市場調查報告書
商品編碼
1394215
全球穀胱甘□樹脂市場評估:依包裝類型、應用、地區、機會、預測(2016-2030)Glutathione Resin Market Assessment, By Packaging Type [Less Than 50 ml, 50-100 ml, Greater Than 100 ml], By Application [Protein Purification, Laboratories Research, Others], By Region, Opportunities and Forecast, 2016-2030F |
全球穀胱甘□樹脂市場規模預計將從 2022 年的 4.513 億美元增至 2030 年的 7.929 億美元,在 2023-2030 年預測期內複合年增長率為 7.3%。
針對具有成本效益的蛋白質純化過程,一種經常探索的解決方案是將穀胱甘□化合物附著到具有適當數量的原子間隔基的瓊脂糖珠上,以減少純化過程中的阻礙效應。 開發此類具有成本效益的化合物的技術創新正在加速,各公司正在推進該領域的研究。 Thermo Fisher Scientific Inc. 成功開發了 Pierce 穀胱甘□,它透過 12 個原子間隔基將穀胱甘□化合物與瓊脂糖珠連接起來,幾乎最大限度地減少了空間位阻。
該公司提供採用預裝色譜管柱的 Pierce 穀胱甘□瓊脂糖產品,用於 FPLC 輸送應用。 該產品為從細胞裂解物中親和純化 GST 標記的融合蛋白提供了高性能和能力。 Pierce 穀胱甘□樹脂價格經濟,可使用五次而不影響純化性能和結合能力,使其成為高性價比產品。 該產品經過臨床驗證,可與該公司的細胞裂解試劑一起從哺乳動物和細菌細胞培養物中提取和純化。
COVID-19的爆發嚴重影響了許多行業和人們的生活,使每個人都更容易感染傳染病。 實驗室關閉以及藥物研究投資的減少導致經濟穩定性惡化。 然而,開發有效藥物來對抗COVID-19 的緊迫性為穀胱甘□樹脂創造了多種機會,可以快速純化穀胱甘□-S-轉移□(GST) 標記的重組蛋白,同時減少破壞性影響。 疫情為市場拓展、企業融入服務創造了巨大潛力。
由於對先進和優化的蛋白質純化製程的需求不斷增加,穀胱甘□樹脂市場正在穩步增長。 Cytiva 開發了 Glutathione Sepharose 4B 產品,這是一種親和層析樹脂,用於批量純化穀胱甘□-S-轉移□ (GST) 標記的蛋白質,實現高結合能力。 這種穀胱甘□樹脂對所有常用的水性緩衝液具有化學穩定性,並廣泛用於研究蛋白質-蛋白質相互作用。
本報告研究和分析了全球穀胱甘□樹脂市場,提供市場規模和預測、市場動態、主要參與者的現狀和前景等。
Global glutathione resin market size was valued at USD 451.3 million in 2022, which is expected to reach USD 792.9 million in 2030, with a CAGR of 7.3% for the forecast period between 2023 and 2030.
Protein purification processes are successively achieved using affinity chromatography, which offers high selectivity, resolution, and capacity in much less time. An effective design affinity chromatography, glutathione resin is a one-step purification process used for recombinant glutathione S-transferase (GST) fusion proteins and relevant binding proteins in insect cells, E. coli, and mammalian cells. Glutathione resin is widely considered an excellent compound for high-performance purifications, especially when high binding capacity is required for batch purification. Elevated glutathione (GSH) levels are significantly observed in several types of cancer cells that increase antioxidant capacity.
Glutathione affinity resins are designed to purify glutathione-S-transferase (GST)-tagged recombinant proteins rapidly. High binding capacity and yield of glutathione-S-transferase (GST) fusion proteins of 5-8 mg/ml settled resin is successfully developed by Merck KGaA, Darmstadt. Also, biological companies are successfully researching to develop cost-effective purification processes while reducing hinderance effect.
Glutathione is an essential compound that increases the immune system and provides a barrier to harmful diseases prone to humans. The rapid purification of glutathione-binding proteins from yeast, insect, bacteria, and glutathione-S-transferase (GST)-tagged recombinant proteins are accomplished by simply designing glutathione affinity resin.
The glutathione ligand is coupled to highly cross-linked 4% agarose beads to optimize and provide high binding capacity for GST-tagged proteins. Flow dependent characteristics is associated with binding of GST to glutathione and lower flow rates usually enhancing the binding capacity.
Merck KGaA, Darmstadt has introduced the trademark product GST. Bind Resins utilize a 14-atom spacer arm to covalently attach reduced glutathione by using sulfide linkage. The yield of glutathione-S-transferase (GST) fusion proteins of 5-8 mg/ml settled resin are achieved by a high degree substation of glutathione, ensuring high binding capacity. In November 2022, LTS Lohmann, a prominent producer of needle-free drug delivery systems, especially transdermal patches, had an investment of USD 14 million with the Global Health Investment Corporation. In addition to successive investment in June 2022, Evonik has partnered with the United States Government, by investing USD 220 million to build innovative drug delivery system for new lipid production facility for mRNA-based therapies.
The solution for a cost-effective purification process for proteins is frequently explored where the glutathione compound is linked to agarose beads with a suitable number of atom spacers that reduces the hindrance effect while undergoing purification. The innovation to develop such cost-effective compounds is accelerating and companies are conducting research in the field. Thermo Fisher Scientific Inc. has successfully developed pierce glutathione where the glutathione compound is linked to agarose beads through 12-atom spacer that substantially minimizes steric hinderance.
The company provides pierce glutathione agarose products in prepacked chromatography cartridges for delivering FPLC applications. The product delivers high performance and capacity properties for affinity purification of GST-tagged fusion proteins from cellular lysates. The pierce glutathione resin is economically priced and can be used five times without compromising purification performance and binding capacity which makes the product cost-effective. The product is clinically validated for its effective use with company's cell lysis reagents to extract and purify from mammalian or bacterial cell cultures.
Immune activity can be enhanced using nutritional or therapeutic composition while performing treatment of mammals. Glutathione precursor comprises of mixtures of glutamic acid, cystine, and glycine along with essential active ingredients like selenium. Selenium is a prominent trace metal found in various food compositions and is significantly incorporated in several non-toxic, water soluble organic or inorganic. Enhancement in cellular and tissue concentrations of glutathione improves resistance to infective agents by improving the immune system. Nutritional requirements are not fulfilled due to limited functionality of bacterial pathogens and commensals to metabolites. Hence, glutathione (GSH) is recognized as an abundant sulfur-content antioxidant present in mammalian tissues and is an incredible source of nutrient sulfur for human pathogens like staphylococcus aureus.
The data published by the Good Food Institute states that, in 2020 the United States market for plant-based foods is around USD 7.4 billion. Plant-based eggs are a modest category that is growing exponentially reaching around USD 39 million in 2021. The growing plant-based products are attracting various biological industries to improve nutritional characteristics which is subsequently creating market opportunities for glutathione resin market.
The outbreak of COVID-19 has severely impacted numerous sectors and human livelihood where every person was vulnerable to infectious disease. The shutdown of research laboratories accompanied by lower investment in pharmaceutical research has deteriorated the economic stability. But the urgency to develop effective drug to combat COVID-19 has created multiple opportunities for glutathione resin to incorporate rapid purification of glutathione-S-transferase (GST)-tagged recombinant proteins while reducing hinderance effect. The pandemic situation has created enormous potential for the market to expand and derive companies to incorporate services.
The glutathione resin market is successfully growing with the increasing demand for advanced and optimized protein purification process. Cytiva has developed Glutathione Sepharose 4B product which is an affinity chromatography resin for performing batch purification of glutathione-S-transferase (GST)-tagged proteins for attaining high binding capacity. The glutathione resin is chemically stable with all commonly used aqueous buffers and substantially used to study protein-protein interactions. Cytiva is successfully offering other life sciences solutions for undergoing purification GST fusion properties.
In October 2023, Cytiva and RoosterBio successively collaborated improving the exosome purification process for promising gene therapies and other significant modalities and manufacturing exosomes in mass quantities. The effective collaboration is developing prominent platform to provide cost-effective manufacturing solutions.
All segments will be provided for all regions and countries covered:
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work.