市場調查報告書
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1276413
淋巴瘤治療藥物全球市場規模,份額和行業趨勢分析報告:按治療類型,疾病類型,給藥途徑(注射,口服)分銷渠道,地區分類的展望和預測,2023-2029Global Lymphoma Therapeutics Market Size, Share & Industry Trends Analysis Report By Treatment Type, By Disease Type, By Route of Administration (Injectable, and Oral Route), By Distribution Channel, By Regional Outlook and Forecast, 2023 - 2029 |
淋巴瘤治療市場規模預計將在 2029 年達到 249 億美元,預測期內復合年增長率為 7.8%。
治療的選擇不僅取決於淋巴瘤的類型和分期,還取決於患者目前的健康狀況和病史等其他標準。 淋巴瘤的治療旨在實現使淋巴瘤患者長期緩解並增加其生存機會的雙重目標。
淋巴系統的癌症稱為淋巴瘤,是一種以異常惡性細胞快速生長為特徵的癌症亞型。 它通常會影響稱為淋巴細胞的白細胞,這些白細胞存在於淋巴結、脾臟、胸腺和骨髓中。 這降低了產生免疫反應的能力。 結果,淋巴結腫大、高燒、體重減輕、氣短和疲勞等症狀作為直接症狀出現。
COVID-19 影響分析
由於診斷和治療的延誤以及臨床試驗的中斷,大流行對淋巴瘤治療市場產生了負面影響。 淋巴瘤藥物對醫療專業人員構成了挑戰,因為化學療法和免疫抑制療法有可能加劇共病感染,這是癌症治療的一個重要方面。 最近接受抗 CD20 抗體治療的 B 細胞非霍奇金淋巴瘤 (B-NHL) 患者可能會患上嚴重的 COVID-19 疾病。
市場增長因素
治療方案的技術進步
淋巴瘤治療中已經引入了以 TAA 為重點的各種治療進展。 腫瘤免疫治療已成為腫瘤治療的重要組成部分。 腫瘤免疫治療已成為腫瘤治療的重要組成部分。 癌症免疫療法不會產生意想不到的脫靶效應,並具有多項臨床優勢。 因此,正在開發對癌症免疫治療有效且副作用很少的定制重組疫苗。 最近開發的免疫檢查點抑製劑 (ICI) 已經改變了癌症治療並提高了患者的生存率。 針對 CTLA-4 和 PD-1 等檢查點蛋白量身定制的 ICI 已被批准用於治療多種癌症類型。 這些因素正在推動市場的增長。
淋巴瘤病例增加,藥物需求增加
2018 年全球報告了大約 500,000 例 NHL 新病例,佔所有癌症診斷的 2.8%。 發現發生 NHL 的性別特定年齡標準化概率男性為 6.7,女性為 4.7。 這表示男性終生累積風險為 0.72%,女性為 0.35%。 此外,在高、低和中 HDI 國家中,每 10 萬男性 7.8 人,每 10 萬女性 5.6 人,每 10 萬女性 2.9 人。 因此,越來越多的淋巴瘤病例,尤其是非霍奇金淋巴瘤 (NHL),預計將在預測期內增加對許多淋巴瘤治療藥物的需求並推動市場增長。
市場製約因素
治療相關的副作用
淋巴瘤治療有副作用。 一些例子包括消化問題、“化療腦”、瘙癢、疼痛、皮膚乾燥、疲勞、噁心、嘔吐、脫髮、睡眠問題、周圍神經病變(神經損傷)和口腔粘膜炎(口腔炎)。 淋巴瘤治療後,感染的風險可能會增加。 因此,了解警告信號和症狀以及必要時如何聯系您的醫療團隊是極其重要的。 癌症治療會導致某些血細胞類型的缺陷。 紅細胞低、白細胞低、血小板低都是貧血的症狀。 預計這些將阻礙淋巴瘤治療市場在預測期內的增長。
按疾病類型劃分的前景
根據疾病類型,淋巴瘤治療市場分為霍奇金淋巴瘤和非霍奇金淋巴瘤。 到 2022 年,霍奇金淋巴瘤部分將在淋巴瘤治療市場中佔據重要的收入份額。 這種增長是由於霍奇金淋巴瘤患病率上升、對該病的認識不斷提高以及老年患者和復發或難治性 (R/R) HL 患者的大量未滿足需求等因素造成的。 霍奇金淋巴瘤是一種中度侵襲性癌症,可以迅速擴散到全身。 儘管如此,它還是最可治癒的癌症之一。
治療類型的前景
按治療類型劃分,淋巴瘤治療市場分為免疫療法、化學療法、靶向療法和放射療法。 到 2022 年,免疫治療部分將佔淋巴瘤治療市場的最高收入份額。 免疫療法的增長歸因於免疫學的進步、免疫療法的更廣泛應用以及全球產品批准數量的增加。 免疫療法已被證明是一種效果良好的治療方法。
管理路線展望
按給藥途徑,淋巴瘤藥物市場分為口服和注射。 注射劑部分在 2022 年佔淋巴瘤治療市場的最大收入份額。 這是因為註射是皮下注射,持續時間為 5-7 分鐘。 這種方法比靜脈內給藥要快得多。 這些產品被批准用於診斷為瀰漫性大 B 細胞淋巴瘤、濾泡性淋巴瘤和慢性淋巴細胞白血病的患者。
銷售渠道前景
淋巴瘤治療市場按分銷渠道分為醫院藥店、零售藥店和其他。 2022 年,零售藥房部門在淋巴瘤治療市場中佔據了很大的收入份額。 這是因為零售藥店不僅負責配製和銷售藥品,還負責指導顧客正確使用藥品,並提供有關可能的藥物相互作用的信息。 您還可以從零售藥劑師那裡獲得有關一般健康問題和市售藥物的建議。
區域展望
按地區分析了北美、歐洲、亞太地區和 LAMEA 的淋巴瘤治療市場。 北美地區將在 2022 年以最大的收入份額引領淋巴瘤治療市場。 這是由於淋巴瘤患病率的增加、包括靶向療法和免疫療法在內的淋巴瘤療法的進步,以及該地區主要市場參與者不斷增加的新產品發布。 此外,主要參與者的存在、獲得尖端藥物的機會、完善的醫療保健系統、強勁的研發支出等都將推動該地區的市場增長。
收購是市場進入者採取的主要策略。 根據發表在 Cardinal Matrix 上的一項分析,Pfizer, Inc.、Johnson &Johnson和 F. Hoffmann-La Roche Ltd. 是淋巴瘤藥物市場的先驅。 Eli Lilly And Company、Gilead Sciences, Inc. 和 Bristol Myers Squibb Company 等公司是淋巴瘤治療市場的領先創新者。
The Global Lymphoma Therapeutics Market size is expected to reach $24.9 billion by 2029, rising at a market growth of 7.8% CAGR during the forecast period.
The term "lymphoma therapeutics" refers to the numerous medical treatments and interventions that are intended to treat lymphoma, a form of cancer that impacts the lymphatic system, which is a component of the immune system of the body. Lymphoma is one of the most common types of cancer globally. The elimination of malignant cells, the prevention of the disease's progression, and an improvement in the patient's standard of life are the primary focuses of lymphoma treatment strategies.
The spleen, the thymus gland, lymph nodes (also known as lymph glands), and bone marrow are all elements that make up the lymphatic system. Lymphoma has the potential to affect not only these areas, but many other organs located throughout the body as well. Lymphoma patients have access to various treatment options, including radiation therapy, chemotherapy, immunotherapy, targeted therapy, and stem cell transplantation, among others.
The choice of treatment is determined not only by the type and stage of lymphoma but also by additional criteria, such as the patient's current state of health and medical history. Lymphoma treatments work toward the dual goals of inducing individuals with lymphoma into a state of long-term remission while also improving their chances of survival.
Cancer of the lymphatic system is referred to as lymphoma, and lymphoma is a subtype of cancer characterized by the fast proliferation of aberrant malignant cells. It typically affects the white blood cells (WBCs), also known as lymphocytes, in the lymph nodes, spleen, thymus, and bone marrow. This has the effect of reducing the body's ability to mount an immune response. As a result, the patient experiences symptoms such as swelling in the lymph nodes, high fever, loss of weight, shortness of breath, and weariness as a direct effect of the condition.
COVID-19 Impact Analysis
The pandemic negatively impacted the lymphoma therapeutics market due to delayed diagnosis and treatment and disruptions to clinical trials. Lymphoma therapeutics pose a challenge for healthcare professionals due to the potential risk of chemotherapeutic and immunosuppressive treatment exacerbating comorbid COVID-19 infections, which are crucial aspect of cancer therapy. Patients with B-cell non-Hodgkin's lymphoma (B-NHL), who have recently undergone treatment with anti-CD20 antibodies, are susceptible to severe COVID-19 disease.
Market Growth Factors
Technological advancement in the treatment options
Various treatment developments have been introduced in lymphoma therapeutics by focusing on TAAs; cancer immunotherapy has become a crucial part of cancer treatment. It does not produce unintended off-target effects and has several clinical advantages. This encourages the creation of highly effective, low-side-effect tailored recombinant vaccines for cancer immunotherapy. Immune checkpoint inhibitors (ICIs), recently developed, have changed cancer treatment and increased patient survival. ICIs tailored to checkpoint proteins, like CTLA-4 or PD-1, have been approved to treat several cancer types. These factors are propelling market growth.
Increasing cases of Lymphoma, raising the demand for therapeutics
Around half a million new cases of NHL were reported globally in 2018, accounting for 2.8% of all cancer diagnoses. The gender-specific age-standardized probability of developing NHL was found to be 6.7 in men and 4.7 in women. This indicates that men have a cumulative lifetime risk of 0.72%, while women have a risk of 0.35%. Furthermore, men's incidence was 7.8/100,000, and women's was 5.6/100,000 and 2.9/100,000 in high and low/medium human development index nations, respectively. Hence, the growing cases of Lymphoma, especially non-Hodgins Lymphoma (NHL), are expected to increase the demand for numerous lymphoma therapeutics boosting the market growth in the projected period.
Market Restraining Factors
The associated side effects of treatments
The treatment for lymphoma is associated with side effects. Some of them are digestive issues, "Chemo brain," itchy, painful, and dry skin, fatigue, nausea, and vomiting, hair loss, sleep issues, peripheral neuropathy (nerve injury), and oral mucositis (sore mouth). The risk of infection may rise after the treatment of lymphoma. Therefore, it's crucial to be aware of the warning signs and symptoms and how to get in touch with the medical team if necessary. Lack of specific blood cell types can result from cancer treatment. Low red blood cells, low white blood cells, and low platelets are all symptoms of anemia. These are expected to hinder the lymphoma therapeutics market growth in the projected period.
Disease Type Outlook
Based on disease Type, the lymphoma therapeutics market is segmented into Hodgkin lymphoma and non-Hodgkin lymphoma. The Hodgkin lymphoma segment acquired a significant revenue share in the lymphoma therapeutics market in 2022. The growth is attributed due to the reasons such as the rising prevalence of Hodgkin lymphoma, increased awareness of the disease, and the significant unmet needs of elderly patients and patients with relapsed or refractory (R/R) HL. The moderately aggressive cancer Hodgkin lymphoma can quickly spread throughout the body. Despite this, it's also one of the cancer forms that is most easily cured.
Treatment Type Outlook
On the basis of treatment Type, the lymphoma therapeutics market is divided into immune therapy, chemotherapy, target therapy and radiation therapy. The immune therapy segment held the highest revenue share in the lymphoma therapeutics market in 2022. The growth of immune therapy can be attributed to the progress in immunology, the wider accessibility of immune therapies, and the increasing number of product approvals globally. Immunotherapy has been found to be a highly successful treatment option with positive outcomes.
Route of Administration Outlook
By route of administration, the lymphoma therapeutics market is classified into oral route and injectable. The injectable segment witnessed the largest revenue share in the lymphoma therapeutics market in 2022. This is because the injection is administered subcutaneously and has a duration of 5-7 minutes. This method is significantly faster than intravenous administration. These products have been approved for usage in patients diagnosed with diffuse large B-cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia.
Distribution Channel Outlook
Based on the distribution channel, the lymphoma therapeutics market is bifurcated into hospital pharmacies, retail pharmacies and others. The retail pharmacies segment recorded a significant revenue share in the lymphoma therapeutics market in 2022. This is because retail pharmacies are responsible for the preparation and distribution of medications, as well as the counseling of customers regarding the proper use of medications and the provision of information regarding probable drug interactions. Also, customers can get advice from retail pharmacists regarding general health concerns as well as over-the-counter medications.
Regional Outlook
Region-wise, the lymphoma therapeutics market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The North America region led the lymphoma therapeutics market by generating the maximum revenue share in 2022. This is due to an increase in lymphoma prevalence, advancements in lymphoma therapeutics, including targeted therapies and immunotherapies, and an increase in the number of new product releases by significant market players in this region. Additionally, the existence of important players, the accessibility of cutting-edge medications, the well-established healthcare system, and substantial R&D spending will surge the market growth in the region.
The major strategies followed by the market participants are Acquisitions. Based on the Analysis presented in the Cardinal matrix; Pfizer, Inc., Johnson & Johnson, and F. Hoffmann-La Roche Ltd. are the forerunners in the Lymphoma Therapeutics Market. Companies such as Eli Lilly And Company, Gilead Sciences, Inc., and Bristol Myers Squibb Company are some of the key innovators in Lymphoma Therapeutics Market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include AstraZeneca PLC, Bayer AG, Bristol Myers Squibb Company, F. Hoffmann-La Roche Ltd., Johnson & Johnson, Gilead Sciences, Inc., Seagen, Inc., Teva Pharmaceutical Industries Ltd., Pfizer, Inc. and Eli Lilly And Company.
Recent Strategies Deployed in Lymphoma Therapeutics Market
Partnerships, Collaborations and Agreements:
Jun-2022: AstraZeneca came into collaboration with GRAIL, LLC, a healthcare company whose focus is to detect cancer early when it can be cured. The collaboration aimed to develop and commercialize companion diagnostic (CDx) assays for their utilization with AstraZeneca's therapies. The partnership first concentrates on creating complementary diagnostic tools to recognize people with high-risk, early-stage diseases. Over the following few years, it is anticipated that additional studies will be conducted across various indications. Patients enrolled in AstraZeneca's clinical trials will be tested using GRAIL's methylation platform.
Apr-2022: Teva Pharmaceuticals signed a partnership with Roche Pharma China for improving lymphoma treatments by integrating the respective strengths and resources for further expanding the availability of Treanda in China. Following the partnership, the latter company reinforced its hematology portfolio and expanded the panorama of lymphoma treatment. Moreover, the companies work together for promoting the standardization of lymphoma treatment in China.
Mergers and Acquisitions:
Jan-2023: AstraZeneca acquired Neogene Therapeutics, Inc., a clinical-stage biotechnology company. Neogene's experience in TCR-T discovery, development, and manufacturing would support AstraZeneca's vision to change patient outcomes as part of a shared mission to provide cell treatments to patients with solid tumors. With the help of this acquisition, the former company's internal oncology cell therapy team will have a rare opportunity to collaborate with world-renowned experts in T-cell receptor biology and cell therapy manufacturing, opening up new avenues for the treatment of cancer.
Aug-2022: AstraZeneca took over TeneoTwo, Inc. (TeneoTwo)i, with TNB-486, Phase I clinical-stage CD19/CD3 T-cell engager, which is currently under evaluation in relapsed and refractory B-cell non-Hodgkin lymphoma. With the acquisition of TNB-486, a potential novel treatment for B-cell hemotologic malignancies like diffuse large B-cell lymphoma and follicular lymphoma is being created. Building on the success of Calquence (acalabrutinib), TNB-486 broadens AstraZeneca's hematology portfolio, which includes several therapeutic modalities and routes to target a variety of blood cancers.
Aug-2022: Bristol Myers Squibb completed the acquisition of Turning Point Therapeutics, a pharmaceutical company engaged in the discovery and development of precision medicine for cancer and other diseases. The acquisition added a product line of investigational medicines designed for targeting the most common mutations related to oncogenesis, to Bristol Myers' portfolio.
Nov-2021: Pfizer acquired Trillium Therapeutics, a clinical-stage immuno-oncology company that develops innovative therapies for cancer treatment. The acquisition added a biologics portfolio that enhanced the patient's innate immune system ability to detect and destroy cancer cells.
Product Launches and Expansions:
Mar-2023: Teva Pharmaceuticals together with NATCO Pharma Limited, announced the additional strengths for the generic version of Revlimid®1 (lenalidomide capsules), in 2.5 mg, and 20 mg strengths, in the United States. Teva's lenalidomide capsules can be utilized for the treatment of multiple myeloma when combined with dexamethasone, specific myelodysplastic syndromes, and mantle cell lymphoma after receiving specific prior treatment.
Trials and Approvals:
Mar-2023: AstraZeneca received approval from National Medical Products Administration (NMPA) in China for Calquence (acalabrutinib), a next-generation, selective Bruton's tyrosine kinase (BTK) inhibitor. This inhibitor is indicated for the treatment of mantale cell lymphoma in adult patients who have already obtained the therapy at least once.
Jan-2023: Eli Lilly and Company announced that U.S. FDA approved Jaypirca™ (pirtobrutinib), the First and Only Non-Covalent (Reversible) BTK Inhibitor. The inhibitor would be used for the treatment of Relapsed or Refractory Mantle Cell Lymphoma After At least Two Lines of Systemic Therapy, Including a BTK Inhibitor, among adult patients.
Nov-2022: Seagen announced that U.S. FDA approved ADCETRIS® (brentuximab vedotin), the new indication for children with untreated high-risk Hodgkin lymphoma. It is suitable for the treatment of pediatric patients 2 years and above.
Aug-2022: AstraZeneca got the approval from US Food and Drug Administration (FDA) for its new tablet formulation of Calquence (acalabrutinib). This tablet formulation provides enhanced flexibility to patients and physicians when making treatment plans for chronic lymphocytic leukemia and mantle cell lymphoma.
Jun-2022: Bristol Myers Squibb got approval from U.S. FDA for CAR T Cell Therapy Breyanzi® for Relapsed or Refractory Large B-cell Lymphoma after a Prior Therapy once. This therapy is indicated for the treatment of follicular lymphoma grade 3B, primary mediastinal large B-cell lymphoma, large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL) not otherwise specified (including DLBCL arising from indolent lymphoma), and high-grade B-cell lymphoma, among adult patients.
Apr-2022: Kite, a Gilead Company, got approval from U.S. Food and Drug Administration (FDA) for Yescarta® (axicabtagene ciloleucel) CAR T-cell therapy. The therapy is beneficial for adult patients with large B-cell lymphoma that is refractory to first-line chemoimmunotherapy or that relapses within 12 months of first-line chemoimmunotherapy.
Feb-2021: Bristol Myers received U.S. Food and Drug Administration approval for Breyanzi (lisocabtagene maraleucel), a cell-based gene therapy. The therapy is indicated for the treatment of adult patients suffering from large B-cell lymphoma. This therapy is suitable for patients who have not responded to, or who have relapsed after, at least two other types of systemic treatment.
Jan-2021: Pfizer got U.S. Food and Drug Administration (FDA) approval for the supplemental New Drug Application (sNDA) for XALKORI® (crizotinib). This drug would be utilized for the treatment of pediatric patients 1 year and older and young adults with refractory or relapsed, systemic anaplastic large cell lymphoma (ALCL) that is anaplastic lymphoma kinase (ALK)-positive.
Market Segments covered in the Report:
By Treatment Type
By Disease Type
By Route of Administration
By Distribution Channel
By Geography
Companies Profiled
Unique Offerings from KBV Research
List of Figures