市場調查報告書
商品編碼
1494760
表皮生長因子受體 (EGFR) 抑制劑到 2030 年的全球市場預測:按類型、藥物類型、給藥方法、分銷管道、應用、最終用戶和地區進行分析Epidermal Growth Factor Receptor Inhibitors Market Forecasts to 2030 - Global Analysis By Type, Drug Type, Mode of Administration, Distribution Channel, Application, End User and By Geography |
根據Stratistics MRC預測,2024年全球表皮生長因子受體(EGFR)抑制劑市場規模將達141億美元,預測期內複合年成長率為14.2%,預計2030年將達314億美元。
表皮生長因子受體 (EGFR) 抑制劑是一種針對錶皮生長因子受體(一種存在於細胞表面的蛋白質)的藥物。 EGFR 參與細胞生長和分裂,其過度活性與某些癌症,特別是肺癌和大腸癌的發生和進展有關。 GFR 抑制劑可單獨使用或與化療或放射線治療等其他癌症治療方法合併用於治療多種癌症。
據美國國立衛生研究院稱,近年來,美國各類主要癌症的新病例顯著增加,包括肺癌、大腸直腸癌和乳腺癌。 2020年,美國預計將有180萬人被診斷出罹患癌症,606,520人將死於該疾病。
擴大標靶治療的採用
市場正在經歷標靶治療的快速採用,反映了不斷變化的治療模式。標靶治療透過特異性針對癌細胞並最大限度地減少對健康組織的損害來提高抗癌的精確度。這種模式轉移是由研究和開發的進步以及對促進癌症進展的分子途徑的深入了解所推動的。隨著個人化治療方法普及普遍,隨著對個別患者的個人化治療的轉變,市場有望實現顯著成長。
替代治療的可用性
市場面臨著適應替代療法的挑戰。儘管 EGFR 抑制劑有效,但免疫療法和標靶治療等替代療法正在相互競爭。此外,EGFR 抑制劑的抗藥性和副作用也增加了複雜性。確保替代療法的可用性、可負擔性和患者意識仍然是重要的障礙。市場必須適應,將這些治療方法整合到治療方案中,並滿足患者的特定需求以獲得最佳結果。
癌症發生率上升
市場上有一個令人擔憂的趨勢:癌症發生率上升。儘管Erlotinib和Gefitinib等 EGFR 抑制劑的治療取得了進展,但依賴這些療法的癌症病例的發生率仍在增加。這可能表明 EGFR 誘發的癌症盛行率增加,或者先前對這些藥物有反應的患者可能出現抗藥性。這些趨勢凸顯了繼續研究癌症生物學和開發創新治療策略的必要性。
昂貴的治療費用
該市場面臨著治療成本高昂的挑戰,為患者的取得造成了障礙。儘管它們在治療某些癌症方面有效,但抑制劑的經濟負擔限制了它們的普及。這個成本因素凸顯了相關人員需要共同努力開發更便宜的選擇並探索津貼途徑,以確保公平地獲得挽救生命的治療。
COVID-19 的爆發對市場產生了重大影響,擾亂了製造、供應鏈和臨床試驗。關閉和限制阻礙了患者進入醫療機構,影響了診斷和治療的開始。然而,隨著遠端醫療和遠端監控的引入,保持了一定的連續性。市場出現了需求波動,並轉向優先考慮基本治療。儘管面臨挑戰,但持續的研究和開發旨在在大流行的挑戰中滿足新的需求並最佳化治療結果。
預計聯合治療領域在預測期內將是最大的。
預計聯合治療領域在預測期內將是最大的。透過同時針對多個途徑,這些療法旨在提高療效並克服抗藥性機制。 EGFR 抑制劑與化療、免疫療法和其他標靶藥物的聯合治療正在進行研究,並在多種癌症類型中顯示出前景。這些方法為個人化治療方法提供了新途徑,並可透過解決異質性腫瘤特徵和適應性抗藥性機制來改善患者預後。
在預測期內,大腸直腸癌領域的複合年成長率最高。
由於標靶治療的進步,預計結直腸癌領域在預測期內將出現最高的複合年成長率。這些抑制劑,如Cetuximab和Panitumumab,透過抑制 EGFR 訊號途徑,在改善患者預後方面顯示出有希望的結果。由於全球大腸直腸癌盛行率不斷上升以及對個人化治療的需求不斷增加,預計 EGFR 抑制劑市場將顯著成長。
由於癌症發病率增加和標靶治療的進步等因素,預計北美在預測期內將佔據最大的市場佔有率。這些抑制劑專注於精準醫療,在肺癌和大腸癌等多種癌症的治療中發揮重要作用。該地區的主要公司繼續投資於研發,旨在推出創新治療方法。
預計亞太地區在預測期內將維持最高的複合年成長率。該地區經常使用 EGFR 抑制劑治療的癌症(例如肺癌和大腸癌)的發生率正在增加。人們對癌症的認知不斷提高,篩檢計畫得到加強,從而能夠及早發現癌症,從而使更多的患者有資格接受標靶治療。此外,不斷上升的醫療保健成本和意識進一步推動市場成長,創造了以持續的臨床試驗和產品發佈為特徵的競爭格局。
According to Stratistics MRC, the Global Epidermal Growth Factor Receptor (EGFR) Inhibitors Market is accounted for $14.1 billion in 2024 and is expected to reach $31.4 billion by 2030 growing at a CAGR of 14.2% during the forecast period. Epidermal Growth Factor Receptor (EGFR) inhibitors are a class of medications that target the epidermal growth factor receptor, a protein found on the surface of cells. EGFR is involved in cell growth and division, and its overactivity is associated with the development and progression of certain types of cancer, particularly lung cancer and colorectal cancer. GFR inhibitors are used in the treatment of various cancers, either alone or in combination with other cancer therapies, such as chemotherapy or radiation therapy.
According to the NIH, the new cases of various types of major cancers, such as lung cancer, colorectal cancer, and breast cancer, in the US have increased significantly in recent years. In 2020, an estimated 1.8 million new cases of cancer were diagnosed in the US, and 606,520 people will die from the disease.
Growing adoption of targeted therapies
The market is witnessing a surge in adoption of targeted therapies, reflecting an evolving treatment landscape. Targeted therapies offer precision in combating cancer by specifically targeting cancer cells, minimizing damage to healthy tissue. This paradigm shift is driven by advancements in research and development, alongside increasing understanding of molecular pathways driving cancer progression. With personalized treatment approaches gaining traction, the market is poised for substantial growth as it moves towards tailored therapies for individual patients.
Availability of alternative therapies
The market faces challenges in accommodating alternative therapies. Despite the effectiveness of EGFR inhibitors, alternative treatments like immunotherapy and targeted therapies pose competition. Additionally, resistance to EGFR inhibitors and adverse effects contribute to the complexity. Ensuring accessibility, affordability, and patient awareness of alternative therapies remain key hurdles. The market must adapt by integrating these therapies into treatment protocols and addressing patient-specific needs for optimal outcomes.
Rising cancer rates
The market has seen a concerning trend of rising cancer rates. Despite advancements in treatment utilizing EGFR inhibitors, such as Erlotinib and Gefitinib, the incidence of cancer cases reliant on these therapies has increased. This may indicate either a growing prevalence of EGFR-driven cancers or potential resistance development in patients previously responsive to these drugs. Such trends underscore the need for continued research into cancer biology and the development of innovative therapeutic strategies.
High cost of treatment
The market faces challenges due to high treatment costs, posing a barrier to accessibility for patients. Despite their efficacy in treating certain cancers, the financial burden associated with these inhibitors limits their widespread adoption. This cost factor underscores the need for collaborative efforts among stakeholders to develop more affordable options or explore avenues for subsidization to ensure equitable access to life-saving treatments.
The COVID-19 pandemic significantly impacted the Market, causing disruptions in manufacturing, supply chains, and clinical trials. Lockdowns and restrictions hindered patient access to healthcare facilities, affecting diagnosis and treatment initiation. However, with the adoption of telemedicine and remote monitoring, some continuity was maintained. The market witnessed fluctuations in demand, with a shift towards prioritizing essential treatments. Despite challenges, ongoing research and development efforts persisted, aiming to address emerging needs and optimize therapeutic outcomes amidst the pandemic's challenges.
The combination therapies segment is expected to be the largest during the forecast period
The combination therapies segment is expected to be the largest during the forecast period. By targeting multiple pathways simultaneously, these therapies aim to enhance efficacy and overcome resistance mechanisms. Combinations of EGFR inhibitors with chemotherapy, immunotherapy, and other targeted agents are being explored, showing potential in various cancer types. Such approaches offer new avenues for personalized treatment regimens and may improve patient outcomes by addressing heterogeneous tumor profiles and adaptive resistance mechanisms.
The colorectal cancer segment is expected to have the highest CAGR during the forecast period
The colorectal cancer segment is expected to have the highest CAGR during the forecast period driven by advancements in targeted therapies. These inhibitors, such as cetuximab and panitumumab, have shown promising results in improving patient outcomes by inhibiting EGFR signaling pathways. With increasing prevalence of colorectal cancer globally, coupled with growing demand for personalized treatment approaches, the EGFR inhibitors market is poised for significant growth.
North America is projected to hold the largest market share during the forecast period driven by factors such as increasing cancer prevalence and advancements in targeted therapies. With a focus on precision medicine, these inhibitors play a crucial role in treating various cancers, including lung and colorectal cancer. Key players in the region continue to invest in research and development, aiming to introduce innovative therapies.
Asia Pacific is projected to hold the highest CAGR over the forecast period. The region has witnessed a rise in the incidence of cancer, including lung cancer and colorectal cancer, which are often treated with EGFR inhibitors. Increasing awareness about cancer and the availability of screening programs have led to earlier detection of cancers, resulting in more patients being eligible for targeted therapies. Moreover, rising healthcare expenditure and awareness further bolster market growth, fostering a competitive landscape characterized by ongoing clinical trials and product launches.
Key players in the market
Some of the key players in Epidermal Growth Factor Receptor (EGFR) Inhibitors market include Novartis AG, F. Hoffmann-La Roche Ltd, Merck & Co., Amgen Inc, Eli Lilly and Company, OSI Pharmaceuticals Inc, Johnson & Johnson, Genentech, Inc, Pfizer, AstraZeneca PLC, Bayer AG, AbbVie, Bristol Myers Squibb, Teva Pharmaceutical Industries, Takeda Pharmaceutical Company Limited, Boehringer Ingelheim and Regeneron Pharmaceuticals.
In May 2023, Eli Lilly and Innovent Biologics, Inc. jointly announced that the National Medical Products Administration (NMPA) of China has approved the supplemental New Drug Application (sNDA) for TYVYT(R) (sintilimab injection) in combination with bevacizumab and chemotherapy (pemetrexed and cisplatin) in patients with epidermal growth factor receptor (EGFR)-mutated non-squamous non-small cell lung cancer (NSCLC).
In September 2022, Novartis announced results from a new pooled exploratory analysis across the entire MONALEESA Phase III program, confirming nearly one year of additional overall survival (OS) benefit in a subgroup of patients with aggressive forms of hormone receptor-positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced breast cancer (aBC)1.
Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.