市場調查報告書
商品編碼
1372012
到 2030 年 G 蛋白偶聯受體 (GPCR) 市場預測:按產品類型、檢測類型、應用和地區進行的全球分析G-Protein Coupled Receptors Market Forecasts to 2030 - Global Analysis By Product, By Assay Type, Application and By Geography |
根據Stratistics MRC預測,2023年全球G蛋白偶聯受體(GPCR)市場規模將達到37億美元,並在預測期內以7.1%的年複合成長率成長,到2030年將達到59.8億美元。
稱為 G 蛋白偶聯受體 (GPCR) 的多種膜受體也稱為 7(透過)跨膜受體。它們存在於細胞膜中,負責與外部化學物質相互作用並將訊號傳遞給細胞內分子。 GPCR 是細胞表面受體,可作為以勝胜肽、蛋白質、光能、脂質和糖等形式傳遞的訊息的收件匣。這些受體經常用於治療多種疾病,包括發炎疾病、代謝紊亂、心臟疾病、癌症和單一疾病。
根據 2021 年《美國心臟協會雜誌》報道,預計到 2035 年,美國將有超過 1.3 億成年人患有某種形式的心臟病。
慢性病的增加是 G 蛋白偶聯受體 (GPCR) 市場的強大促進因素。 GPCR 在許多生理過程的調節中發揮著至關重要的作用,使其成為有價值的藥物研發標靶。隨著糖尿病、心血管疾病和神經退化性疾病等慢性病的全球負擔日益加重,針對 GPCR 的藥物干涉措施的需求不斷成長。研究人員正在探索 GPCR 來尋找創新治療方法,這正在刺激製藥業的研究和開發。
G蛋白偶聯受體(GPCR)細胞株的高價格是GPCR市場的主要抑制因素。取得這些細胞株的高昂成本讓小型研究機構和生物技術新興企業望而卻步,限制了他們從事 GPCR 相關研究和藥物開發的能力。這種定價障礙會抑制創新、減少競爭、阻礙理解和標靶化GPCR 的科學進展,並減緩新藥的發現。
G 蛋白偶聯受體 (GPCR) 在藥物研發中的廣泛採用代表著市場的重大機會。 GPCR 是涉及多種生理過程調節的多種藥物標靶,對於藥物研究至關重要。由於其多樣性和參與許多疾病,包括癌症、神經系統疾病和代謝疾病,它越來越受到人們的關注。隨著藥物研發研究日益全球化,GPCR 代表了創新藥物開發的一種有前途的工具。採用 GPCR 作為新療法的標靶正在加強研究和開發配合措施,為新藥鋪平道路,並增加 GPCR 市場全球顯著成長的潛力。
被稱為 GPCR 的細胞表面受體家族包括許多不同類型的受體,並具有複雜的訊號傳導系統。要了解 GPCR 如何與各種配體和下游訊號級聯相互作用很困難,這使得新藥的發現和現有藥物的開發變得更加困難。這種複雜性使得預測候選藥物的有效性變得困難,並增加了意外不良反應的風險。此外,它需要大量的研究、最尖端科技和協作研究,這是昂貴且耗時的。所有這些因素預計將抑制市場成長。
G蛋白偶聯受體(GPCR)市場在不同方面受到了COVID-19大大流行的顯著影響。由於實驗室關閉以及資源重新分配給大流行相關研究,對藥物研發至關重要的 GPCR 研究已經陷入停滯。另一方面,迫切需要引入計算科學方法和虛擬篩選方法來進行GPCR藥物研發。由於 GPCR 在免疫反應中發揮的作用及其在治療病毒感染疾病的潛力,市場對針對 GPCR 的治療藥物的需求不斷增加。總體而言,疫情影響了 GPCR 市場,透過轉向數位方法推動創新並抑制創新。
cAMP 功能分析領域預計將在預測期內佔據最大的市場佔有率。 cAMP 檢測廣泛用於研究 GPCR 活化和訊號途徑,對於識別潛在候選藥物至關重要。 cAMP 測定使研究人員能夠評估 GPCR 對配體的反應,為藥物功效和安全性提供有價值的見解。隨著針對 GPCR 的藥物需求的增加,cAMP 檢測越來越受到關注,並增強了其在市場上的主導地位。
由於 GPCR 在癌症進展中發揮的關鍵作用,癌症研究領域在預測期內呈現最高的成長率。研究表明,GPCR 參與腫瘤生長、血管生成和轉移,使其成為癌症治療的有吸引力的標靶。此外,對個人化醫療的日益重視以及針對 GPCR 的抗癌藥物的開發也支持了新興市場的成長。隨著對癌症中 GPCR 訊號傳導的了解不斷深入,創新治療方法不斷湧現,對 GPCR 相關研究工具的需求也隨之增加。
在預測期內,北美預計將佔據最大的市場佔有率,其中以美國、加拿大和墨西哥等經濟和技術先進國家為首。據美國癌症協會稱,2022 年,僅美國就會新增 190 萬癌症病例,並有 609,360 例癌症相關死亡。同樣,2021 年加拿大癌症統計數據顯示,大約五分之二的加拿大人在其一生中將被診斷出患有癌症,四分之一的人將死於該疾病。進一步推動北美市場成長的是慢性疾病的負擔,特別是心血管疾病和癌症,這推動了對尖端療法和治療的需求。
由於 NB Health Laboratory、HD Biosciences Co.Ltd.、Sosei Heptares 等許多年輕公司的存在,預計亞太地區在預測期內將出現最高的成長。區域成長受到公司為擴大市場佔有率而採取的一系列配合措施的影響。此外,文明病的日益普及以及中國、印度和其他經濟體不斷成長的人口對受體介導治療的需求也將推動區域擴張。
According to Stratistics MRC, the Global G-Protein Coupled Receptors (GPCRs) Market is accounted for $3.70 billion in 2023 and is expected to reach $5.98 billion by 2030 growing at a CAGR of 7.1% during the forecast period. The diverse group of membrane receptors known as G-Protein Coupled Receptors (GPCRs), also referred to as seven-(pass)-trans membrane receptors. These can be found in the cell membrane and are in charge of interacting with external chemicals and relaying signals to intracellular molecules. GPCRs are cell surface receptors that function as an inbox for messages delivered as peptides, proteins, light energy, lipids, and sugars. These receptors are frequently employed in the management of a wide range of illnesses, including inflammatory disorders, metabolic disturbances, cardiac disorders, cancer, and monogenic disorders.
According to the American Heart Association's 2021 Journal, more than 130 million adults in the United States are expected to have some type of heart disease by 2035.
The increasing prevalence of chronic diseases serves as a robust driver in the G-Protein Coupled Receptors (GPCRs) market. GPCRs play a pivotal role in regulating numerous physiological processes, making them valuable drug targets. With a growing global burden of chronic conditions such as diabetes, cardiovascular diseases, and neurodegenerative disorders, the demand for pharmaceutical interventions that target GPCRs is on the rise. Researchers are exploring GPCRs for innovative therapeutic solutions, which has stimulated research and development in the pharmaceutical industry.
The high price of G-Protein Coupled Receptors (GPCRs) cell lines represents a significant restraint in the GPCR market. The substantial cost associated with acquiring these cell lines can be prohibitive for smaller research institutions and biotech startups, limiting their ability to engage in GPCR-related research and drug development. This pricing barrier can stifle innovation, reduce competition, and impede scientific progress in understanding and targeting GPCRs, potentially slowing down the discovery of new pharmaceuticals.
The widespread adoption of G-Protein Coupled Receptors (GPCRs) in drug discovery represents a significant opportunity for the market. GPCRs are a diverse class of drug targets involved in regulating various physiological processes, making them crucial for pharmaceutical research. Their versatility and involvement in numerous diseases, including cancer, neurological disorders, and metabolic conditions, have led to increased interest. As drug discovery efforts become increasingly globalized, GPCRs offer a promising avenue for innovative drug development. This adoption of GPCRs as targets for new therapeutics enhances research and development initiatives, paving the way for novel medications, and underscores the substantial growth potential in the GPCR market on a global scale.
The family of cell surface receptors known as GPCRs includes many different types of receptors and has complex signaling systems. It can be difficult to comprehend how they interact with different ligands and downstream signaling cascades, which makes it more difficult to find new drugs and develop existing ones. Because of this complexity, it is harder to predict a drug candidate's effectiveness, and there is a higher risk of unanticipated negative effects. Additionally, a lot of research, cutting-edge technology, and collaboration are needed, which are expensive and time-consuming. All of these elements are expected to restrain market growth.
The G-Protein Coupled Receptors (GPCR) market has been significantly impacted by the COVID-19 pandemic in a number of ways. Lab closures and resource redistribution towards pandemic-related studies resulted in a slowdown in the study of GPCRs, which are essential for drug discovery. On the other hand, it has hastened the adoption of computational and virtual screening techniques for GPCR drug development. Due to the role that GPCRs play in immune responses and the potential they provide for treating viral infections, the market saw an increase in demand for GPCR-targeted therapies. Overall, the pandemic affected the GPCR market by fostering innovation and stifling it with a move toward digital methods.
The cAMP functional assays segment is anticipated to register the largest market share in the anticipated timeframe. This is due to its critical role in drug discovery and understanding cellular signaling. cAMP assays are widely utilized for studying GPCR activation and signaling pathways, making them integral to identifying potential drug candidates. They enable researchers to assess GPCR responses to ligands, providing valuable insights into drug efficacy and safety. With the rising demand for GPCR-targeted drugs, cAMP assays have gained prominence, driving their dominance in the market.
The cancer research segment is experiencing the highest growth rate during the forecast period due to the pivotal role GPCRs play in cancer progression. Research has revealed GPCRs' involvement in tumor growth, angiogenesis, and metastasis, making them attractive targets for cancer therapy. Additionally, the market's growth is fueled by the increased emphasis on personalized medicine and the development of GPCR-targeted cancer drugs. Advances in understanding GPCR signaling in cancer have led to a surge in innovative therapies and a growing demand for GPCR-related research tools, positioning this segment for substantial expansion in the near future.
During the forecast period, North America is anticipated to witness largest market share, led by the economically and technologically developed nations of the United States, Canada, and Mexico. According to the American Cancer Society, there will be 1.9 million new cases of cancer and 609,360 cancer-related deaths in the United States alone in 2022. In a similar vein, the Canadian Cancer Statistics 2021 revealed that roughly 2 in 5 Canadians will receive a cancer diagnosis during their lifetime and that 1 in 4 will pass away from the disease. Further bolstering market growth in North America is the burden of chronic diseases, particularly in cardiovascular and cancer applications, which is raising demand for cutting-edge therapies and treatments.
Asia-Pacific is expected to experience the highest growth during the forecast period due to the presence of a number of young businesses like NB Health Laboratory, HD Biosciences Co., Ltd., and Sosei Heptares. Regional growth is influenced by the number of initiatives companies take to enhance their market presence. Furthermore, regional expansion is also fueled by the growing prevalence of lifestyle disorders among the expanding populations of China, India, and other economies, as well as the need to treat them with receptors.
Some of the key players in G-Protein Coupled Receptors (GPCRs) market include: Abcam PLC, Accure Pharma, Actelion, Addex Pharmaceuticals Ltd, Arena Pharmaceuticals, Inc., BD (Becton, Dickinson and Company), BioInvenu, Inc., Cisbio Bioassays, Corning Incorporated, Enzo Life Sciences, Inc., Eurofins DiscoverX, HD Biosciences Co., Ltd, Merck Group, Molecular Devices, LLC., PerkinElmer Inc., Promega Corporation, Qiagen, Thermo Fisher Scientific WuXi AppTec and Confo Therapeutics.
In March 2023, Confo Therapeutics, a leader in targeting G-Protein Coupled Receptors (GPCRs) (GPCRs), this week announced an agreement with Daiichi Sankyo for the discovery and development of small molecule agonists against an undisclosed CNS target. Confo will receive upfront and milestone payments totaling $183 million and tiered royalties on sales from any resulting products.
In December 2022, Sosei Group Corporation announced its partnership with Eli Lilly and Company, a global biopharmaceutical firm. The collaboration aims to facilitate drug discovery for novel G protein-coupled receptor (GPCR) targets linked to diabetes and metabolic diseases, including the development and commercialization of small molecules with therapeutic potential.
In April 2022, Ono Pharmaceutical Co., Ltd. signed a new collaboration agreement with Domain Therapeutics and Universite de Montreal to discover novel small molecules targeting G-Protein Coupled Receptors (GPCRs) (GPCRs) in a metabolic disease area.