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1679199

2030 年透明質酸市場預測：按產品、配方、分銷管道、應用、最終用戶和地區進行的全球分析

Hyaluronic Acid Market Forecasts to 2030 - Global Analysis By Product, Formulation, Distribution Channel, Application, End User and By Geography
出版日期: | 出版商: Stratistics Market Research Consulting | 英文 200+ Pages | 商品交期: 2-3個工作天內

價格

根據 Stratistics MRC 的數據，全球透明質酸市場規模預計在 2024 年達到 15.2 億美元，到 2030 年將達到 27.1 億美元，預測期內的複合年成長率為 9.8%。

透明質酸是一種天然物質，主要存在於結締組織、皮膚和關節中。玻尿酸是Glico，具有鎖水、保濕、潤滑和彈性的作用。 HA 被廣泛用於改善皮膚水分、減少皺紋並使皮膚豐滿。它還可以透過潤滑關節來幫助治療骨關節炎，並用於眼科手術。其保濕特性對於維持皮膚健康和整體組織功能至關重要。

根據國際骨關節炎研究協會 (OARSI) 的數據，大約 90% 的黏性補充補充劑處方都是用於治療骨關節炎的皮質類固醇和透明質酸注射。

對抗衰老產品的需求不斷增加

HA 是精華液、乳霜和真皮填充劑中的關鍵成分，具有鎖住水分、減少皺紋和增加皮膚彈性的功效。人口老化日益加劇、美容意識不斷增強以及對非侵入性美容治療的偏好進一步推動了基於透明質酸的產品的銷售。此外，護膚配方的進步和皮膚科醫生的建議也增強了消費者的信心。化妝品行業的擴張、電子商務平台以及社交媒體的影響也推動了透明質酸市場的成長，使其成為主要的護膚成分。

潛在的副作用

透明質酸 (HA)，尤其是在皮膚填充劑等輸液治療中，會引起潛在的副作用，如發紅、腫脹、過敏反應和感染疾病。在極少數情況下，不當給藥會導致腫塊、血管阻塞和填充物移位。此外，安全問題、不一致的結果以及需要重複治療也不利於長期使用。這些風險引發消費者擔憂和監管挑戰，阻礙了市場成長。

在治療骨關節炎的應用日益廣泛

透明質酸注射劑被稱為黏性補充補充劑，有助於潤滑和緩衝關節、減輕疼痛並改善活動能力。由於人口老化和久坐的生活方式導致骨關節炎病例增加，對非手術和微創治療的需求日益成長。持續的研究和開發進展以及 FDA核准正在提高產品的可用性和有效性。此外，基於HA的療法提供了一種有效的止痛藥和手術的替代方案，進一步鼓勵了其被採用。

產品成本高

透明質酸的生產成本很高，因為它需要基於發酵的萃取、精製和品管過程。生產用於護膚或藥物應用的醫用級或高純度 HA 需要先進的生物技術，這會增加製造成本。此外，研發投資、監管部門核准和專門的配方也會增加成本。這限制了可用性和可負擔性，特別是在購買力較低的新興市場，阻礙了整體市場的擴張。

COVID-19 的影響：

由於供應鏈中斷、選擇性手術減少以及消費者在化妝品上的支出減少，COVID-19 疫情最初擾亂了透明質酸市場。這些診所的關閉導致了皮膚填充劑等美容療程的減少。然而，疫情後的復甦導致對護膚、健康和微創手術的需求增加。此外，隨著醫療系統恢復非緊急程序，包括骨關節炎和眼科護理在內的醫療領域也得到復甦，穩定了市場成長。

預計在預測期內，聚合透明質酸部分將成為最大的部分。

預計預測期內聚合透明質酸部分將佔據最大的市場佔有率。 HMW-HA 是一種具有較大分子鏈的透明質酸，通常超過 1,000 kDa。它可以保持水分，增加皮膚水分，並形成保護屏障，促進創傷治療。它具有強大的抗炎特性，有助於減少氧化壓力。它通常添加到護膚中，提供持久的保濕和豐盈效果。

預計預測期內個人護理和美容領域將出現最高的複合年成長率。

由於其出色的保濕和抗衰老特性，個人護理和美容領域預計將在預測期內見證最高成長率。它能吸引和保留水分，使肌膚看起來更豐滿、更光滑、更年輕。它存在於精華液、乳霜和乳霜中，有助於減少細紋、增強彈性和舒緩粗糙的皮膚。其在世界各地的護膚和化妝品配方中的受歡迎程度持續成長。

佔比最大的地區：

在預測期內，由於護膚意識的增強、抗衰老產品需求的增加以及醫療應用的不斷擴大，預計亞太地區將佔據最大的市場佔有率。受美容產業蓬勃發展和美容程序高採用率的推動，中國、日本、韓國和印度等國家引領市場。該地區人口老化推動了對真皮填充劑和骨關節炎治療的需求，而生物技術的進步則推動了產品創新。此外，韓國美容和日本美容趨勢正在推動基於透明質酸的護膚的銷售。

複合年成長率最高的地區：

預計北美地區在預測期內將呈現最高的複合年成長率，這主要得益於消費者對抗衰老護膚護膚、真皮填充劑和骨關節炎治療的需求。美國憑藉其成熟的美容和保健行業、日益增強的美容意識以及微創手術的興起在市場上佔據主導地位。該地區也廣泛採用基於 HA 的眼科和整形外科治療。此外，主要產業參與者的存在和不斷增加的研發投入進一步支持了市場的成長軌跡。

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  • 地理細分
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    • 根據產品系列、地理分佈和策略聯盟對主要企業基準化分析

目錄

第1章執行摘要

第 2 章 前言

  • 概述
  • 相關利益者
  • 研究範圍
  • 調查方法
    • 資料探勘
    • 資料分析
    • 資料檢驗
    • 研究途徑
  • 研究資訊來源
    • 主要研究資訊來源
    • 二手研究資料資訊來源
    • 先決條件

第3章 市場走勢分析

  • 驅動程式
  • 限制因素
  • 機會
  • 威脅
  • 產品分析
  • 應用分析
  • 最終用戶分析
  • 新興市場
  • COVID-19 的影響

第 4 章 波特五力分析

  • 供應商的議價能力
  • 買家的議價能力
  • 替代品的威脅
  • 新進入者的威脅
  • 競爭對手之間的競爭

第 5 章 全球玻尿酸市場（依產品）

  • 高分子量玻尿酸
  • 中分子量透明質酸
  • 低分子量透明質酸

6. 全球玻尿酸市場（依配方）

  • 注射
  • 局部的
  • 口服

7. 全球透明質酸市場按分銷管道分類

  • 電子商務平台
  • 超級市場/大賣場
  • 藥局和藥局
  • 專賣店
  • 其他分銷管道

8. 全球玻尿酸市場（依應用）

  • 食品和補充品
  • 眼科
  • 整形外科
  • 藥品
  • 個人護理及美容
  • 其他用途

第 9 章 全球玻尿酸市場（依最終用戶分類）

  • 醫院
  • 美容診所
  • 生技公司
  • 研究所
  • 其他最終用戶

第 10 章 全球玻尿酸市場（按地區）

  • 北美洲
    • 美國
    • 加拿大
    • 墨西哥
  • 歐洲
    • 德國
    • 英國
    • 義大利
    • 法國
    • 西班牙
    • 歐洲其他地區
  • 亞太地區
    • 日本
    • 中國
    • 印度
    • 澳洲
    • 紐西蘭
    • 韓國
    • 其他亞太地區
  • 南美洲
    • 阿根廷
    • 巴西
    • 智利
    • 南美洲其他地區
  • 中東和非洲
    • 沙烏地阿拉伯
    • 阿拉伯聯合大公國
    • 卡達
    • 南非
    • 其他中東和非洲地區

第11章 重大進展

  • 協議、夥伴關係、合作和合資企業
  • 收購與合併
  • 新產品發布
  • 業務擴展
  • 其他關鍵策略

第12章 公司概況

  • Allergan Corporation
  • Sanofi Corporation
  • Evonik Industries AG
  • Bloomage Biotechnology Corporation Limited
  • Seikagaku Corporation
  • Anika Therapeutics, Inc.
  • LG Chem
  • Lubrizol Corporation
  • Royal DSM
  • Kewpie Corporation
  • Symatese Group
  • HTL Biotechnology
  • FocusChem Biotech
  • Croda International Plc
  • Stanford Chemicals Company
  • Maruha Nichiro Corporation
  • Evolus, Inc.
  • Contipro as
  • Fidia Farmaceutici SpA
  • Zimmer Biomet
Product Code: SMRC28782

According to Stratistics MRC, the Global Hyaluronic Acid Market is accounted for $1.52 billion in 2024 and is expected to reach $2.71 billion by 2030 growing at a CAGR of 9.8% during the forecast period. Hyaluronic acid is a naturally occurring substance found in the human body, primarily in connective tissues, skin, and joints. It is a glycosaminoglycan known for its ability to retain water, providing hydration, lubrication, and elasticity. HA is widely used to improve skin hydration, reduce wrinkles, and enhance plumpness. It helps treat osteoarthritis by lubricating joints and is used in eye surgeries. Its moisture-binding properties make it essential for maintaining skin health and overall tissue function.

According to the Osteoarthritis Research Society International (OARSI), nearly 90% of visco supplement prescriptions consists of both corticosteroids and hyaluronic acid injections to treat osteoarthritis.

Market Dynamics:

Driver:

Rising demand for anti-aging products

HA is a key ingredient in serums, creams, and dermal fillers, known for its ability to retain moisture, reduce wrinkles, and enhance skin elasticity. The growing aging population, increasing beauty consciousness, and preference for non-invasive cosmetic treatments further boost HA-based product sales. Additionally, advancements in skincare formulations and endorsements by dermatologists fuel consumer trust. The expansion of the cosmetic industry, e-commerce platforms, and social media influence also accelerates HA market growth, making it a dominant skincare ingredient.

Restraint:

Potential side effects

Hyaluronic acid (HA) may cause potential side effects such as redness, swelling, allergic reactions, or infections, especially with injectable treatments like dermal fillers. In rare cases, improper administration can lead to lumps, vascular occlusion, or migration of fillers. Additionally, safety issues, inconsistent results, and the need for repeated treatments discourage long-term use. These risks create consumer concerns and regulatory challenges, hampering market growth.

Opportunity:

Growing use in osteoarthritis treatment

HA injections, known as visco supplementation, help lubricate and cushion joints, reducing pain and improving mobility. As osteoarthritis cases rise due to aging populations and sedentary lifestyles, demand for non-surgical, minimally invasive treatments increases. Ongoing R&D advancements and FDA approvals enhance product availability and effectiveness. Additionally, HA-based therapies offer an effective alternative to painkillers and surgeries, further boosting adoption.

Threat:

High product costs

Hyaluronic acid has high production costs due to its complex fermentation-based extraction, purification, and quality control processes. Producing medical-grade or high-purity HA for skincare and pharmaceutical applications requires advanced biotechnology, increasing manufacturing expenses. Additionally, R&D investments, regulatory approvals, and specialized formulations add to the cost. As a result, restricted accessibility and affordability hinder overall market expansion, especially in developing regions with lower purchasing power.

Covid-19 Impact:

The covid-19 pandemic initially disrupted the hyaluronic acid market due to supply chain interruptions, reduced elective procedures, and lower consumer spending on cosmetics. Lockdowns led to a decline in aesthetic treatments like dermal fillers. However, post-pandemic recovery saw increased demand for skincare, wellness, and minimally invasive procedures. Additionally, the medical segment, including osteoarthritis and ophthalmic treatments, rebounded as healthcare systems resumed non-urgent procedures, stabilizing market growth.

The high molecular weight hyaluronic acid segment is expected to be the largest during the forecast period

The high molecular weight hyaluronic acid segment is expected to account for the largest market share during the forecast period. HMW-HA is a form of hyaluronic acid with large molecular chains, typically above 1,000 kDa. It retains moisture, enhances skin hydration, and promotes wound healing by forming a protective barrier. It has strong anti-inflammatory properties and helps in reducing oxidative stress. Commonly found in skincare, it provides long-lasting hydration and plumping effects.

The personal care & beauty segment is expected to have the highest CAGR during the forecast period

Over the forecast period, the personal care & beauty segment is predicted to witness the highest growth rate due to its exceptional hydrating and anti-aging properties. It attracts and retains moisture, making skin plumper, smoother, and more youthful. Found in serums, creams, and masks, it helps reduce fine lines, improves elasticity, and soothes irritation. Its popularity continues to grow in skincare and cosmetic formulations worldwide.

Region with largest share:

During the forecast period, the Asia Pacific region is expected to hold the largest market share due to rising skincare awareness, increasing demand for anti-aging products, and expanding medical applications. Countries like China, Japan, South Korea, and India lead the market, driven by a booming beauty industry and high adoption of cosmetic procedures. The region's aging population fuels demand for dermal fillers and osteoarthritis treatments, while advancements in biotechnology enhance product innovation. Additionally, the popularity of K-beauty and J-beauty trends boosts HA-based skincare sales.

Region with highest CAGR:

Over the forecast period, the North America region is anticipated to exhibit the highest CAGR driven by consumer demand for anti-aging skincare, dermal fillers, and osteoarthritis treatments. The U.S. dominates the market due to a well-established cosmetic and healthcare industry, increasing aesthetic consciousness, and rising minimally invasive procedures. The region also sees strong adoption of HA-based ophthalmic and orthopedic treatments. Additionally, the presence of key industry players and increasing R&D investments further support the market's growth trajectory.

Key players in the market

Some of the key players in Hyaluronic Acid market include Allergan Corporation, Sanofi Corporation, Evonik Industries AG, Bloomage Biotechnology Corporation Limited, Seikagaku Corporation, Anika Therapeutics, Inc., LG Chem, Lubrizol Corporation, Royal DSM, Kewpie Corporation, Symatese Group, HTL Biotechnology, FocusChem Biotech, Croda International Plc, Stanford Chemicals Company, Maruha Nichiro Corporation, Evolus, Inc., Contipro a.s., Fidia Farmaceutici S.p.A. and Zimmer Biomet.

Key Developments:

In October 2024, Evolus, Inc. announced that it received EU Medical Device Regulation (MDR) certification for four unique injectable hyaluronic acid (HA) gels under the brand name Estyme(R). This certification allows Evolus to enter the European dermal filler market, doubling its addressable market outside the U.S. to $1.8 billion.

In July 2024, Bloomage, a global leader in hyaluronic acid and bioactive substances, introduced MitoPQQ(TM) at the IFT FIRST Expo. This water-soluble compound, naturally found in various foods, enhances mitochondrial function, combats cellular aging, and supports cognitive health. Produced through fermentation, MitoPQQ(TM) is non-GMO and certified by GRAS, KOSHER, and HALAL standards.

Products Covered:

  • High Molecular Weight Hyaluronic Acid
  • Medium Molecular Weight Hyaluronic Acid
  • Low Molecular Weight Hyaluronic Acid

Formulations Covered:

  • Injectable
  • Topical
  • Oral

Distribution Channels Covered:

  • E-commerce Platforms
  • Supermarkets/Hypermarkets
  • Pharmacies & Drug Stores
  • Specialty Stores
  • Other Distribution Channels

Applications Covered:

  • Food & Dietary Supplements
  • Ophthalmology
  • Orthopedics
  • Pharmaceuticals
  • Personal Care & Beauty
  • Other Applications

End Users Covered:

  • Hospitals
  • Aesthetic Clinics
  • Biotechnology Companies
  • Research Institutions
  • Other End Users

Regions Covered:

  • North America
    • US
    • Canada
    • Mexico
  • Europe
    • Germany
    • UK
    • Italy
    • France
    • Spain
    • Rest of Europe
  • Asia Pacific
    • Japan
    • China
    • India
    • Australia
    • New Zealand
    • South Korea
    • Rest of Asia Pacific
  • South America
    • Argentina
    • Brazil
    • Chile
    • Rest of South America
  • Middle East & Africa
    • Saudi Arabia
    • UAE
    • Qatar
    • South Africa
    • Rest of Middle East & Africa

What our report offers:

  • Market share assessments for the regional and country-level segments
  • Strategic recommendations for the new entrants
  • Covers Market data for the years 2022, 2023, 2024, 2026, and 2030
  • Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
  • Strategic recommendations in key business segments based on the market estimations
  • Competitive landscaping mapping the key common trends
  • Company profiling with detailed strategies, financials, and recent developments
  • Supply chain trends mapping the latest technological advancements

Free Customization Offerings:

All the customers of this report will be entitled to receive one of the following free customization options:

  • Company Profiling
    • Comprehensive profiling of additional market players (up to 3)
    • SWOT Analysis of key players (up to 3)
  • Regional Segmentation
    • Market estimations, Forecasts and CAGR of any prominent country as per the client's interest (Note: Depends on feasibility check)
  • Competitive Benchmarking
    • Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances

Table of Contents

1 Executive Summary

2 Preface

  • 2.1 Abstract
  • 2.2 Stake Holders
  • 2.3 Research Scope
  • 2.4 Research Methodology
    • 2.4.1 Data Mining
    • 2.4.2 Data Analysis
    • 2.4.3 Data Validation
    • 2.4.4 Research Approach
  • 2.5 Research Sources
    • 2.5.1 Primary Research Sources
    • 2.5.2 Secondary Research Sources
    • 2.5.3 Assumptions

3 Market Trend Analysis

  • 3.1 Introduction
  • 3.2 Drivers
  • 3.3 Restraints
  • 3.4 Opportunities
  • 3.5 Threats
  • 3.6 Product Analysis
  • 3.7 Application Analysis
  • 3.8 End User Analysis
  • 3.9 Emerging Markets
  • 3.10 Impact of Covid-19

4 Porters Five Force Analysis

  • 4.1 Bargaining power of suppliers
  • 4.2 Bargaining power of buyers
  • 4.3 Threat of substitutes
  • 4.4 Threat of new entrants
  • 4.5 Competitive rivalry

5 Global Hyaluronic Acid Market, By Product

  • 5.1 Introduction
  • 5.2 High Molecular Weight Hyaluronic Acid
  • 5.3 Medium Molecular Weight Hyaluronic Acid
  • 5.4 Low Molecular Weight Hyaluronic Acid

6 Global Hyaluronic Acid Market, By Formulation

  • 6.1 Introduction
  • 6.2 Injectable
  • 6.3 Topical
  • 6.4 Oral

7 Global Hyaluronic Acid Market, By Distribution Channel

  • 7.1 Introduction
  • 7.2 E-commerce Platforms
  • 7.3 Supermarkets/Hypermarkets
  • 7.4 Pharmacies & Drug Stores
  • 7.5 Specialty Stores
  • 7.6 Other Distribution Channels

8 Global Hyaluronic Acid Market, By Application

  • 8.1 Introduction
  • 8.2 Food & Dietary Supplements
  • 8.3 Ophthalmology
  • 8.4 Orthopedics
  • 8.5 Pharmaceuticals
  • 8.6 Personal Care & Beauty
  • 8.7 Other Applications

9 Global Hyaluronic Acid Market, By End User

  • 9.1 Introduction
  • 9.2 Hospitals
  • 9.3 Aesthetic Clinics
  • 9.4 Biotechnology Companies
  • 9.5 Research Institutions
  • 9.6 Other End Users

10 Global Hyaluronic Acid Market, By Geography

  • 10.1 Introduction
  • 10.2 North America
    • 10.2.1 US
    • 10.2.2 Canada
    • 10.2.3 Mexico
  • 10.3 Europe
    • 10.3.1 Germany
    • 10.3.2 UK
    • 10.3.3 Italy
    • 10.3.4 France
    • 10.3.5 Spain
    • 10.3.10 Rest of Europe
  • 10.4 Asia Pacific
    • 10.4.1 Japan
    • 10.4.2 China
    • 10.4.3 India
    • 10.4.4 Australia
    • 10.4.5 New Zealand
    • 10.4.10 South Korea
    • 10.4.7 Rest of Asia Pacific
  • 10.5 South America
    • 10.5.1 Argentina
    • 10.5.2 Brazil
    • 10.5.3 Chile
    • 10.5.4 Rest of South America
  • 10.1 Middle East & Africa
    • 10.10.1 Saudi Arabia
    • 10.10.2 UAE
    • 10.10.3 Qatar
    • 10.10.4 South Africa
    • 10.10.5 Rest of Middle East & Africa

11 Key Developments

  • 11.1 Agreements, Partnerships, Collaborations and Joint Ventures
  • 11.2 Acquisitions & Mergers
  • 11.3 New Product Launch
  • 11.4 Expansions
  • 11.5 Other Key Strategies

12 Company Profiling

  • 12.1 Allergan Corporation
  • 12.2 Sanofi Corporation
  • 12.3 Evonik Industries AG
  • 12.4 Bloomage Biotechnology Corporation Limited
  • 12.5 Seikagaku Corporation
  • 12.6 Anika Therapeutics, Inc.
  • 12.7 LG Chem
  • 12.8 Lubrizol Corporation
  • 12.9 Royal DSM
  • 12.10 Kewpie Corporation
  • 12.11 Symatese Group
  • 12.12 HTL Biotechnology
  • 12.13 FocusChem Biotech
  • 12.14 Croda International Plc
  • 12.15 Stanford Chemicals Company
  • 12.16 Maruha Nichiro Corporation
  • 12.17 Evolus, Inc.
  • 12.18 Contipro a.s.
  • 12.19 Fidia Farmaceutici S.p.A.
  • 12.20 Zimmer Biomet

List of Tables

  • Table 1 Global Hyaluronic Acid Market Outlook, By Region (2022-2030) ($MN)
  • Table 2 Global Hyaluronic Acid Market Outlook, By Product (2022-2030) ($MN)
  • Table 3 Global Hyaluronic Acid Market Outlook, By High Molecular Weight Hyaluronic Acid (2022-2030) ($MN)
  • Table 4 Global Hyaluronic Acid Market Outlook, By Medium Molecular Weight Hyaluronic Acid (2022-2030) ($MN)
  • Table 5 Global Hyaluronic Acid Market Outlook, By Low Molecular Weight Hyaluronic Acid (2022-2030) ($MN)
  • Table 6 Global Hyaluronic Acid Market Outlook, By Formulation (2022-2030) ($MN)
  • Table 7 Global Hyaluronic Acid Market Outlook, By Injectable (2022-2030) ($MN)
  • Table 8 Global Hyaluronic Acid Market Outlook, By Topical (2022-2030) ($MN)
  • Table 9 Global Hyaluronic Acid Market Outlook, By Oral (2022-2030) ($MN)
  • Table 10 Global Hyaluronic Acid Market Outlook, By Distribution Channel (2022-2030) ($MN)
  • Table 11 Global Hyaluronic Acid Market Outlook, By E-commerce Platforms (2022-2030) ($MN)
  • Table 12 Global Hyaluronic Acid Market Outlook, By Supermarkets/Hypermarkets (2022-2030) ($MN)
  • Table 13 Global Hyaluronic Acid Market Outlook, By Pharmacies & Drug Stores (2022-2030) ($MN)
  • Table 14 Global Hyaluronic Acid Market Outlook, By Specialty Stores (2022-2030) ($MN)
  • Table 15 Global Hyaluronic Acid Market Outlook, By Other Distribution Channels (2022-2030) ($MN)
  • Table 16 Global Hyaluronic Acid Market Outlook, By Application (2022-2030) ($MN)
  • Table 17 Global Hyaluronic Acid Market Outlook, By Food & Dietary Supplements (2022-2030) ($MN)
  • Table 18 Global Hyaluronic Acid Market Outlook, By Ophthalmology (2022-2030) ($MN)
  • Table 19 Global Hyaluronic Acid Market Outlook, By Orthopedics (2022-2030) ($MN)
  • Table 20 Global Hyaluronic Acid Market Outlook, By Pharmaceuticals (2022-2030) ($MN)
  • Table 21 Global Hyaluronic Acid Market Outlook, By Personal Care & Beauty (2022-2030) ($MN)
  • Table 22 Global Hyaluronic Acid Market Outlook, By Other Applications (2022-2030) ($MN)
  • Table 23 Global Hyaluronic Acid Market Outlook, By End User (2022-2030) ($MN)
  • Table 24 Global Hyaluronic Acid Market Outlook, By Hospitals (2022-2030) ($MN)
  • Table 25 Global Hyaluronic Acid Market Outlook, By Aesthetic Clinics (2022-2030) ($MN)
  • Table 26 Global Hyaluronic Acid Market Outlook, By Biotechnology Companies (2022-2030) ($MN)
  • Table 27 Global Hyaluronic Acid Market Outlook, By Research Institutions (2022-2030) ($MN)
  • Table 28 Global Hyaluronic Acid Market Outlook, By Other End Users (2022-2030) ($MN)

Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.