市場調查報告書
商品編碼
1261169
BNP和NT-proBNP全球市場規模,份額,行業趨勢分析報告,按測試地點,應用(心肌梗塞,急性冠狀動脈綜合徵(ACS),充血性心力衰竭(CHF)),地區展望和預測,2022-2028 年Global Bnp and Ntprobnp Market Size, Share & Industry Trends Analysis Report By Location of Testing, By Application (Myocardial Infarction, Acute Coronary Syndrome (ACS), Congestive Heart Failure (CHF)), By Regional Outlook and Forecast, 2022 - 2028 |
BNP 和 NT-proBNP 市場規模預計將在 2028 年達到 22 億美元,預測期內市場複合年增長率為 11.4%。
但是,高水平可能表明心臟沒有為身體提供足夠的血液。 在這種情況下會發生心力衰竭,有時稱為充血性心力衰竭。 利鈉□測定法測量血液中 NT-proBNP 或 BNP 的濃度。 兩者都有不同的參數,所有這些都可用於診斷心力衰竭。 選項用戶將依賴提供商提議的實驗室擁有的工具。
BNP 和 NT-proBNP 之間的主要生物學區別是 BNP 作為一種激素並且具有生物活性。 相比之下,NT-proBNP 不僅被動排出體外,而且沒有生物活性。 因此,NT-proBNP 的半衰期往往比 BNP 更長,後者的半衰期明顯更短。 因此,NT-proBNP 在血流中含量豐富,並且在一定程度上以較高水平循環,這表明它對識別早期心力衰竭具有很高的敏感性。
COVID-19 影響分析
COVID-19 大流行封鎖期對 BNP 和 NT-proBNP 市場產生了負面影響。 這是由於政府嚴格控制和限制,心髒病診斷檢查的數量減少了。 此外,COVID 期間知識水平低和診斷測試價格高進一步阻礙了市場增長。 然而,COVID-19 也可引起靜脈和動脈血栓形成、心律失常和心肌梗塞。 因此,優化心髒病的檢測和治療至關重要,最終會增加床旁 BNP 和 NT-proBNP 檢測的使用。
市場增長因素
世界範圍內 CAD、AMI 和 CHF 的患病率正在上升
根據全球健康數據交換數據庫,目前全球估計有 6434 萬充血性心力衰竭 (CHF) 病例。 這相當於 3461.7 億美元用於醫療保健和 991 萬 YLD(因殘疾而損失的年數)。 HF 受年齡的影響很大。 此外,心血管問題會顯著損害患者的功能能力並增加死亡風險。 因此,正確診斷和治療這種疾病對於避免重複住院、優化患者預後和提高生活質量至關重要。 因此,心血管疾病在人群中日益流行將為主要市場進入者提供產品投資和商業化機會,從而加速 BNP 和 NT-proBNP 市場的增長。
擴大 BNP 和 NT-proBNP 檢測在慢性腎病中的應用
心臟會受到這些變化的影響,隨著時間的推移會發展為心肌病和充血性心力衰竭。 這種參與的標誌物包括利鈉□,例如 BNP 和 NT-proBNP。 CKD 患者的利鈉□水平升高,尤其是透析患者。 BNP 水平隨時間的變化已被確定為更準確的 CKD 風險指標。 需要強調的是,腎功能和 NT-pro-BNP 水平在腎功能衰竭中呈高度負相關。 因此,越來越多地使用 BNP 和 NT proBNP 儀表來準確診斷腎功能和治療 CKD 正在推動市場的擴張。
市場約束
BNP 和 NT-proBNP 測定的不相容性
儘管人們普遍認為這兩種測試在臨床上基本等效,但在既定的切點上評估了 HF 排除與 BNP 和 NT-proBNP 排除之間的診斷一致性。沒有已發表的研究。 在測量患者樣本中的 BNP 和 NT-proBNP 時,已經確定了幾個因素,例如抗體與其前體 proBNP 的反應性差異、半衰期、腎臟清除率、蛋白質糖基化以及 HF 患者生化多樣性的變化。有一些很好的- 已知問題。 因此,很明顯 BNP 和 NT-proBNP 不能互換使用。 這增加了這些測試分析的成本並減緩了市場增長。
應用展望
根據應用,BNP 和 NT-proBNP 市場分為心肌梗塞、充血性心力衰竭 (CHF)、急性冠脈綜合徵 (ACS) 等。 在 2021 年的 BNP 和 NT-proBNP 市場中,充血性心力衰竭部分正在獲得可觀的增長率。 充血性心力衰竭 (CHF) 是一種輕微的慢性疾病,會損害心肌的收縮能力。 這些指標已被證明可以降低急診科的成本,並可用於識別心力衰竭,尤其是舒張功能障礙。 BNP 測試的高陰性預測準確性對於排除心力衰竭特別有用。
考察地點前景
根據檢測地點,BNP 和 NT-proBNP 市場分為即時檢測和實驗室檢測。 2021 年的 BNP 和 NT-proBNP 市場將由即時檢測領域主導。 原因包括更好的資源利用、改善患者的便利性、增加對心臟生物標誌物檢測的需求以及改善臨床決策。 這也歸功於改進了心力衰竭的診斷和治療。 許多即時檢測儀器包括試劑盒、化驗、分析儀和測試專用設備。
區域展望
基於區域,對北美、歐洲、亞太地區和 LAMEA 的 BNP 和 NT-proBNP 市場進行了分析。 2021 年,北美地區在 BNP 和 NT-proBNP 市場的收入份額最大。 這可能是由於先進的醫療保健系統以及 BNP 和 NT-proBNP 作為疾病診斷和預後工具的廣泛使用。 此外,由於老年人口的增加,對診斷急性心肌梗死等疾病的生物標誌物檢測的需求增加,對檢測產品的需求也越來越大。 推動該市場擴張的另一個因素是該地區重要公司的集中。
The Global Bnp And Ntprobnp Market size is expected to reach $2.2 billion by 2028, rising at a market growth of 11.4% CAGR during the forecast period.
BNP (B-type natriuretic peptide) & NT-proBNP (N-terminal pro B-type natriuretic peptide) are two extensively used biomarkers that are used to diagnose heart failure and lower ejection fraction, evaluate the effectiveness of therapy, and predict outcomes. As cardiomyocytes stretch, they release proBNP, which breaks down into two circulating fragments. The first fragment is the 32-amino acid C-terminal BNP, and the second fragment is inactive 76-amino acid NT-proBNP.
Both pieces are frequently utilized to aid in detecting heart failure, make predictions about results, and monitor the impact of treatment. The heart produces peptides known as natriuretic peptides. N-terminal pro-B-type natriuretic peptide and Brain natriuretic peptide (BNP) are the two primary forms of these chemicals. BNP & NT-proBNP are typically only detected in trace amounts in the blood.
However, high levels may indicate that the heart isn't supplying the body with enough blood as it requires. Heart failure, sometimes called congestive heart failure, occurs when this happens. Natriuretic peptide assays gauge the blood's levels of NT-proBNP or BNP. Although they employ various parameters, they are both helpful in diagnosing heart failure. The option users will rely on the tools the suggested laboratory of the provider has.
The main biological distinction between BNP & NT-proBNP is that BNP acts as a hormone and is biologically active. In contrast, NT-proBNP is passively excreted from the body as well as is not biologically active. Thus, NT-proBNP tends to have a longer half-life than BNP, which has a significantly shorter half-life. As a result, NT-proBNP circulates in the bloodstream at higher quantities, which suggests that it is more likely to be sensitive for identifying earlier stages of heart failure since it does so at somewhat elevated levels.
COVID-19 Impact Analysis
The COVID-19 pandemic lockdown period had a negative effect on the BNP and NTproBNP market. This is due to stringent governmental controls and limits that resulted in fewer cardiac disease diagnostic tests being performed. In addition, the low level of knowledge and the high price of diagnostic tests during the COVID period further hindered market growth. COVID-19, however, was also capable of causing venous and arterial thrombosis, arrhythmia, and cardiac damage. Thus, optimizing cardiac illness detection and therapy was crucial, which eventually led to a rise in the usage of point-of-care BNP & NT-proBNP testing.
Market Growth Factors
Rising prevalence of CAD, AMI, and CHF around the world
The Global Health Data Exchange database estimates that there is currently 64.34 million congestive heart failure (CHF) cases worldwide. This amounts to USD 346.17 billion spent on healthcare and 9.91 million YLDs (years lost due to disability). HF is significantly influenced by age. Moreover, cardiovascular issues can significantly reduce a patient's functional capacity and raise their mortality risk. Therefore, to avoid repeated hospital stays, optimize patient outcomes, and boost the quality of life, it is crucial to correctly diagnose and treat the disease. As a result, the population's increased prevalence of cardiovascular illness presents an opportunity for leading market participants to invest in and commercialize the products and, in turn, accelerate the growth of the bnp and ntprobnp market.
Growing use of bnp and Ntprobnp assays in chronic kidney disease
The heart is affected by these changes and develops cardiomyopathy and congestive heart failure over time. Markers for this involvement include natriuretic peptides like BNP and NT-proBNP. Natriuretic peptide levels are higher in people with CKD, especially those receiving dialysis. It has been observed that a more accurate risk indicator for CKD is the variations in BNP levels over time. It is important to highlight that renal function and NT-pro-BNP levels are highly inversely correlated in renal failure. Therefore, the increasing use of bnp and ntprobnp assays to diagnose renal function accurately to treat CKD has resulted in market expansion.
Market Restraining Factors
Non-interchangeable nature of bnp and ntprobnp assays
No published investigation had evaluated the diagnostic concordance of BNP & NT-proBNP for ruling out and ruling in HF at the established cut-points, despite the broad recognition that both tests are fundamentally clinically comparable. Measuring BNP or NT-proBNP in patient samples has several well-known problems, such as variable antibody reactivity with the precursor proBNP and changes in half-lives, renal clearance, protein glycosylation, and biochemical variety in HF patients. Hence, it is obvious that BNP and NT-proBNP cannot be used interchangeably. This increases the expense of these test assays and presents factors that will slow down the market's growth.
Application Outlook
Based on application, the Bnp and Ntprobnp market is categorized into myocardial infarction, congestive heart failure (CHF), acute coronary syndrome (ACS), and others. The congestive heart failure segment procured a considerable growth rate in the Bnp and Ntprobnp market in 2021. Congestive heart failure, or CHF, is a gradual, chronic illness that impairs the ability of the heart muscle to contract. These metrics have been demonstrated to reduce costs in the emergency room setting and can be used to identify heart failure, particularly diastolic dysfunction. BNP testing' high negative predictive accuracy is especially useful for excluding heart failure.
Location of Testing Outlook
On the basis of location of testing, the Bnp and Ntprobnp market is divided into point of care testing and laboratory testing. The point of care testing segment acquired the largest revenue share in the Bnp and Ntprobnp market in 2021. Better resource utilization, increased patient convenience, growth in demand for cardiology biomarker testing, and improved clinical decision-making are all credited with this. It also results from improved heart failure diagnosis and treatment. Most point-of-care testing equipment includes kits, assays, analyzers, and devices focused on testing.
Regional Outlook
Based on region, the Bnp and Ntprobnp market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The North America region witnessed the maximum revenue share in the Bnp and Ntprobnp market in 2021. This can be ascribed to the advanced healthcare system and the widespread use of BNP and NTproBNP as diagnostic and prognostic disease tools. In addition, the need for testing products is driven by the growing elderly population's need for biomarker testing to diagnose diseases like acute myocardial infarction. Another factor boosting the expansion of this market is the concentration of important companies in the region.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Abbott Laboratories, Siemens AG, Danaher Corporation, Gentian Diagnostics ASA, PerkinElmer, Inc., BioMerieux S.A., Quidel Corporation, Bio-Rad Laboratories, Inc., F. Hoffmann-La Roche Ltd. (Roche Holding Ltd.), and Scripps Laboratories.
Market Segments covered in the Report:
By Location of Testing
By Application
By Geography
Companies Profiled
Unique Offerings from KBV Research
List of Figures