市場調查報告書
商品編碼
1276338
胃癌全球市場規模/份額/行業趨勢分析報告:按給藥途徑(注射/口服)、治療類型、疾病類型、分銷渠道、藥物類別、地區、展望/預測,2023-2029 年Global Gastric Cancer Market Size, Share & Industry Trends Analysis Report By Route of Administration (Injectable and Oral), By Treatment Type, By Disease Type, By Distribution Channel, By Drug Class, By Regional Outlook and Forecast, 2023 - 2029 |
胃癌市場規模預計到 2029 年將達到 69 億美元,預測期內復合年增長率為 17.6%。
由於癌症在不同時間在胃的不同部位發展,因此症狀和預後各不相同。 治療的選擇可能取決於癌症的起源。 例如,在胃食管交界處出現或開始於胃食管交界處的惡性腫瘤的分期和治療通常與食管腫瘤相似。 胃的最內層粘膜含有引起這些惡性腫瘤的腺細胞。
胃腺癌有兩種基本類型:腸型和瀰漫型。 癌細胞更有可能發生某些基因改變,從而更有可能進行靶向藥物治療。 擴散型通常傳播得更快。 與腸型相比,它的發生頻率較低,而且往往難以治療。
COVID-19 影響分析
診斷和治療的延誤是 COVID-19 大流行對胃癌的主要影響。 癌症診斷和治療的延誤會對患者的預後產生重大影響。 癌症研究,尤其是測試胃癌新療法的臨床試驗,也受到大流行的阻礙。 COVID-19 限制已推遲或暫停了許多臨床試驗,可能會延遲針對該疾病的新療法的開發。 然而,在大流行期間,重症病例仍在接受治療。 考慮到這些因素,我們發現胃癌市場受到了 COVID-19 的適度影響。
市場增長因素
擴大靶向治療和免疫治療的接受度,引入新藥
隨著對疾病分子基礎的了解不斷加深,越來越多的靶向和免疫治療藥物被開發並推向市場。 2010年以來,赫賽汀等抗HER-2藥物陸續上市。 目前,EGFR和PD-1靶向治療和免疫治療正在開髮用於治療胃癌。 此外,臨床管道中藥物的批准和後續上市預計將推動胃癌市場的增長。
胃癌患病率上升
胃癌是東亞地區最普遍的癌症類型。 到 2020 年,預計將有 110 萬新發胃癌病例和 77 萬胃癌相關死亡病例,男性患病率通常是女性的兩倍。 在預測期內,由於胃癌患病率的增加,預計胃癌藥物的需求將增加,這有望作為胃癌藥物的市場趨勢引起人們的關注。 在預測期內,這有望幫助胃癌市場增長。
市場製約因素
有限的治療方案及其相關副作用的組合
可以使用化學療法、放射療法或兩者結合手術來治療癌症。 化學療法中使用的藥物通過攻擊快速分裂的癌細胞起作用,但它們也會損害健康細胞,引起令人不快的副作用,例如噁心、嘔吐和疲勞。。 我們預計這將成為未來幾年市場需求的障礙。 此外,治療成本上升和胃癌治療藥物相對有限等因素預計將阻礙預測期內胃癌市場的增長。
按疾病類型劃分的前景
胃癌市場按疾病類型分為腺癌、淋巴瘤、胃腸道間質瘤、類癌等。 在 2022 年的胃癌市場中,淋巴瘤領域佔據了相當大的收入份額。 免疫系統的淋巴細胞是這些腫瘤首先出現的地方。 一些淋巴瘤起源於胃壁,但大多數淋巴瘤起源於身體的其他部位。 根據淋巴瘤的類型和其他變量,這些腫瘤可以得到治療並具有良好的預後。 預計淋巴瘤意識的增強將促進這一領域的擴張。
治療類型的前景
按治療類型劃分,胃癌市場分為免疫療法、靶向療法、化學療法和放射療法/手術療法。 到 2022 年,胃癌市場將由靶向治療領域主導。 在靶向治療中,癌症患者接受專門針對癌細胞中基因或蛋白質的藥物治療。 靶向癌症療法有多種形式,包括激素劑、基因調節劑、血管生成抑製劑、細胞凋亡誘導劑和信號轉導抑製劑。
藥物類別展望
按照藥物類別,胃癌市場分為 PD-1/PD-L1 抑製劑、抗 HER-2 藥物、VEGFR2 抑製劑等。 2022年,PD-1/PD-L1抑製劑板塊將以最大的收入份額主導胃癌市場。 程序性細胞死亡蛋白 1 (PD-1) 和 PD-L1 等免疫檢查點蛋白通常有助於防止可能損害健康組織的過度免疫反應。 許多 PD-1/PD-L1 抑製劑,包括 nivolumab、pembrolizumab 和 atezolizumab,被批准用於治療嚴重或轉移性胃癌。 有幾種藥物已被證明可以延長晚期胃癌患者的生存期並減緩腫瘤生長。
管理路線展望
根據給藥途徑,胃癌市場分為口服藥物和注射藥物。 到 2022 年,注射劑將在胃癌市場佔據最大的收入份額。 由於注射劑直接進入血液,因此它們可能比口服藥物吸收得更快。 它可以幫助需要立即就醫的晚期或轉移性胃癌患者。 隨著更多的藥物到達靶位點,靜脈內給藥也提高了生物利用度。 這可以減少副作用並改善治療結果。
銷售渠道前景
按分銷渠道,胃癌市場分為專業和零售藥店、醫院藥店等。 預計到 2022 年,醫院藥房部門將在胃癌市場中佔據顯著的收入份額。 政府支持的醫院藥房的建立和優惠報銷是醫院藥房部門增長的主要驅動力。 除了這些原因之外,政府還為癌症治療提供了強有力的支持。 此外,由於患者數量增加、胃癌患病率增加以及癌症治療設施數量增加,預計該領域將擴大。
區域展望
按地區劃分,對北美、歐洲、亞太地區和 LAMEA(拉丁美洲、中東和非洲)的胃癌市場進行了分析。 到 2022 年,亞太地區將佔據最大的收入份額,推動胃癌市場的發展。 亞太地區日益老齡化的人口推動了市場擴張。 胃癌診斷的需求是由胃腸道腫瘤和淋巴瘤的流行驅動的。 此外,亞太地區的胃癌患者正在增加,預計這將在預測期內推動亞太地區的市場增長。
合作夥伴關係是市場進入者採取的主要策略。 根據發表在 Cardinal Matrix 上的一項分析,輝瑞公司是胃癌市場的領先先驅。 默克公司、梯瓦製藥工業有限公司、禮來公司是胃癌市場的領先創新者。
The Global Gastric Cancer Market size is expected to reach $6.9 billion by 2029, rising at a market growth of 17.6% CAGR during the forecast period.
The cells lining the stomach are where gastric cancer, also known as stomach cancer, first develops. Abdominal pain, vomiting, nausea, bloating, and weight loss can all be signs of gastric cancer. Surgery, radiation therapy, chemotherapy, or a combination of these treatments are all possible forms of treatment for gastric cancer.
Cancer develops when the body's cells start to proliferate out of control. Cancerous cells can develop in almost any body portion and spread to other organs. Usually, gastric cancers grow slowly over several decades. Precancerous alterations frequently appear in the inner mucosa of the stomach before genuine cancer develops. Since these early alterations rarely have symptoms, they may go unnoticed.
Different parts of the stomach can develop cancer at different times, which can result in a variety of symptoms and prognoses. Treatment choices may vary depending on the location of the cancer. For instance, malignancies that develop into or begin at the GE junction are often staged and treated similarly to esophageal tumors. The mucosa, the stomach's innermost lining, contains gland cells that give rise to these malignancies.
The intestinal type and diffuse type of stomach adenocarcinomas are the two basic forms. The likelihood of specific gene alterations in cancer cells increases the possibility that they can be treated with targeted medication therapy. The diffuse form typically spreads more rapidly. It is less frequent than the intestinal variety, and it is frequently more challenging to treat.
COVID-19 Impact Analysis
Delays in diagnosis & treatment have been the primary effects of the COVID-19 pandemic on gastric cancer. Delays in cancer diagnosis & treatment were the result, and they can significantly affect how patients turn out. Cancer research, particularly clinical trials looking at novel treatments for gastric cancer, has also been hampered by the pandemic. Due to COVID-19 limits, numerous clinical trials were postponed or suspended, which may be slowing down the creation of new treatments for the illness. However, the severe cases were being treated during the pandemic period. Considering these elements, the gastric cancer market witnessed a moderate impact due to COVID-19.
Market Growth Factors
Growing acceptance of targeted therapy and immunotherapy and introduction of new drugs
The number of targeted medications and immunotherapy treatments being developed and introduced into the market has increased due to a better understanding of the disease's molecular foundation. Since 2010, HER-2-specific medications, such as Herceptin, have been marketed. EGFR and PD-1 targeted therapy and immunotherapies are currently being created to treat gastric cancer. Furthermore, the market for gastric cancer is also anticipated to be driven by the approval and subsequent release of medications in the clinical pipeline aiding the gastric cancer market growth.
Rising Prevalence of Gastric Cancer
Gastric cancer is the most prevalent cancer type in Eastern Asia. 2020 saw an anticipated 1.1 million new cases of stomach cancer and 770 000 gastric cancer-related deaths, with male incidence rates often being twice as high as females. During the forecast period, it is anticipated that the rising prevalence of gastric carcinoma will increase demand for gastric cancer treatments and make them one of the most popular market trends for stomach cancer treatments. During the forecast period, this is expected to help the growth of the gastric cancer market.
Market Restraining Factors
Limited treatment option combined with their associated side effects
Treating cancer using chemotherapy, radiation therapy, or a combination of the two and with surgery is possible. The medications used in chemotherapy function by attacking rapidly dividing cancer cells; however, they can also harm healthy cells, resulting in unpleasant side effects such as nausea, vomiting, and exhaustion. In the next years, it is anticipated that this aspect will function as a barrier to the demand in the market. It is projected that factors such as high therapy costs and relatively limited availability of medications for the treatment of stomach cancer would work together to impede the growth of the gastric cancer market throughout the forecasted period.
Disease Type Outlook
Based on disease type, the gastric cancer market is characterized into adenocarcinoma, lymphoma, gastrointestinal stromal tumor, carcinoid tumor, and others. The lymphoma segment covered a considerable revenue share in the gastric cancer market in 2022. The immune system's lymphocytes are where these tumors develop in the first place. There are some lymphomas that can begin in the stomach wall, while most lymphomas begin in other areas of the body. Depending on the lymphoma type and other variables, these tumors can be treated and have good prognoses. The rising awareness of the lymphoma are predicted to support the segment's expansion.
Treatment Type Outlook
On the basis of treatment type, the gastric cancer market is classified into immunotherapy, targeted therapy, chemotherapy, and radiation therapy & surgery. The targeted therapy segment acquired a substantial revenue share in the gastric cancer market in 2022. With targeted therapy, cancer patients receive treatment by having pharmaceuticals that specifically target the genes or proteins that the cancer cells have. Targeted therapy for cancer comes in various forms, including hormonal treatments, gene expression regulators, angiogenesis inhibitors, apoptosis inducers, signal transduction inhibitors, and several more.
Drug Class Outlook
By drug class, the gastric cancer market is divided into PD-1/PD-L1 inhibitors, HER2 antagonists, VEGFR2 antagonists, and others. In 2022, the PD-1/PD-L1 inhibitors segment dominated the gastric cancer market with the maximum revenue share. Immune checkpoint proteins such as programmed cell death protein 1 (PD-1) and PD-L1 often aid in preventing overactive immune responses that may harm healthy tissues. For the treatment of severe or metastatic gastric cancer, a number of PD-1/PD-L1 inhibitors, such as nivolumab, pembrolizumab, and atezolizumab, have been licensed. In patients with advanced gastric cancer, several medications have demonstrated effectiveness in extending survival and slowing tumor growth
Route of Administration Outlook
Based on route of administration, the gastric cancer market is segmented into oral and injectable. In 2022, the injectable segment registered the maximum revenue share in the gastric cancer market. Since injectable pharmaceuticals are administered directly into the bloodstream, they can be absorbed faster than oral medicines. This helps individuals with advanced or metastatic stomach cancer, where quick action may be required. More of the drug can reach its target site when it is administered intravenously, which increases bioavailability. Less side effects and better therapeutic outcomes may arise from this.
Distribution Channel Outlook
On the basis of distribution channel, the gastric cancer market is classified into specialty & retail pharmacies, hospital pharmacies, and others. The hospital pharmacies segment projected a prominent revenue share in the gastric cancer market in 2022. The creation of government-sponsored hospitals pharmacies as well as advantageous reimbursement are the main causes of the hospital pharmacy segment's growth. These reasons together with the strong support the government has provided for cancer treatment. The segment is also predicted to expand as a result of the growing patient pool, growing prevalence of stomach cancer, and increasing number of cancer treatment facilities.
Regional Outlook
Region wise, the gastric cancer market is analyzed across North America, Europe, Asia Pacific, and LAMEA. In 2022, the Asia Pacific region led the gastric cancer market by generating the largest revenue share. The expansion of the market is being driven by the rise in the geriatric population in the Asia-Pacific region. The demand for gastric cancer diagnostics has been driven by the prevalence of gastrointestinal tumors and lymphomas. Furthermore, the rising case of gastric cancer in the region is anticipated to propel the market growth in the Asia Pacific during the projected period.
The major strategies followed by the market participants are Partnerships. Based on the Analysis presented in the Cardinal matrix; Pfizer, Inc. is the major forerunner in the Gastric Cancer Market. Companies such as Merck & Co., Inc., Teva Pharmaceutical Industries Ltd., Eli Lilly and Company are some of the key innovators in Gastric Cancer Market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Novartis AG, Pfizer, Inc., Viatris, Inc. (Mylan N.V.), F. Hoffmann-La Roche Ltd., Eli Lilly And Company, Merck & Co., Inc., Teva Pharmaceuticals Industries Ltd., Bristol Myers Squibb Company, Celltrion Healthcare Co., Ltd., and Samsung Biologics Co., Ltd. (Samsung Bioepis Co., Ltd.).
Strategies deployed in Gastric Cancer Market
Partnerships, Collaborations, and Agreements:
Feb-2023: Pfizer came into collaboration with Tempus, a technology company focused on advancing precision medicine through the practical application of artificial intelligence in healthcare. Following the collaboration, Pfizer would access Tempus' AI-based platform and multimodal data library, together with its clinical trial matching program and companion diagnostic development capabilities.
Jan-2023: Roche signed an agreement with CHEPLAPHARM, following which the latter company took the commercial rights from Roche for Xeloda (capecitabin) in China. Early in 2022, CHEPLAPHARM already had the rights for the extremely potent anti-cancer drug in every country except China and Japan. By incorporating China, CHEPLAPHARM improves its cancer product line and increases its market share in the world's second-largest pharmaceutical market. In 1997, Xeloda® received approval in China for use as a prescription drug. Shanghai Roche Pharmaceuticals got permission from China's State FDA in 2007 to treat advanced gastric cancer, metastatic breast cancer, and colorectal cancer.
Jan-2023: Roche extended its collaboration with CARsgen Therapeutics Holdings Limited, a manufacturer of innovative therapies for the treatment of solid tumors and hematologic malignancies. Following the expansion, the companies aim to evaluate CARsgen's investigational drug AB011, the first humanized monoclonal antibody against Claudin18.2 (CLDN18.2) that received IND clearance across the world, together with atezolizumab, Roche's PD-L1 checkpoint inhibitor, along with standard-of-care chemotherapy in patients with gastric or gastroesophageal junction carcinoma. In addition, Roche will be in charge of operating and conducting the research while both businesses would split the costs of the study's AB011 treatment arms.
Marr-2022: Celltrion Healthcare announced that they have got the tender in Brazil, from the Brazilian Federal Government to procure the world's first monoclonal antibody biosimilar Remsima (infliximab). Additionally, the company has won 12 State bids in Brazil to supply Remsima, including the largest state in Brazil Sao Paulo.
Mar-2022: Bristol Myers Squibb announced a clinical collaboration with Transcenta Holding Limited, a clinical-stage biopharmaceutical company, for the evaluation of the combination of TST001, an investigational humanized monoclonal antibody targeting Claudin18.2 created by Transcenta, with Opdivo® (nivolumab), Bristol Myers Squibb's anti-PD-1 therapy. This has been indicated for the treatment of unresectable locally advanced or metastatic gastric cancer or gastroesophageal junction cancer (GC/GEJ).
Feb-2022: Bristol Myers Squibb and Ono Pharmaceutical signed an agreement with Prime Research Institute for Medical RWD, Inc. for an industry-sponsored, large-scale, multi-institutional clinical research on gastric cancer patients treated with Opdivo together with chemotherapy. The study would utilize the PRiME-R's "CyberOncology®" data entry support system, which standardizes, organizes, manages, and integrates real-world data in routine cancer clinical practice.
Sep-2021: Roche Diagnostics International came into an agreement with Medical EarlySign, a company focused on developing ML-based decision support tools, for commercializing an AI tool that would detect cancer early. Following the agreement, the companies create the product, clinically validate it, and then market it. The companies would initially concentrate on the field of stomach cancer. EarlySign's software, which includes lab findings, EHR data, and other clinical care, is used in the clinical decision support tool.
Jun-2021: Eli Lilly and Company signed a clinical trial and supply agreement with ALX Oncology, a clinical-stage immuno-oncology company. Following the agreement, the companies aimed to evaluate the combination of Lilly's anti-VEGFR2 antibody, and ALX148, a next-generation CD47 blocker, for the treatment of HER2-positive gastric cancer or gastroesophageal junction cancer patients.
Feb-2021: Novartis Pharma announced a collaboration and license agreement with BeiGene, Ltd., a biotechnology company engaged in the development and commercialization of innovative medicines. The agreement was focused on developing, manufacturing, and commercializing BeiGene's anti-PD-1 antibody tislelizumab in the US, Mexico, Canada, and member countries of the European region, Norway, United Kingdom, Iceland, Switzerland, Russia, Liechtenstein, and Japan. Additionally, both businesses may perform clinical studies around the world to investigate pairings of tislelizumab with other cancer therapies, and BeiGene has the option to co-develop the medicine in North America with Novartis' financial support.
Product Launches and Product Expansions:
Aug-2020: Samsung Bioepis unveiled Ontruzant (trastuzumab), a biosimilar referencing Roche's Herceptin, in Brazil. Ontruzant (150 mg single-dose vials) has been authorized for the treatment of advanced gastric cancer, metastatic HER2-overexpressing breast cancer, and early HER2-overexpressing breast cancer by the Agencia Nacional de Vigilancia Sanitaria (ANVISA), the country's health regulatory body. It was launched in the United States in April 2020.
Mar-2020: Teva Pharmaceuticals USA, Inc., a division of Teva, together with Celltrion Healthcare, announced the availability of HERZUMA®1 (trastuzumab-pkrb) for Injection, a biosimilar to HERCEPTIN®1 in the United States. HERZUMA is approved in combination with cisplatin, capecitabine, or 5-fluorouracil for the treatment of patients with HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma who have not previously undergone treatment for metastatic disease.
Approvals & Trials:
Jun-2022: Eli Lilly and Company and Innovent Biologics, Inc., a biopharmaceutical company, received approval from the National Medical Products Administration (NMPA) of China for the supplemental New Drug Application (sNDA) for TYVYT® (sintilimab injection) together with fluorouracil and platinum-based chemotherapy for the first-line treatment of unresectable, locally advanced, recurrent or metastatic gastric or gastroesophageal junction adenocarcinoma.
Feb-2022: Samsung Bioepis got approval for ONTRUZANT® (also known as SB3), a biosimilar referencing Herceptin ®i (Trastuzumab) from Health Canada. This biosimilar is used for the treatment of Early Breast Cancer, metastatic gastric cancer (MGC), and Metastatic Breast Cancer (MBC), among adults.
Oct-2021: Bristol Myers Squibb got approval from European Commission for Opdivo (nivolumab) in combination with fluoropyrimidine- and platinum-based combination chemotherapy. This biosimilar is utilized for first-line treatment of adult patients with gastroesophageal junction (GEJ), HER2-negative advanced or metastatic gastric, or esophageal adenocarcinoma (EAC) whose tumors express PD-L1 with a combined positive score (CPS) ≥ 5.
Apr-2021: Bristol Myers Squibb received approval from the U.S. Food and Drug Administration (FDA) for Opdivo (nivolumab) (injection for intravenous use), in combination with fluoropyrimidine- and platinum-containing chemotherapy. This biosimilar is utilized for the treatment of patients with gastroesophageal junction cancer, advanced or metastatic gastric cancer, and esophageal adenocarcinoma, regardless of PD-L1 expression status.
Market Segments covered in the Report:
By Route of Administration
By Treatment Type
By Disease Type
By Distribution Channel
By Drug Class
By Geography
Companies Profiled
Unique Offerings from KBV Research
List of Figures