市場調查報告書
商品編碼
1562251
北美轉染試劑和設備市場預測至 2030 年 - 區域分析 - 按產品、方法、應用和最終用戶North America Transfection Reagents and Equipment Market Forecast to 2030 - Regional Analysis - by Product, Method, Application, and End User |
2022年北美轉染試劑和設備市場價值為5.4057億美元,預計2030年將達到9.9553億美元;預計 2022 年至 2030 年複合年成長率為 7.9%。
公司的策略性措施推動北美轉染試劑和設備市場
在北美轉染試劑和設備市場營運的公司專注於策略發展,例如合作、擴張、協議、夥伴關係和新產品發布,這有助於他們提高銷售、擴大地理範圍並增強滿足市場需求的能力。現有的客戶群更大。這些發展也在一定程度上有助於向市場引入新趨勢。以下提到了北美轉染試劑和設備市場的一些值得注意的發展。
2023 年4 月,賽默飛世爾科技推出了Invitrogen Neon NxT 電穿孔系統,即使是最具挑戰性的細胞類型,該系統也能促進轉染,從而實現高效率、細胞回收率和重現性。 Neon NxT 電極經過最佳放置,可提供最小的表面積並產生更均勻的電場,並在轉染過程中保持適當的生理條件,從而使所需的修飾能夠在更多細胞中發生,並減少在此過程中損失的細胞數量。新系統還具有改進的回饋迴路和人體工學增強功能,易於使用。 2021年8月,Mirus Bio推出了TransIT VirusGEN GMP產品線,該產品線提供轉染試劑和增強劑,以支持用於基因療法開發的病毒載體的製造。 TransIT VirusGEN GMP 轉染試劑旨在增強轉移疫苗 DNA 向懸浮細胞和貼壁 HEK 293 細胞的遞送,從而使重組 AAV 和 LV 載體的生產更加高效。 2020 年7 月,Polyplus-transfection SA 為其PEIpro 轉染試劑產品組合推出了首個符合GMP 規定的殘留測試,旨在支持慢病毒和腺相關病毒(AAV) 生產的臨床前、臨床和商業流程的開發細胞和基因療法。此外,Polyplus-transfection 還推出了用於後期和商業化細胞和基因療法的 PEIpro-GMP 產品的雙重採購。因此,推出了轉染試劑和系統等產品;開發針對各種健康問題的創新產品,以創造新的或改進的產品;以及啟動新業務以保持市場競爭力,所有這些透過合作和夥伴關係都可以幫助加快轉染試劑和設備新平台的開發。
北美轉染試劑與設備市場概況
細胞和基因療法(CGT)用於治療嚴重和罕見疾病且治療需求未滿足的患者。製造 CGT 是一個高度複雜的過程,基礎設施和專業知識的不足是一個主要限制。與中間體和最終產品相關的物流相關挑戰也限制了公司的 CGT 製造能力。 CGT的製造過程包括透過「單採術」提取自體細胞,將其送往專門實驗室,然後送回診所給患者施用,所有這些都必須在嚴格的品質控制下進行。迄今為止,美國食品藥物管理局 (FDA) 僅批准了 7 種 CGT 藥物,新產品管線已達到約 1,200 種實驗療法。其中一半正在進行二期臨床試驗。根據《2023 年化學與工程新聞報告》,鑑於這些前景,細胞療法和基因療法的年銷售額預計將分別成長 15% 和 30% 左右。
許多製造商與 Labcorp、Lonza 和 Catalent 等合約開發製造組織 (CDMO) 接洽,以克服與其 CGT 產品生產和商業化相關的障礙。 Lonza 已投資約 920 萬美元來增強其細胞和基因治療製造能力。 CDMO 的此類措施正在促進美國轉染試劑和設備市場的成長。
此外,2022年2月,創新、科學與工業部長Francois-Philippe Champagne宣布透過加拿大創新基金會(CFI)向加拿大政府提供4,500萬美元資金,以確保研究團隊擁有合適的實驗室和基礎設施,以及利用技術部門進行世界一流研究的機會。加拿大衛生研究院 (CIHR) 宣布與魁北克藥物發現聯盟 (CQDM) 建立合作夥伴關係,以開展一項新的個人化醫療合作資助計劃,以加速藥物發現和藥物開發。
北美轉染試劑和設備市場收入及2030年預測(百萬美元)
北美轉染試劑與設備市場細分
北美轉染試劑和設備市場根據產品、方法、應用、最終用戶和國家進行細分。
根據產品,北美轉染試劑和設備市場分為試劑和儀器。 2022 年,試劑細分市場將佔更大佔有率。
從方法來看,北美轉染試劑和設備市場分為病毒方法、非病毒方法和混合方法。 2022 年,非病毒方法部分佔最大佔有率。非病毒部分分為物理/機械方法和化學方法。此外,物理/機械方法細分為電穿孔、顯微注射、生物彈體方法、雷射方法、磁轉染和聲穿孔。此外,化學方法部分又分為基於脂質體/高脂質和基於非脂質體/高脂質。
按應用分類,北美轉染試劑和設備市場分為生物醫學研究、蛋白質生產和治療遞送。 2022 年,生物醫學研究領域佔最大佔有率。
根據最終用戶,北美轉染試劑和設備市場分為學術和研究機構以及製藥和生物技術公司。 2022 年,學術和研究機構領域佔據了更大的佔有率。
依國家分類,北美轉染試劑和設備市場分為美國、加拿大和墨西哥。 2022年,美國主導北美轉染試劑和設備市場。
Thermo Fisher Scientific Inc、Promega Corp、F. Hoffmann-La Roche Ltd、Bio-Rad Laboratories Inc、Mirus Bio LLC、QIAGEN NV、Merck KGaA、Lonza Group AG、MaxCyte Inc 和 Polyplus-Transfection SA 是一些領先公司經營北美轉染試劑和設備市場。
The North America transfection reagents and equipment market was valued at US$ 540.57 million in 2022 and is expected to reach US$ 995.53 million by 2030; it is estimated to register at a CAGR of 7.9% from 2022 to 2030.
Strategic Initiatives by Companies Fuel North America Transfection Reagents and Equipment Market
Companies operating in the North America transfection reagents and equipment market focus on strategic developments such as collaborations, expansions, agreements, partnerships, and new product launches, which help them improve their sales, expand their geographic scope, and enhance their capacities to cater to a larger than existing customer base. These developments also contribute to the introduction of new trends to the market to a certain extent. A few of the noteworthy developments in the North America transfection reagents and equipment market are mentioned below.
In April 2023, Thermo Fisher Scientific launched the Invitrogen Neon NxT Electroporation System that facilitates transfection, even with the most challenging cell types, enabling high efficiency, cell recovery, and reproducibility. Neon NxT electrodes are optimally placed to provide minimal surface area and create a more uniform electric field, and maintain apt physiological conditions during transfection, thereby enabling the desired modification to take place in more cells and reducing the number of cells lost during the process. The new system also features an improved feedback loop and ergonomic enhancements for ease of use. In August 2021, Mirus Bio launched the TransIT VirusGEN GMP Product Line, which provides transfection reagents and enhancers to support the manufacturing of viral vectors for the development of gene therapies. The TransIT VirusGEN GMP transfection reagent was developed to enhance the delivery of transfer vaccine DNA to suspension and adherent HEK 293 cells to make the production of recombinant AAV and LV vectors more efficient. In July 2020, Polyplus-transfection SA launched the first GMP-compliant residual test for its PEIpro product portfolio of transfection reagents designed to support the development of the preclinical, clinical, and commercial process of lentivirus and adeno-associated virus (AAV) production for cell and gene therapies. In addition, Polyplus-transfection also launched dual sourcing for its PEIpro-GMP product for late-stage and commercialization cell and gene therapies. Thus, the introduction of products such as transfection reagents and systems; the development of innovative products targeting various health issues to create new or improved products; and the initiation of new businesses to remain competitive in the market, all, through collaborations and partnerships can help speed up the development of new platforms for transfection reagents and equipment.
North America Transfection Reagents and Equipment Market Overview
Cell and gene therapies (CGTs) are prescribed to treat patients suffering from serious and rare diseases with unaddressed therapeutic needs. Manufacturing CGTs is a highly complex process, with the insufficiency of infrastructure and expertise being a major limiting factor. Logistics-related challenges associated with intermediates and the final product also limit the CGT manufacturing capacity of companies. The CGT manufacturing process involves the extraction of autologous cells through "apheresis," dispatching them to specialized laboratories and sending them back to clinics for administration into patients, all of which must be performed with strict quality control. The US Food and Drug Administration (FDA) has approved only 7 CGT drugs so far, and the pipeline of new products has reached ~1,200 experimental therapies. Half of these are in Phase 2 clinical trials. With these prospects, annual sales of cell therapies and gene therapies are estimated to grow by 15% and ~30%, respectively, as stated in the Chemical & Engineering News Report 2023.
Many manufacturers approach contract development manufacturing organizations (CDMOs) such as Labcorp, Lonza, and Catalent to overcome the barriers associated with the production and commercialization of their CGT products. Lonza has invested ~US$ 9.2 million to strengthen its cell and gene therapy manufacturing capabilities. Such initiatives by CDMOs are contributing to the growth of the transfection reagents and equipment market in the US.
Furthermore, in February 2022, Francois-Philippe Champagne, the minister of Innovation, Science and Industry, announced the funding of US$ 45 million to the Government of Canada through the Canada Foundation for Innovation (CFI) to ensure that research teams have appropriate labs and infrastructure, and access to technology departments for carrying about world-class research. The Canadian Institutes of Health Research (CIHR) announced a partnership with the Quebec Consortium for Drug Discovery (CQDM) for a new collaborative funding program on personalized medicine to accelerate drug discovery and drug development.
North America Transfection Reagents and Equipment Market Revenue and Forecast to 2030 (US$ Million)
North America Transfection Reagents and Equipment Market Segmentation
The North America transfection reagents and equipment market is segmented based on product, method, application, end user, and country.
Based on product, the North America transfection reagents and equipment market is bifurcated into reagents and instruments. The reagents segment held a larger share in 2022.
In terms of method, the North America transfection reagents and equipment market is segmented into viral methods, non-viral methods, and hybrid methods. The non-viral methods segment held the largest share in 2022. The viral segment is sub categorized into retrovirus, adenovirus, adeno associated virus, and herpes virus. The non-viral segment is bifurcated into physical/mechanical method and chemical method. Further, the physical/mechanical method segment is sub categorized into electroporation, microinjection, biolistic method, laser method, magnetofection, and sonoporation. Also, the chemical method segment is sub categorized into liposomal based/high lipid and non-liposomal/high lipid based.
By application, the North America transfection reagents and equipment market is segmented into biomedical research, protein production, and therapeutic delivery. The biomedical research segment held the largest share in 2022.
Based on end user, the North America transfection reagents and equipment market is bifurcated into academics & research institutes and pharmaceutical & biotechnology companies. The academics & research institutes segment held a larger share in 2022.
Based on country, the North America transfection reagents and equipment market is categorized into the US, Canada, and Mexico. The US dominated the North America transfection reagents and equipment market in 2022.
Thermo Fisher Scientific Inc, Promega Corp, F. Hoffmann-La Roche Ltd, Bio-Rad Laboratories Inc, Mirus Bio LLC, QIAGEN NV, Merck KGaA, Lonza Group AG, MaxCyte Inc, and Polyplus-Transfection SA are some of the leading companies operating in the North America transfection reagents and equipment market.