Product Code: RA100372
VIRAL VECTOR MANUFACTURING, NON-VIRAL VECTOR MANUFACTURING AND GENE THERAPY MANUFACTURING MARKET: OVERVIEW
As per Roots Analysis, the global viral vector manufacturing, non-viral vector manufacturing and gene therapy manufacturing market is estimated to grow from USD 0.70 billion in the current year to USD 2.3 billion by 2035, at a CAGR of 11.44% during the forecast period, till 2035.
The market sizing and opportunity analysis has been segmented across the following parameters:
Scale of Operation
- Preclinical
- Clinical
- Commercial
Type of Vector
- Adeno Associated Virus Vectors
- Adenoviral Vectors
- Lentiviral Vectors
- Retroviral Vectors
- Other Vectors
Application Area
- Gene Therapies
- Cell Therapies
- Vaccines
Therapeutic Area
- Oncological Disorders
- Rare Diseases
- Neurological Disorders
- Sensory Disorders
- Metabolic Disorders
- Musculoskeletal Disorders
- Blood Disorders
- Immunological Disorders
- Other Disorders
Type of Manufacturer
- In-house
- Contract Manufacturing Organizations
End User
- Clinics
- Health Insurance Agencies
- Hospitals
- Other End Users
Key Geographical Regions
- North America
- Europe
- Asia
- Latin America and Rest of the World
- Middle East and North Africa
VIRAL VECTOR MANUFACTURING, NON-VIRAL VECTOR MANUFACTURING AND GENE THERAPY MANUFACTURING MARKET: GROWTH AND TRENDS
Over the last few decades, various viral and non-viral vectors have been optimized and standardized for the purpose of gene delivery. It is worth mentioning that, till date, over 30 viral vector based gene therapy products have been approved by different regulatory agencies, globally. In addition, more than 200 viral vector based gene therapies targeting a wide range of disease indications are being evaluated in clinical trials in the US alone. This demonstrates the extensive development efforts being undertaken by stakeholders in this domain. On the contrary, developers continue to face production related complexities for viral and non-viral vectors. In order to overcome such challenges, developers prefer to outsource key operations. At present, over 270 industry and non-industry players are engaged in the production of viral vectors and plasmid DNA in order to meet the growing demand for cell therapies, gene therapies and viral vector vaccines.
As drug developers invest more in these innovative therapies, the market for viral vector manufacturing, non-viral vector manufacturing and gene therapy manufacturing is anticipated to expand further. In addition, the accelerated approval of cell and gene therapies and ongoing clinical trials related to viral vector based gene therapy, has led to a rise in the demand for viral and non viral vectors, offering lucrative opportunities to vector manufacturers.
VIRAL VECTOR MANUFACTURING, NON-VIRAL VECTOR MANUFACTURING AND GENE THERAPY MANUFACTURING MARKET: KEY INSIGHTS
The report delves into the current state of the viral vector, non-viral vector and gene therapy manufacturing market and identifies potential growth opportunities within the industry. Some key findings from the report include:
1. Presently, over 270 industry and non-industry players claim to have the necessary capabilities to manufacture different types of viral and non viral vectors, for in-house requirements and / or contract service engagements.
2. The current viral vector manufacturing market landscape features the presence of more than 85 players that offer contract manufacturing services; among these, ~55% players offer services at all scales of operation.
3. Nearly 55% of the industry players and 75% of the non-industry players are capable of manufacturing adeno-associated viral vectors; this is followed by players manufacturing lentiviral vectors and plasmid DNA.
4. In order to cater to the evolving needs of clients / sponsors, stakeholders have established their presence in multiple regions across the world; currently, the US and EU are considered as the manufacturing hubs.
5. More than 90 innovative technological platforms, developed by nearly 65 players, are available for the discovery, development and delivery of cell therapies, gene therapies and vaccines.
6. In pursuit of gaining a competitive edge, industry stakeholders are actively upgrading their existing capabilities and adding new competencies to enhance their respective vector and gene therapy related portfolios.
7. A growing number of expansion projects undertaken by various players and a notable increase in partnership activity are indicative of the increasing interest in the vector-based cell and gene therapy domain.
8. In order to increase efficiency and optimize the manufacturing processes, several vector and gene therapy innovators are anticipated to forge strategic alliances with vector and gene therapy manufacturers.
9. Nearly 40% of the players claim to offer manufacturing services for emerging vectors; majority of these stakeholders have expertise to carry out manufacturing operations at both preclinical and clinical scale.
10. The pricing of vectors varies considerably and is influenced by parameters such as complex scalability, high cost of manufacturing, complex supply chain and high cost of storage / delivery.
11. Given the numerous benefits of cell and gene therapies, the demand for vector, cell and gene therapy manufacturing is anticipated to increase significantly in future.
12. Over 65% of the global installed gene therapy and vector manufacturing capacity is dedicated to viral vector manufacturing; ~55% of viral vector manufacturing capacity is installed in the facilities located in North America.
13. Driven by the expanding pipeline of cell and gene therapies, and increasing investments in the domain, the vector and gene therapy manufacturing market is poised to witness significant growth in the foreseeable future.
14. In 2035, nearly 40% of the vector and gene therapy manufacturing demand is expected to be generated from the Asia-Pacific region.
15. The overall opportunity associated with the vector manufacturing domain is anticipated to grow at the CAGR of 13%; it is likely to be well distributed across different scales of operation, types of vectors and application areas.
16. In the long term, the vector-based recombinant therapies for oncological disorders, with more than 60% of the market share, are likely to emerge as the key growth driver of the vector and gene therapy manufacturing market.
VIRAL VECTOR MANUFACTURING, NON-VIRAL VECTOR MANUFACTURING AND GENE THERAPY MANUFACTURING MARKET: KEY SEGMENTS
Currently, Clinical Scale Occupies the Largest Share of the Viral Vector Manufacturing, Non-Viral Vector Manufacturing and Gene Therapy Manufacturing Market
Based on the scale of operation, the market is segmented into preclinical, clinical and commercial. At present, majority share is expected to be captured by clinical scale. It is worth highlighting that, over the years, viral vector manufacturing, non-viral vector manufacturing and gene therapy manufacturing market at commercial scale is likely to grow at a relatively higher CAGR during the forecast period.
Lentiviral Vectors Segment is Likely to Capture the Largest Share of the Viral Vector Manufacturing, Non-Viral Vector Manufacturing and Gene Therapy Manufacturing Market During the Forecast Period
Based on the type of vector, the market is segmented into AAV vectors, adenoviral vectors, lentiviral vectors, retroviral vectors and other vectors. It is worth highlighting that lentiviral vectors are likely to drive the market in the forthcoming years. However, the viral vector manufacturing, non-viral vector manufacturing and gene therapy manufacturing market for adenoviral vectors is likely to grow at a relatively higher CAGR during the forecast period.
Cell Therapy Segment is Likely to Dominate the Viral Vector Manufacturing, Non-Viral Vector Manufacturing and Gene Therapy Manufacturing Market During the Forecast Period
Based on the application area, the market is segmented into gene therapies, cell therapies and vaccines. It is worth highlighting that the cell therapy segment is expected to capture the highest share of the market in the coming decade. However, the viral vector manufacturing, non-viral vector manufacturing and gene therapy manufacturing market for vaccines is likely to grow at a relatively higher CAGR during the forecast period.
Oncological Disorders Segment Accounts for the Largest Share of the Viral Vector Manufacturing, Non-Viral Vector Manufacturing and Gene Therapy Manufacturing Market
Based on the therapeutic area, the market is segmented into oncological disorders, rare diseases, neurological disorders, sensory disorders, metabolic disorders, musculoskeletal disorders, blood disorders, immunological disorders and other disorders. While oncological disorders account for a relatively higher market share, it is worth highlighting that the autoimmune disorders segment is expected to witness substantial market growth in the coming years.
At Present, Contract Manufacturing Organizations Occupies the Largest Share of the Viral Vector Manufacturing, Non-Viral Vector Manufacturing and Gene Therapy Manufacturing Market
Based on the type of manufacturer, the market is segmented into in-house and contract manufacturing organizations. It is worth highlighting that the market is primarily driven by revenues generated by contract manufacturing organizations. This trend is unlikely to change in the near future.
North America Accounts for the Largest Share of the Market
Based on key geographical regions, the market is segmented into North America, Europe, Asia-Pacific, Middle East and North Africa, and Latin America and the Rest of the World. Majority share is expected to be captured by manufacturers based in North America and Europe.
Example Players in the Viral Vector Manufacturing, Non-Viral Vector Manufacturing and Gene Therapy Manufacturing Market
- Advanced BioScience Laboratories
- AGC Biologics
- Aldevron
- Altruist Biotechnology
- BioNTech Innovative Manufacturing Service (a subsidiary of BioNTech)
- BioReliance (a subsidiary of Merck KGaA)
- Biovian
- Celonic
- Catalent Biologics
- Cobra Biologics
- Centre for Process Innovation
- CEVEC Pharmaceuticals
- Charles River Laboratories
- CoJourney
- Esco Aster
- Jiangsu Puxin Biopharmaceutical
- Lonza
- Matica Biotechnology
- Nikon CeLL innovation
- NorthX Biologics
- Novartis
- Oxford BioMedica
- Resilience
- Sanofi
- Thermo Fisher Scientific
- VectorBuilder
- Wuxi AppTech
Primary Research Overview
The opinions and insights presented in this study were influenced by discussions conducted with multiple stakeholders. The research report features detailed transcripts of interviews held with the following industry stakeholders:
- Chief Executive Officer, Batavia Biosciences
- Chief Operating Officer, Touchlight
- Business Developer, HALIX
- Chief Executive Officer and Chief Scientific Officer, CEVEC Pharmaceuticals
- Former Business Development Manager and Xavier Leclerc, Head of Gene Therapy, Clean Cells
- Director, Massachusetts General Hospital
- Former Managing Director, CJ PARTNERS
- Director of Marketing and Technical Support, Polypus Transfection
- Former Scientific Director, University of Nantes
- Scientific Director, ACGT
- Former Executive and Scientific Director, Delphi Genetics
- Former Director, Amsterdam BioTherapeutics Unit
- Head of Communications, VIVEBiotech
- Chief Scientific Officer, GEG Tech
- Key Account Management, Richter-Helm BioLogics
- Head of Project Management and Tatjana Buchholz, Former Marketing Manager, Plasmid Factory
- Director of Business Development, Waisman Biomanufacturing
- ATMP Key Account Manager, EFS-West Biotherapy
VIRAL VECTOR MANUFACTURING, NON- VIRAL VECTOR MANUFACTURING AND GENE THERAPY MANUFACTURING MARKET: RESEARCH COVERAGE
- Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the viral vector manufacturing market, focusing on key market segments, including [A] scale of operation, [B] type of vector, [C] application area, [D] therapeutic area, [E] type of manufacturer and [F] key geographical regions.
- Market Landscape (Viral Vector and Gene Therapy Manufacturers): A comprehensive evaluation of companies involved in manufacturing viral vectors and gene therapies, considering various parameters, such as [A] year of establishment, [B] company size, [C] location of headquarters, [D] type of product manufactured, [E] location of manufacturing facility, [F] type of manufacturer, [G] scale of operation, [H] type of vector manufactured and [I] application area. In addition, the chapter also highlights information on the installed production capacity with stakeholders related to vector manufacturing.
- Market Landscape (Plasmid DNA and Gene Therapy Manufacturers): A comprehensive evaluation of companies involved in manufacturing plasmid DNA and gene therapies, considering various parameters, such as [A] year of establishment, [B] company size, [C] location of headquarters, [D] type of product manufactured, [E] location of manufacturing facility, [F] type of manufacturer, [G] scale of operation, [H] type of vector manufactured and [I] application area.
- Market Landscape (Non-Industry Players): A comprehensive evaluation of non-industry players involved in manufacturing viral, non viral and other novel types of vectors and gene therapies, considering various parameters, such as [A] year of establishment, [B] location of vector manufacturing facility, [C] type of manufacturer, [D] scale of operation, [E] type of vector manufactured, and [F] application area.
- Technology Landscape: An analysis of the technologies offered / developed by the companies engaged in this market, based on the [A] type of technology, [B] purpose of technology, [C] scale of operation, [D] type of vector, [E] application area. Additionally, it also highlights the most prominent players within this market, in terms of number of technologies.
- Company Competitiveness Analysis: A comprehensive competitive analysis of peptide contract manufacturers, examining factors such as [A] supplier strength, [B] manufacturing strength, [C] service strength and [D] company size.
- Company Profiles: In-depth profiles of key industry players based in North America, Europe and Asia-Pacific, focusing on [A] company overviews, [B] financial information (if available), [C] manufacturing facilities, [D] vector manufacturing technology, [E] an insightful recent development and [F] future outlook.
- Porter's Five Forces: A qualitative analysis that examines the five competitive forces in the non-viral and viral vector manufacturing market. This includes the threats posed by new entrants, the bargaining power of drug developers, the bargaining power of vector and gene therapy manufacturers, the threats from substitute technologies and the rivalry among existing competitors.
- Partnerships and Collaborations: An analysis of partnerships established in this sector, since 2019, based on several parameters, such as [A] year of partnership, [B] type of partnership, [C] scale of operation, [D] type of vector, [E] therapeutic area, [F] application area and [G] most active players (in terms of number of partnerships). This section also highlights the regional distribution of partnership activity in this market.
- Recent Expansions Analysis: An examination of the different expansion efforts made by various companies in viral vector and non viral vector manufacturing field to enhance their manufacturing capabilities, since 2019. This analysis considers various factors, including the [A] year of expansion, [B] type of expansion, [C] type of vector, [D] application area and [E] geographical location of the expansion.
- Strategic Partner Analysis: An analysis highlighting potential strategic partners segregated based on the likelihood of entering into collaboration with vector and gene therapy product developers. These players have been shortlisted based on several relevant parameters, such as [A] developer strength, [B] product strength, [C] type of vector, [D] therapeutic area and [E] pipeline strength.
- Emerging Trend 1: An elaborate discussion on the emerging trends of other viral / non viral gene delivery approaches that are currently being researched for the development of therapies involving genetic modification.
- Emerging Trend 2: An insightful analysis, highlighting the contemporary market trends in the plasmid DNA and viral vector manufacturing industry, through different representations, based on multiple relevant parameters.
- Cost Price Analysis: An analysis of the various factors that are expected to impact vector pricing, highlighting different models and approaches that product developers and manufacturers may use to determine the prices of their proprietary vectors.
- Outsourcing: Go / No-Go Framework: An insightful framework that emphasizes the key indicators and factors that need to be considered by developers to determine whether to manufacture their respective products in-house or outsource the manufacturing operation to contract service providers.
- Capacity Analysis: The report provides an estimation of global annual vector manufacturing capacity of industry players. The analysis takes into consideration the distribution of global capacity across [A] company size and [B] location of headquarters.
- Demand Analysis: Informed estimates of the annual demand for viral vectors and non viral vectors based on several relevant parameters, such as [A] target patient population, [B] dosing frequency and [C] dose strength.
- Survey Analysis: A survey analysis featuring inputs solicited from the survey conducted on over 400 stakeholders involved in the development of different types of gene therapy vectors. The participants, who were primarily Director / CXO level representatives of their respective companies, helped us develop a deeper understanding on the nature of their services and the associated commercial potential.
- Market Impact Analysis: The report analyzes various factors such as drivers, restraints, opportunities, and challenges affecting market growth.
KEY QUESTIONS ANSWERED IN THIS REPORT
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What kind of partnership models are commonly adopted by industry stakeholders?
- What is the current annual demand for viral and non-viral vectors?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
REASONS TO BUY THIS REPORT
- The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
- Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
- The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.
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TABLE OF CONTENTS
1. PREFACE
- 1.1. Introduction
- 1.2. Key Market Insights
- 1.3. Scope of the Report
- 1.4. Key Questions Answered
- 1.5. Chapter Outlines
2. RESEARCH METHODOLOGY
- 2.1. Chapter Overview
- 2.2. Research Assumptions
- 2.3. Project Methodology
- 2.4. Forecast Methodology
- 2.5. Robust Quality Control
- 2.6. Key Market Segmentations
- 2.7. Key Considerations
- 2.7.1. Demographics
- 2.7.2. Economic Factors
- 2.7.3. Government Regulations
- 2.7.4. Supply Chain
- 2.7.5. COVID Impact
- 2.7.6. Market Access
- 2.7.7. Healthcare Policies
- 2.7.8. Industry Consolidation
3. ECONOMIC AND OTHER PROJECT SPECIFIC CONSIDERATIONS
- 3.1. Chapter Overview
- 3.2. Market Dynamics
- 3.2.1. Time Period
- 3.2.1.1. Historical Trends
- 3.2.1.2. Current and Future Estimates
- 3.2.2. Currency Coverage and Foreign Exchange Rate
- 3.2.2.1. Major Currencies Affecting the Market
- 3.2.2.2. Factors Affecting Currency Fluctuations and Foreign Exchange Rates
- 3.2.2.3. Impact of Foreign Exchange Rate Volatility on the Market
- 3.2.2.4. Strategies for Mitigating Foreign Exchange Risk
- 3.2.3. Trade Policies
- 3.2.3.1. Impact of Trade Barriers on the Market
- 3.2.3.2. Strategies for Mitigating The Risks Associated with Trade Barriers
- 3.2.4. Recession
- 3.2.4.1. Historical Analysis of Past Recessions and Lessons Learnt
- 3.2.4.2. Assessment of Current Economic Conditions and Potential Impact on the Market
- 3.2.5. Inflation
- 3.2.5.1. Measurement and Analysis of Inflationary Pressures in the Economy
- 3.2.5.2. Potential Impact of Inflation on the Market Evolution
4. EXECUTIVE SUMMARY
5. INTRODUCTION
- 5.1. Chapter Overview
- 5.2. Viral and Non-Viral Gene Transfer Techniques
- 5.3. Viral Vectors Used in Genetically Modified Therapies
- 5.4. Types of Viral Vectors
- 5.4.1. Adeno-associated Viral Vectors
- 5.4.1.1. Overview
- 5.4.1.2. Design and Manufacturing
- 5.4.1.3. Advantages
- 5.4.1.4. Limitations
- 5.4.2. Adenoviral Vectors
- 5.4.2.1. Overview
- 5.4.2.2. Design and Manufacturing
- 5.4.2.3. Advantages
- 5.4.2.4. Limitations
- 5.4.3. Lentiviral Vectors
- 5.4.3.1. Overview
- 5.4.3.2. Design and Manufacturing
- 5.4.3.3. Advantages
- 5.4.3.4. Limitations
- 5.4.4. Retroviral Vectors
- 5.4.4.1. Overview
- 5.4.4.2. Design and Manufacturing
- 5.4.4.3. Advantages
- 5.4.4.4. Limitations
- 5.4.5. Other Viral Vectors
- 5.4.5.1. Alphavirus
- 5.4.5.2. Foamy Virus
- 5.4.5.3. Herpes Simplex Virus
- 5.4.5.4. Sendai Virus
- 5.4.5.5. Simian Virus
- 5.4.5.6. Vaccinia Virus
- 5.4.5.7. Chimeric Viral Vectors
- 5.5. Types of Non-Viral Vectors
- 5.5.1. Plasmid DNA
- 5.5.2. Liposomes, Lipoplexes and Polyplexes
- 5.5.3. Oligonucleotides
- 5.5.4. Other Non-Viral Vectors
- 5.6. Gene Delivery using Non-Viral Vectors
- 5.6.1. Biolistic Methods
- 5.6.2. Electroporation
- 5.6.3. Receptor Mediated Gene Delivery
- 5.6.4. Gene Activated Matrix (GAM)
- 5.7. Applications of Viral and Non-Viral Vectors
- 5.7.1. Cell and Gene Therapy
- 5.7.2. Vaccine
- 5.8. Current / Ongoing Trends in Vector Development / Manufacturing
- 5.8.1. Vector Engineering
- 5.8.2. Cargo Engineering
- 5.9. Vector Manufacturing
- 5.9.1. Types of Vector Manufacturers
- 5.9.2. Viral Vector Manufacturing Processes
- 5.9.2.1. Vector Production
- 5.9.2.2. Adherent and Suspension Cultures
- 5.9.2.3. Unit Process Versus Multiple Parallel Processes
- 5.9.2.4. Cell Culture Systems for Production of Viral Vectors
- 5.9.2.4.1. Small Scale / Laboratory Scale Cell Culture Systems
- 5.9.2.4.2. Large Scale Cell Culture Systems
- 5.9.2.4.2.1. Stirred Tank Reactor Systems
- 5.9.2.4.2.2. Fixed Bed Reactors / Packed Bed Reactors
- 5.9.2.4.2.3. Wave Bioreactor Systems
- 5.9.2.5. Serum-Containing versus Serum-Free Media
- 5.9.3. Bioprocessing of Viral Vectors
- 5.9.3.1. AAV Vector Production
- 5.9.3.2. Adenoviral Vector Production
- 5.9.3.3. Lentiviral Vector Production
- 5.9.3.4. Y -Retroviral Vector Production
- 5.9.4. Key Challenges Associated with Vector Manufacturing
- 5.10. Future Perspectives
6. VIRAL VECTOR AND GENE THERAPY MANUFACTURERS (INDUSTRY PLAYERS): MARKET LANDSCAPE
- 6.1. Chapter Overview
- 6.2. Viral Vector and Gene Therapy Manufacturers: Overall Market Landscape
- 6.2.1. Analysis by Year of Establishment
- 6.2.2. Analysis by Company Size
- 6.2.3. Analysis by Location of Headquarters
- 6.2.4. Analysis by Type of Product Manufactured
- 6.2.5. Analysis by Location of Vector Manufacturing Facility
- 6.2.6. Analysis by Type of Manufacturer
- 6.2.7. Analysis by Scale of Operation
- 6.2.8. Analysis by Location of Headquarters and Scale of Operation
- 6.2.9. Analysis by Type of Viral Vector Manufactured
- 6.2.10. Analysis by Scale of Operation and Type of Viral Vector Manufactured
- 6.2.11. Analysis by Application Area
- 6.2.12. Information on Production Capacity
7. VECTOR AND GENE THERAPY MANUFACTURERS (NON-INDUSTRY PLAYERS): MARKET LANDSCAPE
- 7.1. Chapter Overview
- 7.2. Vector and Gene Therapy Manufacturers: Overall Market Landscape
- 7.2.1. Analysis by Year of Establishment
- 7.2.2. Analysis by Location of Headquarters (Region)
- 7.2.3. Analysis by Location of Headquarters (Country)
- 7.2.4. Analysis by Type of Manufacturer
- 7.2.5. Analysis by Scale of Operation
- 7.2.6. Analysis by Type of Vector Manufactured
- 7.2.7. Analysis by Scale of Operation and Type of Vector Manufactured
- 7.2.8. Analysis by Application Area
8. VECTOR AND GENE THERAPY MANUFACTURING TECHNOLOGIES: MARKET LANDSCAPE
- 8.1. Chapter Overview
- 8.2. Vector and Gene Therapy Manufacturing Technologies: Overall Market Landscape
- 8.2.1. Analysis by Type of Technology
- 8.2.2. Analysis by Purpose of Technology
- 8.2.3. Analysis by Scale of Operation
- 8.2.4. Analysis by Type of Vector
- 8.2.5. Analysis by Application Area
- 8.2.6. Most Active Players: Analysis by Number of Technologies
- 8.3. Concluding Remarks
9. COMPANY COMPETITIVENESS ANALYSIS
- 9.1. Chapter Overview
- 9.2. Methodology and Key Parameters
- 9.3. Vector and Gene Therapy In-House Manufacturers: Company Competitiveness Analysis
- 9.3.1. Players based in North America
- 9.3.2. Players based in Europe
- 9.3.3. Players based in Asia-Pacific and Rest of the World
- 9.4. Vector and Gene Therapy Contract Manufacturing Organizations: Company Competitiveness Analysis
- 9.4.1. Players based in North America
- 9.4.2. Players based in Europe
- 9.4.3. Players based in Asia-Pacific and Rest of the World
- 9.5. Vector and Gene Therapy In-house Manufacturers and Contract Manufacturing Organizations: Company Competitiveness Analysis
- 9.5.1. Players based in North America
- 9.5.2. Players based in Europe
- 9.5.3. Players based in Asia-Pacific and Rest of the World
10. VECTOR AND GENE THERAPY MANUFACTURERS IN NORTH AMERICA
- 10.1. Chapter Overview
- 10.2. Key Players
- 10.2.1. Advanced BioScience Laboratories
- 10.2.1.1. Company Overview
- 10.2.1.2. Vector Manufacturing Portfolio
- 10.2.1.3. Recent Developments and Future Outlook
- 10.2.2. Catalent Biologics
- 10.2.2.1. Company Overview
- 10.2.2.2. Financial Information
- 10.2.2.3. Vector Manufacturing Portfolio
- 10.2.2.4. Recent Developments and Future Outlook
- 10.2.3. Charles River Laboratories
- 10.2.3.1. Company Overview
- 10.2.3.2. Financial Information
- 10.2.3.3. Vector Manufacturing Portfolio
- 10.2.3.4. Recent Developments and Future Outlook
- 10.2.4. Thermo Fisher Scientific
- 10.2.4.1. Company Overview
- 10.2.4.2. Financial Information
- 10.2.4.3. Vector Manufacturing Portfolio
- 10.2.4.4. Recent Development and Future Outlook
- 10.2.5. VectorBuilder
- 10.2.5.1. Company Overview
- 10.2.5.2. Financial Information
- 10.2.5.3. Vector Manufacturing Portfolio
- 10.2.5.4. Recent Developments and Future Outlook
- 10.3. Other Key Players
- 10.3.1. AGC Biologics
- 10.3.1.1. Company Overview
- 10.3.1.2. Vector Manufacturing Portfolio
- 10.3.2. Aldevron
- 10.3.2.1. Company Overview
- 10.3.2.2. Vector Manufacturing Portfolio
- 10.3.3. Matica Biotechnology
- 10.3.3.1. Company Overview
- 10.3.3.2. Vector Manufacturing Portfolio
- 10.3.4. Resilience
- 10.3.4.1. Company Overview
- 10.3.4.2. Vector Manufacturing Portfolio
11. VECTOR AND GENE THERAPY MANUFACTURERS IN EUROPE
- 11.1. Chapter Overview
- 11.2. Key Players
- 11.2.1. Lonza
- 11.2.1.1. Company Overview
- 11.2.1.2. Financial Information
- 11.2.1.3. Vector Manufacturing Portfolio
- 11.2.1.4. Recent Developments and Future Outlook
- 11.2.2. Touchlight
- 11.2.2.1. Company Overview
- 11.2.2.2. Vector Manufacturing Portfolio
- 11.2.2.3. Recent Developments and Future Outlook
- 11.3. Other Key Players
- 11.3.1. BioNTech Innovative Manufacturing Service (a subsidiary of BioNTech)
- 11.3.1.1. Company Overview
- 11.3.1.2. Vector Manufacturing Portfolio
- 11.3.2. Biovian
- 11.3.2.1. Company Overview
- 11.3.2.2. Vector Manufacturing Portfolio
- 11.3.3. Celonic
- 11.3.3.1. Company Overview
- 11.3.3.2. Vector Manufacturing Portfolio
- 11.3.4. Centre for Process Innovation
- 11.3.4.1. Company Overview
- 11.3.4.2. Vector Manufacturing Portfolio
- 11.3.5. CEVEC Pharmaceuticals
- 11.3.5.1. Company Overview
- 11.3.5.2. Vector Manufacturing Portfolio
- 11.3.6. NorthX Biologics
- 11.3.6.1. Company Overview
- 11.3.6.2. Vector Manufacturing Portfolio
- 11.3.7. Novartis
- 11.3.7.1. Company Overview
- 11.3.7.2. Vector Manufacturing Portfolio
- 11.3.8. Oxford BioMedica
- 11.3.8.1. Company Overview
- 11.3.8.2. Vector Manufacturing Portfolio
- 11.3.9. Sanofi
- 11.3.9.1. Company Overview
- 11.3.9.2. Vector Manufacturing Portfolio
12. VECTOR AND GENE THERAPY MANUFACTURERS IN ASIA-PACIFIC
- 12.1. Chapter Overview
- 12.2. Key Players
- 12.2.1. CoJourney
- 12.2.1.1. Company Overview
- 12.2.1.2. Vector Manufacturing Portfolio
- 12.2.1.3. Recent Developments and Future Outlook
- 12.2.2. Esco Aster
- 12.2.2.1. Company Overview
- 12.2.2.2. Vector Manufacturing Portfolio
- 12.2.2.3. Recent Developments and Future Outlook
- 12.2.3. Wuxi AppTec
- 12.2.3.1. Company Overview
- 12.2.3.2. Financial Information
- 12.2.3.3. Vector Manufacturing Portfolio
- 12.2.3.4. Recent Developments and Future Outlook
- 12.3. Other Key Players
- 12.3.1. Altruist Biotechnology
- 12.3.1.1. Company Overview
- 12.3.1.2. Vector Manufacturing Portfolio
- 12.3.2. Jiangsu Puxin Biopharmaceutical
- 12.3.2.1. Company Overview
- 12.3.2.2. Vector Manufacturing Portfolio
- 12.3.3. Nikon CeLL innovation
- 12.3.3.1. Company Overview
- 12.3.3.2. Vector Manufacturing Portfolio
13. PORTER'S FIVE FORCES ANALYSIS
- 13.1 Chapter Overview
- 13.2. Methodology and Assumptions
- 13.3. Key Parameters
- 13.3.1. Threats of New Entrants
- 13.3.2. Bargaining Power of Suppliers
- 13.3.3. Bargaining Power of Buyers
- 13.3.4. Threats of Substitute Products
- 13.3.5. Rivalry Among Existing Competitors
- 13.4. Concluding Remarks
14. PARTNERSHIPS AND COLLABORATIONS
- 14.1. Chapter Overview
- 14.2. Partnership Models
- 14.3. Vector and Gene Therapy Manufacturing: Partnerships and Collaborations
- 14.3.1. Analysis by Year of Partnership
- 14.3.2. Analysis by Type of Partnership
- 14.3.3. Analysis by Scale of Operation
- 14.3.4. Analysis by Type of Vector Manufactured
- 14.3.5. Analysis by Therapeutic Area
- 14.3.6. Analysis by Application Area
- 14.3.7. Most Active Players: Analysis by Number of Partnerships
- 14.3.8. Analysis by Geography
- 14.3.8.1. Local and International Agreements
- 14.3.8.2. Intercontinental and Intracontinental Agreements
- 14.4. Other Collaborations
15. RECENT EXPANSIONS
- 15.1. Chapter Overview
- 15.2. Type of Expansions
- 15.3. Vector and Gene Therapy Manufacturing: Recent Expansions
- 15.3.1. Analysis by Year of Expansion
- 15.3.2. Analysis by Type of Expansion
- 15.3.3. Analysis by Year and Type of Expansion
- 15.3.4. Most Active Players: Analysis by Number of Expansions
- 15.3.5. Most Active Players: Analysis by Amount Invested
- 15.3.6. Analysis by Type of Manufacturing Facility
- 15.3.7. Analysis by Scale of Operation
- 15.3.8. Analysis by Type of Vector Manufactured
- 15.3.9. Analysis by Application Area
- 15.3.10. Analysis by Geography
- 15.3.10.1. Intercontinental and Intracontinental Expansions
- 15.3.10.2. Analysis by Location of Expansion
16. STRATEGIC PARTNER ANALYSIS
- 16.1. Chapter Overview
- 16.2. Methodology and Key Parameters
- 16.3. Strategic Partner Analysis: Viral Vector based Therapy Developers
- 16.3.1. Opportunity for AAV Vector based Therapy Developers
- 16.3.1.1. Most Likely Partners
- 16.3.1.2. Likely Partners
- 16.3.1.3. Less Likely Partners
- 16.3.1.4. Least Likely Partners
- 16.3.2. Opportunity for Adenoviral Vector based Therapy Developers
- 16.3.2.1. Most Likely Partners
- 16.3.2.2. Likely Partners
- 16.3.2.3. Less Likely Partners
- 16.3.2.4. Least Likely Partners
- 16.3.3. Opportunity for Lentiviral Vector based Therapy Developers
- 16.3.3.1. Most Likely Partners
- 16.3.3.2. Likely Partners
- 16.3.3.3. Less Likely Partners
- 16.3.3.4. Least Likely Partners
- 16.3.4. Opportunity for Retroviral Vector based Therapy Developers
- 16.3.4.1. Most Likely Partners
- 16.3.4.2. Likely Partners
- 16.3.4.3. Less Likely Partners
- 16.3.4.4. Least Likely Partners
- 16.3.5. Opportunity for Other Viral Vector based Therapy Developers
- 16.3.5.1. Most Likely Partners
- 16.3.5.2. Likely Partners
- 16.3.5.3. Less Likely Partners
- 16.3.5.4. Least Likely Partners
- 16.4. Strategic Partner Analysis: Viral Vector based Purification Product Developers
- 16.5. Methodology and Key Parameters
- 16.5.1. Opportunity for AAV Vector based Purification Product Developers
- 16.5.1.1. Most Likely Partners
- 16.5.1.2. Likely Partners
- 16.5.2. Opportunity for Adenoviral Vector based Purification Product Developers
- 16.5.2.1. Most Likely Partners
- 16.5.2.2. Likely Partners
- 16.5.3. Opportunity for Lentiviral Vector based Purification Product Developers
- 16.5.3.1. Most Likely Partners
- 16.5.3.2. Likely Partners
- 16.5.4. Opportunity for Retroviral Vector based Purification Product Developers
- 16.5.4.1. Most Likely Partners
- 16.5.4.2. Likely Partners
- 16.5.5. Opportunity for Other Viral Vector based Purification Product Developers
- 16.5.5.1. Most Likely Partners
- 16.5.5.2. Likely Partners
17. EMERGING VECTORS
- 17.1. Chapter Overview
- 17.1.1. Alphavirus based Vectors
- 17.1.2. Anc80 based Vectors
- 17.1.3. Bifidobacterium longum based Vectors
- 17.1.4. Cytomegalovirus based Vectors
- 17.1.5. Listeria monocytogenes based Vectors
- 17.1.6. Minicircle DNA based Vectors
- 17.1.7. Myxoma Virus based Vectors
- 17.1.8. Self-Complementary Vectors
- 17.1.9. Sendai Virus based Vectors
- 17.1.10. Sleeping Beauty Transposons
- 17.1.11. Vaccinia Virus and Modified Vaccinia Ankara based Vectors
- 17.1.12. Chimeric Viral Vectors
18. KEY INSIGHTS
- 18.1. Chapter Overview
- 18.2. Vector and Gene Therapy Manufacturers: Key Insights
- 18.2.1. Analysis by Type of Manufacturer, Type of Vector Manufactured and Scale of Operation
- 18.2.2. Analysis by Type of Vector Manufactured and Company Size
- 18.2.3. Analysis by Type of Organization and Geography
- 18.2.3.1. Contract Manufacturing Organizations
- 18.2.3.2. In-House Manufacturers
- 18.2.3.3. In-House and Contract Manufacturing Organizations
- 18.2.4. Analysis by Type of Vector Manufactured and Location of Headquarters
- 18.2.4.1. AAV Vector Manufacturers
- 18.2.4.2. Adenoviral Vector Manufacturers
- 18.2.4.3. Lentiviral Vector Manufacturers
- 18.2.4.4. Retroviral Vector Manufacturers
- 18.2.4.5. Plasmid DNA Manufacturers
19. COST PRICE ANALYSIS
- 19.1. Chapter Overview
- 19.2. Factors Contributing to High Price of Viral Vector and Plasmid DNA based Therapies
- 19.3. Viral Vector and Plasmid DNA based Therapies: Pricing Models
- 19.3.1. Pricing Models Based on Expert Opinions
- 19.3.2. Pricing Models Based on Manufacturing Cost
- 19.3.2.1. Pricing Models Based on Technology Used
- 19.3.2.2. Pricing Models Based on Scale of Operation
- 19.3.2.3. Pricing Models Based on Type of Client
- 19.3.3. Prices of Different Types of Vectors
- 19.4. Concluding Remarks
20. OUTSOURCING: GO / NO-GO FRAMEWORK
- 20.1. Chapter Overview
- 20.2. Outsourcing: Go / No-Go Framework
- 20.3. Vector Manufacturing Outsourcing: Go / No-Go Framework
- 20.3.1. Key Parameters and Assumptions
- 20.3.2. Methodology
- 20.3.3. Results and Interpretations
- 20.3.3.1. Outsourcing: Go / No-Go Framework for Small Companies
- 20.3.3.2. Outsourcing: Go / No-Go Framework for Mid-Sized Companies
- 20.3.3.3. Outsourcing: Go / No-Go Framework for Large Companies
21. CAPACITY ANALYSIS
- 21.1. Chapter Overview
- 21.2. Methodology and Key Assumptions
- 21.3. Viral Vector and Plasmid DNA Manufacturing: Global Installed Capacity
- 21.4. Viral Vector Manufacturing: Global Installed Capacity
- 21.4.1. Analysis by Company Size
- 21.4.2. Analysis by Scale of Operation
- 21.4.3. Analysis by Location of Headquarters (Region)
- 21.4.4. Analysis by Location of Manufacturing Facility
- 21.5. Plasmid DNA Manufacturing: Global Installed Capacity
- 21.5.1. Analysis by Company Size
- 21.5.2. Analysis by Scale of Operation
- 21.5.3. Analysis by Location of Headquarters (Region)
- 21.5.4. Analysis by Location of Manufacturing Facility
- 21.6. Concluding Remarks
22. DEMAND ANALYSIS
- 22.1. Chapter Overview
- 22.2. Assumptions and Methodology
- 22.3. Global Demand for Viral Vectors and Plasmid DNA, till 2035
- 22.4. Global Clinical Demand for Viral Vectors and Plasmid DNA, till 2035
- 22.4.1. Analysis by Type of Vector
- 22.4.2. Analysis by Type of Therapy
- 22.4.3. Analysis by Therapeutic Area
- 22.4.4. Analysis by Geography
- 22.5. Global Commercial Demand for Viral Vectors and Plasmid DNA, till 2035
- 22.5.1. Analysis by Type of Vector
- 22.5.2. Analysis by Type of Therapy
- 22.5.3. Analysis by Therapeutic Area
- 22.5.4. Analysis by Geography
- 22.6. Demand and Supply Analysis
23. MARKET IMPACT ANALYSIS: DRIVERS, RESTRAINTS, OPPORTUNITIES AND CHALLENGES
- 23.1. Chapter Overview
- 23.2. Market Drivers
- 23.3. Market Restraints
- 23.4. Market Opportunities
- 23.5. Market Challenges
- 23.6. Conclusion
24. GLOBAL VECTOR MANUFACTURING MARKET
- 24.1. Chapter Overview
- 24.2. Key Assumptions and Methodology
- 24.3. Global Vector Manufacturing Market, Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 24.3.1. Scenario Analysis
- 24.3.1.1. Conservative Scenario
- 24.3.1.2. Optimistic Scenario
- 24.4. Key Market Segmentations
25. VECTOR MANUFACTURING MARKET, BY SCALE OF OPERATION
- 25.1. Chapter Overview
- 25.2. Key Assumptions and Methodology
- 25.3. Vector Manufacturing Market: Distribution by Scale of Operation, 2018, 2023 and 2035
- 25.3.1. Preclinical Scale: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 25.3.2. Clinical Scale: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 25.3.3. Commercial Scale: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 25.4. Data Triangulation and Validation
26. VECTOR MANUFACTURING MARKET, BY TYPE OF VECTOR
- 26.1. Chapter Overview
- 26.2. Key Assumptions and Methodology
- 26.3. Vector Manufacturing Market: Distribution by Type of Vector, 2018, 2023 and 2035
- 26.3.1. AAV Vectors: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 26.3.2. Adenoviral Vectors: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 26.3.3. Lentiviral Vectors: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 26.3.4. Retroviral Vectors: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 26.3.5. Other Vectors: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 26.4. Data Triangulation and Validation
27. VECTOR MANUFACTURING MARKET, BY APPLICATION AREA
- 27.1. Chapter Overview
- 27.2. Key Assumptions and Methodology
- 27.3. Vector Manufacturing Market: Distribution by Application Area, 2018, 2023 and 2035
- 27.3.1. Cell Therapy: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 27.3.2. Gene Therapy: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 27.3.3. Vaccines: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 27.4. Data Triangulation and Validation
28. VECTOR MANUFACTURING MARKET, BY THERAPEUTIC AREA
- 28.1. Chapter Overview
- 28.2. Key Assumptions and Methodology
- 28.3. Vector Manufacturing Market: Distribution by Therapeutic Area, 2018, 2023 and 2035
- 28.3.1. Oncological Disorders: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.2. Rare Diseases: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.3. Immunological Disorders: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.4. Neurological Disorders: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.5. Sensory Disorders: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.6. Metabolic Disorders: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.7. Blood Disorders: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.8. Musculoskeletal Disorders: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.9. Infectious Diseases: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.10. Ophthalmic Disorders: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.3.11. Autoimmune Disorders: Forecasted Estimates (2026-2035)
- 28.3.12. Other Disorders: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 28.4. Data Triangulation and Validation
29. VECTOR MANUFACTURING MARKET, BY TYPE OF MANUFACTURER
- 29.1. Chapter Overview
- 29.2. Key Assumptions and Methodology
- 29.3. Vector Manufacturing Market: Distribution by Type of Manufacturer, 2018, 2023 and 2035
- 29.3.1. In-house Manufacturers: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 29.3.2. Contract Manufacturing Organizations: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 29.4. Data Triangulation and Validation
30. VECTOR MANUFACTURING MARKET, BY GEOGRAPHY
- 30.1. Chapter Overview
- 30.2. Key Assumptions and Methodology
- 30.3. Vector Manufacturing Market: Distribution by Geography, 2018, 2023 and 2035
- 30.3.1. North America: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 30.3.2. Europe: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 30.3.3. Asia-Pacific: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 30.3.4. Middle East and North Africa: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 30.3.5. Latin America and Rest of the World: Historical Trends (since 2018) and Forecasted Estimates (till 2035)
- 30.4. Data Triangulation and Validation
31. SURVEY ANALYSIS
- 31.1. Chapter Overview
- 31.2. Analysis by Seniority Level of Respondents
- 31.3. Analysis by Type of Manufacturer
- 31.4. Analysis by Scale of Operation
- 31.5. Analysis by Type of Vector Manufactured
32. CONCLUDING REMARKS
33. EXECUTIVE INSIGHTS
- 33.1. Chapter Overview
- 33.2. Batavia Biosciences
- 33.2.1. Company Snapshot
- 33.2.2. Interview Transcript: Chief Executive Officer
- 33.3. Touchlight
- 33.3.1. Company Snapshot
- 33.3.2. Interview Transcript: Chief Operating Officer
- 33.4. HALIX
- 33.4.1. Company Snapshot
- 33.4.2. Interview Transcript: Business Developer
- 33.5. CEVEC Pharmaceuticals
- 33.5.1. Company Snapshot
- 33.5.2. Interview Transcript: Chief Executive Officer and Chief Scientific Officer
- 33.6. Clean Cells
- 33.6.1. Company Snapshot
- 33.6.2. Interview Transcript: Co-Founder / President, Former Business Development Manager and Head of Gene Therapy
- 33.7. Massachusetts General Hospital
- 33.7.1. Organization Snapshot
- 33.7.2. Interview Transcript: Director
- 33.8. CJ PARTNERS
- 33.8.1. Company Snapshot
- 33.8.2. Interview Transcript: Former Managing Director
- 33.9. Polypus Transfection
- 33.9.1. Company Snapshot
- 33.9.2. Interview Transcript: Director of Marketing and Technical Support
- 33.10. University of Nantes
- 33.10.1. Organization Snapshot
- 33.10.2. Interview Transcript: Former Scientific Director
- 33.11. ACGT
- 33.11.1. Company Snapshot
- 33.11.2. Interview Transcript: Scientific Director
- 33.12. Delphi Genetics
- 33.12.1. Company Snapshot
- 33.12.2. Interview Transcript: Former Executive and Scientific Director
- 33.13. Amsterdam BioTherapeutics Unit
- 33.13.1. Organization Snapshot
- 33.13.2. Interview Transcript: Former Director
- 33.14. VIVEBiotech
- 33.14.1. Company Snapshot
- 33.14.2. Interview Transcript: Head of Communications
- 33.15. GEG Tech
- 33.15.1. Company Snapshot
- 33.15.2. Interview Transcript: Chief Scientific Officer
- 33.16. Richter-Helm BioLogics
- 33.16.1. Company Snapshot
- 33.16.2. Interview Transcript: Key Account Management
- 33.17. Plasmid Factory
- 33.17.1. Company Snapshot
- 33.17.2. Interview Transcript: Head of Project Management and Former Marketing Manager
- 33.18. Waisman Biomanufacturing
- 33.18.1. Company Snapshot
- 33.18.2. Interview Transcript: Director of Business Development
- 33.19. EFS-West Biotherapy
- 33.19.1. Company Snapshot
- 33.19.2. Interview Transcript: ATMP Key Account Manager
- 33.20. Independent Consultant
- 33.20.1. Interview Transcript
34. APPENDIX 1: TABULATED DATA
35. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS