市場調查報告書
商品編碼
1276458
多發性骨髓瘤全球市場規模,份額,行業趨勢分析:按最終用戶,按疾病(症狀性多發性骨髓瘤,冒煙(無症狀)多發性骨髓瘤)藥物類型,地區展望和預測,2023-2029Global Multiple Myeloma Market Size, Share & Industry Trends Analysis Report By End User, By Disease Type (Active Multiple Myeloma and Smoldering Multiple Myeloma), By Drug Type, By Regional Outlook and Forecast, 2023 - 2029 |
多發性骨髓瘤市場規模預計到 2029 年將達到 375 億美元,預測期內復合年增長率為 9.8%。
多發性骨髓瘤是一個術語,用於描述已發展成惡性腫瘤的漿細胞不受控制的生長。 單克隆免疫球蛋白,或 M 蛋白、M 刺突蛋白和副蛋白,是由漿細胞產生的異常蛋白質(抗體)。 健康的漿細胞產生的免疫球蛋白可有效對抗感染,因為它們可以識別和消除細菌。
然而,癌性漿細胞在多發性骨髓瘤患者的骨髓中積聚並破壞健康的血細胞。 因此,身體會產生一種稱為副蛋白的異常蛋白質,它會積聚並損害組織和器官。 多發性骨髓瘤有多種副作用,包括頻繁感染、貧血、骨痛和腎臟問題。 治療選擇包括靶向治療、化學療法、放射療法和乾細胞移植。
COVID-19 影響分析
由於大流行嚴重擾亂了研發工作,多發性骨髓瘤的新藥和□□治療方法的開發也被大大推遲。 此外,根據 2021 年 12 月的 Blood Cancer Journal,與 2019 年相比,2020 年新確診的多發性骨髓瘤病例將減少,這些病例的存活率也在下降。 多發性骨髓瘤患者在 2020 年死亡和感染 COVID-19 的風險增加。 因此,大流行對多發性骨髓瘤市場產生了不利影響。
市場增長因素
全球範圍內政府支持計劃的增加
在醫療實踐的同時,政府和組織還應解決當前與醫療保健提供者關係中出現的其他問題(費用結構和報銷、醫療保健設施、藥物輸送路線、政治和其他網絡問題)。正在擴大。 這些問題已通過接受以患者護理為導向的醫療設施得到解決,初級保健醫生在這些設施中與專家和其他專家協調護理,並在商業和醫療保險/醫療補助領域建立負擔得起的腫瘤中心。我們正在推動實踐更多的是付款人和提供者的聯合倡議。 因此,預計政府支持的增加將增加對多發性骨髓瘤治療和藥物的需求,從而刺激市場擴張。
全球多發性骨髓瘤病例增加
包括多發性骨髓瘤在內的幾種血液系統惡性腫瘤的發病率不斷上升,是推動市場發展的關鍵因素之一。 儘管多發性骨髓瘤被認為是一種罕見的癌症,但全世界有大量癌症患者,這增加了對有效、尖端治療的需求。 有效的尖端治療可為患者帶來更好的臨床結果。 這一點非常重要,因為 MM 的流行在全球呈上升趨勢。 此外,研究和開發導致治療取得進展,需要更複雜的藥物來改善結果。
市場製約因素
沒有永久的解決辦法,許多現有的治療方法都有副作用
Kyprolis 的常見副作用包括疲勞、低血液和血小板計數、腹瀉、便秘、噁心、氣短、發燒、四肢腫脹、上呼吸道感染、支氣管炎和肺炎。 此外,某些副作用包括低血鉀、高血糖、低血鈣、肌肉痙攣、四肢麻木或麻痺以及高血壓。 放射治療還會導致疲勞、皮膚刺激、噁心、腹瀉、治療部位脫髮、不育、感染風險增加、食慾不振、後續癌症風險增加以及治療部位附近器官受損。有副作用比如傷害。
藥物類型展望
按藥物類型劃分,多發性骨髓瘤市場分為化學療法、蛋白□抑製劑、單克隆抗體等。 2022年,單克隆抗體領域在多發性骨髓瘤市場取得了大幅增長。 隨著最近引入的單克隆抗體 (mAb),多發性骨髓瘤的治療選擇發生了根本性的變化。 elotuzumab 和 daratumumab 在復發/難治性患者中的療效引起了人們對該疾病的 mAb 的極大興趣。
最終用戶視角
根據最終用戶,多發性骨髓瘤市場被細分為醫院、診所等。 2022 年,醫院部門在多發性骨髓瘤市場佔據了最大的收入份額。 由於患者入院人數增加、多發性骨髓瘤患病率上升以及這些設施擁有合格的醫務人員可以改善患者服務等因素,醫院部門正在增長。 用於治療的藥物通常在醫院開處方和給藥,這一事實是該細分市場佔據主導地位的重要組成部分。
按疾病類型劃分的前景
多發性骨髓瘤市場按疾病類型分為症狀性多發性骨髓瘤和冒煙(無症狀)多發性骨髓瘤。 在 2022 年的多發性骨髓瘤市場中,冒煙(無症狀)多發性骨髓瘤細分市場實現了顯著的增長。 該細分市場的增長歸因於人們對這種疾病的認識不斷提高。 冒煙型(無症狀)多發性骨髓瘤可能需要數年才能變得活躍。 因此,一些患有這種綜合徵的人不會經歷有症狀的 MM。 醫療保健專業人員通過觀察症狀轉變為症狀性多發性骨髓瘤來控制 SMM。
區域展望
按地區分析了北美、歐洲、亞太地區和 LAMEA 的多發性骨髓瘤市場。 到 2022 年,北美部分將在多發性骨髓瘤市場獲得最高的收入份額。 由於主要競爭對手的強大存在以及多發性骨髓瘤藥物發布和產品批准的增加,預計北美多發性骨髓瘤市場在預測期內將顯著擴大。 此外,由於多發性骨髓瘤的患病率上升,市場有望發展。 例如,美國癌症協會預測,到 2023 年,美國將發現 35,730 例多發性骨髓瘤病例。
市場進入者採取的主要策略是收購。 根據基數矩陣中的分析,Novartis AG、Johnson &Johnson、Pfizer, Inc.是多發性骨髓瘤市場的先驅。 Amgen, Inc.、Sanofi S.A. 和 Bristol Myers Squibb Company 等公司是多發性骨髓瘤市場的領先創新者。
The Global Multiple Myeloma Market size is expected to reach $37.5 billion by 2029, rising at a market growth of 9.8% CAGR during the forecast period.
Multiple myeloma or plasma cell cancer is a disease. The immune system is significantly dependent on healthy plasma cells, which are located in the bone marrow. In order to combat infections and other diseases, the immune system is composed of various cell types. T cells and B cells are two of the most common types of lymphocytes (lymph cells) in the immune system. The lymph nodes, bone marrow, intestines, and circulation are just a few of the organs where lymphocytes can be found.
B cells develop into plasma cells due to the immune system's response to an infection. Antibodies, also known as immunoglobulins, are produced by plasma cells and aid the body's defense against pathogens. Bone marrow contains the majority of plasma cells. Soft tissue found inside bones is called bone marrow. Other blood cells, including red, white, and platelets, are also found in the normal bone marrow and plasma cells.
Multiple myeloma is the term used to describe plasma cells that have developed malignancy and are growing uncontrollably. Monoclonal immunoglobulin, or M-protein, M-spike, or paraprotein, is an aberrant protein (antibody) produced by plasma cells. Immunoglobulins made by healthy plasma cells can recognize and eliminate germs, which is helpful in the fight against infections.
However, cancerous plasma cells gather in the bone marrow of patients with multiple myeloma and destroy healthy blood cells. As a result, the body produces paraproteins, aberrant proteins that can accumulate and harm tissues and organs. Multiple myeloma has several side effects, including frequent infections, anemia, bone pain, and renal problems. Targeted therapy, chemotherapy, radiation therapy, and stem cell transplantation are available as alternatives for treatment.
COVID-19 Impact Analysis
Since R&D operations were substantially hampered by the pandemic, developing novel medicines and treatments for multiple myeloma also slowed considerably. Moreover, the Blood Cancer Journal reported in December 2021 that fewer new instances of multiple myeloma were identified in 2020 in comparison with 2019 and that the survival rate for those cases declined concurrently. Patients with multiple myeloma had a higher mortality rate and COVID-19 infection risk in 2020. Therefore, the pandemic had a detrimental effect on the multiple myeloma market.
Market Growth Factors
Increasing government support initiatives worldwide
Along with care practices, governments and organizations are also extending support for other current problems in provider relations include fee schedules & reimbursement, sites of care, route of drug administration, and politics as well as other network issues. These problems are pushing oncology practices into more payer-provider collaborative initiatives, including accepting patient-care medical homes, where primary care doctors coordinate care with experts and other specialists and creating affordable oncology healthcare institutions in both the commercial and Medicare/Medicaid spaces. Hence, the increasing support of governments is projected to increase demand for treatments or medications for multiple myeloma, thereby fueling market expansion.
Rising cases of multiple myeloma worldwide
The rising incidence of several types of blood malignancies, including multiple myeloma, is one of the major market-driving factors. Although MM is regarded as a more uncommon cancer kind, there are a sizable number of cases of cancer worldwide, and the demand for effective and cutting-edge therapies is rising. Patients frequently experience better and more favorable clinical results when effective and cutting-edge therapies are administered. This is crucial because current trends point to an increase in the prevalence of MM around the globe. In addition, as a result of ongoing R&D, treatment has advanced, necessitating more complex medicines to improve prognosis.
Market Restraining Factors
Lack of permanent solutions and side effects of many existing treatments
Common side effects of Kyprolis include fatigue, a low blood cell count and blood platelet levels, diarrhea, constipation, nausea, shortness of breath, fever, swelling of the extremities, upper respiratory tract infection, bronchitis, and pneumonia. Additionally, certain side effects of the drug include low blood potassium, high blood sugar, low blood calcium, muscle spasms, numbness and tingling in the extremities, and high blood pressure. In addition, radiation therapy can cause adverse effects such as fatigue, irritation of the skin, nausea, diarrhea, loss of hair in the treatment area, infertility, higher risk of infection, loss of appetite, increased risk of subsequent cancer, and harm to organs located near the treatment area.
Drug Type Outlook
Based on drug type, the multiple myeloma market is categorized into chemotherapy, protease inhibitors, monoclonal antibody, and others. The monoclonal antibodies segment procured a considerable growth rate in the multiple myeloma market in 2022. The therapeutic options for multiple myeloma have radically changed due to the recent introduction of monoclonal antibodies (mAbs). The effectiveness of elotuzumab and daratumumab in relapsed/refractory patients has sparked much interest in mAbs for this condition.
End User Outlook
On the basis of end user, the multiple myeloma market is divided into hospitals, clinics, and others. The hospitals segment acquired the largest revenue share in the multiple myeloma market in 2022. The hospital segment is growing due to factors including an increase in patient admissions, a rise in the prevalence of multiple myeloma, and the availability of qualified medical staff in these facilities that enable improved patient services. The fact that the medications used in treatment can be routinely prescribed and given in hospital settings accounts for a significant portion of this segment's dominance.
Disease Type Outlook
Based on disease type, the multiple myeloma market is segmented into active multiple myeloma and smoldering multiple myeloma. The smoldering multiple myeloma segment garnered a remarkable growth rate in the multiple myeloma market in 2022. The growth of the segment is owed to the increasing awareness of the disease. It may take years for smoldering multiple myeloma to develop into an active form. As a result, some individuals with this syndrome never experience active MM. Healthcare professionals' control SMM by watching for symptoms that it's turning into active multiple myeloma.
Regional Outlook
On the basis of region, the multiple myeloma market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The North America segment procured the highest revenue share in the multiple myeloma market in 2022. Due to the strong presence of key competitors and the rise in multiple myeloma drug launches and product approvals, the North American multiple myeloma market is predicted to expand considerably over the forecast period. Moreover, the market is anticipated to develop because of the rising prevalence of multiple myeloma. For instance, the American Cancer Society forecasted that by 2023, 35,730 incidences of multiple myeloma would have been discovered in the United States.
The major strategies followed by the market participants are Acquisitions. Based on the Analysis presented in the Cardinal matrix; Novartis AG, Johnson & Johnson, and Pfizer, Inc. are the forerunners in the Multiple Myeloma Market. Companies such as Amgen, Inc., Sanofi S.A., and Bristol Myers Squibb Company are some of the key innovators in Multiple Myeloma Market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Novartis AG, Bristol Myers Squibb Company, Amgen, Inc., AbbVie, Inc., Sanofi S.A., Johnson & Johnson, Baxter International, Inc., Takeda Pharmaceutical Company Limited, Teva Pharmaceuticals Industries Ltd., and Pfizer, Inc.
Recent Strategies Deployed in Multiple Myeloma Market
Partnerships, Collaborations and Agreements:
Mar-2022: Sanofi came into collaboration with Blackstone Life Sciences, a US-based private equity firm focused on investing in pharmaceutical, life science, and medical research companies. The collaboration involves the private equity firm contributing up to 300 million euros to advance studies and clinical development programs for the development and delivery of the anti-CD38 antibody Sarclisa focused on treating patients with multiple myeloma.
Jan-2020: Sanofi partnered with Sebia, a France-based provider of clinical protein electrophoresis equipment. The partnership focuses on co-developing treatment for multiple myeloma. The agreement includes, Sebia developing in vitro diagnostic (IVD) tests and acting as its supplier.
Acquisitions and Mergers:
Dec-2022: Johnson & Johnson took over Abiomed, a US-based medical device technology company. The addition of Abiomed advances the acquiring company's MedTech business division, by providing innovational medical technologies. Further, the acquisition broadens Johnson & Johnson's cardiovascular product offerings.
Dec-2021: Baxter acquired Hillrom, a US-based medical device company. The acquisition advances the company's mission to transform healthcare and patient care.
Nov-2021: Pfizer acquired Trillium Therapeutics, a Canada-based clinical-stage immuno-oncology company. The acquisition strengthens the acquiring company's devotion to seeking scientific breakthroughs. Further, the addition of Trillium expands Pfizer's hematology product offerings.
Oct-2021: Amgen completed the acquisition of Teneobio, a US-based biotechnology company. The acquisition of Teneobio broadens the acquiring company's skills and further accelerates its aim to design, build and bring innovations to the markets to better serve their patients. Further, the addition of Teneobio's proprietary bispecific and multispecific antibody technologies perfectly complements Amgen's BiTE platform and its already existing antibody capabilities.
Product Launches and Expansions:
Mar-2023: Teva and Natco together launched extra strengths for the generic version of Revlimid. The medicine is intended to use by adult patients for the cure of multiple myeloma, specific myelodysplastic syndromes, and mantle cell lymphoma. The added strengths reflect the company's devotion to making generic drugs accessible to patients who need them.
Feb-2022: Sandoz, part of Novartis introduced lenalidomide, a generic oncology medicine. The medicine is intended for various haemato-oncology conditions and is available in the form of hard capsules. Lenalidomide is a cost-saving treatment, thereby increasing the treatment's accessibility amongst patients.
Dec-2021: Novartis introduced T-Charge, a CAR-T platform that would act as a base for multiple investigational CAR-T cell therapies. The T-Charge eradicates the need for extended culture time outside the body (ex-vivo), as it primarily happens within a patient's body.
Trials and Approvals:
Oct-2022: The US FDA issued clearance for Johnson & Johnson's Tecvayli, a BCMA-targeted bispecific drug intended for treating patients with refractory or relapsed multiple myeloma. The conditions to be met to use the recently approved drug, patients must have undergone a minimum of four lines of therapy.
Jan-2022: Bristol Myers Squibb received approval for Abecma in Japan. Abecma is a CAR T therapy intended for adult patients with refractory or relapsed (R/R) multiple myeloma. The adult patient should have already received a minimum of three therapies and should have experienced disease progression on the last therapy. Further, the approval demonstrates the company's devotion to catering to the unmet medical needs in Japan.
Dec-2021: U.S. Food and Drug Administration (FDA) approved Amgen's expansion of KYPROLIS to use it in combination with DARZALEX FASPRO, and dexamethasone. The new combination is intended for adult patients with refractory or relapsed multiple myeloma, who have undergone one to three lines of therapy. Further, the combination provides enhanced flexibility and easiness to the patients.
Mar-2020: Sanofi announced FDA approved the use of Sarclisa in combination with dexamethasone and pomalidomide. The combination is intended for the treatment of adults with relapsed refractory multiple myeloma (RRMM), who have already received two therapies. The approval provides patients with hard-to-treat multiple myeloma with a new treatment option.
Market Segments covered in the Report:
By End User
By Disease Type
By Drug Type
By Geography
Companies Profiled
Unique Offerings from KBV Research
List of Figures