市場調查報告書
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1454069
CAR-T細胞療法的市場至2030年的預測:按藥物類型、目標抗原、應用、最終用戶和地區的全球分析CAR-T Cell Therapy Market Forecasts to 2030 - Global Analysis By Drug Type (Brexucabtagene Autoleucel, Axicabtagene Ciloleucel, Tisagenlecleucel and Other Drug Types), Target Antigen, Application, End User and By Geography |
根據 Stratistics MRC 的資料,2023年全球 CAR-T 細胞治療市場規模為 33 億美元,預計預測期內年複合成長率為 30.5%,到2030年將達到 218 億美元。
CAR-T細胞療法是嵌合體受體T細胞療法的縮寫,是用於治療某些類型癌症的突破性免疫療法。患者自身的 T 細胞(一種免疫細胞)經過基因改造,可在其表面表達嵌合體抗原受體(CAR)。這個過程通常首先從患者的血液中採集 T 細胞,這個過程稱為白血球分離術。然後,這些 T 細胞在實驗室中經過基因改造,在其表面表達稱為 CAR 的特定受體。這些受體目的是識別並結合通常存在於癌細胞表面的特定蛋白質。
根據世界癌症研究基金會發表的癌症資料,2020年將新增白血病病例474,519例、多發性骨髓瘤病例176,404例、淋巴瘤病例627,439例。
癌症盛行率增加
儘管 CAR-T 技術取得了令人鼓舞的進展,但癌症發生率的增加帶來了重大挑戰。人口老化、環境因素和生活方式的改變等因素促成了這一趨勢。隨著對有效癌症治療的需求不斷增加,解決這一不斷上升的盛行率已成為 CAR-T 療法領域的醫療保健提供者和研究人員的當務之急。因此,市場正經歷著癌症患者不斷增加的令人擔憂的趨勢。
核准的治療方法數量有限
在快速發展的 CAR-T 細胞治療領域,核准的治療方法有限。這些治療方法對某些類型的血癌(包括白血病和淋巴瘤)顯示出顯著療效。然而,由於高成本、製造流程複雜以及需要進一步研究以擴大適應症和改善安全性,市場仍相對受到限制。
技術進步
CAR-T 細胞療法的進步徹底改變癌症治療並提供個人化免疫療法解決方案。增強的製造技術,例如借用的病毒載體設計和自動化細胞處理系統,可簡化生產、提高可擴展性並降低成本。 CAR 構建體的標靶修飾可提高腫瘤特異性、減少脫靶效應並增強治療效果。
製造成本高
CAR-T 細胞市場面臨巨大的製造成本,這主要是由於製程複雜且集中。製造 CAR-T 細胞需要先進的細胞工程技術、廣泛的品管措施和專門的基礎設施。此外,治療的個人化性質也增加了成本,因為每種治療都是針對個別患者量身定做的。這些高昂的成本對 CAR-T 細胞療法的普及和可及性構成了挑戰,限制了其在更廣泛的患者群體中的使用。
COVID-19 的爆發對 CAR-T 細胞治療市場產生了重大影響,擾亂了臨床試驗、生產和患者的使用。供應鏈中斷和醫院容量減少推遲治療並阻礙市場成長。此外,資源轉移和 COVID-19 治療的優先順序轉移人們對 CAR-T 療法開發和部署的注意力。儘管面臨挑戰,但從長遠來看,對免疫療法和創新療法的更多關注可能會推動市場復甦和成長。
Tisagenleucel 業務預計將在預測期內成為最大的業務
Tissagenleucel 業務預計將成為預測期內最大的業務。這種藥物目的是針對特定癌細胞,在某些類型的白血病和淋巴瘤患者中顯示出顯著的療效。它的核准標誌著免疫治療的一個重要里程碑,為已經用盡常規治療方法的患者帶來了新的希望。這項成功很快就使 Tisagenlecleucel 成為 CAR-T 細胞治療市場的中流砥柱,推動了該領域的進步和進一步研究。
預計淋巴瘤細分市場在預測期內年複合成長率最高
由於免疫療法的進步,預計淋巴瘤領域在預測期內將出現最高的年複合成長率。 CAR T 細胞療法修改患者自身的免疫細胞,以便更佳識別和攻擊癌細胞。這種個人化方法在各種淋巴瘤亞型中顯示出有希望的結果,特別是對傳統治療沒有反應的患者。由於進行的研究和臨床試驗,淋巴瘤治療市場預計將進一步成長。
預計北美在預測期內將佔據最大的市場佔有率。 CAR-T療法致力於個人化醫療,在白血病和淋巴瘤等多種癌症的治療中越來越受歡迎。該地區強大的醫療基礎設施,加上支持性的法律規範,促進市場擴張。此外,製藥公司和學術機構之間的合作加速這一前景廣闊的領域的創新,預示著光明的市場前景。
預計亞太地區在預測期內年複合成長率最高。每個國家的癌症盛行率不斷上升,再加上人們所認知的提高和診斷技術的改進,日益擴大可能受益於 CAR T 細胞療法的患者數量。各國進行的CAR-T細胞治療臨床試驗數量也大幅增加。這些臨床試驗評估不同 CAR-T 療法在不同類型癌症中的安全性和有效性,有助於該地區該領域的進展。
According to Stratistics MRC, the Global CAR-T Cell Therapy Market is accounted for $3.3 billion in 2023 and is expected to reach $21.8 billion by 2030 growing at a CAGR of 30.5% during the forecast period. CAR-T cell therapy, short for chimeric antigen receptor T-cell therapy, is a groundbreaking form of immunotherapy used in the treatment of certain types of cancer. It involves genetically modifying a patient's own T cells (a type of immune cell) to express chimeric antigen receptors (CARs) on their surface. The process typically starts by collecting T cells from the patient's blood through a process called leukapheresis. These T cells are then genetically engineered in a laboratory to express specific receptors called CARs on their surface. These receptors are designed to recognize and bind to specific proteins, typically found on the surface of cancer cells.
According to the cancer data published by World Cancer Research Fund International, there were 474,519 new cases of leukemia, 176,404 new cases of multiple myeloma and 627,439 new cases of lymphoma worldwide in 2020.
Increasing prevalence of cancer
Despite the promising advancements in CAR-T technology, the rise in cancer incidence poses significant challenges. Factors such as aging populations, environmental factors, and lifestyle changes contribute to this trend. As the demand for effective cancer treatments grows, addressing this rising prevalence becomes imperative for healthcare providers and researchers in the field of CAR-T therapy. Thus, the market is experiencing a concerning trend with an increasing prevalence of cancer cases.
Limited number of approved therapies
In the rapidly evolving field of CAR-T cell therapy, only a limited number of treatments have gained approval. These therapies have shown remarkable efficacy in treating certain types of blood cancers, including leukemia and lymphoma. However, the market remains relatively constrained due to high costs, complex manufacturing processes, and the need for further research to expand indications and improve safety profiles.
Advancements in technology
Advancements in CAR-T cell therapy have revolutionized cancer treatment, offering personalized immunotherapy solutions. Enhanced manufacturing techniques, such as lent viral vector design and automated cell processing systems, streamline production, improving scalability and reducing costs. Targeted modifications to CAR constructs enhance tumour specificity and reduce off-target effects, boosting therapeutic efficacy.
High manufacturing costs
The market faces significant manufacturing costs, primarily due to the complex and labor-intensive process involved. Manufacturing CAR-T cells requires sophisticated cell engineering techniques, extensive quality control measures, and specialized infrastructure. Additionally, personalized nature of the therapy adds to the expenses, as each treatment is tailored to individual patients. These high costs pose challenges for widespread adoption and accessibility of CAR-T cell therapy, limiting its availability to a broader patient population.
The COVID-19 pandemic has significantly impacted the CAR-T cell therapy market, causing disruptions in clinical trials, manufacturing, and patient access. Supply chain disruptions and reduced hospital capacity have delayed treatments and hindered market growth. Additionally, diverted resources and prioritization of COVID-19 care have diverted attention from CAR-T therapy development and deployment. Despite challenges, increased focus on immunotherapy and innovative treatments may drive market recovery and growth in the long term.
The tisagenlecleucel segment is expected to be the largest during the forecast period
The tisagenlecleucel segment is expected to be the largest during the forecast period. Engineered to target specific cancer cells, it has shown remarkable efficacy in patients with certain types of leukemia and lymphoma. Its approval marked a significant milestone in immunotherapy, offering new hope for patients who have exhausted conventional treatments. With its success, Tisagenlecleucel has quickly become a pivotal player in the CAR-T cell therapy market, driving advancements and further research in the field.
The lymphoma segment is expected to have the highest CAGR during the forecast period
The lymphoma segment is expected to have the highest CAGR during the forecast period driven by advancements in immunotherapy. CAR-T cell therapy involves modifying a patient's own immune cells to better recognize and attack cancer cells. This personalized approach has shown promising results in various lymphoma subtypes, particularly in patients who have not responded to conventional treatments. With ongoing research and clinical trials, the market for therapy in lymphoma is poised for further growth.
North America is projected to hold the largest market share during the forecast period. With a focus on personalized medicine, CAR-T therapies are gaining traction for treating various types of cancers, including leukemia and lymphoma. The region's robust healthcare infrastructure, coupled with supportive regulatory frameworks, fosters market expansion. Moreover, collaborations between pharmaceutical companies and academic institutions contribute to accelerating innovation in this promising field, promising a bright outlook for the market.
Asia Pacific is projected to hold the highest CAGR over the forecast period. The rising prevalence of cancer in countries, coupled with growing awareness and improved diagnosis, was creating a larger pool of patients who could potentially benefit from CAR-T cell therapy. There was a significant increase in the number of clinical trials for CAR-T cell therapies being conducted in countries. These trials were evaluating the safety and efficacy of various CAR-T treatments across different types of cancer, contributing to the advancement of the field in the region.
Key players in the market
Some of the key players in CAR-T Cell Therapy market include Gilead Sciences Inc., Bristol-Myers Squibb, Novartis AG, Cartesian Therapeutics Inc., Merck & Co. Inc., Intellia Therapeutics, Juno Therapeutics Inc., Bluebird Bio Inc., Sorrento Therapeutics Inc., Autolus Therapeutics, Caribou Biosciences Inc., Miltenyi Biotech, Celgene Corporation, Aurora Biopharma Inc. and Pfizer, Inc.
In December 2023, Bristol-Myers Squibb announced that it received manufacturing and marketing approval of the supplemental New Drug Application for an additional indication for Abecma (idecabtagene vicleucel), a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cell immunotherapy.
In May 2023, Autolus Therapeutics plc announced that the abstract for the pivotal Phase 2 FELIX study of obecabtagene autoleucel (obe-cel) in relapsed/refractory (r/r) adult B-cell Acute Lymphoblastic Leukemia (ALL) has been selected for an oral presentation at the European Hematology Association (EHA) 2023 Congress.