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1530844

2030 年生物技術市場預測：按類型、產品類型、技術、應用、最終用戶和地區進行的全球分析

Biotechnology Market Forecasts to 2030 - Global Analysis By Type (Bio-pharmacy, Bio-industries, Bio-services, Bio-agriculture, Bio-informatics and Other Types), Product Type, Technology, Application, End User and by Geography
出版日期: | 出版商: Stratistics Market Research Consulting | 英文 200+ Pages | 商品交期: 2-3個工作天內

價格

根據 Stratistics MRC 的數據，2024 年全球生技市場規模為 16,514.8 億美元，預計到 2030 年將達到 69,294 億美元，預測期內複合年成長率為 27.0%。

生物技術是一個快速發展的領域，利用生物系統、有機體或其衍生物來開發和創造用於各種應用的技術和產品。結合生物學和技術的概念來解決醫療保健、農業和環境管理等行業的問題。生物技術正在幫助開發基因療法和個人化醫療等尖端治療方法。在農業方面，它正在幫助開發具有更高產量和抗蟲性的基因改造作物。

根據世界衛生組織 (WHO) 的說法，生物技術有可能透過提供新的​​治療方法方法來解決以前無法治療的疾病，從而徹底改變醫療保健。

對個人化治療的興趣日益濃厚

醫療保健正因向個人化醫療的轉變而轉變，個人化醫療根據患者獨特的遺傳、環境和生活方式因素量身定做治療。生物技術使針對患者特定需求的精準治療和診斷成為可能。此外，基因組學和生物標記的進步使得標靶藥物的開發成為可能，與傳統治療方法相比，副作用更少，療效更高。

安全和道德問題

生物技術經常引發有關安全和倫理的問題，特別是在基因改造和幹細胞研究等領域。對基因資料潛在濫用、基因改造的長期影響以及研究對象的人道待遇的擔憂也可能引起公眾的反對和監管審查。此外，研究進展和市場接受度也可能受到這些擔憂的影響。

個體化醫療的發展

個人化醫療有很大的發展空間，它可以根據患者獨特的遺傳、環境和生活方式特徵量身定做治療方法。基因組資料的不斷增加和生物資訊學的進步使生物技術公司能夠開發出更準確、更有效的治療方法。此外，標靶治療、基因診斷和個人化癌症治療的成長就是這一趨勢的例子，為創新和市場擴張創造了新的機會。

來自替代技術的威脅

傳統藥物、學名藥和非生物治療方法是與生物技術市場競爭的一些替代技術和治療方法。利用生物技術的產品可能面臨其他領域創新的競爭，例如合成生物學和奈米技術。此外，讓您的產品在擁擠的市場中脫穎而出並保持技術進步的領先地位可能是一項挑戰。

COVID-19 的影響：

COVID-19 大流行對生物技術產業產生了重大影響，加速了治療方法、疫苗和診斷設備的開發和傳播。生技公司、政府和研究機構之間前所未有的合作，滿足對解決方案的迫切需求，使得疫苗技術（包括 mRNA 疫苗）的快速發展成為可能。此外，這場大流行暴露了生物技術在解決全球突發衛生事件中的關鍵作用，並刺激了該領域的投資和創新。

預計生物製藥領域在預測期內將是最大的。

生物製藥產業佔據生物技術市場的最大佔有率。該領域專門透過應用生物技術技術（例如基因治療、單株抗體和重組DNA技術）來開發和生產藥品。生物製藥的市場主導地位是其對癌症、自體免疫疾病和遺傳性疾病等疾病的治療做出的重大貢獻的結果。此外，對生技藥品和個人化醫療不斷成長的需求在生物技術產業的整體成長中發揮著重要作用，進一步增強了該產業的主導地位。

DNA定序領域預計在預測期內複合年成長率最高

在生物技術市場中，DNA定序領域的複合年成長率最高。尋找 DNA 分子內準確的核苷酸順序稱為 DNA定序，在基因組學、個人化醫療和基因研究等許多領域至關重要。此外，次世代定序(NGS) 等定序技術的快速進步顯著降低了成本並提高了通量，導致對 DNA定序服務和產品的需求激增。

比例最高的地區：

北美地區佔據生物技術市場的最大佔有率。這項優勢背後的主要因素是強大的研發網路、廣泛的醫療基礎設施以及對生物技術創新的大量投資。領先的生物技術公司和研究機構主要位置美國，為基因組學、藥物開發和生物製藥的進步創造了有利的環境。此外，有利的政府法規、生物技術研究的高額資金以及高額醫療保健支出都有助於北美在全球生物技術市場中佔據主導地位。

複合年成長率最高的地區：

在生物技術市場中，亞太地區的複合年成長率最高。這種快速成長的推動因素包括該地區不斷擴大的醫療基礎設施、生物技術研究投資的增加以及對改善醫療保健結果的更加重視。生物技術新興企業的增加、鼓勵創新的政府計劃以及中國和印度等國家生物技術行業的快速擴張都是這一成長的關鍵因素。此外，亞太地區龐大的人口和慢性病盛行率也推動了對個人化醫療和先進生物技術解決方案的需求，使亞太地區成為全球生物技術市場中最大的高成長率地區。

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    • 根據產品系列、地理分佈和策略聯盟對主要企業基準化分析

目錄

第1章執行摘要

第2章 前言

  • 概述
  • 相關利益者
  • 調查範圍
  • 調查方法
    • 資料探勘
    • 資料分析
    • 資料檢驗
    • 研究途徑
  • 研究資訊來源
    • 主要研究資訊來源
    • 二次研究資訊來源
    • 先決條件

第3章市場趨勢分析

  • 促進因素
  • 抑制因素
  • 機會
  • 威脅
  • 產品分析
  • 技術分析
  • 應用分析
  • 最終用戶分析
  • 新興市場
  • COVID-19 的影響

第4章波特五力分析

  • 供應商的議價能力
  • 買方議價能力
  • 替代品的威脅
  • 新進入者的威脅
  • 競爭公司之間的敵對關係

第5章全球生技市場：依類型

  • 生物製藥
  • 生物產業
  • 生物服務
  • 生物農業
  • 生物資訊學
  • 其他類型

第6章全球生技市場：依產品類型

  • 裝置
  • 試劑
  • 軟體和服務
  • 其他產品類型

第7章全球生技市場：依技術分類

  • 奈米生物技術
  • 組織工程和再生
  • DNA序列分析
  • 基於細胞的檢測
  • 發酵
  • 聚合酵素鏈鎖反應（PCR）技術
  • 層析法
  • 其他技術

第8章全球生技市場：依應用分類

  • 衛生保健
  • 食品和農業
  • 自然資源與環境
  • 工業加工
  • 其他用途

第9章全球生技市場：依最終用戶分類

  • 製藥和生物技術公司
  • 合約調查機構
  • 學術研究所
  • 其他最終用戶

第10章全球生技市場：按地區

  • 北美洲
    • 美國
    • 加拿大
    • 墨西哥
  • 歐洲
    • 德國
    • 英國
    • 義大利
    • 法國
    • 西班牙
    • 其他歐洲國家
  • 亞太地區
    • 日本
    • 中國
    • 印度
    • 澳洲
    • 紐西蘭
    • 韓國
    • 其他亞太地區
  • 南美洲
    • 阿根廷
    • 巴西
    • 智利
    • 南美洲其他地區
  • 中東/非洲
    • 沙烏地阿拉伯
    • 阿拉伯聯合大公國
    • 卡達
    • 南非
    • 其他中東和非洲

第11章 主要進展

  • 合約、夥伴關係、協作和合資企業
  • 收購和合併
  • 新產品發布
  • 業務拓展
  • 其他關鍵策略

第12章 公司概況

  • Siemens
  • Novartis AG
  • Amgen Inc.
  • Johnson & Johnson Services, Inc.
  • Merck KGaA
  • General Electric
  • Abbott Laboratories
  • Novo Nordisk A/S
  • Pfizer, Inc.
  • Sanofi
  • F. Hoffmann-La Roche Ltd.
  • Vertex Pharmaceuticals Inc.
  • Agilent Technologies Inc
  • Olympus Corporation
  • Sysmex Corporation
  • Bristol-Myers Squibb
  • Thermo Fisher Scientific
  • AstraZeneca
  • Danaher
Product Code: SMRC26956

According to Stratistics MRC, the Global Biotechnology Market is accounted for $1651.48 billion in 2024 and is expected to reach $6929.40 billion by 2030 growing at a CAGR of 27.0% during the forecast period. Biotechnology is a quickly developing field that uses biological systems, organisms, or their derivatives to develop or create technologies and products for a range of uses. It addresses issues in industries like healthcare, agriculture, and environmental management by fusing concepts from biology and technology. Biotechnology helps to develop cutting-edge medical treatments such as gene therapies and personalized medicine. It aids in the development of genetically modified crops in agriculture, which provide higher yields and insect resistance.

According to the World Health Organization (WHO), biotechnology has the potential to revolutionize healthcare by providing new treatments and therapies that can address previously untreatable conditions.

Market Dynamics:

Driver:

Growing interest in customized treatment

Healthcare is being transformed by the move toward personalized medicine, which adjusts treatments based on a patient's unique genetic, environmental, and lifestyle factors. Precision therapies and diagnostics that are tailored to each patient's specific needs are made possible in large part by biotechnology. Moreover, the development of targeted medications, which have fewer side effects and greater efficacy than conventional therapies, is made possible by developments in genomics and biomarkers.

Restraint:

Safety and ethical issues

Biotechnology frequently raises questions about safety and ethics, especially in fields like genetic modification and stem cell research. Public opposition and regulatory scrutiny may result from concerns about the possible misuse of genetic data, the long-term effects of genetic alterations, and the humane treatment of research subjects. Additionally, research advancement and market acceptability may be impacted by these worries.

Opportunity:

Developments in customized medicine

There is significant room for growth in personalized medicine, which adjusts therapies based on a patient's unique genetic, environmental, and lifestyle characteristics. Biotechnology companies can now develop more precise and effective therapies owing to the growing availability of genomic data and advances in bioinformatics. Moreover, the growth of targeted therapies, genetic diagnostics, and personalized cancer treatments are examples of this trend, which is creating new opportunities for innovation and market expansion.

Threat:

Threats from alternative technologies

Traditional pharmaceuticals, generic medications, and non-biological treatments are some of the alternative technologies and therapies that compete with the biotechnology market. Products made using biotechnology may face competition from innovations in other fields like synthetic biology and nanotechnology. Additionally, differentiating products in a crowded market and staying ahead of technological advancements can be difficult tasks.

Covid-19 Impact:

The COVID-19 pandemic had a significant effect on the biotechnology industry, hastening the creation and uptake of treatments, vaccines, and diagnostic instruments. Rapid advancements in vaccine technology, including mRNA vaccines, were made possible by the unprecedented collaboration of biotech companies, governments, and research institutions in response to the pressing need for solutions. Furthermore, the pandemic also brought to light the vital role that biotechnology plays in resolving international health emergencies, spurring more investment and innovation in the field.

The Bio-pharmacy segment is expected to be the largest during the forecast period

The largest share of the biotechnology market is held by the biopharmacy segment. This section is dedicated to the development and production of pharmaceutical products through the application of biotechnological techniques, including gene therapy, monoclonal antibodies, and recombinant DNA technology. Biopharmacy's dominant position in the market is a result of its significant contributions to the treatment of diseases such as cancer, autoimmune disorders, and genetic conditions. Moreover, this sector's prominence is further enhanced by the growing demand for biologic drugs and personalized medicine, which plays a major role in the overall growth of the biotechnology industry.

The DNA sequencing segment is expected to have the highest CAGR during the forecast period

In the biotechnology market, the DNA sequencing segment is growing at the highest CAGR. Finding the exact nucleotide order within a DNA molecule is known as DNA sequencing, and it is essential for many fields, such as genomics, personalized medicine, and genetic research. Additionally, the demand for DNA sequencing services and products has surged as a result of the rapid advancements in sequencing technologies, such as next-generation sequencing (NGS), which have drastically reduced costs and increased throughput.

Region with largest share:

The largest share of the biotechnology market is held by the North American region. The main factors contributing to this dominance are the existence of a strong research and development network, a large healthcare infrastructure, and significant investments in biotech innovation. Leading biotechnology companies and research institutes are primarily located in the United States, creating an environment that is favorable for advances in genomics, drug development, and biopharmaceuticals. Moreover, favorable government regulations, significant funding for biotech research and high healthcare spending all contribute to North America's dominant position in the world biotechnology market.

Region with highest CAGR:

In the biotechnology market, the Asia-Pacific region is growing at the highest CAGR. The region's expanding healthcare infrastructure, growing investments in biotech research, and growing emphasis on enhancing healthcare outcomes are all contributing factors to this rapid growth. Growing biotech start-ups, government programs to encourage innovation and the rapidly expanding biotech sectors of nations like China and India are all major factors in this growth. Furthermore, the demand for personalized medicine and advanced biotech solutions is also being driven by the region's large population base and rising chronic disease prevalence, making Asia-Pacific the region with the fastest rate of growth in the global biotechnology market.

Key players in the market

Some of the key players in Biotechnology market include Siemens, Novartis AG, Amgen Inc., Johnson & Johnson Services, Inc., Merck KGaA, General Electric, Abbott Laboratories, Novo Nordisk A/S, Pfizer, Inc., Sanofi, F. Hoffmann-La Roche Ltd., Vertex Pharmaceuticals Inc., Agilent Technologies Inc, Olympus Corporation, Sysmex Corporation, Bristol-Myers Squibb, Thermo Fisher Scientific, AstraZeneca and Danaher.

Key Developments:

In July 2024, Boson Energy and Siemens AG have signed a Memorandum of Understanding (MoU) to facilitate collaboration on technology that converts non-recyclable waste into clean energy. The collaboration aims to advance sustainable, local energy security, enabling hydrogen-powered electric vehicle charging infrastructure without compromising grid stability or impacting consumer prices.

In June 2024, Novartis has entered an agreement to make a voluntary public takeover offer to acquire MorphoSys AG, a Germany-based, global biopharmaceutical company developing oncology medicines, for €2.7 billion. The acquisition, subject to customary closing conditions, further expands Novartis' oncology pipeline as well as its global footprint in hematology.

In May 2024, Merck, a leading science and technology company, has signed a definitive agreement to acquire life science company Mirus Bio for US$ 600 million. Based in Madison, Wisconsin, USA, Mirus Bio is a specialist in the development and commercialization of transfection reagents.

Types Covered:

  • Bio-pharmacy
  • Bio-industries
  • Bio-services
  • Bio-agriculture
  • Bio-informatics
  • Other Types

Product Types Covered:

  • Instruments
  • Reagents
  • Software and Service
  • Other Product Types

Technologies Covered:

  • Nanobiotechnology
  • Tissue Engineering and Regeneration
  • DNA Sequencing
  • Cell-based Assays
  • Fermentation
  • Polymerase Chain Reaction (PCR) Technology
  • Chromatography
  • Other Technologies

Applications Covered:

  • Healthcare
  • Food & Agriculture
  • Natural Resources & Environment
  • Industrial Processing
  • Other Applications

End Users Covered:

  • Pharmaceutical and Biotechnology Companies
  • Contract Research Organizations
  • Academic and Research Institutes
  • Other End Users

Regions Covered:

  • North America
    • US
    • Canada
    • Mexico
  • Europe
    • Germany
    • UK
    • Italy
    • France
    • Spain
    • Rest of Europe
  • Asia Pacific
    • Japan
    • China
    • India
    • Australia
    • New Zealand
    • South Korea
    • Rest of Asia Pacific
  • South America
    • Argentina
    • Brazil
    • Chile
    • Rest of South America
  • Middle East & Africa
    • Saudi Arabia
    • UAE
    • Qatar
    • South Africa
    • Rest of Middle East & Africa

What our report offers:

  • Market share assessments for the regional and country-level segments
  • Strategic recommendations for the new entrants
  • Covers Market data for the years 2022, 2023, 2024, 2026, and 2030
  • Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
  • Strategic recommendations in key business segments based on the market estimations
  • Competitive landscaping mapping the key common trends
  • Company profiling with detailed strategies, financials, and recent developments
  • Supply chain trends mapping the latest technological advancements

Free Customization Offerings:

All the customers of this report will be entitled to receive one of the following free customization options:

  • Company Profiling
    • Comprehensive profiling of additional market players (up to 3)
    • SWOT Analysis of key players (up to 3)
  • Regional Segmentation
    • Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
  • Competitive Benchmarking
    • Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances

Table of Contents

1 Executive Summary

2 Preface

  • 2.1 Abstract
  • 2.2 Stake Holders
  • 2.3 Research Scope
  • 2.4 Research Methodology
    • 2.4.1 Data Mining
    • 2.4.2 Data Analysis
    • 2.4.3 Data Validation
    • 2.4.4 Research Approach
  • 2.5 Research Sources
    • 2.5.1 Primary Research Sources
    • 2.5.2 Secondary Research Sources
    • 2.5.3 Assumptions

3 Market Trend Analysis

  • 3.1 Introduction
  • 3.2 Drivers
  • 3.3 Restraints
  • 3.4 Opportunities
  • 3.5 Threats
  • 3.6 Product Analysis
  • 3.7 Technology Analysis
  • 3.8 Application Analysis
  • 3.9 End User Analysis
  • 3.10 Emerging Markets
  • 3.11 Impact of Covid-19

4 Porters Five Force Analysis

  • 4.1 Bargaining power of suppliers
  • 4.2 Bargaining power of buyers
  • 4.3 Threat of substitutes
  • 4.4 Threat of new entrants
  • 4.5 Competitive rivalry

5 Global Biotechnology Market, By Type

  • 5.1 Introduction
  • 5.2 Bio-pharmacy
  • 5.3 Bio-industries
  • 5.4 Bio-services
  • 5.5 Bio-agriculture
  • 5.6 Bio-informatics
  • 5.7 Other Types

6 Global Biotechnology Market, By Product Type

  • 6.1 Introduction
  • 6.2 Instruments
  • 6.3 Reagents
  • 6.4 Software and Service
  • 6.5 Other Product Types

7 Global Biotechnology Market, By Technology

  • 7.1 Introduction
  • 7.2 Nanobiotechnology
  • 7.3 Tissue Engineering and Regeneration
  • 7.4 DNA Sequencing
  • 7.5 Cell-based Assays
  • 7.6 Fermentation
  • 7.7 Polymerase Chain Reaction (PCR) Technology
  • 7.8 Chromatography
  • 7.9 Other Technologies

8 Global Biotechnology Market, By Application

  • 8.1 Introduction
  • 8.2 Healthcare
  • 8.3 Food & Agriculture
  • 8.4 Natural Resources & Environment
  • 8.5 Industrial Processing
  • 8.6 Other Applications

9 Global Biotechnology Market, By End User

  • 9.1 Introduction
  • 9.2 Pharmaceutical and Biotechnology Companies
  • 9.3 Contract Research Organizations
  • 9.4 Academic and Research Institutes
  • 9.5 Other End Users

10 Global Biotechnology Market, By Geography

  • 10.1 Introduction
  • 10.2 North America
    • 10.2.1 US
    • 10.2.2 Canada
    • 10.2.3 Mexico
  • 10.3 Europe
    • 10.3.1 Germany
    • 10.3.2 UK
    • 10.3.3 Italy
    • 10.3.4 France
    • 10.3.5 Spain
    • 10.3.6 Rest of Europe
  • 10.4 Asia Pacific
    • 10.4.1 Japan
    • 10.4.2 China
    • 10.4.3 India
    • 10.4.4 Australia
    • 10.4.5 New Zealand
    • 10.4.6 South Korea
    • 10.4.7 Rest of Asia Pacific
  • 10.5 South America
    • 10.5.1 Argentina
    • 10.5.2 Brazil
    • 10.5.3 Chile
    • 10.5.4 Rest of South America
  • 10.6 Middle East & Africa
    • 10.6.1 Saudi Arabia
    • 10.6.2 UAE
    • 10.6.3 Qatar
    • 10.6.4 South Africa
    • 10.6.5 Rest of Middle East & Africa

11 Key Developments

  • 11.1 Agreements, Partnerships, Collaborations and Joint Ventures
  • 11.2 Acquisitions & Mergers
  • 11.3 New Product Launch
  • 11.4 Expansions
  • 11.5 Other Key Strategies

12 Company Profiling

  • 12.1 Siemens
  • 12.2 Novartis AG
  • 12.3 Amgen Inc.
  • 12.4 Johnson & Johnson Services, Inc.
  • 12.5 Merck KGaA
  • 12.6 General Electric
  • 12.7 Abbott Laboratories
  • 12.8 Novo Nordisk A/S
  • 12.9 Pfizer, Inc.
  • 12.10 Sanofi
  • 12.11 F. Hoffmann-La Roche Ltd.
  • 12.12 Vertex Pharmaceuticals Inc.
  • 12.13 Agilent Technologies Inc
  • 12.14 Olympus Corporation
  • 12.15 Sysmex Corporation
  • 12.16 Bristol-Myers Squibb
  • 12.17 Thermo Fisher Scientific
  • 12.18 AstraZeneca
  • 12.19 Danaher

List of Tables

  • Table 1 Global Biotechnology Market Outlook, By Region (2022-2030) ($MN)
  • Table 2 Global Biotechnology Market Outlook, By Type (2022-2030) ($MN)
  • Table 3 Global Biotechnology Market Outlook, By Bio-pharmacy (2022-2030) ($MN)
  • Table 4 Global Biotechnology Market Outlook, By Bio-industries (2022-2030) ($MN)
  • Table 5 Global Biotechnology Market Outlook, By Bio-services (2022-2030) ($MN)
  • Table 6 Global Biotechnology Market Outlook, By Bio-agriculture (2022-2030) ($MN)
  • Table 7 Global Biotechnology Market Outlook, By Bio-informatics (2022-2030) ($MN)
  • Table 8 Global Biotechnology Market Outlook, By Other Types (2022-2030) ($MN)
  • Table 9 Global Biotechnology Market Outlook, By Product Type (2022-2030) ($MN)
  • Table 10 Global Biotechnology Market Outlook, By Instruments (2022-2030) ($MN)
  • Table 11 Global Biotechnology Market Outlook, By Reagents (2022-2030) ($MN)
  • Table 12 Global Biotechnology Market Outlook, By Software and Service (2022-2030) ($MN)
  • Table 13 Global Biotechnology Market Outlook, By Other Product Types (2022-2030) ($MN)
  • Table 14 Global Biotechnology Market Outlook, By Technology (2022-2030) ($MN)
  • Table 15 Global Biotechnology Market Outlook, By Nanobiotechnology (2022-2030) ($MN)
  • Table 16 Global Biotechnology Market Outlook, By Tissue Engineering and Regeneration (2022-2030) ($MN)
  • Table 17 Global Biotechnology Market Outlook, By DNA Sequencing (2022-2030) ($MN)
  • Table 18 Global Biotechnology Market Outlook, By Cell-based Assays (2022-2030) ($MN)
  • Table 19 Global Biotechnology Market Outlook, By Fermentation (2022-2030) ($MN)
  • Table 20 Global Biotechnology Market Outlook, By Polymerase Chain Reaction (PCR) Technology (2022-2030) ($MN)
  • Table 21 Global Biotechnology Market Outlook, By Chromatography (2022-2030) ($MN)
  • Table 22 Global Biotechnology Market Outlook, By Other Technologies (2022-2030) ($MN)
  • Table 23 Global Biotechnology Market Outlook, By Application (2022-2030) ($MN)
  • Table 24 Global Biotechnology Market Outlook, By Healthcare (2022-2030) ($MN)
  • Table 25 Global Biotechnology Market Outlook, By Food & Agriculture (2022-2030) ($MN)
  • Table 26 Global Biotechnology Market Outlook, By Natural Resources & Environment (2022-2030) ($MN)
  • Table 27 Global Biotechnology Market Outlook, By Industrial Processing (2022-2030) ($MN)
  • Table 28 Global Biotechnology Market Outlook, By Other Applications (2022-2030) ($MN)
  • Table 29 Global Biotechnology Market Outlook, By End User (2022-2030) ($MN)
  • Table 30 Global Biotechnology Market Outlook, By Pharmaceutical and Biotechnology Companies (2022-2030) ($MN)
  • Table 31 Global Biotechnology Market Outlook, By Contract Research Organizations (2022-2030) ($MN)
  • Table 32 Global Biotechnology Market Outlook, By Academic and Research Institutes (2022-2030) ($MN)
  • Table 33 Global Biotechnology Market Outlook, By Other End Users (2022-2030) ($MN)

Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.