Product Code: RA100369
T-CELL THERAPY MARKET: OVERVIEW
As per Roots Analysis, the global T-Cell therapy market is estimated to grow from USD 3.5 billion in the current year to USD 33.72 billion by 2035, at a CAGR of 23% during the forecast period, till 2035.
The market sizing and opportunity analysis has been segmented across the following parameters:
Type of Therapy
Target Indication
- Acute Lymphoblastic Leukemia
- Non-Hodgkin's Lymphoma
- Melanoma
- Bladder Cancer
- Lung Cancer
- Head and Neck Cancer
- Multiple Myeloma
- Sarcoma
- Chronic Lymphocytic Leukemia
- Ovarian Cancer
- Esophageal Cancer
- Colorectal Cancer
- Nasopharyngeal Carcinoma
- Hepatocellular Carcinoma
- Acute Myeloid Leukemia
- Renal Cell Carcinoma
Type of Target Antigens
- CD19
- BCMA
- CD19/22
- EGFR
- NY-ESO-1
- Gp100
- P53
- EBV
- MUC2
Key Geography
- North America
- Europe
- Asia-Pacific
- Latin America
- Middle East and North Africa
T-CELL THERAPY MARKET: GROWTH AND TRENDS
Cancer is one of the leading causes of mortality worldwide. As per the International Agency for Research on Cancer (IARC), by 2040, there are likely to be 27.5 million new cases and 16.3 million deaths related to cancer, globally. Despite the fact that cancer therapeutics is one of the most active areas, in terms of drug development, there are several unmet needs in this domain. Moreover, conventional cancer treatments, such as chemotherapy, surgery, and radiation therapy, have demonstrated very limited efficacy in late-stage cancers. In order to cater to the unmet needs of the industry, more initiatives are being taken to develop more targeted anti-cancer therapies, T-cell immunotherapy, specifically CAR-T cell therapies, has emerged as a highly potent option to selectively eliminate the tumor cells with minimal side effects. Immunotherapies essentially make use of body's own immune system, or its components, to fight against cancer.
Over the past few years, CAR-T therapies have been successful in carving out a significant share of the pharmaceutical market. A number of such targeted therapies have already been approved whilst a robust development pipeline indicates that CAR-T therapies market is likely to grow at a steady pace in the foreseen future. Moreover, the ongoing research activity in this field has led to the discovery of several novel molecular targets, further strengthening the research pipelines of the companies in this domain. Driven by the availability of innovative technology platforms, lucrative funding and encouraging clinical trial results suggest that the CAR-T therapies market is poised to grow in the long run, as multiple product candidates are expected to receive marketing approval in the coming decade.
T-CELL THERAPY MARKET: KEY INSIGHTS
The report delves into the current state of the T-Cell therapy market and identifies potential growth opportunities within the industry. Some key findings from the report include:
1. With some approved therapies and over 970 preclinical / clinical product candidates, CAR-T cell immunotherapies comprise the most active segment of this domain.
2. More than 100 industry and non-industry players are currently evaluating the potential of over 190 TCR cell immunotherapies to treat various oncological and non-oncological disorders.
3. In addition, over 75 TIL immunotherapies are being evaluated across different stages of preclinical / clinical development either as monotherapies or in combination with other drugs.
4. Apart from CAR-T, TCR and TIL-based products, close to 205 other T-cell immunotherapies are marketed / under development for the treatment of a wide range of oncological and non-oncological indications.
5. Close to 200 players claim to have the required capabilities to manufacture different types of cell therapies; such firms also offer a wide range of services across different stages of product development.
6. Across each type of T-cell therapy, at least 80% of the players are developing autologous therapy candidates targeting various disease indications; CD19 and BCMA emerged as the most popular target antigens.
7. A number of scientists from renowned universities are presently involved in clinical development efforts of TCR-based therapies; these KOLs are primarily based in the US and China.
8. Specifically, for CAR-T cell therapies, extensive efforts are underway to improve the CAR constructs across successive generations, involving alterations in the scFv region and using different types of gene delivery vectors.
9. In the last 10 years, over 750 clinical trials have been registered across different geographies for CAR-T cell therapies; extensive efforts are underway to improve successive generations of therapies.
10. A rise in partnerships, in the recent past, involving both international and indigenous stakeholders, validates the growing interest in this domain.
11. More than 75 patents have been granted / filed for TCR-based therapies, primarily led by the non-industry players.
12. With the growing focus on the development pipeline and encouraging clinical results, the market is anticipated to witness an annualized growth rate of over 20%, during the next decade.
13. The projected opportunity within the T-cell Therapies market is expected to be well distributed across different geographical regions and key / emerging players.
T-CELL THERAPY MARKET: KEY SEGMENTS
CAR-T Therapy is Likely to Dominate the T-Cell Therapy Market During the Forecast Period
Based on the type of therapy, the market is segmented into CAR T cell therapy, TCR therapy, and TIL therapy. At present, CAR-T therapy segment holds the maximum share of the T-Cell therapy market and this trend is likely to remain the same in the coming decade. This can be primally attributed to the proven efficacy of CAR-T therapy in various cancer treatments, such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, multiple myeloma, myeloid leukemia, and non-Hodgkin's lymphoma. It is worth highlighting that T-cell therapy market for TCR therapy is likely to grow at a relatively higher CAGR, during the forecast period.
Currently, Non-Hodgkin's Lymphoma Segment Occupies the Largest Share of the T-Cell Therapy Market
Based on the type of target indications, the market is segmented into acute lymphoblastic leukemia, non-Hodgkin's lymphoma, melanoma, bladder cancer, lung cancer, head and neck cancer, multiple myeloma, sarcoma, chronic lymphocytic leukemia, ovarian cancer, esophageal cancer, colorectal cancer, nasopharyngeal carcinoma, hepatocellular carcinoma, acute myeloid leukemia and renal cell carcinoma. At present, non-Hodgkin's lymphoma holds the maximum share of the T-Cell therapy market. This trend is likely to remain the same in the forthcoming years. It is worth highlighting that T-Cell therapy market for sarcoma is likely to grow at a relatively higher CAGR, during the forecast period.
Currently, CD19 Captures the Largest Share of the T-Cell Therapy Market
Based on the type of target antigens, the market is segmented into CD19, BCMA, CD19/22, EGFR, NY-ESO-1, gp100, p53, EBV, MUC1, WT-1 and others. At present, the CD19 segment holds the maximum share of the T-Cell therapy market. Owing to its proven efficacy against various types of cancer, such as leukemia and lymphoma, CD19 antigen is anticipated to foster the demand for T-cell therapy over the forecast period.
Europe Accounts for the Largest Share of the Market
Based on key geographical regions, the market is segmented into North America, Europe, Asia-Pacific, Middle East and North Africa, and Latin America. Majority share is expected to be captured by drug developers based in Europe. It is worth highlighting that rising prevalence various types of cancer, such as hematologic malignancies and solid tumors, and a surge in demand for cancer treatment will drive the growth of the market in Europe.
Example Players in the T-Cell Therapy Market
- Autolus
- Adaptimmune Therapeutics
- Alaunos Therapeutics
- bluebird Bio
- Bristol Myers Squibb
- Carsgen Therapeutics
- Cellectis
- Cellular Biomedicine Group
- Gilead Sciences
- GlaxoSmithKline
Primary Research Overview
The opinions and insights presented in this study were influenced by discussions conducted with multiple stakeholders. The research report features detailed transcripts of interviews held with the following industry stakeholders:
- Former Chief Executive Officer, Cell Therapies
- Chief Executive Officer, Glycostem Therapeutics
- Chief Executive Officer, Gracell Biotechnologies
- Co-Founder and Chief Executive Officer, Lion TCR
- Chief Executive Officer, TxCell
- Vice President, Scientific Affairs, Kite Pharma
- Manager of Business Development, Waisman Biomanufacturing
- Vice President (Immuno-Oncology), Celyad
- Former Director, Process Development, Iovance Biotherapeutics
- Former Competitive Intelligence Manager, Strategy & Business Development, Theravectys
- Professor of Medicine and Director, Department of Oncology, Changhai Hospital
- Assistant Professor of Medicine, University of Colorado
T-CELL THERAPY MARKET: RESEARCH COVERAGE
- Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the T-Cell therapy market, focusing on key market segments, including [A] type of therapy, [B] target indications, [C] target antigens and [D] key geographical regions.
- Market Landscape: A comprehensive evaluation of T-cell immunotherapies, considering various parameters, such as [A] type of developer, [B] phase of development, [C] therapeutic area, [D] key target indication, [E] key target antigen, [F] source of T-cells, [G] route of administration, [H] dose frequency, [I] patient segment, [J] type of therapy and [K] most active industry and non-industry players (in terms of number of pipeline candidates). Additionally, it highlights the developer landscape based on some relevant parameters, including [L] year of establishment, [M] company size and [N] location of headquarters.
- Key Insights: An analysis of key insights derived from the study featuring a competitive analysis, highlighting the popular target antigens related to hematological malignancies and solid tumors. Additionally, it includes CAR construct analysis of clinical-stage CAR-T therapies based on the generation of CAR (first generation, second generation, third generation, and fourth generation), type of binding domain (murine, humanized, fully human, and rabbit derived), type of virus used (lentivirus and retrovirus), type of gene transfer method used (transduction and transfection) and type of co-stimulatory domain used.
- Clinical Trials Analysis: Examination of completed, ongoing, and planned clinical studies of various CAR-Ts, TCRs, and TIL therapies, based on parameters like [A] trial registration year, [B] enrolled patient population, [C] trial recruitment status, [D] trial phase, [E] target patient segment, [F] type of sponsor/collaborator, [G] most active players and [H] regional distribution of trials.
- Key Opinion Leaders (KOLs) Analysis: An in-depth examination that emphasizes the key opinion leaders (KOLs) within this field includes an evaluation of various principal investigators overseeing clinical trials associated with CAR-Ts, TCRs and TILs therapies. In addition, the chapter highlights the most prominent KOLs, based on our proprietary and third-party scoring criteria.
- Drug Profiles: In-depth profiles of marketed and mid- to late-stage clinical products (phase I/II or above), focusing on [A] therapy overviews, [B] its mechanism of action, [C] dosage information, [D] details on the cost, [E] sales information (wherever available), [F] clinical development plan, [G] and key clinical trial results.
- Company Profiles: In-depth profiles of key industry players in engaged in the development of T-cell immunotherapies, focusing on [A] product portfolio specific to CAR-T, TCR and TIL therapies, [B] technology portfolio (if available), [C] recent developments related to T-cell immunotherapies, [D] manufacturing capabilities of the companies and [E] details related to the strategic / venture capital investments made in these companies.
- Emerging Technologies: A comprehensive examination of advanced technology platforms utilized in the development of T-cell therapies, including profiles of major technology providers. Additionally, it includes a comparative analysis of various gene editing platforms employed in T-cell therapy development, focusing on several parameters, such as ease of system design, cost of technology, level of toxicity and efficiency of technology.
- Partnerships and Collaborations: An analysis of partnerships established in this sector, covering R&D agreements, license agreements (specific to technology platforms and product candidates), product development and commercialization agreements, manufacturing agreements, clinical trial collaborations, product supply management agreements, joint ventures and others.
- Funding and Investment Analysis: A detailed evaluation of the investments received by the companies that have proprietary T-cell based products/technologies, encompassing seed financing, venture capital financing, capital raised from IPOs and subsequent offerings, grants and debt financing.
- Patent Analysis: Detailed analysis of various patents filed / granted related to CAR-Ts, TCRs and TILs therapies based on [A] type of patent, [B] publication year, [C] geographical distribution, [D] cooperative patent classification (CPC) symbols, [E] emerging focus areas, [F] type of applicant, [G] leading players (on the basis of number of patents) and [H] patent benchmarking. It also includes a patent benchmarking analysis and a detailed valuation analysis.
- Case Study 1: A case study on other T-cell-based therapies, apart from CAR-Ts, TCRs and TILs, including a detailed analysis of approved / pipeline products, featuring information on the current phase of development, target therapeutic area(s), type of T-cells used and source of T-cells.
- Case Study 2: A case study on manufacturing cell therapy products, highlighting the key challenges, and a detailed list of contract service providers and in-house manufacturers involved in this space.
- Cost Price Analysis: A comprehensive exploration of the various factors that form the pricing of cell-based therapies. This includes an examination of the different models and strategies that pharmaceutical companies may consider when determining the price of T-cell-based immunotherapies that are likely to enter the market in the near future.
- Promotional Analysis: A review of the key promotional strategies being adopted by the developers of the approved CAR-T cell therapies, namely Kymriah(R), Yescarta(R), Tecartus(TM), Breyanzi(R), Abecma(TM), Carvykti(TM) and TCR-based therapies (Kimmtrak(R)).
KEY QUESTIONS ANSWERED IN THIS REPORT
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What kind of partnership models are commonly adopted by industry stakeholders?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
REASONS TO BUY THIS REPORT
- The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
- Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
- The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.
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TABLE OF CONTENTS
1. PREFACE
- 1.1. Scope of the Report
- 1.2. Market Segmentations
- 1.3. Research Methodology
- 1.4. Key Questions Answered
- 1.5. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
- 3.1. Chapter Overview
- 3.2. Pillars of Cancer Therapy
- 3.3. Overview of Immunotherapies
- 3.4. Fundamentals of Cancer Immunotherapy
- 3.5. Classification of Cancer Immunotherapies
- 3.5.1. By Mechanism of Action
- 3.5.2. By Type of Target
- 3.5.3. By Approach
- 3.5.4. By Product Class
- 3.6. T-Cell Immunotherapies
- 3.6.1. Historical Evolution
- 3.6.2. Key Considerations for Developing T-Cell Immunotherapies
- 3.6.3. Strategies Employed for the Redirection of T-Cells
- 3.6.4. Manufacturing of Engineered T-Cells
- 3.6.5. T-Cell Transduction and Transfection Methods
- 3.7. Chimeric Antigen Receptor T-Cell (CAR-T) Therapy
- 3.7.1. Development History
- 3.7.2. Anatomical Layout of CAR
- 3.7.3. Development of CAR-T Cells
- 3.7.4. Universal CAR-T Cells
- 3.7.5. Route of Administration
- 3.7.6. Case Study on CD19 CAR-T Cell Therapies
- 3.7.7. Challenges Associated with Use of CAR-T Cell Therapies
- 3.8. T-Cell Receptor (TCR)-based Cell Therapy
- 3.8.1. Development History
- 3.8.2. Anatomical Layout of TCR
- 3.8.3. Development of TCR Therapy
- 3.8.4. Comparison of CAR-T and TCR-based Therapies
- 3.9. Tumor Infiltrating Lymphocyte (TIL)-based Cell Therapy
- 3.9.1. Development History
- 3.9.2. Development of TILs Therapy
- 3.10. Key Benefits and Roadblocks
- 3.11. Concluding Remarks
4. CAR-T CELL THERAPIES: MARKET LANDSCAPE
- 4.1. Chapter Overview
- 4.2. CAR-T Cell Therapies: Overall Market Landscape
- 4.2.1. Analysis by Type of Developer
- 4.2.2. Analysis by Phase of Development
- 4.2.3. Analysis by Therapeutic Area
- 4.2.4. Analysis by Phase of Development and Therapeutic Area
- 4.2.5. Analysis by Key Target Indications
- 4.2.6. Analysis by Key Target Antigens
- 4.2.7. Analysis by Source of T-Cells
- 4.2.8. Analysis by Phase of Development and Source of T-Cells
- 4.2.9. Analysis by Route of Administration
- 4.2.10. Analysis by Dosing Frequency
- 4.2.11. Analysis by Target Patient Segment
- 4.2.12. Analysis by Type of Therapy
- 4.2.13. Most Active Industry Players: Analysis by Number of CAR-T Cell Therapies
- 4.2.14. Most Active Non-Industry Players: Analysis by Number of CAR-T Cell Therapies
- 4.3. CAR-T Cell Therapies: Overall Developer Landscape
- 4.3.1. Analysis by Year of Establishment
- 4.3.2. Analysis by Company Size
- 4.3.3. Analysis by Location of Headquarters
5. TCR-BASED THERAPIES: MARKET LANDSCAPE
- 5.1. Chapter Overview
- 5.2. TCR-based Therapies: Overall Market Landscape
- 5.2.1. Analysis by Type of Developer
- 5.2.2. Analysis by Phase of Development
- 5.2.3. Analysis by Therapeutic Area
- 5.2.4. Analysis by Phase of Development and Therapeutic Area
- 5.2.5. Analysis by Key Target Indication
- 5.2.6. Analysis by Key Target Antigen
- 5.2.7. Analysis by Source of T-Cells
- 5.2.8. Analysis by Route of Administration
- 5.2.9. Analysis by Phase of Development and Route of Administration
- 5.2.10. Analysis by Dosing Frequency
- 5.2.11. Analysis by Target Patient Segment
- 5.2.12. Analysis by Type of Therapy
- 5.2.13. Analysis by Phase of Development and Type of Therapy
- 5.2.14. Most Active Industry Players: Analysis by Number of TCR-based Therapies
- 5.2.15. Most Active Non-Industry Players: Analysis by Number of TCR-based Therapies
- 5.3. TCR-based Therapies: Overall Developer Landscape
- 5.3.1. Analysis by Year of Establishment
- 5.3.2. Analysis by Company Size
- 5.3.3. Analysis by Location of Headquarters
6. TIL-BASED THERAPIES: MARKET LANDSCAPE
- 6.1. Chapter Overview
- 6.2. TIL-based Therapies: Overall Market Landscape
- 6.2.1. Analysis by Type of Developer
- 6.2.2. Analysis by Phase of Development
- 6.2.3. Analysis by Therapeutic Area
- 6.2.4. Analysis by Key Target Indication
- 6.2.5. Analysis by Source of T-Cells
- 6.2.6. Analysis by Route of Administration
- 6.2.7. Analysis by Dosing Frequency
- 6.2.8. Analysis by Target Patient Segment
- 6.2.9. Analysis by Type of Therapy
- 6.2.10. Most Active Industry Players: Analysis by Number of TIL-based Therapies
- 6.2.11. Most Active Non-Industry Players: Analysis by Number of TIL-based Therapies
- 6.3. TIL-based Therapies: Overall Developer Landscape
- 6.3.1. Analysis by Year of Establishment
- 6.3.2. Analysis by Company Size
- 6.3.3. Analysis by Location of Headquarters
7. KEY INSIGHTS
- 7.1. Chapter Overview
- 7.2. T-Cell Immunotherapies: Competitive Analysis by Popular Target Antigen
- 7.2.1. Popular Targets Related to Hematological Malignancies
- 7.2.2. Popular Targets Related to Solid Tumors
- 7.3. T-Cell Immunotherapies: CAR Construct Analysis
- 7.3.1. Analysis by Generation of CAR
- 7.3.2. Analysis by Type of scFv Antibody
- 7.3.3. Analysis by Type of Virus Used
- 7.3.4. Analysis by Type of Gene Transfer Method Used
- 7.3.5. Analysis by Co-Stimulatory Domain
8. CLINICAL TRIAL ANALYSIS
- 8.1. Chapter Overview
- 8.2. Scope and Methodology
- 8.3. CAR-T Cell Therapies: Clinical Trial Analysis
- 8.3.1. Analysis by Trial Registration Year
- 8.3.2. Analysis by Trial Registration Year and Enrolled Patient Population
- 8.3.3. Analysis by Trial Status
- 8.3.4. Analysis by Trial Registration Year and Trial Status
- 8.3.5. Analysis by Trial Phase
- 8.3.6. Analysis by Trial Phase and Enrolled Patient Population
- 8.3.7. Analysis by Target Patient Segment
- 8.3.8. Analysis by Type of Sponsor / Collaborator
- 8.3.9. Analysis by Study Design
- 8.3.10. Most Active Industry Players: Analysis by Number of Registered Trials
- 8.3.11. Most Active Non-Industry Players: Analysis by Number of Registered Trials
- 8.3.12. Analysis by Key Focus Areas (Word Cloud Representation)
- 8.3.13. Analysis of Clinical Trials by Geography
- 8.3.14. Analysis of Enrolled Patient Population by Geography
- 8.4. TCR-based Therapies: Clinical Trial Analysis
- 8.4.1. Analysis by Trial Registration Year
- 8.4.2. Analysis by Trial Registration Year and Enrolled Patient Population
- 8.4.3. Analysis by Trial Status
- 8.4.4. Analysis by Trial Registration Year and Trial Status
- 8.4.5. Analysis by Trial Phase
- 8.4.6. Analysis by Trial Phase and Enrolled Patient Population
- 8.4.7. Analysis by Target Patient Segment
- 8.4.8. Analysis by Type of Sponsor / Collaborator
- 8.4.9. Analysis by Study Design
- 8.4.10. Most Active Industry Players: Analysis by Number of Registered Trials
- 8.4.11. Most Active Non-Industry Players: Analysis by Number of Registered Trials
- 8.4.12. Analysis by Key Focus Areas (Word Cloud Representation)
- 8.4.13. Analysis of Clinical Trials by Geography
- 8.4.14. Analysis of Enrolled Patient Population by Geography
- 8.5. TIL-based Therapies: Clinical Trial Analysis
- 8.5.1. Analysis by Trial Registration Year
- 8.5.2. Analysis by Trial Registration Year and Enrolled Patient Population
- 8.5.3. Analysis by Trial Status
- 8.5.4. Analysis by Trial Registration Year and Trial Status
- 8.5.5. Analysis by Trial Phase
- 8.5.6. Analysis by Trial Phase and Enrolled Patient Population
- 8.5.7. Analysis by Target Patient Segment
- 8.5.8. Analysis by Type of Sponsor / Collaborator
- 8.5.9. Analysis by Study Design
- 8.5.10. Most Active Industry Players: Analysis by Number of Registered Trials
- 8.5.11. Most Active Non-Industry Players: Analysis by Number of Registered Trials
- 8.5.12. Analysis by Key Focus Areas (Word Cloud Representation)
- 8.5.13. Analysis of Clinical Trials by Geography
- 8.5.14. Analysis of Enrolled Patient Population by Geography
9. KEY OPINION LEADERS
- 9.1. Chapter Overview
- 9.2. Assumptions and Key Parameters
- 9.3. Methodology
- 9.4. CAR-T Cell Therapies: Key Opinion Leaders
- 9.4.1. Analysis by Type of Organization
- 9.4.2. Analysis by Affiliated Organization
- 9.4.3. Analysis by Qualification
- 9.4.4. Analysis by Geographical Location of KOLs
- 9.4.5. KOL Activeness versus KOL Strength
- 9.4.6. Most Prominent KOLs: Analysis by RA score
- 9.4.7. Most Prominent KOLs: Comparison of RA Score and Third-Party Score
- 9.5. TCR-based Therapies: Key Opinion Leaders
- 9.5.1. Analysis by Type of Organization
- 9.5.2. Analysis by Affiliated Organization
- 9.5.3. Analysis by Qualification
- 9.5.4. Analysis by Geographical Location of KOLs
- 9.5.5. KOL Activeness versus KOL Strength
- 9.5.6. Most Prominent KOLs: Analysis by RA score
- 9.5.7. Most Prominent KOLs: Comparison of RA Score and Third-Party Score
- 9.6. TIL-based Therapies: Key Opinion Leaders
- 9.6.1. Analysis by Type of Organization
- 9.6.2. Analysis by Affiliated Organization
- 9.6.3. Analysis by Qualification
- 9.6.4. Analysis by Geographical Location of KOLs
- 9.6.5. KOL Activeness versus KOL Strength
- 9.6.6. Most Prominent KOLs: Analysis by RA score
- 9.6.7. Most Prominent KOLs: Comparison of RA Score and Third-Party Score
10. CAR-T CELL THERAPY PROFILES
- 10.1. Chapter Overview
- 10.2. Kymriah / Tisagenlecleucel / CTL019 (Novartis)
- 10.2.1. Therapy Overview
- 10.2.2. Clinical Trial Information
- 10.2.3. Clinical Trial Endpoints
- 10.2.4. Clinical Trial Results
- 10.2.5. Estimated Sales Revenues
- 10.3. Yescarta / Axiscabtagene Ciloleucel / KTE-C19 (Gilead Sciences)
- 10.3.1. Therapy Overview
- 10.3.2. Clinical Trial Information
- 10.3.3. Clinical Trial Endpoints
- 10.3.4. Clinical Trial Results
- 10.3.5. Estimated Sales Revenues
- 10.4. Tecartus / Brexucabtagene Autoleucel (Gilead Sciences)
- 10.4.1. Therapy Overview
- 10.4.2. Clinical Trial Information
- 10.4.3. Clinical Trial Endpoints
- 10.4.4. Clinical Trial Results
- 10.4.5. Estimated Sales Revenues
- 10.5. Breyanzi / Lisocabtagene Maraleucel / JCAR017 (Bristol Myers Squibb)
- 10.5.1. Therapy Overview
- 10.5.2. Clinical Trial Information
- 10.5.3. Clinical Trial Endpoints
- 10.5.4. Clinical Trial Results
- 10.5.5. Estimated Sales Revenues
- 10.6. Abecma / BB2121 / Idecabtagene Vicleucel (Bristol Myers Squibb)
- 10.6.1. Therapy Overview
- 10.6.2. Clinical Trial Information
- 10.6.3. Clinical Trial Endpoints
- 10.6.4. Clinical Trial Results
- 10.6.5. Estimated Sales Revenues
- 10.7. Carvykti / Ciltacabtagene Autoleucel / LCAR-B38M CAR-T / JNJ-68284528 (Janssen)
- 10.7.1. Therapy Overview
- 10.7.2. Clinical Trial Information
- 10.7.3. Clinical Trial Endpoints
- 10.7.4. Clinical Trial Results
- 10.7.5. Estimated Sales Revenues
- 10.8. Carteyva / Relmacabtagene Autoleucel / JWCAR029 (JW Therapeutics)
- 10.8.1. Therapy Overview
- 10.8.2. Clinical Trial Information
- 10.8.3. Clinical Trial Endpoints
- 10.8.4. Clinical Trial Results
- 10.8.5. Estimated Sales Revenues
- 10.9. TBI-1501 / CD19 CAR-T Cell Therapy (Takara Bio)
- 10.9.1. Therapy Overview
- 10.9.2. Clinical Trial Information
- 10.9.3. Clinical Trial Endpoints
- 10.9.4. Estimated Sales Revenues
- 10.10. AUTO1 / Obecabtagene Autoleucel / obe-cel (Autolus)
- 10.10.1. Therapy Overview
- 10.10.2. Clinical Trial Information
- 10.10.3. Clinical Trial Endpoints
- 10.10.4. Clinical Trial Results
- 10.10.5. Estimated Sales Revenues
- 10.11. AUTO3 / CD19/22 CAR-T (Autolus)
- 10.11.1. Therapy Overview
- 10.11.2. Clinical Trial Information
- 10.11.3. Clinical Trial Endpoints
- 10.11.4. Clinical Trial Results
- 10.11.5. Estimated Sales Revenues
11. TCR-BASED THERAPY PROFILES
- 11.1. Chapter Overview
- 11.2. Kimmtrak / IMCgp100 / Tebentafusp (Immunocore)
- 11.2.1. Therapy Overview
- 11.2.2. Clinical Trial Information
- 11.2.3. Clinical Trial Endpoints
- 11.2.4. Clinical Trial Results
- 11.2.5. Estimated Sales Revenues
- 11.3. GSK3377794 / NY-ESO-1C259 T-Cells / Letetresgene Autoleucel (GlaxoSmithKline)
- 11.3.1. Therapy Overview
- 11.3.2. Clinical Trial Information
- 11.3.3. Clinical Trial Endpoints
- 11.3.4. Clinical Trial Results
- 11.3.5. Estimated Sales Revenues
- 11.4. ADP-A2M4 / Afamitresgene Autoleucel / Afami-cel (Adaptimmune Therapeutics)
- 11.4.1. Therapy Overview
- 11.4.2. Clinical Trial Information
- 11.4.3. Clinical Trial Endpoints
- 11.4.4. Clinical Trial Results
- 11.4.5. Estimated Sales Revenues
- 11.5. JTCR016 (Juno Therapeutics)
- 11.5.1. Therapy Overview
- 11.5.2. Clinical Trial Information
- 11.5.3. Clinical Trial Endpoints
- 11.5.4. Estimated Sales Revenues
- 11.6. TBI-1301 (Takara Bio)
- 11.6.1. Therapy Overview
- 11.6.2. Clinical Trial Information
- 11.6.3. Clinical Trial Endpoints
- 11.6.4. Clinical Trial Results
- 11.6.5. Estimated Sales Revenues
- 11.7. MDG1011 (Medigene)
- 11.7.1. Therapy Overview
- 11.7.2. Clinical Trial Information
- 11.7.3. Clinical Trial Endpoints
- 11.7.4. Clinical Trial Results
- 11.7.5. Estimated Sales Revenues
12. TIL-BASED THERAPY PROFILES
- 12.1. Chapter Overview
- 12.2. LN-144 / Lifileucel (Iovance Biotherapeutics)
- 12.2.1. Therapy Overview
- 12.2.2. Clinical Trial Information
- 12.2.3. Clinical Trial Endpoints
- 12.2.4. Clinical Trial Results
- 12.2.5. Estimated Sales Revenues
- 12.3. LN-145 (Iovance Biotherapeutics)
- 12.3.1. Therapy Overview
- 12.3.2. Clinical Trial Information
- 12.3.3. Clinical Trial Endpoints
- 12.3.4. Clinical Trial Results
- 12.3.5. Estimated Sales Revenues
- 12.4. ITIL-168 (Instil Bio)
- 12.4.1. Therapy Overview
- 12.4.2. Clinical Trial Information
- 12.4.3. Clinical Trial Endpoints
- 12.4.4. Clinical Trial Results
- 12.4.5. Estimated Sales Revenues
- 12.5. LTX-315 (Lytix Biopharma)
- 12.5.1. Therapy Overview
- 12.5.2. Clinical Trial Information
- 12.5.3. Clinical Trial Endpoints
- 12.5.4. Clinical Trial Results
- 12.5.5. Estimated Sales Revenues
13. EMERGING TECHNOLOGIES
- 13.1. Chapter Overview
- 13.2. Genome Editing Technologies
- 13.2.1. Technology Overview
- 13.2.2. Applications of Genome Editing Technologies
- 13.2.3. Emerging Technology Platforms for T-Cell Therapies
- 13.2.3.1. CRISPR / CAS9 System
- 13.2.3.1.1. Key Components
- 13.2.3.1.2. Mechanism of Action
- 13.2.3.1.3. Targeting Efficiency and Challenges
- 13.2.3.1.4. Next-Gen CRISPR Technology
- 13.2.3.1.5. Technology Providers
- 13.2.3.1.5.1. Intellia Therapeutics
- 13.2.3.1.5.2. Editas Medicine
- 13.2.3.1.5.3. CRISPR Therapeutics
- 13.2.3.1.5.4. Beam Therapeutics
- 13.2.3.1.5.5. Gracell Technologies
- 13.2.3.1.5.6. Caribou Biosciences
- 13.2.3.1.5.7. Nanjing Bioheng Biotech
- 13.2.3.1.5.8. Intima Biosciences
- 13.2.3.1.5.9. KSQ Therapeutics
- 13.2.3.1.5.10. Refuge Biotechnologies
- 13.2.3.2. TALENS
- 13.2.3.2.1. Key Components and Function
- 13.2.3.2.2. Mechanism of Action
- 13.2.3.2.3. Advantages and Challenges
- 13.2.3.2.4. Technology Providers
- 13.2.3.2.4.1. Cellectis
- 13.2.3.2.4.2. Editas Medicine
- 13.2.3.3. MegaTAL
- 13.2.3.3.1. Mechanism of Action
- 13.2.3.3.2. Technology Providers
- 13.2.3.3.2.1. bluebird bio
- 13.2.3.3.2.2. Precision Biosciences
- 13.2.3.4. Zinc Finger Nuclease
- 13.2.3.4.1. Mechanism of Action
- 13.2.3.4.2. Technology Providers
- 13.2.3.4.2.1. Sangamo Therapeutics
- 13.2.4. Competitive Analysis: Gene Editing Platforms
- 13.3. Designing T-Cell Therapies with Improved Characteristics
- 13.3.1. Technologies for Targeting Multiple Cancers
- 13.3.1.1. Antibody Coupled T-Cell Receptor
- 13.3.1.1.1. Cogent Biosciences
- 13.3.1.2. NKR-T Platform
- 13.3.1.2.1. Celyad
- 13.3.1.2.2. Glycostem
- 13.3.1.2.3. CatamaranBio
- 13.3.2. Technologies for Improved Safety
- 13.3.2.1. Armored CAR and EGFRt Technology
- 13.3.2.1.1. Juno Therapeutics
- 13.3.2.2. Rheoswitch Therapeutic System
- 13.3.2.2.1. Intrexon
- 13.3.2.2.2. Precigen
- 13.3.2.3. Inducible Caspase 9 Safety Switch
- 13.3.2.3.1. Bellicum Pharmaceuticals
- 13.3.2.3.1.1. CaspaCIDe Technology
- 13.3.2.3.1.2. CIDeCAR Technology
- 13.3.2.3.1.3. GoCAR-T Technology
- 13.3.2.4. On-OFF Switch, Multiple Companies
- 13.3.2.4.1. Inhibitory CAR (iCAR) (Juno Therapeutics)
- 13.3.2.4.2. On-OFF Switch (Theravectys)
- 13.3.2.5. Other Technologies to Improve CAR-T Safety
- 13.3.3. Allogeneic Technologies
- 13.3.3.1. CIK CAR-T Cells (Formula Pharmaceuticals)
- 13.3.3.2. Allogeneic Platform (CELYAD)
- 13.3.3.3. Allogeneic Platform (Cellectis)
- 13.3.3.4. AlloCAR T (Allogene Therapeutics)
- 13.4. Future Perspectives
14. PARTNERSHIPS AND COLLABORATIONS
- 14.1. Chapter Overview
- 14.2. Partnership Models
- 14.3. T-Cell Immunotherapies Market: Partnerships and Collaborations
- 14.3.1. Analysis by Year of Partnership
- 14.3.2. Analysis by Type of Partnership
- 14.3.3. Analysis by Type of Product
- 14.3.4. Analysis by Year of Partnership and Type of Product
- 14.3.5. Analysis by Type of Partnership and Type of Product
- 14.3.6. Analysis by Type of Partner
- 14.3.7. Analysis by Type of Product and Type of Partner
- 14.3.8. Most Popular Products: Analysis by Number of Partnerships
- 14.3.9. Most Active Industry Players: Analysis by Number of Partnerships
- 14.3.10. Most Active Non-Industry Players: Analysis by Number of Partnerships
- 14.3.11. Analysis by Geography
- 14.3.11.1. Intercontinental and Intracontinental Agreements
- 14.3.11.2. International and Local Deals
15. FUNDING AND INVESTMENT ANALYSIS
- 15.1. Chapter Overview
- 15.2. Type of Funding
- 15.3. T-Cell Immunotherapy Market: Funding and Investment Analysis
- 15.3.1. Analysis of Instances by Year
- 15.3.2. Analysis of Amount Invested by Year
- 15.3.3. Analysis by Type of Funding
- 15.3.4. Analysis of Amount Invested across Different Types of Therapies
- 15.3.5. Analysis by Type of Investor
- 15.3.6. Most Active Players: Analysis by Number of Instances
- 15.3.7. Most Active Investors: Analysis by Amount Invested
- 15.3.8. Analysis of Amount Invested by Geography
- 15.3.9. Most Active Investors: Analysis by Number of Funding Instances
16. PATENT ANALYSIS
- 16.1. Chapter Overview
- 16.2. Scope and Methodology
- 16.3. Patent Analysis: Distribution by Type of Patent
- 16.4. CAR-T Cell Therapies: Patent Analysis
- 16.4.1. Analysis by Patent Publication Year
- 16.4.2. Analysis by Patent Application Year
- 16.4.3. Analysis by Geography
- 16.4.4. Analysis by Type of Player
- 16.4.5. Analysis by CPC Symbols
- 16.4.6. Analysis by Key Focus Area
- 16.4.7. Leading Players: Analysis by Number of Patents
- 16.4.8. Car-T Cell Therapies: Patent Benchmarking
- 16.4.9. Analysis By Patent Characteristics
- 16.4.10. Car-T Cell Therapies: Patent Valuation
- 16.5. TCR- based Therapies
- 16.5.1. Analysis by Patent Publication Year
- 16.5.2. Analysis By Patent Application Year
- 16.5.3. Analysis by Geography
- 16.5.4. Analysis by Type of Player
- 16.5.5. Analysis by CPC Symbols
- 16.5.6. Analysis by Key Focus Area
- 16.5.7. Leading Player: Analysis by Number of Patents
- 16.5.8. TCR-based Therapies: Patent Benchmarking
- 16.5.9. Analysis By Patent Characteristics
- 16.5.10. TCR-based Cell Therapies: Patent Valuation
- 16.6. TIL- based Therapies
- 16.6.1. Analysis by Patent Publication Year
- 16.6.2. Analysis By Patent Application Year
- 16.6.3. Analysis by Geography
- 16.6.4. Analysis by Type of Player
- 16.6.5. Analysis by CPC Symbols
- 16.6.6. Analysis by Key Focus Area
- 16.6.7. Leading Player: Analysis by Number of Patents
- 16.6.8. TIL-based Therapies: Patent Benchmarking
- 16.6.9. Analysis By Patent Characteristics
- 16.6.10. TIL-based Therapies: Patent Valuation
17. OTHER T-CELL IMMUNOTHERAPIES
- 17.1. Chapter Overview
- 17.2. Other T-Cell Immunotherapies
- 17.2.1. Fucosylated T-Cell Therapies
- 17.2.2. Gamma Delta T-Cell Therapies
- 17.2.3. PD-1 Knockout Engineered T-Cell Therapies
- 17.2.4. TAC T-Cell Therapies
- 17.2.5. T-Cell Vaccines
- 17.2.6. Treg Cell Therapies
- 17.2.7. Virus-Driven T-Cell Therapies
- 17.3. Other T-Cell Immunotherapies: Market Overview
- 17.3.1. Analysis by Type of T-Cell
- 17.3.2. Analysis by Source of T-Cell
- 17.3.3. Analysis by Phase of Development
- 17.3.4. Analysis by Therapeutic Area
- 17.4. Key Considerations for Developing T-Cell Immunotherapies
- 17.5. Concluding Remarks
18. CASE STUDY: CELL THERAPY MANUFACTURING
- 18.1. Chapter Overview
- 18.2. Overview of Cell Therapy Manufacturing
- 18.3. Cell Therapy Manufacturing Models
- 18.3.1. Centralized Manufacturing Model
- 18.3.2. Decentralized Manufacturing Model
- 18.4. Scalability of Cell Therapy Manufacturing Processes
- 18.4.1. Scale-Up
- 18.4.2. Scale-Out
- 18.5. Types of Cell Therapy Manufacturers
- 18.6. Key Challenges Related to Manufacturing of Cell Therapies
- 18.7. Important Factors for Cell Therapy Manufacturing
- 18.7.1. Characterization
- 18.7.2. Cost of Goods
- 18.8. Automation of Cell Therapy Manufacturing Process
- 18.9. Cell Therapy Manufacturing Supply Chain
- 18.10. Comparison of Player Having In-House Capabilities and Contract Manufacturers
- 18.11. Regulatory Landscape
- 18.12. Future Perspectives
19. COST PRICE ANALYSIS
- 19.1. Chapter Overview
- 19.2. Factors Contributing to the High Price of Cell / Gene Therapies
- 19.3. Pricing Models for T-Cell Immunotherapies
- 19.3.1. Based on Associated Costs
- 19.3.2. Based on Availability of Competing Products
- 19.3.3. Based on Patient Segment
- 19.3.4. Based on Opinions of Industry Experts
- 19.4. Reimbursement related Considerations for T-Cell Immunotherapies
- 19.4.1. Case Study: The National Institute for Health and Care Excellence (NICE) Appraisal of CAR-T therapies
20. MARKET FORECAST AND OPPORTUNITY ANALYSIS
- 20.1. Chapter Overview
- 20.2. Scope and Limitations
- 20.3. Key Assumptions And Forecast Methodology
- 20.4. Overall T-Cell Immunotherapy Market, till 2035
- 20.4.1. T-Cell Immunotherapy Market: Analysis by Type of Therapy
- 20.4.2. T-Cell Immunotherapy Market: Analysis by Target Indication
- 20.4.3. T-Cell Immunotherapy Market: Analysis by Target Antigen
- 20.4.4. T-Cell Immunotherapy Market: Analysis by Key Players
- 20.4.5. T-Cell Immunotherapy Market: Analysis by Geography
- 20.5. T-Cell Immunotherapy Market: Value Creation Analysis
- 20.6. Overall CAR-T Cell Therapies Market, till 2035
- 20.6.1. CAR-T Cell Therapies Market: Analysis by Target Indication
- 20.6.2. CAR-T Cell Therapies Market: Analysis by Target Antigen
- 20.6.3. CAR-T Cell Therapies Market: Analysis by Key Players
- 20.6.4. CAR-T Cell Therapies Market: Analysis by Geography
- 20.6.5. Product Wise Sales Forecast
- 20.6.5.1. Kymriah / Tisagenlecleucel / CTL019 (Novartis)
- 20.6.5.1.1. Sales Forecast (USD Million)
- 20.6.5.1.2. Net Present Value
- 20.6.5.1.3. Value Creation Analysis
- 20.6.5.2. Yescarta / Axiscabtagene Ciloleucel / KTE-C19 (Gilead Sciences)
- 20.6.5.2.1. Sales Forecast (USD Million)
- 20.6.5.2.2. Net Present Value (USD Million)
- 20.6.5.2.3. Value Creation Analysis
- 20.6.5.3. Tecartus / Brexucabtagene Autoleucel (Gilead Sciences)
- 20.6.5.3.1. Sales Forecast (USD Million)
- 20.6.5.3.2. Net Present Value (USD Million)
- 20.6.5.3.3. Value Creation Analysis
- 20.6.5.4. Abecma / BB2121 / Idecabtagene Vicleucel (Bristol Myers Squibb)
- 20.6.5.4.1. Sales Forecast (USD Million)
- 20.6.5.4.2. Net Present Value (USD Million)
- 20.6.5.4.3. Value Creation Analysis
- 20.6.5.5. Carvykti / Ciltacabtagene Autoleucel / LCAR-B38M CAR-T / JNJ-68284528 (Janssen)
- 20.6.5.5.1. Sales Forecast (USD Million)
- 20.6.5.5.2. Net Present Value (USD Million)
- 20.6.5.5.3. Value Creation Analysis
- 20.6.5.6. Breyanzi / Lisocabtagene Maraleucel / JCAR017 (Bristol Myers Squibb)
- 20.6.5.6.1. Sales Forecast (USD Million)
- 20.6.5.6.2. Net Present Value (USD Million)
- 20.6.5.6.3. Value Creation Analysis
- 20.6.5.7. Carteyva / Relmacabtagene Autoleucel / JWCAR029 (JW Therapeutics)
- 20.6.5.7.1. Sales Forecast (USD Million)
- 20.6.5.7.2. Net Present Value (USD Million)
- 20.6.5.7.3. Value Creation Analysis
- 20.6.5.8. BCMA CAR-T Cells (Shanghai Unicar-Therapy Bio-medicine Technology)
- 20.6.5.8.1. Sales Forecast (USD Million)
- 20.6.5.8.2. Net Present Value (USD Million)
- 20.6.5.8.3. Value Creation Analysis
- 20.6.5.9. CD19 CAR-T (Wuhan Si'an Medical Technology)
- 20.6.5.9.1. Sales Forecast (USD Million)
- 20.6.5.9.2. Net Present Value (USD Million)
- 20.6.5.9.3. Value Creation Analysis
- 20.6.5.10. Descartes-11 (Cartesian Therapeutics)
- 20.6.5.10.1. Sales Forecast (USD Million)
- 20.6.5.10.2. Net Present Value (USD Million)
- 20.6.5.10.3. Value Creation Analysis
- 20.6.5.11. Descartes-08 (Cartesian Therapeutics)
- 20.6.5.11.1. Sales Forecast (USD Million)
- 20.6.5.11.2. Net Present Value (USD Million)
- 20.6.5.11.3. Value Creation Analysis
- 20.6.5.12. Zamtocabtagene Autoleucel / MB-CART2019.1 (Miltenyi Biomedicine)
- 20.6.5.12.1. Sales Forecast (USD Million)
- 20.6.5.12.2. Net Present Value (USD Million)
- 20.6.5.12.3. Value Creation Analysis
- 20.6.5.13. CNCT19 / HY001 (Juventas Cell Therapy)
- 20.6.5.13.1. Sales Forecast (USD Million)
- 20.6.5.13.2. Net Present Value (USD Million)
- 20.6.5.13.3. Value Creation Analysis
- 20.6.5.14. CD30.CAR-T / TT11 (Tessa Therapeutics)
- 20.6.5.14.1. Sales Forecast (USD Million)
- 20.6.5.14.2. Net Present Value (USD Million)
- 20.6.5.14.3. Value Creation Analysis
- 20.6.5.15. TAK-007 (Takeda)
- 20.6.5.15.1. Sales Forecast (USD Million)
- 20.6.5.15.2. Net Present Value (USD Million)
- 20.6.5.15.3. Value Creation Analysis
- 20.6.5.16. AUTO1 (Autolus)
- 20.6.5.16.1. Sales Forecast (USD Million)
- 20.6.5.16.2. Net Present Value (USD Million)
- 20.6.5.16.3. Value Creation Analysis
- 20.6.5.17. AUTO3 (Autolus)
- 20.6.5.17.1. Sales Forecast (USD Million)
- 20.6.5.17.2. Net Present Value (USD Million)
- 20.6.5.17.3. Value Creation Analysis
- 20.6.5.18. CD19-CAR-T (Bioray Laboratories)
- 20.6.5.18.1. Sales Forecast (USD Million)
- 20.6.5.18.2. Net Present Value (USD Million)
- 20.6.5.18.3. Value Creation Analysis
- 20.6.5.19. Humanized CD19-CAR-T (Shanghai Unicar-Therapy Bio-medicine Technology)
- 20.6.5.19.1. Sales Forecast (USD Million)
- 20.6.5.19.2. Net Present Value (USD Million)
- 20.6.5.19.3. Value Creation Analysis
- 20.6.5.20. IM19 CAR-T (Beijing Immunochina Medical Science & Technology)
- 20.6.5.20.1. Sales Forecast (USD Million)
- 20.6.5.20.2. Net Present Value (USD Million)
- 20.6.5.20.3. Value Creation Analysis
- 20.6.5.21. CCT301 CAR-T (Shanghai PerHum Therapeutics)
- 20.6.5.21.1. Sales Forecast (USD Million)
- 20.6.5.21.2. Net Present Value (USD Million)
- 20.6.5.21.3. Value Creation Analysis
- 20.6.5.22. BinD19 (Shenzhen BinDeBio)
- 20.6.5.22.1. Sales Forecast (USD Million)
- 20.6.5.22.2. Net Present Value (USD Million)
- 20.6.5.22.3. Value Creation Analysis
- 20.6.5.23. CARCIK-CD19 (CoImmune)
- 20.6.5.23.1. Sales Forecast (USD Million)
- 20.6.5.23.2. Net Present Value (USD Million)
- 20.6.5.23.3. Value Creation Analysis
- 20.6.5.24. PBCAR269A (Precision BioSciences / Servier)
- 20.6.5.24.1. Sales Forecast (USD Million)
- 20.6.5.24.2. Net Present Value (USD Million)
- 20.6.5.24.3. Value Creation Analysis
- 20.6.5.25. CD123 CAR-T cells (Chongqing Precision Biotechnology)
- 20.6.5.25.1. Sales Forecast (USD Million)
- 20.6.5.25.2. Net Present Value (USD Million)
- 20.6.5.25.3. Value Creation Analysis
- 20.6.5.26. BCMA CAR-T (Chongqing Precision Biotechnology)
- 20.6.5.26.1. Sales Forecast (USD Million)
- 20.6.5.26.2. Net Present Value (USD Million)
- 20.6.5.26.3. Value Creation Analysis
- 20.6.5.27. CD19/CD22-CAR-T (Shanghai Unicar-Therapy Bio-medicine Technology)
- 20.6.5.27.1. Sales Forecast (USD Million)
- 20.6.5.27.2. Net Present Value (USD Million)
- 20.6.5.27.3. Value Creation Analysis
- 20.6.5.28. GC012F / Dual CAR-BCMA-19 (Gracell Biotechnology)
- 20.6.5.28.1. Sales Forecast (USD Million)
- 20.6.5.28.2. Net Present Value (USD Million)
- 20.6.5.28.3. Value Creation Analysis
- 20.6.5.29. iC9-CAR19 T cells (Bellicum Pharmaceuticals)
- 20.6.5.29.1. Sales Forecast (USD Million)
- 20.6.5.29.2. Net Present Value (USD Million)
- 20.6.5.29.3. Value Creation Analysis
- 20.6.5.30. ALLO-501A / ALLO-501 (Allogene Therapeutics)
- 20.6.5.30.1. Sales Forecast (USD Million)
- 20.6.5.30.2. Net Present Value (USD Million)
- 20.6.5.30.3. Value Creation Analysis
- 20.6.5.31. CD19/CD20-CAR-T (Yake Biotechnology)
- 20.6.5.31.1. Sales Forecast (USD Million)
- 20.6.5.31.2. Net Present Value (USD Million)
- 20.6.5.31.3. Value Creation Analysis
- 20.6.5.32. CD7 CAR-T (PersonGen BioTherapeutics)
- 20.6.5.32.1. Sales Forecast (USD Million)
- 20.6.5.32.2. Net Present Value (USD Million)
- 20.6.5.32.3. Value Creation Analysis
- 20.6.5.33. Anti-FLT3 CAR-T / TAA05 (PersonGen BioTherapeutics)
- 20.6.5.33.1. Sales Forecast (USD Million)
- 20.6.5.33.2. Net Present Value (USD Million)
- 20.6.5.33.3. Value Creation Analysis
- 20.6.5.34. CT053 (CARsgen Therapeutics)
- 20.6.5.34.1. Sales Forecast (USD Million)
- 20.6.5.34.2. Net Present Value (USD Million)
- 20.6.5.34.3. Value Creation Analysis
- 20.6.5.35. Anti-ALPP CAR-T Cells (TCRCure Biopharma)
- 20.6.5.35.1. Sales Forecast (USD Million)
- 20.6.5.35.2. Net Present Value (USD Million)
- 20.6.5.35.3. Value Creation Analysis
- 20.6.5.36. BCMA targeted prime CAR-T cells (Chongqing Precision Biotechnology)
- 20.6.5.36.1. Sales Forecast (USD Million)
- 20.6.5.36.2. Net Present Value (USD Million)
- 20.6.5.36.3. Value Creation Analysis
- 20.6.5.37. ALLO-605 (Allogene Therapeutics)
- 20.6.5.37.1. Sales Forecast (USD Million)
- 20.6.5.37.2. Net Present Value (USD Million)
- 20.6.5.37.3. Value Creation Analysis
- 20.6.5.38. WU CART 007 (Wugen)
- 20.6.5.38.1. Sales Forecast (USD Million)
- 20.6.5.38.2. Net Present Value (USD Million)
- 20.6.5.38.3. Value Creation Analysis
- 20.6.5.39. CT103A (Nanjing IASO Biotherapeutics)
- 20.6.5.39.1. Sales Forecast (USD Million)
- 20.6.5.39.2. Net Present Value (USD Million)
- 20.6.5.39.3. Value Creation Analysis
- 20.7. Overall TCR-based Therapies Market
- 20.7.1. TCR-Based Therapies Market: Analysis by Target Indication
- 20.7.2. TCR-Based Therapies Market: Analysis by Target Antigen
- 20.7.3. TCR-Based Therapies Market: Analysis by Key Players
- 20.7.4. TCR-Based Therapies Market: Analysis by Geography
- 20.7.5. Product Wise Sales Forecast
- 20.7.5.1. Kimmtrak (IMCgp100 / Tebentafusp) (Immunocore)
- 20.7.5.1.1. Sales Forecast (USD Million)
- 20.7.5.1.2. Net Present Value (USD Million)
- 20.7.5.1.3. Value Creation Analysis
- 20.7.5.2. GSK3377794 (GlaxoSmithKline)
- 20.7.5.2.1. Sales Forecast (USD Million)
- 20.7.5.2.2. Net Present Value (USD Million)
- 20.7.5.2.3. Value Creation Analysis
- 20.7.5.3. YT-E001 (China Immunotech)
- 20.7.5.3.1. Sales Forecast (USD Million)
- 20.7.5.3.2. Net Present Value (USD Million)
- 20.7.5.3.3. Value Creation Analysis
- 20.7.5.4. ADP-A2M4 / Afamitresgene Autoleucel / Afami-cel (Adaptimmune Therapeutics)
- 20.7.5.4.1. Sales Forecast (USD Million)
- 20.7.5.4.2. Net Present Value (USD Million)
- 20.7.5.4.3. Value Creation Analysis
- 20.7.5.5. EBV-specific TCR-T cell with anti-PD1 auto-secreted element (TCRCure Biopharma)
- 20.7.5.5.1. Sales Forecast (USD Million)
- 20.7.5.5.2. Net Present Value (USD Million)
- 20.7.5.5.3. Value Creation Analysis
- 20.7.5.6. NTLA-5001 (Intellia Therapeutics)
- 20.7.5.6.1. Sales Forecast (USD Million)
- 20.7.5.6.2. Net Present Value (USD Million)
- 20.7.5.6.3. Value Creation Analysis
- 20.7.5.7. TBI-1301 (Takara Bio)
- 20.7.5.7.1. Sales Forecast (USD Million)
- 20.7.5.7.2. Net Present Value (USD Million)
- 20.7.5.7.3. Value Creation Analysis
- 20.7.5.8. LMBP2-specific TCR-T (Xinqiao Hospital of Chongqing / TCR CURE Biopharma Technology)
- 20.7.5.8.1. Sales Forecast (USD Million)
- 20.7.5.8.2. Net Present Value (USD Million)
- 20.7.5.8.3. Value Creation Analysis
- 20.7.5.9. FH-MCVA2TCR (TCRCure Biopharma)
- 20.7.5.9.1. Sales Forecast (USD Million)
- 20.7.5.9.2. Net Present Value (USD Million)
- 20.7.5.9.3. Value Creation Analysis
- 20.8. Overall TIL-Based Therapies Market
- 20.8.1. TIL-Based Therapies Market: Analysis by Target Indication
- 20.8.2. TIL-Based Therapies Market: Analysis by Key Players
- 20.8.3. TIL-Based Therapies Market: Analysis by Geography
- 20.8.3.1. Lifileucel / LN-144 (Iovance Biotherapeutics)
- 20.8.3.1.1. Sales Forecast (USD Million)
- 20.8.3.1.2. Net Present Value (USD Million)
- 20.8.3.1.3. Value Creation Analysis
- 20.8.3.2. LN-145 (Iovance Biotherapeutics)
- 20.8.3.2.1. Sales Forecast (USD Million)
- 20.8.3.2.2. Net Present Value (USD Million)
- 20.8.3.2.3. Value Creation Analysis
- 20.8.3.3. LTX-315 and TILs (Lytix Biopharma)
- 20.8.3.3.1. Sales Forecast (USD Million)
- 20.8.3.3.2. Net Present Value (USD Million)
- 20.8.3.3.3. Value Creation Analysis
- 20.8.3.4. TILs (Prometheus Laboratories)
- 20.8.3.4.1. Sales Forecast (USD Million)
- 20.8.3.4.2. Net Present Value (USD Million)
- 20.8.3.4.3. Value Creation Analysis
- 20.8.3.5. Donor Lymphocyte Infusion (Incyte)
- 20.8.3.5.1. Sales Forecast (USD Million)
- 20.8.3.5.2. Net Present Value (USD Million)
- 20.8.3.5.3. Value Creation Analysis
- 20.8.3.6. ITIL-168 (Instil Bio)
- 20.8.3.6.1. Sales Forecast (USD Million)
- 20.8.3.6.2. Net Present Value (USD Million)
- 20.8.3.6.3. Value Creation Analysis
- 20.8.3.7. IOV-2001 (Iovance Biotherapeutics)
- 20.8.3.7.1. Sales Forecast (USD Million)
- 20.8.3.7.2. Net Present Value (USD Million)
- 20.8.3.7.3. Value Creation Analysis
- 20.8.3.8. TILs (CAR-T (Shanghai) Cell Biotechnology)
- 20.8.3.8.1. Sales Forecast (USD Million)
- 20.8.3.8.2. Net Present Value (USD Million)
- 20.8.3.8.3. Value Creation Analysis
- 20.8.3.9. TILs (Bristol-Myers Squibb)
- 20.8.3.9.1. Sales Forecast (USD Million)
- 20.8.3.9.2. Net Present Value (USD Million)
- 20.8.3.9.3. Value Creation Analysis
21. PROMOTIONAL ANALYSIS
- 21.1. Chapter Overview
- 21.2. Channels Used for Promotional Campaigns
- 21.3. Summary of Product Website Analysis
- 21.4. Summary of Patient Support Services and Informative Downloads
- 21.5. Kymriah: Promotional Analysis
- 21.5.1. Drug Overview
- 21.5.2. Product Website Analysis
- 21.5.2.3. Informative Downloads
- 21.5.3. Patient Support Services
- 21.6. Yescarta: Promotional Analysis
- 21.6.1. Drug Overview
- 21.6.2. Product Website Analysis
- 21.6.2.3. Informative Downloads
- 21.6.3. Patient Support Services
- 21.7. Tecartus: Promotional Analysis
- 21.7.1. Drug Overview
- 21.7.2. Product Website Analysis
- 21.7.3. Patient Support Services
- 21.8. Breyanzi: Promotional Analysis
- 21.8.1. Drug Overview
- 21.8.2. Product Website Analysis
- 21.8.3. Patient Support Services
- 21.9. Abecma: Promotional Analysis
- 21.9.1. Drug Overview
- 21.9.2. Product Website Analysis
- 21.9.3. Patient Support Services
- 21.10. Carvykti: Promotional Analysis
- 21.10.1. Drug Overview
- 21.10.2. Product Website Analysis
- 21.10.3. Patient Support Services
- 21.11. Kimmtrak: Promotional Analysis
- 21.11.1. Drug Overview
- 21.11.2. Product Website Analysis
- 21.11.3. Patient Support Services
22. COMPANY PROFILES
- 22.1. Chapter Overview
- 22.2. Adaptimmune Therapeutics
- 22.3. Alaunos Therapeutics
- 22.4. Autolus
- 22.5. bluebird Bio
- 22.6. Bristol Myers Squibb
- 22.7. Carsgen Therapeutics
- 22.8. Cellectis
- 22.9. Cellular Biomedicine Group
- 22.10. Gilead Sciences
- 22.11. GlaxoSmithKline
- 22.12. Immatics
- 22.13. Immunocore
- 22.14. Innovative Cellular Therapeutics
- 22.15. Iovance Biotherapeutics
- 22.16. Kuur Therapeutics
- 22.17. Lion TCR
- 22.18. Noile-Immune Biotech
- 22.19. Novartis
- 22.20. Shanghai GeneChem
- 22.21. Sinobioway Cell Therapy
- 22.22. Takara Bio
- 22.23. Wellington Zhaotai Therapies
- 22.24. Zelluna immunotherapy
23. CONCLUDING REMARKS
24. EXECUTIVE INSIGHTS
- 24.1. Chapter Overview
- 24.2. Cell Therapies
- 24.2.1. Interview Transcript: Former Chief Executive Officer
- 24.3. Glycostem Therapeutics
- 24.3.1. Interview Transcript: Chief Executive Officer
- 24.4. Gracell Biotechnologies
- 24.4.1. Interview Transcript: Chief Executive Officer
- 24.5. Lion TCR
- 24.5.1. Interview Transcript: Co-Founder and Chief Executive Officer
- 24.6. TxCell
- 24.6.1. Interview Transcript: Chief Executive Officer
- 24.7. Kite Pharma
- 24.7.1. Interview Transcript: Vice President, Scientific Affairs
- 24.8. Celyad
- 24.8.1. Interview Transcript: Vice President, Immuno-Oncology
- 24.9. Iovance Biotherapeutics
- 24.9.1. Interview Transcript: Former Director, Process Development
- 24.10. Waisman Biomanufacturing
- 24.10.1. Interview Transcript: Director, Business Development
- 24.11. Theravectys
- 24.11.1. Interview Transcript: Former Competitive Intelligence Manager, Strategy & Business Development
- 24.12. Changhai Hospital
- 24.12.1. Interview Transcript: Professor of Medicine and Director, Department of Oncology
- 24.13. University of Colorado
- 24.13.1. Interview Transcript: Assistant Professor of Medicine
25. APPENDIX 1: TABULATED DATA
26. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS