市場調查報告書
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1261357
胃食管反流藥物全球市場規模、份額、按類型分類的行業趨勢分析報告(抗酸劑、質子泵抑製劑 (PPI)、H2 受體阻滯劑、促動力藥),區域展望和預測,2022 年 2028-2028 年Global Gastroesophageal Reflux Disease Therapeutics Market Size, Share & Industry Trends Analysis Report By Type (Antacids, Proton Pump Inhibitors (PPIs), H2 Receptor Blockers, and Pro-kinetic Agents), By Regional Outlook and Forecast, 2022 - 2028 |
在預測期內,胃食管反流病市場規模預計將以 2.2% 的複合年增長率增長,到 2028 年達到 56 億美元。
此外,患有胃酸反流的人可能會出現持續咳嗽、喉炎、喘息、灼痛或喉嚨痛、哮喘加劇以及夜間睡眠困難。 在極少數情況下,持續反流會導致狹窄、食管炎、轉化和惡性腫瘤。 下食管括約肌的內在壓力、胸膈對 LES 的外在壓迫以及希氏銳角被認為構成了抗反流屏障。 一過性 LES 鬆弛 (TLESR)、LES 低血壓和食管胃交界處 (EGJ) 的物理障礙,即食管裂孔疝,已被確定為反流的三個最常見原因。
TLESR 發生在吞嚥過程中,並允許食團從食道進入胃部,是很大一部分健康人和 GERD 患者最重要的反流機制。 還誘導了二次蠕動,它通過迷走神經反射起源於食道中段,迷走神經反射啟動主要位於下心區的胃感受器的激活。 因此,導致 TLESR 的主要因素是胃擴張,通常由胃中存在空氣或食物引起。 這解釋了為什麼 TLESR 主要是餐後事件。
COVID-19 影響分析
COVID-19 大流行對市場產生了負面影響。 自大流行開始以來,COVID-19 對人類健康的影響一直備受爭議,胃食管反流病 (GERD) 也不例外。 人們擔心病毒可能會從 GI(胃腸道)道逸出,並通過腸肺軸在其他器官系統(例如呼吸系統)中引起症狀、感染或炎症。 腸道是人體最大的免疫器官,可能含有快速生長的 COVID-19 病毒群落。 此類分析和研究表明 COVID-19 與 GERD 之間存在聯繫,這極大地阻礙了市場的增長。
市場增長因素
過度進食快餐導致消化系統紊亂
快餐中含有各種毒素和化學物質以及過量的鹽分,自然會增加腹脹、胃潰瘍甚至胃癌的機率。 當您(從快餐中)吸收更多的鹽分時,鈉會導致更多的水分滯留,從而導致胃痛、腹部腫脹和腹脹。 成年人的快餐消費隨著財富的增加而增加,隨著年齡的增長而減少。 男性和女性的快餐消費量大致相同,男性在午餐時吃得更多,而女性在兩餐之間吃得更多。 全球快餐消費的增長正在增加胃食管反流病的病例數量,推動市場的增長。
酒精消費激增
個人因素包括年齡、性別、家庭環境和社會經濟地位。 雖然沒有單一的風險因素占主導地位,但更容易出現酒精相關問題的人更有可能飲酒。 與富人相比,不太富裕的人因飲酒而面臨更多的健康和社會問題。 研究還表明,飲酒會增加胃食管反流病的風險。 飲酒量的增加可能會影響這種疾病的總體患病率,並成為胃食管反流病市場擴張的推動力。
市場約束
與胃食管反流藥物相關的副作用示例
抗酸劑會導致某些人過敏,並使他們更容易對某些食物過敏。 抗酸劑的副作用通常是由於劑量不當引起的。 一些抗酸劑含有鈣,包括 Maalox、Mylanta、Rolaids 和 Tums。 如果患者服用的劑量超過或超過推薦量,則可能會出現鈣過量。 鈣攝入過多的症狀包括噁心、嘔吐、精神狀態改變和腎結石。 鈣攝入過多也會引起鹼中毒。 在這種狀態下,身體無法產生足夠的酸來有效工作。 如果患者覺得他們需要服用大量抗酸劑才能感覺好些,則可能表明存在另一種疾病。
按類型劃分的前景
根據類型,胃食管反流藥物市場分為抗酸劑、H2 受體阻滯劑、質子泵抑製劑 (PPI) 和促動力劑。 2021 年,胃食管反流藥物市場由質子泵抑製劑 (PPI) 部分主導。 這是因為它們是最常推薦用於治療胃灼熱和缺氧相關症狀的一組藥物。 這些藥物通過抑制胃壁細胞產生酸來發揮作用。 PPI 可通過非處方藥和處方藥獲得。 奧美拉唑和蘭索拉唑是歷史最悠久、醫生和患者最為熟知的藥物。
區域展望
按地區劃分,對北美、歐洲、亞太地區和 LAMEA 的胃食管反流病市場進行了分析。 到 2021 年,北美將佔據胃食管反流病市場的最高收入份額。 這是由於社區中 GERD 發病率的增加以及 GERD 藥物使用的增加。 也有越來越多的運動來提高公眾對該問題的認識,從而增加了對 GERD 治療藥物的需求。 該活動旨在為患有 GERD 的人提供一個簡單的食譜來防止反流。
The Global Gastroesophageal Reflux Disease Therapeutics Market size is expected to reach $5.6 billion by 2028, rising at a market growth of 2.2% CAGR during the forecast period.
A digestive illness called gastroesophageal reflux disease (GERD) occurs when stomach contents, including acid, food, and liquids, leak into the esophagus. The lining of the esophagus is irritated, giving patients a burning feeling. Heartburn (reflux) and regurgitation are the primary esophageal symptoms defining GERD. Moreover, GERD may result in esophageal inflammation if ignored for a long time. It is linked to sleep problems and low quality of life.
Upper endoscopy, an ambulatory acid (PH) probe test, esophageal manometry, and X-rays are the primary methods used to diagnose it. Changing one's lifestyle and using regulated drugs might help manage certain conditions, but others may also need surgery or powerful medications. Burning in the chest, dysphagia, belching, epigastric discomfort, trouble swallowing, regurgitation of food or sour liquid, and a lump in the throat are typical indications and symptoms of the condition.
Moreover, acid reflux sufferers may have a persistent cough, laryngitis, wheezing, burning or painful throat sensations, increasing asthma, and sleep difficulties at night. In rare cases, persistent reflux may result in stricture, esophagitis, metaplasia, or malignancy. The lower esophageal sphincter's intrinsic pressure, the crural diaphragm's extrinsic compression of the LES, and the acute angle of His are hypothesized to make up the anti-reflux barrier. Transient LES relaxations (TLESRs), LES hypotension, and physical disruption of the esophagogastric junction (EGJ), or hiatus hernia, are the three most common causes of reflux.
TLESRs, which occur during swallows to allow the passage of a bolus from the esophagus into the stomach, are the most important mechanism of reflux in healthy subjects and a significant portion of GERD patients. They are also induced by secondary peristalsis, which starts from the mid-esophagus due to a vago-vagal reflex beginning with the activation of gastric receptors primarily located in the sub-cardiac region. As a result, the primary factor that causes a TLESR is stomach distension, often brought on by gastric air or the presence of food, which explains why TLESRs are mostly a postprandial event.
COVID-19 Impact Analysis
The COVID-19 pandemic affected the market negatively during the pandemic phase. COVID-19's effects on many aspects of human health have been extensively discussed since the start of the pandemic, and gastroesophageal reflux disease (GERD) is no exception. There was a worry that the virus may move beyond the GI (gastrointestinal) tract by generating symptoms in other organ systems, such as the respiratory system, through a gut-lung axis or by causing infection or inflammation. The gut, the body's biggest immunological organ, may be home to colonies of COVID-19 virus, which reproduces quickly. Because of the association between COVID-19 and GERD shown by such analysis and research, the market growth was hampered significantly.
Market Growth Factors
High intake of fast food causing digestive diseases
Fast food naturally raises the chance of bloating, stomach ulcers, and sometimes even stomach cancer since it includes a variety of hazardous substances, chemicals, and excessive amounts of salt. If the body absorbs more salt (from fast food), the sodium will retain more water, which may cause stomach pain and abdominal swelling or bloating. Fast food consumption among adults rose with wealth while decreasing with age. Fast food consumption was similar across men and women, with a more significant proportion of men eating it for lunch and a higher proportion of women eating it as a snack. The growing consumption of fast food globally will increase the cases of gastroesophageal reflux diseases and propel market growth.
The surging consumption of alcohol
Personal factors include age, gender, domestic circumstances, and socioeconomic status. Although no one risk factor predominates, those who are more vulnerable to alcohol-related problems are more likely to use alcohol. Less wealthy individuals have more significant health and social issues due to alcohol use than more affluent individuals. Studies have also shown that drinking alcohol increases the risk of gastroesophageal reflux disease. The growing use of alcohol will have an impact on the disease's overall prevalence and may help drive the gastroesophageal reflux diseases market expansion.
Market Restraining Factors
Some side effects associated with gastroesophageal reflux disease's medications
Antacids may cause allergies in certain persons and make it more likely for people to become allergic to certain foods. Antacid side effects are often caused by improper dosage. Several antacids include calcium, including Maalox, Mylanta, Rolaids, and Tums. A calcium overdose is possible if the patient takes them in excess or longer than recommended. Symptoms of too much calcium include nausea, vomiting, altered mental state, and kidney stones. Alkalosis may also result from too much calcium. The body can't produce enough acid in this state for it to work effectively. It might indicate another disease if the patient feels they need to take a lot of antacids to feel better.
Type Outlook
Based on type, the gastroesophageal reflux disease therapeutics market is segmented into antacids, H2 receptor blockers, proton pump inhibitors (PPIs) and pro-kinetic agents. The proton pump inhibitors (PPIs) segment acquired a significant revenue share in the gastroesophageal reflux disease therapeutics market in 2021. This is due to the fact that it is the most often recommended family of medications for treating heartburn and conditions linked to acidity. They work by inhibiting acid production in the stomach's parietal cells. Both over-the-counter and prescription PPIs are offered. Omeprazole and lansoprazole are two medications that have been around the longest and are thus the most well-known to doctors and patients.
Regional Outlook
Region-wise, the gastroesophageal reflux disease therapeutics market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The North America region generated the highest revenue share in the gastroesophageal reflux disease therapeutics market in 2021. This is owing to the increased incidence of GERD in the local population and the rising use of GERD therapies. Also, there are more and more campaigns to raise public awareness of the problem, driving up demand for GERD treatments. The campaign aimed to provide GERD sufferers with simple-to-follow recipes that are reflux-friendly.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include AstraZeneca PLC, Eisai Co., Ltd., GlaxoSmithKline PLC, Takeda Pharmaceutical Company Limited, Ironwood Pharmaceuticals, Inc., Johnson & Johnson, Medigus Ltd., Sebela Pharmaceuticals, Phathom Pharmaceuticals, Inc., and Camber Pharmaceuticals, Inc. (Hetero Labs Limited).
Market Segments covered in the Report:
By Type
By Geography
Companies Profiled
Unique Offerings from KBV Research
List of Figures