市場調查報告書
商品編碼
1470760
核酸分離和精製市場:按產品、方法、類型、應用和最終用戶 - 2024-2030 年全球預測Nucleic Acid Isolation & Purification Market by Product, Method, Type, Application, End User - Global Forecast 2024-2030 |
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核酸分離和精製市場規模預計2023年為69.4億美元,2024年達到75.8億美元,預計2030年將達到131.8億美元,複合年成長率為9.59%。
核酸分離和精製是分子生物學、遺傳學和生物技術中的基本技術,可從細胞、組織和生物體中提取高品質的核酸,包括 DNA 和 RNA。該過程包括將這些必需生物分子與蛋白質、脂質、碳水化合物和下游應用的潛在抑制劑分離的步驟。多種分離技術用於根據核酸的大小、電荷和序列進行分析,包括使用管柱基基質或陰離子交換樹脂的柱層析法、有機溶劑萃取、使用鹽或醇的沉澱以及使用磁珠的分離。於基於特異性的選擇性結合和洗脫。分子生物學和生物技術研究的基礎技術,使科學家能夠在分子層面上研究遺傳訊息,闡明細胞機制,並在醫學、農業和環境科學等多個領域開發創新解決方案。該市場正在經歷顯著成長,主要是由於製藥和生物技術行業對純核酸的需求不斷增加、有利的政府指導方針和法規以及基因工程、生命科學研究和法醫學的資金籌措增加。然而,建立核酸分離精製設施的成本高昂以及缺乏專業知識可能會阻礙市場開拓。然而,核酸萃取和精製技術創新的激增,以及動植物細胞 DNA 萃取的潛在進展,正在釋放這個充滿活力的市場空間的進一步潛力。
主要市場統計 | |
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基準年[2023] | 69.4億美元 |
預測年份 [2024] | 75.8億美元 |
預測年份 [2030] | 131.8億美元 |
複合年成長率(%) | 9.59% |
對自動化設備的需求不斷增加,以減少產品日常任務的時間
核酸分離精製設備對於從各類樣本中高效、可靠地萃取和精製核酸至關重要。這些儀器包括離心機、熱迴圈儀、微孔盤和光譜系統,有助於減少樣品污染,確保高產量和準確性。套件提供用於核酸分離和精製的「一體化」解決方案,通常包括所有必要的組分,例如緩衝液、試劑和分離工具。它們經過精心設計,可實現有效的細胞裂解、結合、清洗以及將核酸洗脫到精製基質。可處理的樣品類型、分離所需的時間以及所需設備的水平各不相同。用於分離和精製核酸的試劑通常執行特定功能:裂解細胞和組織,去除蛋白質和污染物,以及沉澱和洗脫核酸。這些包括有機溶劑、鹽、清洗、酵素等。所用試劑的品質直接影響分離精製核酸的產量和完整性。自動設備和手動套件的選擇取決於操作規模、人事費用和任務的時間敏感度。同樣,試劑的選擇可能會受到原料的性質和所需的核酸純度的影響。
方法 基於管柱的分離和精製具有高度可擴展性,無論樣本大小如何,都可以進行有效的精製和分離。
基於管柱的分離和精製依賴於使用基於二氧化矽的管柱的尺寸排除層析法的原理。在離液鹽存在的情況下,核酸選擇性地結合到二氧化矽基質上,並且污染物穿過管柱。隨後的清洗和洗脫步驟從管柱中釋放純核酸。此方法可在各種樣品類型中提供高產量、高純度和一致的結果。以微珠為基礎磁珠的分離和精製利用在特定條件下與核酸結合的功能化磁珠。樣本與這些珠子混合,核酸附著在其表面。然後使用磁鐵將與珠子結合的核酸與溶液中的污染物分開。該方法為不同的樣本大小和處理容量要求提供了出色的可擴展性和彈性,並且封閉式管形式降低了交叉污染的風險。基於試劑的分離和精製使用苯酚-氯仿或硫氰酸胍-苯酚-氯仿混合物等試劑,透過相分離條件下溶解度的差異將核酸與蛋白質分離。離心後,可以用乙醇或異丙醇沉澱從水相中回收核酸。選擇很大程度上取決於計劃的特定要求。基於管柱的分離和精製提供可擴展性和高純度,而以微珠為基礎的分離適用於可重複和高通量的應用。
循環核酸的分離和精製主要從血漿或血清中分離循環遊離DNA (cfDNA) 和RNA。基因組DNA分離和精製的重點是從基因組中提取DNA,從而獲得遺傳資訊的全面圖譜。精製的基因組 DNA 在遺傳學、藥物基因組學和疾病研究等各個領域都有應用。傳訊RNA分離精製以傳訊RNA(mRNA)為標靶,該技術在基因調控研究中扮演重要角色。它提供了基因表現譜的重要見解,並有助於癌症和神經系統疾病的治療研究。 微型RNA分離和精製重點在於微型RNA (miRNA),即控制基因表現的小非編碼 RNA 分子。尋找 miRNA 對於在分子層面上理解疾病具有深遠的意義,特別是在腫瘤學、心臟病學和病毒學領域。 PCR淨化是一種精製PCR擴增產物的技術。去除引子、核苷酸、酶和鹽非常重要,它們會抑制隨後的酶促反應。質體DNA 分離和精製質體DNA 的標靶分離對於基因工程和基因克隆至關重要。質體作為基因載體具有重要的生物技術應用,例如基因治療和疫苗開發。總RNA分離和精製方法旨在獲得所有類型的RNA,包括mRNA、tRNA和rRNA。這在各個研究領域都至關重要,特別是在探索轉錄組以了解基因功能、結構和表達方面。因此,分離和精製方法的選擇取決於特定的核酸類型和研究需求。這些技術進步正在為基因組學和遺傳學研究領域帶來前所未有的機遇,並不斷擴大其範圍。
我們透過核酸分離和精製在應用診斷中的廣泛應用提供治療指南。
在農業和動物研究中,核酸有助於檢測基因改造作物(GMO)、識別作物和牲畜中的病原體,並促進選擇性育種以獲得所需性狀。核酸萃取技術的研究和發展使研究人員能夠及早發現疾病並為受感染的動植物製定有效的治療策略。在診斷中,核酸的快速分離和精製對於識別細菌和病毒等傳染源、幫助醫療保健專業人員診斷疾病並確保及時進行醫療干預至關重要。藥物發現和開發在很大程度上依賴核酸分析來識別與特定疾病相關的目標分子。透過檢查基因對新治療化合物的反應行為,研究人員可以評估藥物的有效性並預測潛在的副作用。個人化醫療利用核酸資訊根據患者的基因組成客製化個人化治療。這種方法允許醫療保健提供者透過考慮藥物代謝和特定疾病易感性等因素來最佳化治療方法。因此,個人化醫療有望改善治療結果,同時減少潛在的副作用。
最終用戶:尋求可靠結果和快速週轉時間的 CRO 擴大核酸分離和精製的使用
學術和政府研究機構主要使用核酸分離和精製技術進行遺傳學和分子生物學研究。嚴格的品質標準和處理各種樣品(包括挑戰)的能力在這裡非常重要。委外研發機構(CRO) 定期參與藥物發現、臨床前測試和臨床試驗,其中準確、高通量的核酸分離至關重要。 CRO 希望解決方案具有可靠的結果、擴充性和快速的周轉時間。精製通訊協定的準確性和穩定性對於臨床診斷至關重要。隨著基因檢測和個人化醫療在患者照護中的重要性日益增加,醫院和診斷中心需要更快、更靈敏、更擴充性的套件。製藥和生物技術公司經常致力於開發新的治療方法和診斷方法。特別是在診斷試劑、疫苗和生物製藥的生產中,核酸分離需要高度可靠且可擴展的技術。每個最終用戶都重視可靠性、擴充性和快速週轉時間,但每個業務領域都有獨特的要求。製造商必須考慮這些需求來改進核酸分離和精製技術。
區域洞察
在美洲,生物技術和製藥領域的強勁研發投資以及遺傳疾病數量的增加為市場注入了活力。分子生物學技術的不斷發展、慢性病盛行率的增加以及對個人化醫療的需求不斷增加,正在推動該地區對核酸萃取方法的需求。此外,Thermo Fisher Scientific Inc.、QIAGEN NV 和 Illumina Inc. 等主要企業的存在正在推動產品創新,以滿足實驗室和診斷中心日益成長的需求。由於歐洲人口老化,政府和私人實體增加了醫療保健支出,歐洲、中東和非洲地區正在取得重大進展。中東和非洲國家也大力投資醫療基礎建設計劃,進一步提升該地區的市場前景。眾多大學和研究機構之間的合作也正在加速核酸分離方法的科學進展。由於醫療保健產業的快速開拓、政府對生命科學研究的支持力度加大以及人口基數較高,亞太地區核酸分離精製市場具有巨大的拓展潛力。此外,中國、印度、日本、韓國和澳洲等新興經濟體為產業相關人員提供了利潤豐厚的機會,以開拓開拓的成長潛力。總之,由於技術進步、需要有效診斷和治療性介入的疾病盛行率不斷增加,美洲、歐洲、中東和非洲和亞太地區的核酸分離和精製市場呈現出積極的趨勢。
FPNV定位矩陣
FPNV定位矩陣對於評估核酸分離精製市場至關重要。我們檢視與業務策略和產品滿意度相關的關鍵指標,以對供應商進行全面評估。這種深入的分析使用戶能夠根據自己的要求做出明智的決策。根據評估,供應商被分為四個成功程度不同的像限:前沿(F)、探路者(P)、利基(N)和重要(V)。
市場佔有率分析
市場佔有率分析是一種綜合工具,可以對核酸分離和精製市場供應商的現狀進行深入而深入的研究。全面比較和分析供應商在整體收益、基本客群和其他關鍵指標方面的貢獻,以便更好地了解公司的績效及其在爭奪市場佔有率時面臨的挑戰。此外,該分析還提供了對該行業競爭特徵的寶貴見解,包括在研究基準年觀察到的累積、分散主導地位和合併特徵等因素。這種詳細程度的提高使供應商能夠做出更明智的決策並制定有效的策略,從而在市場上獲得競爭優勢。
1. 市場滲透率:提供有關主要企業所服務的市場的全面資訊。
2. 市場開拓:我們深入研究利潤豐厚的新興市場,並分析其在成熟細分市場的滲透率。
3. 市場多元化:提供有關新產品發布、開拓地區、最新發展和投資的詳細資訊。
4.競爭評估與資訊:對主要企業的市場佔有率、策略、產品、認證、監管狀況、專利狀況、製造能力等進行全面評估。
5. 產品開發與創新:提供對未來技術、研發活動和突破性產品開發的見解。
1.核酸分離精製市場的市場規模與預測為何?
2.在核酸分離精製市場的預測期內,有哪些產品、細分市場、應用和領域需要考慮投資?
3.核酸分離精製市場的技術趨勢與法規結構是什麼?
4.核酸分離精製市場主要廠商的市場佔有率如何?
5.進入核酸分離精製市場的合適型態和策略手段是什麼?
[181 Pages Report] The Nucleic Acid Isolation & Purification Market size was estimated at USD 6.94 billion in 2023 and expected to reach USD 7.58 billion in 2024, at a CAGR 9.59% to reach USD 13.18 billion by 2030.
Nucleic acid isolation and purification is a basic technique in molecular biology, genetics, and biotechnology to extract high-quality nucleic acids, including DNA and RNA, from cells, tissues, or organisms. This process involves steps that separate these essential biomolecules from proteins, lipids, carbohydrates, and potential inhibitors of downstream applications. Several separation techniques, such as column chromatography with silica-based matrices or anion-exchange resins, organic solvent extraction, precipitation using salts or alcohol, and magnetic bead-based separation, can be employed for the selective binding and elution of nucleic acids based on their size, charge, or sequence specificity. Nucleic acid isolation & purification is a cornerstone technique for molecular biology and biotechnology research, enabling scientists to study genetic information at a molecular level, elucidate cellular mechanisms, and develop innovative solutions across various fields, including medicine, agriculture, and environmental science. The market is experiencing significant growth, driven primarily by the rising demand for pure nucleic acids in pharmaceutical and biotechnological industries, favorable government guidelines and regulations, and rising funding for genetic engineering, life science research, and forensics. However, the high cost of setting up nucleic acid isolation and purification facilities and the lack of subject expertise may hinder the market development. Nevertheless, surging innovations in nucleic acid extraction and purification techniques and potential advancements in extracting DNA from plant and animal cells unlock further potential in this dynamic market space.
KEY MARKET STATISTICS | |
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Base Year [2023] | USD 6.94 billion |
Estimated Year [2024] | USD 7.58 billion |
Forecast Year [2030] | USD 13.18 billion |
CAGR (%) | 9.59% |
Product: Growing demand for automation instruments to reduce the time for routine tasks
Nucleic acid isolation and purification instruments are crucial for efficient and reliable extraction and purification of nucleic acids from various types of samples. Such instruments range from centrifuges, thermocyclers, microplate readers, and spectroscopy systems, which aid in reducing sample contamination ensuring high yields and precision. Kits provide an 'all in one' solution for nucleic acid isolation and purification, typically including all necessary components such as buffers, reagents, and separation tools. These are carefully designed to achieve efficient cell lysis, binding of nucleic acids to a purification matrix, washing, and elution. They can vary in the type of sample they're able to process, the time required for isolation, and the level of equipment needed. Reagents used in nucleic acid isolation and purification typically serve specific functions, the lysis of cells and tissues, the removal of proteins and contaminants, and the precipitation or elution of the nucleic acids. These include organic solvents, salts, detergents, and enzymes. The quality of reagents used directly impacts the yield and integrity of the isolated and purified nucleic acids. The choice between an automated instrument or a manual kit might depend on the scale of operations, labor costs, and the time-sensitivity of tasks. Similarly, the choice of reagents could be influenced by the source material's nature and the nucleic acids' desired purity.
Method: Significant adoption of column-based isolation & purification owing to scalability, allowing effective purification and isolation irrespective of the sample size
Column-based isolation & purification relies on the principle of size exclusion chromatography by using silica-based columns. Nucleic acids bind selectively to the silica matrix in the presence of chaotropic salts while contaminants pass through the column. Subsequent washing and elution steps release pure nucleic acids from the column. This method offers high yield, purity, and consistent results across various sample types. Magnetic bead-based isolation & purification utilizes functionalized magnetic beads that bind to nucleic acids under certain conditions. The sample is mixed with these beads, allowing nucleic acids to attach to their surface. A magnet is then applied to separate the bead-bound nucleic acids from contaminants within the solution. This method provides excellent scalability and flexibility for various sample sizes and throughput requirements and reduces cross-contamination risks due to its closed-tube format. Reagent-based isolation & purification involves reagents such as phenol-chloroform or guanidinium thiocyanate-phenol-chloroform mixtures that separate nucleic acids from proteins via solubility differences under phase separation conditions. After centrifugation, nucleic acids can be recovered from the aqueous phase through precipitation using ethanol or isopropanol. The choice largely depends on the particular requirements of your project. Column-Based isolation & purification offers scalability and high purity, magnetic bead-based isolation favors reproducibility and high-throughput applications, and reagent-based isolation is more economical and suitable for large-scale isolation despite its possible limitations in purity.
Circulating nucleic acid isolation and purification primarily involves isolating circulating cell-free DNA (cfDNA) and RNA from blood plasma or serum. Genomic DNA Isolation and purification focuses on extracting DNA from the genome, yielding a comprehensive map of genetic information. The purified genomic DNA is applied in various areas, including genealogy, pharmacogenomics, and disease research. Messenger RNA isolation and purification targets messenger RNA (mRNA), and this technique plays a vital role in studying gene regulation. It provides critical insights into gene expression profiles, aiding therapeutic research for cancer and neurological disorders. Micro RNA isolation and purification focuses on micro RNA (miRNA), small non-coding RNA molecules that regulate gene expression. Exploring miRNA has profound implications for understanding diseases at the molecular level, especially oncology, cardiology, and virology. PCR Cleanup is a technique to purify PCR amplification products. Removing primers, nucleotides, enzymes, and salts is vital, which may interfere with subsequent enzymatic reactions. Plasmid DNA isolation and purification targeting plasmid DNA isolation is essential for genetic engineering and gene cloning. As genetic carriers, plasmids have significant biotechnological applications, including gene therapy and vaccine development. The total RNA Isolation and purification method aims to obtain all types of RNA, including mRNA, tRNA, and rRNA. It's pivotal in various fields of study, notably in exploring the transcriptome for understanding gene function, structure, and expression. Illustratively, the isolation and purification method choice pivots on the specific nucleic acid type and research necessity. Advancements in these techniques are continually broadening the scope, invigorating unprecedented opportunities in the genomic and genetic research sphere.
Application: Wider application of nucleic acid isolation & purification in diagnostics to provide guidance on therapy
In agriculture and animal research, nucleic acid helps to detect genetically modified organisms (GMOs), identify pathogens in crops and livestock, and facilitate selective breeding for desirable traits. Advancements in nucleic acid extraction techniques have allowed researchers to detect diseases early and develop effective treatment strategies for infected plants or animals. In diagnostics, rapid isolation & purification of nucleic acids are essential for identifying infectious agents such as bacteria or viruses, assisting healthcare professionals to diagnose diseases and take timely medical interventions accurately. Drug discovery and development rely heavily on nucleic acid analysis to identify target molecules associated with specific diseases. Researchers can assess drug efficacy and predict potential side effects by examining the behavior of genes in response to new therapeutic compounds. Personalized medicine uses nucleic acid information for tailoring individualized treatments based on a patient's genetic makeup. This approach allows healthcare providers to optimize therapeutic regimens by considering factors such as drug metabolism or predisposition toward certain diseases. As a result, personalized medicine promises improved treatment outcomes while reducing potential adverse reactions.
End User: Growing usage of nucleic acid isolation & purification by the CROs for reliable results, and fast turnaround time
Academic and government research institutions predominantly use nucleic acid isolation and purification techniques for genetics and molecular biology research. Here, stringent quality standards and the ability to handle a broad range of sample types, including more challenging ones, are critical. Contract research organizations (CROs) regularly deal with drug discovery, preclinical studies, and clinical trials, where precise and high-throughput nucleic acid isolation is vital. They seek solutions with reliable results, scalability, and fast turnaround time. In clinical diagnostics, the accuracy and stability of purification protocols are essential. With the growing importance of genetic testing and personalized medicine in patient care, hospitals, and diagnostic centers need more rapid, sensitive, and scalable kits. Pharmaceutical and biotechnology companies often work on developing novel therapeutics and diagnostic assays. They require highly reliable and scalable techniques for nucleic acid isolation - especially in the production of diagnostics, vaccines, and biopharmaceuticals. Although all end users value reliability, scalability, and quick turnaround time, each has unique requirements influenced by its specific work sector. Consideration of these needs is essential for manufacturers to improve nucleic acid isolation and purification techniques.
Regional Insights
In the Americas, the market is fueled by strong research and development investments in the biotechnology and pharmaceutical sectors and rising incidences of genetic disorders. The increasing molecular biology techniques, the rising prevalence of chronic diseases, and the accelerating need for personalized medicine have enhanced the need for nucleic acid extraction methods in the region. Furthermore, the presence of key organizations, such as Thermo Fisher Scientific Inc., QIAGEN N.V., and Illumina Inc., has been pushing product innovation to cater to the growing demand from research labs and diagnostic centers. The EMEA region is witnessing substantial progress due to increased healthcare expenditure by governments and private entities within Europe's aging population. Additionally, countries within the Middle East and Africa invest heavily in medical infrastructure development projects, further enhancing regional market prospects. The collaboration between numerous universities and research institutes has also accelerated scientific progress in nucleic acid isolation methods. APAC region holds immense potential for expansion of the nucleic acid isolation & purification market due to its rapidly developing healthcare sector, increasing government support for life science research, and high population base. Moreover, Emerging economies, such as China, India, Japan, South Korea, and Australia, present lucrative opportunities for industry stakeholders to tap into unexplored areas of growth potential. In conclusion, the nucleic acid isolation & purification market demonstrates a positive trend across the Americas, EMEA, and APAC regions owing to technological advancements and growing disease prevalence rates necessitating efficient diagnosis and therapeutic interventions.
FPNV Positioning Matrix
The FPNV Positioning Matrix is pivotal in evaluating the Nucleic Acid Isolation & Purification Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).
Market Share Analysis
The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the Nucleic Acid Isolation & Purification Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.
Key Company Profiles
The report delves into recent significant developments in the Nucleic Acid Isolation & Purification Market, highlighting leading vendors and their innovative profiles. These include A&A Biotechnology, Abcam PLC, ABNova Corporation, Agilent Technologies Inc., Analytik Jena GmbH+Co. KG, Becton, Dickinson and Company, Bio-Rad Laboratories, Inc., Biomatik Corporation, Bioneer Corporation, Danaher Corporation, F. Hoffmann-La Roche Ltd., Genaxxon bioscience GmbH, Geneaid Biotech Ltd., GeneProof a.s, Genscript Biotech, Hamilton Company, HiMedia Laboratories Private Limited, Illumina Inc., MACHEREY-NAGEL GmbH & Co. KG, Merck KGaA, MP Biomedicals, New England Biolabs, Inc., Norgen Biotec Corp., NZYTech, Omega Bio-tek, Inc., Perkin Elmer Inc., Promega Corporation, Takara Bio Inc., Thermo Fisher Scientific Inc., and Zymo Research Corporation.
Market Segmentation & Coverage
1. Market Penetration: It presents comprehensive information on the market provided by key players.
2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.
3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.
4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.
5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.
1. What is the market size and forecast of the Nucleic Acid Isolation & Purification Market?
2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the Nucleic Acid Isolation & Purification Market?
3. What are the technology trends and regulatory frameworks in the Nucleic Acid Isolation & Purification Market?
4. What is the market share of the leading vendors in the Nucleic Acid Isolation & Purification Market?
5. Which modes and strategic moves are suitable for entering the Nucleic Acid Isolation & Purification Market?