市場調查報告書
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1395542
癌症抗體聯合治療的全球市場:市場機會和臨床試驗分析(2028)Global Cancer Antibody Combinations Market Opportunity & Clinical Trials Insight 2028 |
本報告分析結果及摘要如下:
近年來,隨著抗體聯合療法的出現,癌症治療領域發生了典範轉移。 這是一種動態方法,結合了針對特定分子的抗體的精確性與不同抗體的協同效應。 透過將不同類型的單株抗體與其他治療藥物結合,可以同時靶向涉及癌症發展的許多途徑,從而可能產生相加或協同效應。 理論上,抗體聯合療法有助於限制多餘的毒性,並且缺乏藥物動力學(PK)相互作用,使得抗體聯合療法成為癌症治療的可行選擇,這是一種非常合適的方法。
將抗體與其他治療藥物結合的假說最早於20 世紀90 年代末提出,當時研究人員和科學家合作解決癌症惡性腫瘤中觀察到的抗藥性菌株的出現和逃脫機制。單株抗體的臨床前測試(單株抗體)與化療、放療和其他治療藥物合併使用。 這些研究的主要目的是擴大單株抗體的治療指數和潛力。 在臨床前研究中,已觀察到抗體組合具有諸如提高治療效率、降低毒性、延遲治療和抗藥性起效以及減少劑量等優點。
化學療法和放射療法等傳統療法有可能損害健康細胞,但抗體聯合療法的出現徹底改變了標靶醫學的模式。 目前,多種抗體聯合療法如Phesgo、赫賽汀和帕妥珠單抗、雷莫蘆單抗和多西他賽、阿特珠單抗、貝伐單抗和化療、阿特珠單抗和貝伐單抗、伊匹單抗和納武單抗等已被FDA、EMA、NICE等批准用於多種癌症的治療。它一直。
在癌症治療領域,抗體聯合治療領域的初步臨床開發重點是抗PD-1、抗CTLA-4、抗PD-L1單株抗體的打造(mAb)聯合療法。化療以及針對血管內皮生長因子受體(VEGFR)和血小板源性生長因子受體(PDGFR)的各種治療已被用作多種癌症的一線治療,包括晚期實體瘤和血液癌。在利用單株抗體與口服小分子多激□抑制劑聯合使用的潛力方面,已經觀察到了改進。 中國浙江大學正在進行一項臨床試驗,以評估抗 PD-1 抗體與多激□抑制劑多納非尼聯合治療方案的安全性和有效性。
另一家中國製藥公司Chia Tai Tianqing Pharmaceutical Group推出了抗PD-1抗體penplimab與多靶點受體TKI安羅替尼的聯合療法,用於治療肝細胞癌(HCC)患者。我報道過。 本研究的主要目的是評估合併療法作為輔助療法的療效。 該研究為隨機、雙盲、安慰劑對照、多中心 3 期研究,預計於 2023 年 5 月開始,於 2026 年 12 月完成。
迄今為止,用於癌症治療的抗體聯合療法的臨床管線主要由CTLA-4、PD-1、PD-L1等免疫檢查點抑制劑、PP2A抑制劑、CDK4/6抑制劑、單株抗體組成標靶 HER 2、TIGIT mAb、雙特異性抗體、CAR-T 細胞療法和抗體/藥物組合。 我們當然可以期望在不久的將來見證用於治療癌症惡性腫瘤的創新抗體聯合療法,製藥業日益增長的興趣以及 FDA 對新型聯合療法的指定推廣就證明了這一點。 例如,2023年8月,Agenas 因其用於治療結直腸癌患者的創新抗體組合 botencilimab (AGEN1181) 和 balstilimab (AGEN2034) 獲得快速通道指定。
隨著癌症類型數量以驚人的速度增加,世界各地的癌症患者都在尋求更好的治療方法,這些治療方法除了治療之外還能帶來意想不到的益處,越來越需要開發創新的抗體組合療法。 此外,利用抗體聯合療法領域將涉及各種利益相關者,包括Pfizer、Bristol-Myers Squibb、AstraZeneca、Daiichi Sankyo、Agenus、Novartis、Celldex Therapeutics、Merck等製藥和生物技術公司,這一趨勢正在不斷增長。 在目前的市場情況下,抗體藥物組合市場的未來是充滿希望的,臨床試驗數量的增加、研發活動的增加以及各利益相關者對該領域的參與都證明了這一點,預計將擴大。
“Global Cancer Antibody Combinations Market Opportunity & Clinical Trials Insight 2028” Report Findings & Highlights:
In recent years, the landscape of cancer therapeutics has witnessed a paradigm shift with the emergence of antibody combination therapies, a dynamic approach that intertwines the precision of antibodies to target specific molecules with the synergistic benefits of different types of antibodies. By merging different types of monoclonal antibodies with other therapeutic agents, numerous pathways that are involved in the pathogenesis of cancer may be targeted simultaneously, thereby, possibly leading to additive or else synergistic effects. Theoretically, the combinations of antibodies are very suitable approach that can be employed for the treatment of cancer modalities because of the fact that the antibody combination therapy aids to limit overlapping toxicity along with lack of pharmacokinetic (PK) interactions.
The hypothesis of combining antibodies with other therapeutic agents began in the late 1990s when the researchers together with scientists amplified the preclinical testing that includes a combinations of monoclonal antibodies (mAb) with chemotherapy, radiotherapy or any other therapeutic agents in order to address the occurrence of drug resistant strains or the escape mechanism for observed in cancer malignancies. The main purpose of these investigations was to expand the therapeutic index as well as the potential of mAbs. Advantages such as amended efficiency, diminished toxicities, delayed development of therapy or drug resistances in addition dose reduction were observed in the preclinical studies that come along with antibody combinations.
In dichotomy with the conventional treatments such as chemotherapy and radiotherapy, which clenches the possibility to damage healthy cells, with the arrival of antibody combination therapies has transformed the landscape of targeted medicine. As of now, multiple antibody combination therapies such as Phesgo, Herceptin with Perjeta, Ramucirumab with docetaxel, atezolizumab, Bevacizumab with chemotherapy, atezolizumab and bevacizumab, and ipilimumab and nivolumab etc have been approved by the FDA, EMA, NICE and others for the treatment of diverse type of cancers.
In the realm of cancer therapy, the preliminary clinical development for the domain of antibody combinations were focused on creating anti-PD-1, anti-CTLA-4 and anti-PD-L1 monoclonal antibody (mAb) combinations, there has been modern improvement observed in harnessing the potential of mAb in conjugation with chemotherapy or with various oral small molecule multikinase inhibitor of vascular endothelial growth factor receptor (VEGFR) or platelet derived growth factor receptor (PDGFR) as the first-line treatment for multiple types of cancer like advanced solid tumors, hematological cancer, etc. Zhejiang University based in China is conducting clinical studies in which the combination of anti-PD-1 antibody with Donafenib, multikinase inhibitor, is ongoing to evaluate the safety and efficacy of the treatment regimen.
Another pharmaceutical company based in China, Chia Tai Tianqing Pharmaceutical Group reported another combination of anti-PD-1 antibody, Penpulimab with multi targeted receptor TKI, Anlotinib for the treatment of patients suffering from hepatocellular cancer (HCC). The primary goal of this study is to assess the effectiveness of combined treatment regimen for adjuvant therapy. It is a randomized, double-blind, placebo-controlled, multicenter phase 3 study which was initiated in May 2023 and is expected to be complete by December 2026.
Hitherto, the clinical pipeline for the domain of antibody combination therapy for treating cancer modalities majorly consists of immune checkpoint inhibitors, such as CTLA-4, PD-1 and PD-L1, PP2A inhibitors, CDK4/6 inhibitors, mAbs targeting HER 2, TIGIT mAbs, bispecific antibodies, CAR T cell therapies, antibody drug conjugates, and others. It is expected that the imminent years will certainly witness innovative antibody combinations for the treatment of cancer malignancies as evident from augmenting interest in pharmaceutical sectors and fostering FDA designations to novel combination therapy. For instance, in August 2023, Agenus was granted the Fast Track Designation for its innovative antibody combination, botensilimab (AGEN1181) and balstilimab (AGEN2034) for the treatment of colorectal cancer patients.
With the increasing prevalence of cancer types at an alarming gait urges the need to develop better as well as innovative antibody combination therapies which could provide cure in addition to anticipation amidst the populace suffering from cancer across the globe. Furthermore, an inclining market trend towards utilizing the realm of antibody combination has been observed due to involvement of various stakeholders from pharmaceutical and biotech companies such as Pfizer, Bristol-Myers Squibb, AstraZeneca, Daiichi Sankyo, Agenus, Novartis, Celldex Therapeutics and Merck. With the current market scenario, the future of the antibody combination market looks promising and is expected to multiple further as evident from the growing clinical trials, rising research and development and involvement of various stakeholders in the domain.