

此外，該行業的主要參與者更加關注研發活動和產品發布，這將推動 3D 水凝膠培養市場的成長。例如，2024 年 6 月，印度科學研究所 (IISc) 生物工程系 (BE) 的研究人員開發了一種創新的 3D 水凝膠培養系統，可以緊密複製哺乳動物的肺部環境。

此外，2023 年6 月，新型生物相容性水凝膠樹脂的推出代表了生物列印領域的關鍵時刻，標誌著一個新時代的開始，該時代的特點是創建複雜、高解析度生物結構的能力增強。這種創新樹脂有利於 2 光子聚合 (2PP)，這是一種尖端的 3D 列印技術，可以精確製造從微米到介觀尺度的結構。

限制

高生產成本、原料供應有限以及嚴格的監管要求等因素預計將阻礙市場發展。

3D hydrogel cell culture is an advanced method for cultivating cells within a three-dimensional (3D) hydrogel matrix that simulates the natural extracellular environment. Hydrogels are networks of cross-linked, hydrophilic polymers capable of absorbing significant amounts of water while retaining their structural integrity.

In this technique, cells are embedded within the hydrogel matrix, enabling them to interact with their surroundings in all three dimensions, akin to their behavior in living tissues. This setup offers a more physiologically relevant model than traditional two-dimensional (2D) cell cultures, as it more accurately reflects the intricate interactions between cells and their extracellular matrix (ECM) that occur in vivo.

The hydrogels used for 3D cell culture can be sourced from natural materials such as collagen, fibrin, and alginate, or they can be synthetic, like polyethylene glycol (PEG) and polyacrylamide. These hydrogels can be customized to replicate specific tissue characteristics by modifying their composition, stiffness, and porosity. This adaptability is crucial for various applications in research and medicine, including cancer studies, stem cell research, tissue engineering, and drug discovery.

Market Dynamics: Drivers

Technological advancements

The demand for the global 3D hydrogel culture market is driven by multiple factors. One of the primary factors is the technological advancements. Innovations in hydrogel formulations and their applications, particularly with the emergence of products like JellaGel Hydrogel, are playing a pivotal role in the expansion of the 3D hydrogel culture market. JellaGel, made from jellyfish collagen, provides researchers with a novel non-mammalian alternative that meets the growing demand for reliable and consistent materials in cell culture.

Moreover, key players in the industry more focus on R&D activities and product launches that would drive this 3D hydrogel culture market growth. For instance, in June 2024, researchers from the Department of Bioengineering (BE) at the Indian Institute of Science (IISc) developed an innovative 3D hydrogel culture system that closely replicates the mammalian lung environment.

Also, in June 2023, the launch of a new biocompatible hydrogel resin represents a pivotal moment in the field of bioprinting, marking the beginning of a new era characterized by enhanced capabilities in creating complex, high-resolution bio-structures. This innovative resin facilitates 2-photon polymerization (2PP), a cutting-edge 3D printing technology that allows for the precise fabrication of structures ranging from the micro- to mesoscale.

Restraints

Factors such as high production costs, limited availability of raw materials, and stringent regulatory requirements, are expected to hamper the market.

Segment Analysis

The global 3D hydrogel culture market is segmented based on product, application, end-user, and region.

The scaffold based segment accounted for approximately 52.1% of the global 3D hydrogel culture market share

The scaffold based segment is expected to hold the largest market share over the forecast period. Scaffold-based 3D hydrogel cell cultures utilize scaffolds to provide essential physical support for cells, enabling them to aggregate, proliferate, and migrate effectively. Traditionally, cells have been cultured on extracellular matrix (ECM) proteins in two-dimensional (2D) environments; however, this approach often fails to accurately replicate the complexities of the in vivo environment.

scaffold-based 3D hydrogel cultures allow cells to be embedded within a supportive matrix, which means that the characteristics of the scaffold material can significantly influence cellular behavior. Therefore, it is crucial to select the most appropriate scaffold for your specific application to ensure it aligns well with the requirements of drug screening and development processes.

Moreover, key player's strategies such as partnerships & collaborations, and research activities would drive this segment growth in the 3D hydrogel culture market. For instance, in April 2022, Cell Guidance Systems Ltd, a company specializing in the control, manipulation, and monitoring of cells both in vitro and in vivo, partnered with Manchester BIOGEL, a biotechnology firm focused on designing and manufacturing 3D synthetic peptide hydrogels, to introduce PODS-PeptiGels. This new kit integrates the advantages of two innovative cell culture technologies: synthetic peptide hydrogels (PeptiGels) and a selection of sustained-release growth factors (PODS). The collaboration aims to provide researchers with a reproducible and highly adaptable environment for 3D cell culture, enhancing experimental flexibility and reliability.

Similarly, in a research publication in Frontiers in May 2022, scaffold-based 3D hydrogel cultures, 3D bioprinting, and ECM-based bioinks present promising opportunities for replicating native tissue architectures, but several significant challenges persist. To fully realize the potential of this technology and enable its application in clinical environments, it is crucial to tackle these issues through dedicated research and interdisciplinary collaboration. This approach will help transform healthcare and enhance the quality of life for patients.

Geographical Analysis

North America accounted for approximately 44.6% of the global 3D hydrogel culture market share

North America region is expected to hold the largest market share over the forecast period owing to the growing prevalence of chronic diseases, including diabetes, cardiovascular conditions, and obesity, which has led to an increased demand for effective treatment solutions. Hydrogel-based products are being increasingly adopted for their therapeutic advantages in addressing these issues, especially in areas like wound care and drug delivery systems.

Moreover, in this region, a major number of key player's presence, well-advanced healthcare infrastructure, strong investment in research and development, favorable regulatory environment, and technological advancements help to propel this 3D hydrogel culture market growth. For instance, in December 2021, Inventia Life Science, an Australian specialist in 3D bioprinting, successfully closed a Series B funding round, raising $25 million (USD).

This funding was led by Blackbird Ventures and supported by long-time investor Skip Capital, bringing the company's total funding to $32 million. With this new capital, Inventia Life Science plans to accelerate the rollout of its flagship product, the RASTRUM 3D bioprinter. A key focus of this expansion will be in the U.S. market, where Inventia sees significant potential. The company estimates that the biomedical research and drug discovery sector in the U.S. is worth over $40 billion, indicating a substantial opportunity for their technology.

Market Segmentation

By Product

Scaffold Based
- Hydrogels
- Polymeric Scaffolds
- Micropatterned Surface Microplates
- Nanofiber Based Scaffolds
Scaffold Free
- Hanging Drop Microplates
- Spheroid Microplates with ULA coating
- Magnetic Levitation
Bioreactors
Microfluidic
Bioprinting

By Application

Cancer Research
Stem Cell Research & Tissue Engineering
Drug Discovery & Toxicology Testing
Others

By End-User

Pharmaceutical & Biotechnology Companies
Academic & Research Institutes
Hospitals
Others

By Region

North America
- U.S.
- Canada
- Mexico
Europe
- Germany
- U.K.
- France
- Spain
- Italy
- Rest of Europe
South America
- Brazil
- Argentina
- The rest of South America
Asia-Pacific
- China
- India
- Japan
- South Korea
- Rest of Asia-Pacific
Middle East and Africa

Competitive Landscape

The major global 3D hydrogel culture market players include Corning Incorporated, Thermo Fisher Scientific, Inc., Lonza., Merck KGaA, Advanced BioMatrix, 3D Biotek LLC., PromoCell GmbH, Avantor, Inc., MIMETAS, and CN Bio Innovations Ltd, among others.

Key Developments

In May 2023, AMSBIO announced the launch of MatriMix, an innovative 3D culture substrate designed to advance cell biology and tissue engineering research. This innovative hydrogel is notable for its fully defined components, which include medical-grade collagens, laminin-511 E8 fragments, and hyaluronic acid.
In July 2022, Dolomite Bio launched new hydrogel-focused reagent kits designed to facilitate the high-throughput encapsulation of cells within hydrogel scaffolds. The two kits, named nadAROSE and nadi3D, specifically cater to researchers working on projects involving both agarose encapsulation and collagen-based hydrogels in the realm of 3D cell culture.

Why Purchase the Report?

To visualize the global 3D hydrogel culture market segmentation based on product, application, end-user, and region and understand key commercial assets and players.
Identify commercial opportunities by analyzing trends and co-development.
Excel data sheet with numerous data points of the 3D hydrogel culture market with all segments.
PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
Product mapping is available in excel consisting of key products of all the major players.

The global 3D hydrogel culture market report would provide approximately 62 tables, 56 figures, and 182 pages.

Target Audience 2023

Manufacturers/ Buyers
Industry Investors/Investment Bankers
Research Professionals
Emerging Companies

1. Methodology and Scope

1.1. Research Methodology
1.2. Research Objective and Scope of the Report

2. Definition and Overview

3. Executive Summary

3.1. Snippet by Product
3.2. Snippet by Application
3.3. Snippet by End-User
3.4. Snippet by Region

4. Dynamics

4.1. Impacting Factors
- 4.1.1. Drivers
  - 4.1.1.1. Technological Advancements
- 4.1.2. Restraints
  - 4.1.2.1. High Production Cost
- 4.1.3. Opportunity
- 4.1.4. Impact Analysis

5. Industry Analysis

5.1. Porter's Five Force Analysis
5.2. Supply Chain Analysis
5.3. Pricing Analysis
5.4. Regulatory Analysis

6. By Product

6.1. Introduction
- 6.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 6.1.2. Market Attractiveness Index, By Product
6.2. Scaffold Based *
- 6.2.1. Introduction
- 6.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
- 6.2.3. Hydrogels
- 6.2.4. Polymeric Scaffolds
- 6.2.5. Micropatterned Surface Microplates
- 6.2.6. Nanofiber Based Scaffolds
6.3. Scaffold Free
- 6.3.1. Hanging Drop Microplates
- 6.3.2. Spheroid Microplates with ULA coating
- 6.3.3. Magnetic Levitation
6.4. Bioreactors
6.5. Microfluidic
6.6. Bioprinting

7. By Application

7.1. Introduction
- 7.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 7.1.2. Market Attractiveness Index, By Application
7.2. Cancer Research*
- 7.2.1. Introduction
- 7.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
7.3. Stem Cell Research & Tissue Engineering
7.4. Drug Discovery & Toxicology Testing
7.5. Others

8. By End-User

8.1. Introduction
- 8.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 8.1.2. Market Attractiveness Index, By End-User
8.2. Pharmaceutical & Biotechnology Companies *
- 8.2.1. Introduction
- 8.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
8.3. Academic & Research Institutes
8.4. Hospitals
8.5. Others

9. By Region

9.1. Introduction
- 9.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Region
- 9.1.2. Market Attractiveness Index, By Region
9.2. North America
- 9.2.1. Introduction
- 9.2.2. Key Region-Specific Dynamics
- 9.2.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.2.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.2.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 9.2.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 9.2.6.1. U.S.
  - 9.2.6.2. Canada
  - 9.2.6.3. Mexico
9.3. Europe
- 9.3.1. Introduction
- 9.3.2. Key Region-Specific Dynamics
- 9.3.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.3.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.3.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 9.3.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 9.3.6.1. Germany
  - 9.3.6.2. U.K.
  - 9.3.6.3. France
  - 9.3.6.4. Spain
  - 9.3.6.5. Italy
  - 9.3.6.6. Rest of Europe
9.4. South America
- 9.4.1. Introduction
- 9.4.2. Key Region-Specific Dynamics
- 9.4.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.4.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.4.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 9.4.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 9.4.6.1. Brazil
  - 9.4.6.2. Argentina
  - 9.4.6.3. Rest of South America
9.5. Asia-Pacific
- 9.5.1. Introduction
- 9.5.2. Key Region-Specific Dynamics
- 9.5.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.5.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.5.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
- 9.5.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
  - 9.5.6.1. China
  - 9.5.6.2. India
  - 9.5.6.3. Japan
  - 9.5.6.4. South Korea
  - 9.5.6.5. Rest of Asia-Pacific
9.6. Middle East and Africa
- 9.6.1. Introduction
- 9.6.2. Key Region-Specific Dynamics
- 9.6.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product
- 9.6.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Application
- 9.6.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User

10. Competitive Landscape

10.1. Competitive Scenario
10.2. Market Positioning/Share Analysis
10.3. Mergers and Acquisitions Analysis

11. Company Profiles

11.1. Corning Incorporated *
- 11.1.1. Company Overview
- 11.1.2. Product Portfolio and Description
- 11.1.3. Financial Overview
- 11.1.4. Key Developments
11.2. Thermo Fisher Scientific, Inc.
11.3. Lonza.
11.4. Merck KGaA
11.5. Advanced BioMatrix
11.6. 3D Biotek LLC.
11.7. PromoCell GmbH
11.8. Avantor, Inc.
11.9. MIMETAS
11.10. CN Bio Innovations Ltd

LIST NOT EXHAUSTIVE