市場調查報告書
商品編碼
1445542
血管生成抑制劑和促進劑市場評估:按產品、應用、最終用戶和地區劃分的機會和預測(2017-2031)Angiogenesis Inhibitors and Stimulators Market Assessment, By Product, By Application, By End-user By Region, Opportunities and Forecast, 2017-2031F |
2024-2031年預測期內,全球血管生成抑制劑和促進劑市場規模將以10.01%的複合年增長率增長,從2023年的251.5億美元增長到2031年的539億美元,預計將增長至5000萬美元。
各種類型的癌症(包括肺癌、乳癌和攝護腺癌)的負擔日益增加,導致對治療方法開發的投資增加。 據美國癌症協會稱,2023 年僅美國就將報告 1,958,310 例新癌症病例和 609,820 例癌症相關死亡。 此外,人們對使用血管生成抑制劑和促進劑治療各種疾病的認識的提高和技術的進步也支持了市場的成長。 技術進步正在徹底改變血管生成抑制劑和促進劑的開發。 新的藥物傳輸系統,包括脂質體和奈米顆粒,正在減少副作用並提高藥物療效。 此外,組織工程技術和生物材料的整合正在支持調節血管生成新方法的開發。
癌症盛行率的增加支持市場成長
世界各地各種類型癌症的盛行率不斷增加,增加了對血管生成抑制劑的需求。 這些抑制劑透過抑制新血管的形成來阻止腫瘤生長並穩定腫瘤。 根據約翰霍普金斯大學醫學發表的論文,血管生成抑制劑貝伐單抗已被證明可有效治療多種類型的癌症,包括轉移性腎細胞癌、大腸直腸癌、神經內分泌腫瘤、非小細胞肺癌、膠質母細胞瘤和肝癌癌症。它可用於癌症治療。
重視研發活動
研發活動有許多好處,包括支持創新、促進新產品和服務的開發以及提高現有產品的有效性。 這些活動提高了標靶治療的準確性和有效性,並使研究人員能夠減少其產品現有的限制。 各個參與公司和研究機構都致力於研發活動,以加速治療有效產品的開發,並了解現有治療方法與其他治療方法相結合的有效性。 武田藥品工業株式會社發起了一項幹預措施,旨在評估魯沙佐米聯合地塞米松和來那度胺對先前接受硼替佐米誘導治療的患者在2 年內對多發性骨髓瘤進展的影響。該試驗的第4 期試驗目前正在進行中。 本研究正在調查接受地塞米松和來那度胺合併魯沙佐米全口服合併治療的參與者的安全性和有效性。
本報告調查了全球血管生成抑制劑和促進劑市場,提供了市場定義和概述、市場規模趨勢和預測、各個細分市場和地區的詳細分析、行業結構和市場成長。影響因素分析、案例研究、競爭優勢分析主要公司的概況和概況。
Global angiogenesis inhibitors and stimulators market is projected to witness a CAGR of 10.01% during the forecast period 2024-2031, growing from USD 25.15 billion in 2023 to USD 53.95 billion in 2031. The growing burden of different types of cancers, including lung, breast, and prostate cancer, is increasing investments in developing different therapeutic treatments. As per the American Cancer Society, in 2023, 1,958,310 new cancer cases and 609,820 cancer related deaths occurred in the United States alone. Furthermore, the growing awareness about the utilization of angiogenesis inhibitors and stimulators for the treatment of various conditions and technological advancements are supporting the market growth. Advancements in technology are revolutionizing the development of angiogenesis stimulators and inhibitors. Novel drug delivery systems, including liposomes and nanoparticles, reduce side effects and improve drug efficacy. Additionally, tissue engineering techniques and the integration of biomaterials are supporting the development of novel avenues for modulation of angiogenesis.
The growth of medical tourism in different regions across the globe is also expected to augment the growth of the market in the coming years. Such factors encourage different governments and research organizations to support novel product development and research activities. Key players and market and research institutions are heavily engaged in research and development activities to develop novel products that offer enhanced therapeutic efficacy. For instance, the National Cancer Institute of Naples are in the phase 4 of a study that is being conducted to explore the role of biological and clinical factors in patients with ovarian cancer who are receiving paclitaxel and carboplatin with bevacizumab.
Increasing Prevalence of Cancer Supports Market Growth
The growing prevalence of different types of cancer in various regions across the globe is propelling the requirement for angiogenesis inhibitors. These inhibitors prevent the growth of the tumor and stabilize it by blocking the formation of new blood vessels. According to an article published by Johns Hopkins Medicine, Bevacizumab, an angiogenesis inhibitor medicine, aids in the treatment of different types of cancer, including metastatic renal cell cancer, colorectal cancer, neuroendocrine tumors, non-small cell lung cancer, glioblastoma, and liver carcinoma.
Due to the central role of the VEGF/VEGFR signaling axis in cancer angiogenesis, various anti-angiogenic medicines, including VEGFR tyrosine kinase inhibitors (TKIs), anti-VEGF antibodies, and anti-VEGFR antibodies, have been authorized for different types of cancer. Researchers Rapisarda A, Hollingshead M, Uranchimeg B, Bonomi CA, Borgel SD, Carter JP, et al. discovered that treatment with Bevacizumab and hypoxia-inducible factor 1(HIF-1) inhibitors have a greater anti-cancer impact as opposed to therapy with Bevacizumab only in glioma xenografts. Furthermore, various market players are also investing in evaluating the safety and efficacy of Bevacizumab, including Hoffmann-La Roche, which is conducting a stage four clinical trial in an interventional study of Bevacizumab in patients suffering from metastatic or advanced epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer.
Increasing Emphasis on Research and Development Activities
Research and development activities offer various benefits, including supporting innovation, facilitating the development of novel products and services, and enhancing the efficacy of existing products. These activities enhance the accuracy and efficacy of targeted therapies and allow researchers to reduce the existing limitations of the product. Various market players and research organizations are heavily engaged in research and development activities to promote the development of products that provide enhanced therapeutic efficacy and understand the effects of existing therapies in combination with others. For instance, Takeda Pharmaceuticals is in phase 4 of their interventional study that aims to evaluate the effect of lxazomib in combination with dexamethasone and lenalidomide on the progression of multiple myeloma in two years in patients who had previously received a bortezomib-based induction regimen. The study will look at the safety and effectiveness of participants who are taking the all-oral combination of dexamethasone and lenalidomide with lxazomib.
North America Dominates Angiogenesis Inhibitors and Stimulators Market
North America is expected to account for a significant share of the market owing to the strong presence of various leading market players and the rapid expansion of the biotechnology and pharmaceutical industry in the region. The large patient base and expansion of the treatment seeking population in North America are further bolstering the market growth.
Due to the increasing prevalence of various diseases, including diabetic retinopathy, metastasis, and tumor formulation, various research institutions and organizations are heavily investing in research activities for the development of novel therapies and enhancing their efficacy. For instance, the Greater Houston Retina Research is in the phase four of their interventional study of long-term efficacy and safety of intravitreal aflibercept injections for treating diabetic retinopathy for subjects who completed the 2-year PANORAMA trial. The subjects will be evaluated for efficacy with the aid of best corrected visual acuity by using spectral domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), optical coherence tomography angiography (OCT-A), FP, 4-meter ETDRS protocol with normal-luminance, and Humphrey Visual Field (HVF) through 112 weeks.
In Vitro Angiogenesis Accounts for Significant Market Share
The in vitro application accounts for a significant share of the market owing to the increasing utilization of the device for the measurement of proteins among other substances available in tissues and biological fluids, such as serum, blood, and urine. For instance, the CHEMICON In Vitro Angiogenesis Kit provides a system for evaluating tube formation by endothelial cells in a 96-well format. This kit represents a simple model of angiogenesis where the inhibition or induction of tube formation by exogenous signals is monitored easily. The assay can be used for monitoring the extent of tube assembly in different endothelial cells such as bovine capillary endothelial cells and human umbilical vein cells.
Hospitals Expected to Witness Significant Growth Over Forecast Period
The hospital segment is expected to generate significant revenue due to the high demand for angiogenesis inhibitors and stimulators owing to increased awareness and rising incidences of patients with uncontrolled angiogenesis. The increased spending of hospitals on angiogenesis inhibitor and stimulator therapies can also be attributed to the growing requirement for innovative therapies due to the expansion of the medical tourism industry. The increasing prevalence of age-related macular degeneration is further encouraging hospitals to invest in angiogenesis inhibitors as they are critical for the treatment and prevention of the disease. According to an article published in Journal Cureus, in September 2022, it was estimated that 200 million people suffer from AMD. This number is projected to increase to roughly 300 million by 2040.
Future Market Scenario (2024 - 2031F)
Takeda Pharmaceuticals, one of the leading research and development driven pharmaceutical companies, is involved in an interventional study that aims to evaluate the effect of lxazomib in combination with dexamethasone and lenalidomide on the progression of multiple myeloma in two years in patients who had previously received a bortezomib-based induction regimen. The study is expected to conclude in November 2026.
The National Cancer Institute of Naples is in the phase 4 of a study that is being conducted to explore the role of biological and clinical factors in patients with ovarian cancer that are receiving paclitaxel and carboplatin with bevacizumab. The study is expected to conclude in December 2024.
Key Players Landscape and Outlook
Key participants in the angiogenesis inhibitors and stimulators market include F. Hoffmann-La Roche, Ltd., Bristol-Myers Squibb Company, Eyetech, Inc., Bayer AG, and Takeda Pharmaceutical Company Ltd. The market is witnessing significant growth owing to rising investments in healthcare infrastructure, advancements in precision medicine, and increasing prevalence of cancer.
Hoffmann-La Roche, a multinational healthcare and pharmaceutical company, is conducting a stage four clinical trial in an interventional study of Bevacizumab in patients suffering from metastatic or advanced epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer. The study is expected to conclude in June 2025.
All segments will be provided for all regions and countries covered
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work