市場調查報告書
商品編碼
1540908
2024-2032 年按產品、應用(PCR 引子、PCR 測定和麵板、定序、DNA 微陣列、螢光原位雜合技術、反義寡核苷酸等)、最終用途和區域分類的寡核苷酸合成市場報告Oligonucleotide Synthesis Market Report by Product, Application (PCR Primers, PCR Assays and Panels, Sequencing, DNA Microarrays, Fluorescence In-Situ Hybridization, Antisense Oligonucleotides, and Others), End Use, and Region 2024-2032 |
IMARC Group年全球寡核苷酸合成市場規模達30億美元。遺傳性疾病在大眾中的日益流行、新型治療策略的開發以及使用小干擾 RNA (siRNA) 和反義寡核苷酸的療法的廣泛採用是推動市場的一些主要因素。
寡核苷酸合成是指依照預定序列建構短 DNA 或 RNA 分子(稱為寡核苷酸)的過程。它們的長度範圍可以從幾個鹼基到大約 200 個核苷酸。該過程是在受控實驗室環境中以化學方式完成的,通常使用固相亞磷醯胺化學。在這種方法中,核苷酸被順序添加到不斷成長的鏈中,每次添加都涉及一系列化學反應。該技術使科學家能夠產生用於各種應用的客製化寡核苷酸,包括基因合成、聚合酶鍊式反應 (PCR)、基因編輯工具(如 CRISPR-Cas9)和分子診斷測試。寡核苷酸合成的進步極大地加速了基因組學和分子生物學的研究,為醫學和生物學研究的許多突破奠定了基礎。
大眾遺傳疾病盛行率的上升主要推動了全球市場。這就需要開發新的治療策略,其中基於寡核苷酸的療法發揮重要作用。例如,正在研究使用小干擾 RNA (siRNA) 和反義寡核苷酸的療法,並將其用於治療遺傳性疾病,例如杜氏肌肉營養不良症和脊髓性肌肉萎縮症。因此,遺傳疾病的日益普及推動了全球範圍內的需求。同時,生物資訊學和資料科學的發展對寡核苷酸合成產業產生直接影響。分析大型基因組資料集的能力不斷增強也對市場產生了積極影響。因此,計算能力的提高正在推動對新型寡核苷酸合成的需求增加。此外,寡核苷酸,特別是反義寡核苷酸,已被證明是表觀遺傳學研究和治療的有效工具,有助於調節基因表達,從而創造了積極的市場前景。
醫療保健和製藥業的需求不斷成長
全球對個人化醫療和治療的需求正在迅速成長,導致寡核苷酸合成市場空前擴張。這些合成的序列是開發針對各種遺傳性疾病和疾病(包括癌症)的標靶療法的不可或缺的組成部分。同時,反義寡核苷酸、適體、siRNA 和免疫刺激寡核苷酸等治療性寡核苷酸的進步,透過特異性抑製或改變基因表達,正在徹底改變疾病治療。此外,客製化寡核苷酸的合成是疫苗生產的基礎,包括基於 mRNA 的 COVID-19 疫苗,該疫苗已被證明有效且現已廣泛使用。隨著製藥公司和研究人員不斷發現寡核苷酸在治療和預防疾病方面的新應用,寡核苷酸合成的需求即將上升。
技術進步與創新
寡核苷酸合成技術的穩定發展和完善正在推動市場成長。此外,合成製程的創新,包括高通量和自動化合成系統,提高了寡核苷酸生產的效率、準確性和可擴展性。此外,生物資訊學和合成生物學的發展,包括DNA定序和基因編輯(例如CRISPR-Cas9),在很大程度上依賴準確合成寡核苷酸的能力。這些進步允許創建具有更大複雜性和多樣性的客製化序列,並促進合成生物學中的快速原型測試,從而促進更有效的研究和開發。這些不斷的技術進步和發展也在為市場做出貢獻。
不斷加強的合作和夥伴關係
製藥公司、生技公司和研究機構之間的合作和夥伴關係已成為推動遺傳疾病寡核苷酸療法的開發和商業化的重要驅動力。這些合作匯集了不同的專業知識、資源和資金,創造了一個協同環境,加速將科學發現轉化為實際有效的治療方法。製藥公司在藥物開發、臨床試驗和監管流程方面擁有豐富的經驗,為此合作貢獻了重要的專業知識。他們擁有必要的基礎設施、知識和資源來應對藥物開發的複雜局面,並確保寡核苷酸療法符合安全性和有效性的監管標準。他們的參與有助於利用現有網路、製造能力和分銷管道簡化商業化之路。
The global oligonucleotide synthesis market size reached US$ 3.0 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 8.0 Billion by 2032, exhibiting a growth rate (CAGR) of 11.1% during 2024-2032. The growing prevalence of genetic diseases among the masses, the development of novel therapeutic strategies, and the widespread adoption of therapies using small interfering RNAs (siRNAs), and antisense oligonucleotides are some of the major factors propelling the market.
Oligonucleotide synthesis refers to the process of constructing short DNA or RNA molecules, called oligonucleotides, in a predetermined sequence. These can range from just a few bases to around 200 nucleotides in length. The process is accomplished chemically in a controlled laboratory environment, typically using solid phase phosphoramidite chemistry. In this method, nucleotides are sequentially added to a growing chain, each addition involving a series of chemical reactions. This technology enables scientists to generate custom-made oligonucleotides for various applications including gene synthesis, polymerase chain reaction (PCR), gene editing tools, such as CRISPR-Cas9, and molecular diagnostic tests. Advances in oligonucleotide synthesis have dramatically accelerated research in genomics and molecular biology, underpinning many breakthroughs in medical and biological research.
The rising prevalence of genetic diseases among the masses majorly drives the global market. This necessitates the development of novel therapeutic strategies, where oligonucleotide-based therapies play a significant role. For instance, therapies using small interfering RNAs (siRNAs) and antisense oligonucleotides are being investigated and utilized in the treatment of genetic disorders, such as Duchenne muscular dystrophy and spinal muscular atrophy. As such, the growing prevalence of genetic diseases drives the demand on the global level. Along with this, the growth of bioinformatics and data science has a direct impact on the oligonucleotide synthesis industry. The escalating capacity to analyze large genomic datasets is also positively influencing the market. Therefore, the rising computational capability is driving an increased demand for the synthesis of novel oligonucleotides. Furthermore, oligonucleotides particularly antisense oligonucleotides, have been shown to be effective tools in epigenetic research and therapy, helping to modulate gene expression, which is creating a positive market outlook.
Rising Demand in the Healthcare and Pharmaceutical Industries
The global demand for personalized medicine and therapeutics is rapidly increasing, leading to an unprecedented expansion in the oligonucleotide synthesis market. These synthesized sequences are integral components in developing targeted therapies for various genetic disorders and diseases, including cancer. Along with this, the advancement of therapeutic oligonucleotides, such as antisense oligonucleotides, aptamers, siRNAs, and immunostimulatory oligonucleotides, is revolutionizing disease treatment by specifically inhibiting or altering gene expression. Furthermore, the synthesis of custom oligonucleotides is fundamental to the production of vaccines, including mRNA-based COVID-19 vaccines, which have proven effective and are now widely used. As pharmaceutical companies and researchers continue to discover novel applications for oligonucleotides in the treatment and prevention of diseases, the demand for oligonucleotide synthesis is poised to rise.
Technological Advancements and Innovation
The steady development and refinement of oligonucleotide synthesis technologies are driving market growth. In addition, innovations in the synthesis process, including high-throughput and automated synthesis systems, have increased the efficiency, accuracy, and scalability of oligonucleotide production. Moreover, developments in bioinformatics and synthetic biology, including DNA sequencing and gene editing (e.g., CRISPR-Cas9), heavily rely on the ability to synthesize oligonucleotides accurately. These advancements allow for the creation of custom sequences with greater complexity and diversity and facilitate rapid prototype testing in synthetic biology, thereby fostering more efficient research and development. These continuous technological advancements and developments are also contributing to the market.
Growing Collaborations and Partnerships
Collaborations and partnerships between pharmaceutical companies, biotechnology firms, and research institutions have become essential drivers in advancing the development and commercialization of oligonucleotide therapies for genetic diseases. These collaborations bring together diverse expertise, resources, and funding, creating a synergistic environment that accelerates the translation of scientific discoveries into practical and effective treatments. Pharmaceutical companies, with their experience in drug development, clinical trials, and regulatory processes, contribute vital expertise to the collaboration. They have the infrastructure, knowledge, and resources necessary to navigate the complex landscape of drug development and ensure that oligonucleotide therapies meet regulatory standards for safety and efficacy. Their involvement helps streamline the path to commercialization by leveraging existing networks, manufacturing capabilities, and distribution channels.
IMARC Group provides an analysis of the key trends in each segment of the global oligonucleotide synthesis market report, along with forecasts at the global, regional and country levels from 2024-2032. Our report has categorized the market based on product, application and end use.
Synthesized Oligonucleotide Products
Reagents
Equipment
Services
Synthesized oligonucleotide products dominate the market
The report has provided a detailed breakup and analysis of the market based on the product. This includes synthesized oligonucleotide products, reagents, equipment, and services. According to the report, synthesized oligonucleotide products represented the largest segment.
The market for synthesized oligonucleotide products in the oligonucleotide synthesis industry is being driven by the ever-increasing demand from pharmaceutical and biotechnological companies for drug discovery and development, especially for personalized medicine and targeted therapeutics. Along with this, the rise in genomics and molecular research, fueled by significant advancements in technologies such as Next Generation Sequencing (NGS) and CRISPR gene-editing, is enhancing the requirement for synthesized oligonucleotides. Additionally, the growth in diagnostic applications of oligonucleotides, such as in PCR and microarray assays for genetic and infectious diseases, is propelling the market forward. The expanding field of epigenetics also represents a key driver, with oligonucleotides playing a crucial role in gene expression studies. Moreover, the increasing prevalence of genetic disorders and the resultant demand for novel therapeutic strategies involving oligonucleotides further accelerates the market growth for synthesized oligonucleotide products.
PCR Primers
PCR Assays and Panels
Sequencing
DNA Microarrays
Fluorescence In-Situ Hybridization (FISH)
Antisense Oligonucleotides
Others
PCR primers dominate the market
A detailed breakup and analysis of the market based on the application has also been provided in the report. This includes PCR primers, PCR assays and panels, sequencing, DNA microarrays, Fluorescence In-Situ Hybridization (FISH), antisense oligonucleotides, and others. According to the report, the PCR primers represented the largest segment.
The demand for PCR primers in the oligonucleotide synthesis industry is driven by the ongoing global health crisis necessitating extensive viral testing, in which PCR is a primary method. Furthermore, the increasing application of PCR in medical diagnostics, forensics, and research to detect genetic mutations and infectious diseases fuels the demand for primers. In the field of genomics and molecular biology, PCR is considered a crucial tool for DNA sequencing, cloning, and genetic manipulation, and this broad utilization further drives the need for PCR primer synthesis. Apart from this, technological advancements in PCR techniques, such as real-time PCR and digital PCR, are also playing a role in boosting demand. Moreoevr, the growing funding for research in healthcare and life sciences has resulted in expanded use of PCR, thus driving the demand for PCR primers in the overall industry.
Pharmaceutical and Biotechnology Companies
Hospital and Diagnostic Laboratories
Academic Research Institutes
Academic research institutes dominate the market
The report has provided a detailed breakup and analysis of the market based on the end use. This includes pharmaceutical and biotechnology companies, hospital and diagnostic laboratories, and academic research institutes. According to the report, academic research institutes represented the largest segment.
The demand for oligonucleotide synthesis in academic research institutes is driven by a rise in genomics and molecular biology research, particularly studies related to gene expression, genetic disorders, and the development of novel therapeutic strategies. Additionally, advancements in technologies such as Next-Generation Sequencing (NGS) and CRISPR gene-editing, which rely on synthesized oligonucleotides, are stimulating demand. In addition, the rising trend of interdisciplinary studies involving bioinformatics and data science, which necessitate the use of oligonucleotides for data validation, further drives the need. Governmental and institutional funding for genomics and biotechnology research is another major driver, enabling academic institutes to invest in oligonucleotide synthesis for various projects. Academic research institutes, with their focus on fundamental research and discovery, often possess cutting-edge knowledge and innovative ideas. By partnering with industry, they can translate their scientific findings into practical applications and commercial products.
North America
United States
Canada
Asia-Pacific
China
Japan
India
South Korea
Australia
Indonesia
Others
Europe
Germany
France
United Kingdom
Italy
Spain
Russia
Others
Latin America
Brazil
Mexico
Others
Middle East and Africa
North America exhibits a clear dominance, accounting for the largest oligonucleotide synthesis market share
The report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa.
The North American market for oligonucleotide synthesis is propelled by a robust pharmaceutical and biotech industry, with a strong focus on drug discovery and development. The region's emphasis on personalized medicine and targeted therapies further propels this need. Additionally, North America's sophisticated healthcare system with advanced diagnostic capabilities increases the demand for oligonucleotides in diagnostic assays. The region also hosts numerous top-tier academic and research institutes conducting extensive genomics and molecular biology research, which necessitates oligonucleotide synthesis. Moreover, strong governmental and private sector investment in healthcare and life sciences research, particularly in genomics and personalized medicine, fuels the growth of industry in North America. Moreover, the advancements in delivery systems and formulations for oligonucleotide-based therapeutics in North America demonstrate the region's commitment to pushing the boundaries of innovation in this field. These developments not only contribute to the growth of the market but also have the potential to revolutionize the treatment of various diseases, including genetic disorders, cancers, and rare diseases.
The global oligonucleotide synthesis market is experiencing significant growth due to the escalating investments in the development of new production facilities, upgrading existing ones, and implementing more efficient production processes. Therefore, Companies are heavily investing in research and development to innovate their offerings, including developing new synthesis techniques, improving the scale and accuracy of synthesis, and creating new types of oligonucleotide products to support various applications in diagnostics, therapeutics, and research. Along with this, companies are entering into strategic collaborations, partnerships, and acquisitions to co-develop oligonucleotide-based drugs, share technology and expertise, or expand into new markets. In addition, the introduction of therapeutics, such as antisense oligonucleotides, siRNAs, and miRNAs, offer new avenues for treating a wide range of diseases, including genetic disorders and cancers is positively influencing the market. Furthermore, key players are offering services for the custom synthesis of oligonucleotides. This allows researchers and developers to order specific oligonucleotide sequences tailored to their needs, which is particularly important in fields like genomics, molecular biology, and personalized medicine.
Agilent Technologies Inc.
Biolegio B.V.
Bio-Synthesis Inc
Eurofins Genomics
GenScript
Horizon Discovery Ltd
Integrated DNA Technologies Inc (Danaher Corporation)
Kaneka Eurogentec S.A. (Kaneka Corporation)
LGC Limited
Nitto Denko Avecia Inc (Nitto Denko Corporation)
Thermo Fisher Scientific Inc.
In May 2023, GenScript increased the size of its principal manufacturing plant in Zhenjiang, Jiangsu, China for the manufacture of oligonucleotides and peptides. The expansion builds on GenScript's history of providing top-notch oligo and peptides to scientists all across the world for 20 years.
In January 2023, Agilent Technologies Inc. announced to increase its production of therapeutic nucleic acids, also known as oligonucleotides. The initiative is the most recent in a series of investments done by the sector in response to rapid development. At Agilent's plant in Frederick, Colorado, where the installation of a line announced in 2020 is slated to commence operating later this year, the project will add two oligonucleotide production lines.
In February 2022, Kaneka Eurogentec S.A. (Kaneka Corporation) stated that a 25 g batch of mRNA for a US customer had been successfully manufactured at its mRNA synthesis facility. In its present facility in Belgium, Eurogentec's GMP mRNA production service provides in vitro transcription (IVT), purification, quality control, and batch release of GMP material up to 25 g scale.