市場調查報告書
商品編碼
1445543
特發性膜性腎病變(IMN)市場評估:類型(苯丁酸氮芥、烷化劑、環磷□胺等)、應用(診所、醫院、其他)地區劃分機會和預測-2017-2031Idiopathic Membranous Nephropathy (IMN) Market Assessment, By Type [Chlorambucil, Alkylating Agents, Cyclophosphamide, Others], By Application [Clinics, Hospitals, Others], By Region, Opportunities and Forecast, 2017-2031F |
2024-2031年預測期內,全球特發性膜性腎病變(IMN)市場規模將以8.83%的複合年增長率增長,從2023年的2.014億美元增長至2023年的3.9618億美元。
人們對 IMN 的認識不斷提高,以及政府為提高診斷解決方案的可負擔性而採取的舉措,正在為市場創造有利的成長機會。 這導致越來越多的研究努力確定 IMN 患者聯合治療的趨勢,這已成為一個重要的市場趨勢。 人口老化、久坐生活方式的增加以及腎臟疾病發病率的上升進一步推動了市場需求。
政府措施的增加支持市場成長
各政府機構加強支持研發活動,為市場創造了利潤豐厚的成長機會。 已經進行了各種研究以確定藥物對不同 IMN 患者的有效性。
增加研發活動支持市場發展
研發活動有多種好處,包括促進創新、加速新產品的開發、提高現有產品的有效性。 研究人員也正在研究聯合療法的效果。 中國北京協和醫院正在進行一項幹預研究,以探討 RTX 與環孢素聯合治療 IMN 是否比單獨使用 RTX 更有效。 IMN 的第一線免疫抑制治療包括利妥昔單抗 (RTX) 或環磷□胺和皮質類固醇的組合,因為它們具有出色的安全性。 然而,利妥昔單抗單藥治療的長期緩解率約為60%。 由於環孢素和RTX對足細胞和免疫系統的影響不同,作用時間也不同,因此在特發性膜性腎病變的治療中有望發揮協同作用。
北美佔較大市佔率
預計北美地區在預測期內將佔據市場的主要份額。 這種增長歸因於各種大型進入者的強勁存在以及該地區各個研究機構的研究活動的增加。 美國 NIAID 正在進行一項研究,評估靜脈注射利妥昔單抗和貝利尤單抗與單一利妥昔單抗相比,在 IMN 患者中誘導完全緩解的有效性。 這項幹預研究調查了與單獨使用利妥昔單抗治療相比,使用利妥昔單抗和貝利尤單抗聯合治療特發性膜性腎病變是否能更有效地阻止對腎臟的免疫攻擊。
本報告調查了全球特發性膜性腎病變(IMN) 市場,並提供了市場定義和概述、市場規模趨勢和預測、各個細分市場和地區、行業結構和市場的詳細分析。它總結了影響成長的因素、案例分析主要公司的研究、競爭格局和概況。
Global idiopathic membranous nephropathy (IMN) market is projected to witness a CAGR of 8.83% during the forecast period 2024-2031F, growing from USD 201.4 million in 2023 to USD 396.18 million in 2031. The growing awareness about idiopathic membranous nephropathy and rising government efforts to increase the affordability of diagnostic solutions are providing lucrative growth opportunities to the market. In line with this, research activities are increasingly being conducted to determine the effects of combination therapy in patients with idiopathic membranous nephropathy, which is acting as a crucial market trend. The market demand is further driven by an increasing aging population, growing adoption of a sedentary lifestyle, and rising rate of renal diseases.
Increasing research activities by different research institutions to understand the effects of different treatments in patients with idiopathic membranous nephropathy is further supporting the market expansion. For instance, Beijing Friendship Hospital is conducting an interventional, randomized, open controlled study to understand the influence of various treatment schemes on the cognitive status of patients suffering from idiopathic membranous nephropathy. The exploration of the possible pathophysiological mechanism is expected to be conducted with the help of brain magnetic resonance imaging technology. The study aims to provide a theoretical basis for enhanced prevention of cognitive impairment and clinical treatment scheme selection and more information about the clinical cognitive status of idiopathic membranous nephropathy. The study is expected to conclude in 2025.
Rising Government Efforts Support Market Growth
Increasing efforts by various government institutes to support research and development activities are providing lucrative growth opportunities to the market. Different research studies are being conducted to determine the efficacy of drugs in different patients with idiopathic membranous nephropathy. The National Natural Science Foundation of China is supporting different research activities for treating idiopathic membranous nephropathy. Various studies have been conducted to demonstrate the efficacy of drugs in patients suffering from idiopathic membranous nephropathy with high or moderate proteinuria, however, systemic comparison has yet to be confirmed. Therefore, a network meta-analysis was performed for comparing the efficacy of idiopathic membranous nephropathy treatments in patients with high and moderate proteinuria, while comparing the risk of adverse events with idiopathic membranous nephropathy regimens.
Increasing Research and Development Activities are Boosting the Market Expansion
Research and development activities offer various benefits, including facilitation of innovation and accelerated development of new products as well as aid in improving the efficacy of existing products. They also allow researchers to study the effects of combination therapy. For instance, Peking Union Medical College Hospital, Beijing, China is conducting an interventional study to determine whether RTX combined with cyclosporine is more effective than RTX alone for treating idiopathic membranous nephropathy. The first-line immunosuppressive therapy of idiopathic membranous nephropathy includes Rituximab (RTX) or cyclophosphamide in combination with corticosteroids due to their superior safety profile. However, the long-term remission rate of Rituximab monotherapy is about 60%. Cyclosporin and RTX are expected to have a synergistic effect for treating idiopathic membranous nephropathy as they have different effects on podocytes and the immune system and different time of action.
North America Accounts for Significant Market Share
North America is expected to account for a significant share of the market over the forecast period. This growth can be attributed to the strong presence of various leading market players and increasing research activities by different research organizations in the region. For instance, the National Institute of Allergy and Infectious Diseases (NIAID) is conducting a study to evaluate the effectiveness of intravenous rituximab and belimumab at inducing complete remission as compared to just rituximab in patients suffering from idiopathic membranous nephropathy. In this interventional study, researchers will evaluate if treating idiopathic membranous nephropathy in combination with rituximab and belimumab will effectively block the immune attacks on kidney in comparison to rituximab alone. Rituximab works by decreasing B cells, they are known to have a role in membranous nephropathy. Upon the removal of these cells, the disease might become less active or even completely inactive. Belimumab works by changing the type of new B cells produced in the body and decreasing the B cells. Belimumab has received approval from the Food and Drug Administration (FDA) for treating systemic lupus erythematosus, whereas rituximab is approved for treating vasculitis, rheumatoid arthritis, and some types of cancer. Treating membranous nephropathy with a combination of rituximab and belimumab has previously not been studied, however the combination has been tested for treating other autoimmune diseases. The study is expected to reach completion in 2030.
Cyclophosphamide Expected to Witness Significant Expansion
Recent studies have shown that alternating glucocorticoid-cyclophosphamide is superior to rituximab for proteinuria remission. RI-CYCLO and STARMEN confirmed the efficacy of glucocorticoid-cyclophosphamide in patients suffering from high-risk membranous nephropathy. For treating high-risk patients, the 2021 KDIGO guidelines recommend initiation of immunosuppressive treatments with cyclophosphamide associated with steroids, calcineurin, or RTX. The only recommended option for treatment in very high-risk patients is corticosteroids plus cyclophosphamide. Potential new strategies for the treatment of idiopathic membranous nephropathy include the utilization of an induction phase with intravenous cyclophosphamide on a monthly basis or a combination of RTX with low-dose cyclophosphamide. These strategies showcased encouraging immunological remission and clinical results, with excellent safety profile.
Hospitals Account for Significant Market Share
Hospitals are expected to account for a significant market share as some patients often face life threatening and severe nephrotic syndrome even while the excretory renal functions are working normally. Various medical college hospitals are conducting studies to understand the effects of different immunosuppressive therapies in patients suffering from idiopathic membranous nephropathy, which is expected to create positive market opportunities. For instance, Peking Union Medical College Hospital, Beijing, China, is conducting an interventional study for comparing the twenty-four-month remissions in idiopathic membranous nephropathy by different immunosuppressive therapies. The investigators designed this study for comparing the efficacy of corticosteroids plus cyclophosphamide with rituximab in treating idiopathic membranous nephropathy. The study is estimated to reach completion in 2027.
Future Market Scenario (2024 - 2031F)
Different research activities are underway in various regions across the globe for determining the tolerability, safety, and efficacy of different treatments for idiopathic membranous nephropathy. For instance, Nagoya University, Nagoya, Japan is conducting an interventional study to confirm the safety and efficacy of intravenous administration of rituximab for the treatment of idiopathic membranous nephropathy with nephrotic syndrome. The clinical study is going to be double-blind, randomized, multi-center, and placebo controlled and is estimated to reach completion in December 2026. Furthermore, various biotech companies, including SynAct Pharma Aps, are also conducting different studies to evaluate the efficacy and pharmacokinetic effects of different treatments in patients with idiopathic membranous nephropathy.
Key Players Landscape and Outlook
Key participants in the idiopathic membranous nephropathy (IMN) market include Pfizer, Inc., Novartis AG, F. Hoffmann-La Roche Ltd, Astellas Pharma Inc., and GlaxoSmithKline. The market is expected to witness significant growth over the forecast period due to rising research and development activities by different market players and the conduct of several clinical trials.
Novartis AG, one of the leading pharmaceutical corporations, received positive results for their phase 3 trials for targeted factor B inhibitor iptacopan. The company plans on initiating discussions with the FDA to receive accelerated approval for iptacopan, whose target indications include idiopathic membranous nephropathy, C3 glomerulopathy, and atypical haemolytic uraemic syndrome.
All segments will be provided for all regions and countries covered
Companies mentioned above DO NOT hold any order as per market share and can be changed as per information available during research work