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市場調查報告書

商品編碼

1495975

全球微載體市場 - 2024 年至 2029 年預測

Global Microcarrier Market - Forecasts from 2024 to 2029

出版日期: 2024年04月16日 | 出版商:

Knowledge Sourcing Intelligence | 英文 140 Pages | 商品交期: 最快1-2個工作天內

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簡介目錄

預計微載體市場在預測期內將以 11.55% 的複合年成長率成長，從 2022 年的 925,914,000 美元達到 2029 年的 1,989,084,000 美元。

微載體是用於組織培養的微小珠子或球體，可增加貼壁依賴性細胞附著和產量的表面積，並作為支持基質使貼壁細胞在反應器中生長。微載體廣泛用於在生技藥品和疫苗的大規模商業生產中繁殖產生病毒和產生蛋白質的貼壁細胞群。微載體市場的成長可歸因於生技藥品和生物相似藥產業的快速成長。

對細胞疫苗的需求不斷成長以及技術進步預計將對微載體市場產生積極影響。然而，細胞生技藥品和細胞療法的高成本可能會阻礙指定預測期內的市場成長。此外，高密度微載體培養的成長限制也預計將抑制預測期內微載體市場的成長。此外，微載體市場分為產品、應用、最終用戶和地區。

市場促進因素：

由於對細胞疫苗的需求不斷增加，微載體市場將會成長。

流感、猴痘、伊波拉出血熱和COVID-19等新病毒感染疾病的增加增加了全球對疫苗的需求，導致市場對微載體的需求增加，我們支持在預測期內對微載體的需求增加。市場的成長。例如，世界衛生組織（WHO）的疾病爆發新聞（DONs）為潛在關注的事件提供了已確認的急性公共衛生事件，以及2022年9月剛果民主共和國爆發的伊波拉病毒疫情。

剛果民主共和國衛生署在 RT-PCR 實驗室檢測證實北基伍省貝尼衛生區出現一例死亡病例後宣布爆發疫情。同時，烏干達截至9月25日，已確診18例由蘇丹病毒引起的伊波拉出血熱病例。此類感染疾病患者數量的增加和大流行風險的增加是全球疫苗需求的關鍵因素。此外，許多組織正在重點開發針對日益增多的感染疾病的疫苗。例如，美國疾病管制與預防中心 (CDC) 在 2022 年 9 月更新的疫苗考量摘要中指出，JYNNEOS 疫苗已被核准用於預防猴痘和天花疾病。

此外，CDC 指出，ACAM2,000 疫苗已被核准用於天花疫苗接種，根據擴大使用臨床實驗新藥通訊協定也可用於猴痘疫苗。北美地區預計將佔據微載體市場的很大佔有率。由於研發活動、基因治療以及生技藥品和技術進步的興起，美國等國家正在增加對細胞研究的投資。

此外，老牌製藥公司的普及擴大了其地理範圍並繼續促進其疫苗的廣泛行銷，預計將推動該地區的市場擴張。此外，隨著感染疾病和癌症盛行率的上升，增加了疫情期間疫苗接種的需求，預計該地區的規模將會成長。

另一方面，由於市場領先企業的增加和技術創新利用率的提高，歐洲在預期期間在微載體市場中佔據第二大佔有率。由於研發投入的增加，預計該地區將推動產品開發和市場需求。

主要發展

2023 年 10 月 - Thermo Fisher Scientific 推出 Gibco CTS Detachable Dynabeads，這是一個用於細胞療法製造的具有主動釋放機制的平台。儘管 Gibco CTS Detachable Dynabeads CD3/CD28 試劑盒提供一步式分離和激活，但 CTS Dynabeads 磁珠可以在此過程中的任何時刻從目標細胞中釋放。該套件包含包裝在與 CTS DynaCellect 磁分離系統相容的生物製程容器中的活性釋放緩衝液，可在分離和磁分離後透過競爭性結合機制將目標細胞主動從磁珠上分離。
2023 年 10 月 - 可樂麗有限公司開發出用於再生醫學細胞培養的 PVA 水凝膠微載體。這種支架材料是一種安全的材料，不易受到損壞，不會產生碎片，並且可以進行有效的細胞培養。當PVA水凝膠微載體被引入反應器並大量培養時，細胞會黏附並增殖，從而實現有效的分離和恢復。它也被證實是安全的並且表現出更高的細胞培養效率。
2023 年 6 月，Teijin Frontier 開發了一種不織布微載體，可實現高效、大規模的細胞培養。這種支架材料促進各種細胞類型的3D黏附和增殖。這種不織布將帝人Frontier獨特的纖維加工技術和不織布設計技術與福井大學前沿科學學院藤田聰教授掌握的纖維生物醫學領域知識相結合。
2023年3月，大日本印刷公司和Hyperion Drug Discovery開發了用於再生醫學細胞培養的可溶性微載體。這些微載體在基於細胞和基因的產品、胞外體、生物製藥和培養肉的細胞培養過程中充當支架劑。與傳統的 2D 培養相比，這種方法減少了工作步驟，並實現了高效的大規模細胞培養。

公司產品

SoloHill(R) 微載體入門套件- Sartorius AG 的 SoloHill(R) 微載體入門套件是一個 10 克的套件，包含六種類型的 SoloHill(R) 微載體（蛋白質包被的和無塗布的），適用於特定的細胞類型。這種低成本解決方案可加速微載體評估，並允許為特定應用選擇最佳微載體類型，確保最佳的細胞附著和增殖。
HarvestainerTM 微載體分離系統 - Thermo Fisher Scientific 提供 HarvestainerTM 微載體分離系統，這是貼壁細胞培養生產過程中分離微載體珠的理想解決方案。該系統非常適合小型和大規模線上微載體分離應用。與傳統程序相比，該系統有助於提高產品產量，同時減少就地清潔、就地蒸汽和注入水的需求。
Corning® 微載體康寧提供用於生物製程放大的 Corning® 微載體，旨在簡化放大過程。微載體以封閉式系統包裝提供，是無菌的，並準備用於反應器。微載體經過進一步的表面處理，以改善細胞黏附並增加細胞產量和活力。

Microcarriers are microscopic beads or spheres used to increase the surface area in tissue culture for the attachment and yield of anchorage-dependent cells and act as a support matrix, which allows the growth of adherent cells in bioreactors. Microcarriers are extensively used in the large-scale commercial production of biologics and vaccines to grow virus-generating or protein-producing adherent cell populations. The growth in the microcarriers market may be attributed to the rapid growth in the biologics and biosimilar industries.

Rising demand for cell-based vaccines, along with technological advancements, will positively impact the market for microcarriers. However, the high cost of cell biologics and cell-based therapies might hamper the market growth during the given forecast period. Growth limitations of high-density microcarrier cultures will also restrain the microcarrier's market growth during the anticipated period. Further, the microcarrier market is segmented into product, application, end-user, and geography.

Market Drivers:

The Microcarriers market will grow due to the rising demand for cell-based vaccines.

Due to the growing number of new virus outbreaks such as influenza, monkeypox, Ebola, and COVID-19, among others, the demand for vaccines is increasing globally, consequently increasing the demand for microcarriers in the market and supporting the microcarrier market growth during the forecast period. For instance, the World Health Organization's Disease Outbreak News (DONs), which provided confirmed acute public health events of potential events of concern, reported an Ebola virus outbreak in the Democratic Republic of the Congo in September 2022.

The Ministry of Health of the Democratic Republic of the Congo declared the outbreak following the confirmed laboratory test via RT-PCR in a fatal case in Beni Health Zone, North Kivu Province. During the same period, Uganda also witnessed a confirmed 18 cases as of 25th September 2022 Ebola virus, which were caused by the Sudan Virus. Such increasing cases of infectious diseases and the growing risk of pandemics are the prime factors driving the demand for vaccines worldwide. Further, many organizations are putting efforts into developing vaccines for the rising disease. For instance, the Centers for Disease Control and Prevention (CDC) mentions in its Vaccine Considerations summary, updated in September 2022, that the JYNNEOS vaccine is approved for the prevention of monkeypox and smallpox diseases.

Further, the ACAM2000 Vaccines has been approved for immunization against smallpox which is made available for use against monkeypox under Expanded Access Investigational New Drug protocol, mentions the CDC. The microcarrier market is expected to be dominated by the North American region, which is expected to hold a significant share of the Microcarrier market. The rising research and development activities, gene therapies, and biologics, coupled with technological advancement and investment in cell-based research in countries like the US.

Additionally, the prevalence of established pharmaceutical companies, who continually work to expand their geographic reach and promote the widespread marketing of their vaccines, is anticipated to spur market expansion in this region. Moreover, this region will grow due to the increased need for immunizations during pandemics. due to the rise in the prevalence of infectious and cancerous illnesses.

On the other hand, Europe holds the second largest share of the microcarrier market during the anticipated period owing to the increasing number of leading firms in the market and growing usage of technical innovations. It is anticipated that increased R&D utilization will enhance product development and market demand in this region.

Key Developments:

October 2023- Thermo Fisher Scientific introduced the Gibco CTS Detachable Dynabeads, a platform with an active release mechanism for cell therapy manufacturing. The Gibco CTS Detachable Dynabeads CD3/CD28 Kit offers one-step isolation and activation but allows for the release of CTS Dynabeads magnetic beads from target cells at any point in the process. The kit contains an active release buffer enclosed in a CTS DynaCellect Magnetic Separation System-compatible bioprocess container, allowing for the active detachment of target cells from the beads through a competitive binding mechanism after isolation and magnetic separation.
October 2023- Kuraray Co., Ltd. developed PVA hydrogel microcarriers for cell cultures in regenerative medicine. These scaffolding materials are damage-resistant, debris-free, and safe for efficient cell culturing. When PVA hydrogel microcarriers are introduced into bioreactors for mass cell culture, these microcarriers allow cells to adhere and proliferate, facilitating efficient detachment and recovery. They are also safe, have been verified, and exhibit higher cell culture efficiency.
June 2023- Teijin Frontier developed new nonwoven microcarriers for efficient and large-scale cell culture. These scaffolding materials facilitate adherence and growth in three dimensions for various cell types. The nonwoven microcarriers combine Teijin Frontier's proprietary fiber process and nonwoven design technology with fiber-related bio-medical expertise from Professor Satoshi Fujita at the University of Fukui's Department of Frontier Fiber Technology and Science.
March 2023- Dai Nippon Printing Co. and Hyperion Drug Discovery developed soluble microcarriers for cell culture in regenerative medicine. These microcarriers serve as scaffolding agents in cell culture processes, including cell and gene-based products, exosomes, biopharmaceuticals, and cultured meat. This approach reduces the number of work processes and allows for efficient large-scale cell culture compared to traditional two-dimensional cultures.

Company Products:

SoloHill(R) Microcarrier Starter Kit- Sartorius AG's SoloHill(R) Microcarrier Starter Kit is a 10-gram kit containing six different types of SoloHill(R) microcarriers, both protein-coated and non-coated, for specific cell types. This low-cost solution accelerates microcarrier evaluation, allowing for the selection of the optimal microcarrier type for specific applications, ensuring optimal cell attachment and growth.
HarvestainerTM Microcarrier Separation system- Thermo Fisher Scientific offers the HarvestainerTM Microcarrier Separation system, which is an ideal solution for the separation of microcarrier beads during adherent cell culture production. It is an ideal system for smaller-scale as well as larger-scale applications for in-line microcarrier separation. In comparison to conventional procedures, the system helps to boost product yields while lowering the need for clean-in-place, steam-in-place, and water for injection.
Corning(R) Microcarriers- Corning incorporated offers Corning(R) Microcarriers for Bioprocess scale-up that are designed to simplify the scale-up processes. The microcarriers are provided in closed systems packaging, are sterile, and are prepared for use with bioreactors. The microcarriers are additionally surface-treated to improve cell adhesion and increase cell production and survival.

Market Segments:

By Product Type

Equipment
Consumables
Reagents
Microcarrier Beads
Others

By Application

Biopharmaceutical Production
Cell and gene therapy
Others

By End-Users

Pharmaceuticals & Biotechnology Companies
Research Institutes
Contract Research Organizations

By Geography

North America
USA
Canada
Mexico
South America
Brazil
Argentina
Others
Europe
United Kingdom
Germany
France
Spain
Others
Middle East and Africa
Saudi Arabia
UAE
Israel
Others
Asia Pacific
China
India
Japan
South Korea
Indonesia
Others

1. INTRODUCTION

1.1. Market Overview
1.2. Market Definition
1.3. Scope of the Study
1.4. Market Segmentation
1.5. Currency
1.6. Assumptions
1.7. Base and Forecast Years Timeline
1.8. Key Benefits to the Stakeholder

2. RESEARCH METHODOLOGY

2.1. Research Design
2.2. Research Processes

3. EXECUTIVE SUMMARY

3.1. Key Findings

4. MARKET DYNAMICS

4.1. Market Drivers
4.2. Market Restraints
4.3. Porter's Five Forces Analysis
- 4.3.1. Bargaining Power of Suppliers
- 4.3.2. Bargaining Power of Buyers
- 4.3.3. Threat of New Entrants
- 4.3.4. Threat of Substitutes
- 4.3.5. Competitive Rivalry in the Industry
4.4. Industry Value Chain Analysis
4.5. Analyst View

5. GLOBAL MICROCARRIERS MARKET BY PRODUCT TYPE

5.1. Introduction
5.2. Equipment
- 5.2.1. Market Opportunities and Trends
- 5.2.2. Growth Prospects
- 5.2.3. Geographic Lucrativeness
5.3. Consumables
- 5.3.1. Market Opportunities and Trends
- 5.3.2. Growth Prospects
- 5.3.3. Geographic Lucrativeness
5.4. Reagents
- 5.4.1. Market Opportunities and Trends
- 5.4.2. Growth Prospects
- 5.4.3. Geographic Lucrativeness
5.5. Microcarrier Beads
- 5.5.1. Market Opportunities and Trends
- 5.5.2. Growth Prospects
- 5.5.3. Geographic Lucrativeness
5.6. Others
- 5.6.1. Market Opportunities and Trends
- 5.6.2. Growth Prospects
- 5.6.3. Geographic Lucrativeness

6. GLOBAL MICROCARRIERS MARKET BY APPLICATION

6.1. Introduction
6.2. Biopharmaceutical Production
- 6.2.1. Market Opportunities and Trends
- 6.2.2. Growth Prospects
- 6.2.3. Geographic Lucrativeness
6.3. Cell and gene therapy
- 6.3.1. Market Opportunities and Trends
- 6.3.2. Growth Prospects
- 6.3.3. Geographic Lucrativeness
6.4. Others
- 6.4.1. Market Opportunities and Trends
- 6.4.2. Growth Prospects
- 6.4.3. Geographic Lucrativeness

7. GLOBAL MICROCARRIERS MARKET BY END-USERS

7.1. Introduction
7.2. Pharmaceuticals & Biotechnology Companies
- 7.2.1. Market Opportunities and Trends
- 7.2.2. Growth Prospects
- 7.2.3. Geographic Lucrativeness
7.3. Research Institutes
- 7.3.1. Market Opportunities and Trends
- 7.3.2. Growth Prospects
- 7.3.3. Geographic Lucrativeness
7.4. Contract Research Organizations
- 7.4.1. Market Opportunities and Trends
- 7.4.2. Growth Prospects
- 7.4.3. Geographic Lucrativeness

8. GLOBAL MICROCARRIERS MARKET BY GEOGRAPHY

8.1. Introduction
8.2. North America
- 8.2.1. By Product Type
- 8.2.2. By Application
- 8.2.3. By End Users
- 8.2.4. By Country
  - 8.2.4.1. USA
    - 8.2.4.1.1. Market Opportunities and Trends
    - 8.2.4.1.2. Growth Prospects
  - 8.2.4.2. Canada
    - 8.2.4.2.1. Market Opportunities and Trends
    - 8.2.4.2.2. Growth Prospects
  - 8.2.4.3. Mexico
    - 8.2.4.3.1. Market Opportunities and Trends
    - 8.2.4.3.2. Growth Prospects
8.3. South America
- 8.3.1. By Product Type
- 8.3.2. By Application
- 8.3.3. By End Users
- 8.3.4. By Country
  - 8.3.4.1. Brazil
    - 8.3.4.1.1. Market Opportunities and Trends
    - 8.3.4.1.2. Growth Prospects
  - 8.3.4.2. Argentina
    - 8.3.4.2.1. Market Opportunities and Trends
    - 8.3.4.2.2. Growth Prospects
  - 8.3.4.3. Others
    - 8.3.4.3.1. Market Opportunities and Trends
    - 8.3.4.3.2. Growth Prospects
8.4. Europe
- 8.4.1. By Product Type
- 8.4.2. By Application
- 8.4.3. By End Users
- 8.4.4. By Country
  - 8.4.4.1. United Kingdom
    - 8.4.4.1.1. Market Opportunities and Trends
    - 8.4.4.1.2. Growth Prospects
  - 8.4.4.2. Germany
    - 8.4.4.2.1. Market Opportunities and Trends
    - 8.4.4.2.2. Growth Prospects
  - 8.4.4.3. France
    - 8.4.4.3.1. Market Opportunities and Trends
    - 8.4.4.3.2. Growth Prospects
  - 8.4.4.4. Spain
    - 8.4.4.4.1. Market Opportunities and Trends
    - 8.4.4.4.2. Growth Prospects
  - 8.4.4.5. Others
    - 8.4.4.5.1. Market Opportunities and Trends
    - 8.4.4.5.2. Growth Prospects
8.5. Middle East and Africa
- 8.5.1. By Product Type
- 8.5.2. By Application
- 8.5.3. By End Users
- 8.5.4. By Country
  - 8.5.4.1. Saudi Arabia
    - 8.5.4.1.1. Market Opportunities and Trends
    - 8.5.4.1.2. Growth Prospects
  - 8.5.4.2. UAE
    - 8.5.4.2.1. Market Opportunities and Trends
    - 8.5.4.2.2. Growth Prospects
  - 8.5.4.3. Israel
    - 8.5.4.3.1. Market Opportunities and Trends
    - 8.5.4.3.2. Growth Prospects
  - 8.5.4.4. Others
    - 8.5.4.4.1. Market Opportunities and Trends
    - 8.5.4.4.2. Growth Prospects
8.6. Asia Pacific
- 8.6.1. By Product Type
- 8.6.2. By Application
- 8.6.3. By End Users
- 8.6.4. By Country
  - 8.6.4.1. China
    - 8.6.4.1.1. Market Opportunities and Trends
    - 8.6.4.1.2. Growth Prospects
  - 8.6.4.2. India
    - 8.6.4.2.1. Market Opportunities and Trends
    - 8.6.4.2.2. Growth Prospects
  - 8.6.4.3. Japan
    - 8.6.4.3.1. Market Opportunities and Trends
    - 8.6.4.3.2. Growth Prospects
  - 8.6.4.4. South Korea
    - 8.6.4.4.1. Market Opportunities and Trends
    - 8.6.4.4.2. Growth Prospects
  - 8.6.4.5. Indonesia
    - 8.6.4.5.1. Market Opportunities and Trends
    - 8.6.4.5.2. Growth Prospects
  - 8.6.4.6. Others
    - 8.6.4.6.1. Market Opportunities and Trends
    - 8.6.4.6.2. Growth Prospects