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市場調查報告書
商品編碼
1519373
2024-2032 年按類型、疾病類型、分子類型、藥物類型、給藥途徑、配銷通路和地區分類的潰瘍性結腸炎市場報告Ulcerative Colitis Market Report by Type, Disease Type, Molecule Type, Drug Type, Route of Administration, Distribution Channel, and Region 2024-2032 |
2023年全球潰瘍性結腸炎IMARC Group規模達78億美元。由於疾病盛行率上升、醫療進步、政府支持政策以及全球意識的提高,潰瘍性結腸炎市場正在擴大,這些都推動了發達和發展中地區對創新療法的需求。
主要市場促進因素:全球潰瘍性結腸炎數量激增,以及人們對發炎性腸道疾病存在的認知,刺激了患者對創新治療和診斷方法的需求。此外,技術進步、生物製劑的擴展和新療法的發明加強了市場發展。已開發國家和發展中國家不斷成長的醫療保健支出也促進了市場擴大。
主要市場趨勢:治療潰瘍性結腸炎的個人化醫療趨勢日益明顯,強調基於遺傳、環境和表現型特徵的客製化治療方法。此外,擴大採用生物製劑和生物相似藥來治療重症病例,正在顯著影響該市場製藥業的方向。
地理趨勢:由於先進的醫療設施、高醫療支出和成熟的製藥公司,北美引領潰瘍性結腸炎市場。然而,鑑於以中國和印度等地區為中心的醫療設施、患者意識和醫療旅遊的增加,預計亞太地區將以顯著的速度發展。
競爭格局:潰瘍性結腸炎產業的一些主要市場參與者包括雅培實驗室、艾伯維公司、阿斯特捷利康公司、百時美施貴寶公司、禮來公司、羅氏有限公司、葛蘭素史克公司、強生公司強生、默克、輝瑞、武田製藥有限公司及梯瓦製藥工業有限公司等。
挑戰與機會:市場的主要挑戰是治療成本高昂,這可能會對低收入國家的取得造成障礙,特別是在涉及生物製劑時。另一個因素是勞動密集且漫長的藥物核准過程,這可能會延遲新療法進入市場。儘管挑戰很嚴峻,但挑戰可以成為機會的基礎。開發具有成本效益的療法並簡化核准流程可以使全球企業受益。
潰瘍性結腸炎的盛行率增加
潰瘍性結腸炎盛行率的成長以及人們對發炎性腸道疾病存在的認知的傳播刺激了患者對創新治療和診斷方法的需求。此外,技術進步、生物製劑的擴展和新療法的發明加強了市場發展。已開發國家和發展中國家不斷成長的醫療保健支出也促進了市場擴大。根據國家醫學圖書館的數據,潰瘍性結腸炎的發生率為每年每 10 萬人中 9 至 20 例。其盛行率為每年每 10 萬人 156 至 291 例。
醫學治療的進步
隨著生物製劑和小分子藥物的發展,潰瘍性結腸炎的醫學治療取得了長足的進展。這項進展所帶來的正面精神,創造了更多有利的市場相關因素。一方面,診斷技術的進步和新的標靶治療方法的開發對市場產生了積極影響,因為更有效的治療方法的開發推動了採用率的增加。例如,輝瑞公司於2023 年宣布,美國食品藥物管理局(FDA) 已批准VELSIPITY(TM) (etrasimod),這是一種口服、每日一次的選擇性1-磷酸鞘氨醇(S1P) 受體調節劑,用於成人中度至重度活動性潰瘍性結腸炎(UC)。
政府和監管支持
有利的政府政策和醫療保健支出的增加極大地影響了潰瘍性結腸炎市場的成長。隨著監管部門的批准促進新的有效藥物快速進入市場,患者可以獲得先進的治療選擇。此外,一些政府增加了研發資金,鼓勵製藥公司投資潰瘍性結腸炎的創新療法,這進一步刺激了市場成長。
The global ulcerative colitis market size reached US$ 7.8 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 12.2 Billion by 2032, exhibiting a growth rate (CAGR) of 5.02% during 2024-2032. The ulcerative colitis market is expanding due to rising disease prevalence, advancements in medical treatments, supportive government policies, and increasing global awareness, which drive the demand for innovative therapies in developed and developing regions.
Major Market Drivers: The surging number of ulcerative colitis globally, and the awareness about the existence of inflammatory bowel diseases, stimulate the demand for innovative treatments and diagnostic methods among patients. In addition, technological progress, the expansion of biologics and the invention of new therapies intensify market development. The growing expenditure on healthcare in developed and developing countries also promotes market enlargement.
Key Market Trends: There is an increasing trend toward personalized medicine in treating ulcerative colitis, emphasizing customized therapeutic methods based on genetic, environmental, and phenotypic characteristics. Furthermore, the increased adoption of biologics and biosimilars for managing severe cases is significantly influencing the direction of the pharmaceutical industry in this market.
Geographical Trends: North America leads the ulcerative colitis market due to advanced healthcare facilities, high healthcare expenditure, and established pharmaceutical companies. However, Asia Pacific is anticipated to develop at a significant rate, given the increased health facilities, patient awareness, and medical tourism centering the region, such as China and India.
Competitive Landscape: Some of the major market players in the ulcerative colitis industry include Abbott Laboratories, AbbVie Inc., AstraZeneca plc, Bristol-Myers Squibb Company, Eli Lilly and Company, F. Hoffmann-La Roche Ltd., GlaxoSmithKline plc, Johnson & Johnson, Merck & Co. Inc., Pfizer Inc., Takeda Pharmaceutical Company Limited, and Teva Pharmaceutical Industries Ltd. among many others.
Challenges and Opportunities: The primary challenge of the market is the high cost of treatment, which may create barriers to access in low-income countries, particularly when biologics are involved. Another factor is the labor-intensive and lengthy drug approval process, which could delay new treatments from entering the market. Despite its severity, the challenge can serve as a basis for opportunities. Developing cost-effective therapies and streamlining the approval process can become beneficial for businesses across the globe.
Increasing Prevalence of Ulcerative Colitis
The growth in the prevalence of ulcerative colitis, as well as the spread of awareness about the existence of inflammatory bowel diseases, stimulates the demand for innovative treatments and diagnostic methods among patients. In addition, technological progress, the expansion of biologics, and the invention of new therapies intensify market development. The growing expenditure on healthcare in developed and developing countries also promotes market enlargement. According to the NATIONAL LIBRARY OF MEDICINE, ulcerative colitis has an incidence of 9 to 20 cases per 100,000 persons per year. Its prevalence is 156 to 291 cases per 100,000 persons per year.
Advancements in Medical Treatments
Medical treatment of ulcerative colitis has come a long way with the development of biologics and small-molecule drugs. The positive spirit brought about by this progress has created more favorable market-related factors. On the one hand, advances in diagnostic technologies and the development of new targeted treatment approaches have positively affected the market due to increased adoption driven by the development of more effective treatments. For instance, Pfizer Inc. in 2023 announced that the U.S. Food and Drug Administration (FDA) has approved VELSIPITY(TM) (etrasimod), an oral, once-daily, selective sphingosine-1-phosphate (S1P) receptor modulator for adults with moderately to severely active ulcerative colitis (UC).
Government and Regulatory Support
Favorable government policies and increased healthcare spending significantly impact the ulcerative colitis market growth. With regulatory approvals facilitating the rapid market entry of new and effective drugs, patients gain access to advanced treatment options. Additionally, several governments have ramped up funding for research and development, encouraging pharmaceutical companies to invest in innovative therapies for ulcerative colitis, which further stimulates market growth.
IMARC Group provides an analysis of the key trends in each segment of the market, along with forecasts at the global, regional, and country levels for 2024-2032. Our report has categorized the market based on type, disease type, molecule type, drug type, route of administration, and distribution channel.
Mild UC
Moderate UC
Severe UC
Mild UC accounts for the majority of the market share
The report has provided a detailed breakup and analysis of the market based on the type. This includes mild UC, moderate UC, and severe UC. According to the report, mild UC represented the largest segment.
The mild ulcerative colitis segment dominates owing to the greater prevalence of mild cases compared to moderate and severe forms. Patients with mild UC generally experience fewer symptoms, which can typically be managed with oral medications, such as aminosalicylates. It benefits from numerous first-line treatment options that are less expensive and have fewer side effects, making them accessible and favored by patients and healthcare providers. The availability of effective and affordable treatments contributes significantly to the dominance of this segment in increasing the overall ulcerative colitis market demand. Mild ulcerative colitis is treated with mesalamine (5-aminosalicylic acid, 5-ASA) and other UC medications across all countries. As per the American College of Gastroenterology (ACG) treatment instruction, ulcerative colitis (UC) is categorized as mild in patients who have fewer than four (4) bowel movements per day, minimal bleeding, and no appreciable urgency or abdominal pain. In comparative studies of 2.4 g and 4.8 g daily doses of mesalamine, it was found that patients with mild disease will improve with 2.4 g and 4.8 g doses of mesalamine.
Ulcerative Proctitis
Proctosigmoiditis
Left-sided Colitis
Pancolitis or Universal Colitis
Fulminant Colitis
Ulcerative proctitis holds the largest share in the industry
A detailed breakup and analysis of the market based on the disease type have also been provided in the report. This includes ulcerative proctitis, proctosigmoiditis, left-sided colitis, pancolitis or universal colitis, and fulminant colitis. According to the report, ulcerative proctitis accounted for the largest market share.
Ulcerative proctitis is considered the mildest due to the inflammation being confined to the rectum. Patients usually experience such symptoms as rectal bleeding, urgency, and tenesmus. As per the study by Matthew Mutch, in Shackelford's Surgery of the Alimentary Tract, 2 Volume Set (Eighth Edition), 2019, patients with ulcerative pancolitis for more than 8 years are at higher risk of colorectal cancer, with the risk ranging from 0.5% to 1% per year. The localized nature of symptoms is why it is easier to treat the condition with medicines that require the closest interaction with the perished area rather than using more invasive and less patient-friendly systemic treatment. The focused treatment combines fewer systemic side effects, which is why patients prefer using suppositories or enemas as treatment. Facing better treatment opportunities, patients with ulcerative proctitis have a very good prognosis. Hence, the demand for quality treatments is growing.
Small Molecules
Biologics
Biologics represents the leading market segment
The report has provided a detailed breakup and analysis of the market based on the molecule type. This includes small molecules and biologics. According to the report, biologics represented the largest segment.
Biologics represent the largest segment in the market. The key reasons for the popularity of this therapy type involve its high efficiency in reducing inflammation and achieving and maintaining remission in patients suffering from moderate to severe disease. These protein-containing drugs work by aiming at particular parts of the immune system that encourage developing inflammation in the body. The increasing demand for biologics is explained by the growing number of approvals and biosimilars, which will make these drugs more available and less costly. For illustration purposes, in March 2024, Johnson & Johnson unveiled the submission of a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration pursuing approval of TREMFYA(R) (guselkumab) to treat adult patients with moderately to severely active ulcerative colitis. It is supported by data from the Phase 3 QUASAR program evaluating the efficacy and safety of TREMFYA(R) to treat patients with moderately to severely active UC who had an inadequate response or intolerance to traditional therapy, prior biologics and/or JAK inhibitors.
Anti-Inflammatory Drugs
Anti-TNF Biologics
Immunosuppressant
Calcineurin Inhibitors
Others
Anti-TNF biologics exhibits a clear dominance in the market
A detailed breakup and analysis of the market based on the drug type have also been provided in the report. This includes anti-inflammatory drugs, anti-TNF biologics, immunosuppressant, calcineurin inhibitors, and others. According to the report, anti-TNF biologics accounted for the largest market share.
The market is currently dominated by anti-TNF biologics, primarily due to their ability to control inflammation and sustain remission in patients with moderate-to-severe conditions. Anti-TNF biologics are accustomed to neutralizing the action of a protein in the body known as TNF that causes inflammation, making them a preferable option for patients who are not treated with monotherapy. In addition, the established success of anti-TNF biologics in patient quality of life would agree with these results, despite concerns about costs and side effects.
Oral
Injectable
Injectable dominates the market
The report has provided a detailed breakup and analysis of the market based on the route of administration. This includes oral and injectable. According to the report, injectables represented the largest segment.
Injectable medications hold a prominent position in the ulcerative colitis market revenue, primarily due to their capacity to deliver treatments directly to the bloodstream, effectively bypassing the digestive system. This category includes biologics such as infliximab and adalimumab, which are particularly used for moderate to severe cases. The preference for injectables stems from their rapid action and high efficacy, especially beneficial for patients who do not respond to oral medications. Additionally, the less frequent dosing requirement compared to oral medications enhances the appeal of injectables, making them a popular choice in managing ulcerative colitis and contributing to their substantial market share. Top of FormFor instance, in 2023, the Food and Drug Administration (FDA) indicated that the subcutaneous administration of vedolizumab is an approvable maintenance therapy for moderate to severe ulcerative colitis following intravenous infusion. It is the only FDA-approved biologic in ulcerative colitis maintenance therapy that is based on IV and SC dose-approved medication.
Hospital Pharmacies
Retail Pharmacies
Drug Store
Others
Hospital pharmacies are the predominant market segment
A detailed breakup and analysis of the market based on the distribution channel have also been provided in the report. This includes hospital pharmacies, retail pharmacies, drug store, and others. According to the report, hospital pharmacies accounted for the largest market share.
Hospital pharmacies constitute the largest segment in the ulcerative colitis market forecast. Their pivotal role in distributing treatments stems from their proximity to patient care settings and their responsibilities in administering and monitoring therapies. Hospitals are often the first to receive new drug approvals, positioning them as primary channels for distributing advanced therapeutics. This segment benefits from direct interactions with pharmaceutical manufacturers and often engages in price negotiations, which can significantly influence treatment accessibility and adoption rates among patients. For instance, the Apollo Hospital pharmacy business is about to touch 10,000 crore in revenue this year with 5,790 pharmacies, Apollo is the largest pharmacy chain, adding 400-500 stores each year.
North America
United States
Canada
Asia-Pacific
China
Japan
India
South Korea
Australia
Indonesia
Others
Europe
Germany
France
United Kingdom
Italy
Spain
Russia
Others
Latin America
Brazil
Mexico
Others
Middle East and Africa
North America leads the market, accounting for the largest ulcerative colitis market share
The market research report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa. According to the report, North America accounted for the largest market share.
North America dominates the ulcerative colitis market on account of the high occurrence of the disorder, superior medical facilities, and extensive funding for R&D activities. The American and Canadian health systems ensure the substantial usage of progressive treatments, and private insurance plans and campaigns further enhance the consumer understanding of products. Companies in the pharmaceutical and biotech sectors accelerate the development of innovative treatment methods. They integrate the most successful ones into their treatment protocols at an early stage, advancing the market. At present, ulcerative colitis has an incidence of 9 to 20 cases per 100,000 persons per year and 156 to 291 cases per 100,000 persons per year as per National Institute of Health (NIH). Ulcerative colitis market recent opportunities include numerous key players collaborating to expand their market growth. For instance, Teva Pharmaceuticals, a U.S. subsidiary of Teva Pharmaceuticals Industries Ltd., and Sanofi collaborated to create and co-commercialize asset TEV'574, to treat Ulcerative Colitis and Crohn's Disease.
The market research report has also provided a comprehensive analysis of the competitive landscape in the market. Detailed profiles of all major companies have also been provided. Some of the major market players in the keyword industry include Abbott Laboratories, AbbVie Inc., AstraZeneca plc, Bristol-Myers Squibb Company, Eli Lilly and Company, F. Hoffmann-La Roche Ltd., GlaxoSmithKline plc, Johnson & Johnson, Merck & Co. Inc., Pfizer Inc., Takeda Pharmaceutical Company Limited, Teva Pharmaceutical Industries Ltd.
(Please note that this is only a partial list of the key players, and the complete list is provided in the report.)
Leading players in the ulcerative colitis market recent developments include the development of advanced biologics and small molecule therapies, improved drug delivery systems, and expansion into untapped markets. The leading players are also involved in strategic initiatives such as partnerships, mergers, acquisitions, and increasing investment in research and innovation to enhance treatment efficacies. These efforts are aimed at boosting market share and addressing the unmet needs in ulcerative colitis management. Besides this, Pfizer Inc. unveiled that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion for VELSIPITY(TM) (etrasimod), an oral, once-daily, selective sphingosine-1-phosphate (S1P) receptor modulator. This medication is intended for the treatment of patients aged 16 and older with moderately to severely active ulcerative colitis (UC) who have had an inadequate response, lost response, or were intolerant to either conventional therapy or a biological agent.
November 2021: Bristol Myers Squibb received European Commission approval for Zeposia (ozanimod) for the treatment of adults with moderately to severely active ulcerative colitis.Top of Form
March 2024: AbbVie Inc., and Landos Biopharma Inc. unveiled that AbbVie entered into a definitive agreement that provides for the acquisition of Landos, a clinical-stage biopharmaceutical corporation keen on developing advanced novel oral therapeutics for individuals with autoimmune disorders.