市場調查報告書
商品編碼
1371994
2030 年胃滯留給藥系統市場預測:按類型、劑型、配銷通路和地區分類的全球分析Gastro-retentive Drug Delivery Systems Market Forecasts to 2030 - Global Analysis By Type, Dosage Form, Distribution Channel and By Geography |
根據 Stratistics MRC 的數據,2023 年全球胃滯留給藥系統市場規模為 149 億美元,預測期內年複合成長率為 12.1%,到 2030 年將達到 331 億美元。
「胃滯留藥物遞送」指用於將藥物化合物遞送至胃腸道內目標部位的方法、製劑、製造技術、儲存系統和技術,並決定藥物遞送系統的功效和安全性。應用製造、給藥途徑、位點特異性標靶、代謝和毒性來提高藥物生產。透過胃滯留給藥方法加強黏膜保護可用於預防和控制病理。
根據亞利桑那大學發表的論文,新興國家的幽門螺旋桿菌病菌感染高於已開發國家。在開發中國家% 。
主要製藥公司配合措施改善胃滯留藥物傳輸系統,以及由於生物利用度提高而增加的藥物需求和減少的給藥,推動了市場成長。此外,胃滯留藥物輸送系統在治療各種類型的胃病(包括消化性潰瘍和胃潰瘍)方面的功效已得到證實,而導致胃炎和胃癌的幽門螺旋桿菌病菌感染的患病正在增加。使胃滯留藥物得以使用,並對市場擴張產生了重大影響。
由於這些新的給藥技術具有創新性,因此很難被患者接受。此外,傳統的口服劑型可能是優選的,特別是對於吞嚥困難或喜歡較小劑型的患者。此外,確保一致的依從性也很困難,因為它依賴於患者遵循特定的給藥指示。因此,有些患者發現胃滯留藥物輸送系統(GRDDS)的尺寸和特性較不方便,市場可能會大幅下降。
胃滯留給藥技術的使用已被證明是控制各種藥物給藥同時提高生物利用度的有效技術。此外,近年來,超越胃排空時間不規則和胃停留時間短等物理挑戰的技術創新導致了受控口服給藥系統的改進。此外,once-GRDDS可以透過延長在上胃腸道的停留時間來提高治療效果和口服生物利用度。因此,這些進步是推動市場規模擴大的驅動力。
在創造能夠始終黏附在胃腸黏膜或漂浮在胃中同時以受控速率釋放藥物的藥物製劑中,需要克服一些挑戰。此外,實現黏度、浮力和控制釋放之間的平衡需要精確的配方方法和徹底的研究。此外,需要確保藥物在胃腸道環境中的穩定性進一步增加了難度。因此,這些困難往往會導致更長的開發時間和更高的價格,從而影響市場成長。
胃滯留給藥系統 (GRDDS) 市場受到了 COVID-19 爆發的負面影響。當醫療保健系統專注於對抗病毒時,基於 GRDDS 的藥物開發的臨床試驗和研究被推遲。此外,進入醫療保健設施受到限制,影響了臨床試驗的患者招募和創新藥物輸送方法的引入。此外,經濟限制和供應鏈中斷阻礙了 GRDDS 產品的生產和分銷。因此,由於疫情導致醫療保健系統的財政負擔日益增加,《新藥交付法案》的預算受到影響,逐漸阻礙了市場的成長。
預計浮動給藥系統領域將佔最大佔有率。這些藥物製劑會長時間懸浮在胃中。此外,這些方法允許藥物在胃液中漂浮的同時逐漸釋放,改善藥物吸收並延長治療效果。漂浮藥物輸送系統(FDDS)可以減少副作用、減少給藥頻率並增加藥物吸收。此外,它對吸收窗較小的藥物特別有效,用於治療多種胃腸道疾病。因此,FDDS作為一種最先進的改善藥物傳遞的方法,可以提高患者的依從性並確保胃腸滯留藥物的治療效果,從而擴大市場規模。
由於在藥物配方中使用小球形顆粒來改善藥物在胃腸道的吸收,因此預計微球細分市場在預測期內將出現最高的年複合成長率。此外,這些微球可以含有控制釋放的藥物,並且通常由生物相容性材料製成。這些提供了消費後的好處,例如更長的給藥、更少的給藥和更少的副作用。使用微球的GRDDS已用於治療各種胃腸道疾病,提高了患者的依從性和治療效果。因此,本節提出了獨特的藥理學策略,以增強消化器官系統藥物吸收和治療效果,從而顯著推動市場。
由於其優異的藥物吸收和患者依從性,亞太地區在預測期內佔據了最大的市場佔有率。此外,亞太地區還在醫學研究和基礎設施開發上投入資金,這正在推動創新和市場成長。法規變化和慢性病的增加進一步加速了 GRDDS 的採用。因此,GRDDS 行業的藥房、研究人員和醫療保健專業人員在該地區有很多機會。
歐洲在 GRDDS 技術的進步中發揮著重要作用,預計在預測期內將表現出最高的年複合成長率,因為它同時注重創新和優質醫療保健。此外,該地區高齡化和胃腸道疾病的高患病需要更好的給藥方法。此外,歐洲醫療保健系統正在鼓勵 GRDDS 的開發和部署,以改善治療結果、患者依從性和生活品質。因此,嚴格的法規標準確保了產品安全和充滿活力的市場。
According to Stratistics MRC, the Global Gastro-retentive Drug Delivery Systems Market is accounted for $14.9 billion in 2023 and is expected to reach $33.1 billion by 2030 growing at a CAGR of 12.1% during the forecast period. The term "gastro-retentive drug delivery" refers to methods, formulations, production techniques, storage systems, and technologies used to deliver pharmaceutical compounds to the target location in the gastro-intestinal tract, to enhance the effectiveness and safety of a drug delivery system, principles relating to drug manufacturing, route of administration, site-specific targeting, metabolism, and toxicity are applied. The enhancement of mucosal protection by the gastro-retentive drug delivery method can be used to prevent and control the condition.
According to the article published by the University of Arizona, H.pylori infection is higher in developing countries than the developed countries. The incidence of new infections in developing countries is 3 to 10% of the population compared to 0.5% in developed economies.
The market's growth has been accelerated by large pharmaceutical companies' efforts to improve gastro-retentive drug delivery systems, together with dose reductions due to improved bioavailability and an increase in the demand for drugs. Additionally, the market is greatly influenced by the well-established effectiveness of gastro-retentive drug delivery systems in treating various kinds of stomach disorders, including peptic ulcer and gastric ulcer, as well as an increase in the prevalence of H.pylori infection, which can lead to gastritis and gastric cancer which enabled the use of gastro-retentive drugs resulting in market expansion.
The innovative nature of these new medicine delivery techniques may make them difficult for patients to accept. Additionally, patients may prefer traditional oral dosage forms especially for individuals who have difficulty swallowing or who prefer smaller-sized dosage forms. Moreover, ensuring consistent compliance is also challenging, as it relies on patients following specific administration instructions. Thus, some patients may find the size or characteristics of Gastro-retentive Drug Delivery Systems (GRDDS) less convenient by which the market gets significantly retrain.
The use of gastro-retentive drug delivery technology has proven to be an effective technique to control the dosage of a variety of pharmaceuticals while increasing bioavailability. Moreover, technology innovations that go beyond physical challenges like erratic stomach emptying timings and brief gastric residency times have led to improvements in controlled oral medicine administration systems in recent years. Additionally, once-GRDDS can improve therapeutic effectiveness and oral bioavailability by prolonging their duration in the upper GI tract. Hence, these advancements drive the market size.
There are challenging obstacles to overcome when creating pharmacological formulations that can consistently stick to the gastrointestinal mucosa or float in the stomach while releasing the drug at a controlled rate. Moreover, it takes exact formulation methods and in-depth research to achieve this balance of adhesion, buoyancy, and controlled release. Additionally, the difficulty is increased further by the need to ensure the drug's stability in the gastrointestinal environment. Therefore, these difficulties frequently lead to longer development times and higher prices, which have an effect on market growth.
The market for gastro-retentive drug delivery systems (GRDDS) has been negatively impacted by the COVID-19 epidemic. Clinical trials and research for the development of GRDDS-based drugs were delayed while healthcare systems concentrated on fighting the virus. Additionally, access to medical facilities became restricted, which had an impact on the recruitment of patients for clinical trials and the uptake of innovative drug delivery methods. Moreover, economical limitations and supply chain interruptions have hampered the manufacture and distribution of GRDDS goods. Therefore, budgets for novel drug delivery methods were impacted as a result of the pandemic's increasing financial load on healthcare systems which gradually hampered the market growth.
The floating drug delivery system segment is estimated to hold the largest share. These are drug formulations that remain buoyant in the stomach for an extended period. Additionally, these methods allow medications to release gradually while floating on the gastric fluid, improving drug absorption and extending therapeutic benefits. Floating drug delivery system (FDDS) can reduce side effects, decrease dosage frequency, and increase drug absorption. Furthermore, they are particularly helpful for medications with small absorption windows and are used in the treatment of a variety of gastrointestinal ailments. Therefore, a cutting-edge method for improving medication delivery, FDDS ensures higher patient compliance and therapeutic effectiveness in gastro-retentive medicines thereby increasing the market expansion.
The microspheres segment is anticipated to have highest CAGR during the forecast period due to the use of small, spherical particles in medicine formulations to improve absorption of the medicament in the gastrointestinal tract. Additionally, these microspheres can contain medications for controlled release and are typically made of biocompatible substances. They provide advantages after consumption, including longer drug administration, decreased dosage frequency, and reduced side effects. GRDDS with microspheres is used to treat a variety of gastrointestinal illnesses, enhancing patient compliance and therapeutic results. Hence, this section shows an original pharmacological strategy for enhancing gastrointestinal system drug absorption and therapeutic efficacy by significantly driving the market.
Asia Pacific commanded the largest market share during the extrapolated period owing to due to their better drug absorption and patient compliance. Additionally, the Asia-Pacific region is spending money on medical research and infrastructure, which encourages innovation and market growth. Adoption of GRDDS is further fuelled by regulatory changes and the rise in chronic diseases. Therefore, pharmacies, researchers, and healthcare practitioners in the GRDDS industry have a lot of opportunities in this region.
Europe is expected to witness highest CAGR over the projection period, owing to a major role in the advancement of GRDDS technology, placing a strong emphasis on both innovation and high-quality healthcare. Additionally, there is a need for better drug delivery methods due to the aging population in the area and the high prevalence of gastrointestinal illnesses. Moreover, in order to improve treatment outcomes, patient compliance, and quality of life, European healthcare systems encourage the development and deployment of GRDDS. Hence, stringent regulatory standards ensure product safety, making it a thriving market.
Some of the key players in the Gastro-retentive Drug Delivery Systems Market include: Ranbaxy, GlaxoSmithKline, Competition Deep Dive, Depomed, Pharmacia, Alcon, Inc., Lupin, Galanix, Sun Pharma and F. Hoffmann La Roche.
In October 2023, Sun Pharmaceutical Industries Ltd announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for deuruxolitinib, an investigational oral selective inhibitor of Janus kinases, for the treatment of adults with moderate to severe alopecia areata.
In March 2023, Sun Pharmaceutical Industries Limited announced the successful completion of its acquisition of Concert Pharmaceuticals, Inc., a late-stage clinical biopharmaceutical company that is developing deuruxolitinib, a novel, deuterated, oral JAK1/2 inhibitor, for the potential treatment of adult patients with moderate to severe alopecia area.