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市場調查報告書
商品編碼
1519389
2024-2032 年按技術、產品和服務、應用、最終用戶和地區分類的高通量篩選市場報告High-throughput Screening Market Report by Technology, Products and Services, Applications, End User, and Region 2024-2032 |
IMARC Group年,全球高通量篩選市場規模達252億美元。 3D細胞培養模型的採用增加、個人化藥物篩選分析的需求不斷成長以及基於CRISPR的篩選技術的應用不斷增加是推動高通量篩選市場成長的一些關鍵因素。
主要市場促進因素:擴大利用高溫超導技術來最大限度地縮短藥物製造所需的時間,這主要推動了市場的成長。此外,治療各種危及生命的疾病的新藥的開發也刺激了對高溫超導技術的需求。
主要市場趨勢:將人工智慧(AI)和機器學習(ML)等先進技術與高通量篩選相結合以促進自動化和快速資料處理是重要趨勢之一,促進了市場的成長。
地理景觀:高通量篩選市場預測報告提供了基於區域的詳細市場區隔和分析。其中包括北美、亞太地區、歐洲、拉丁美洲、中東和非洲。由於高通量篩選的日益採用、研發支出的增加以及組合化學和基因組學領域的不斷進步等因素,預計北美將在高通量篩選市場中佔據重要的市場佔有率。
競爭格局:一些領先的高通量篩選市場公司包括安捷倫科技公司、Aurora Biomed Inc.、Axxam SpA、Beckman Coulter Inc.(丹納赫公司)、Bio-RAD Laboratories Inc.、Charles River Laboratories International Inc.、康寧Incorporated、Luminex Corporation (DiaSorin)、Perkinelmer Inc.、Sygnature Discovery、Tecan Group Ltd. 和 Thermo Fisher Scientific 等。
挑戰與機會:高通量篩選市場的挑戰包括資料管理複雜性和對更多生理相關檢測模型的需求,而機會則在於自動化、人工智慧和晶片器官系統等先進技術,以提高效率和預測篩選過程。
高溫超導設施數量不斷增加
用於治療各種危及生命的疾病的新藥的開發主要推動了市場的成長。此外,為了最大限度地減少藥物製造所需時間而使用 HTS 的增加也促進了市場的成長。除此之外,高通量篩選(HTS)設施數量的不斷增加也催化了高通量篩選市場的近期價格上漲。這些中心的顯著優勢之一是研究人員、科學家、研究人員等之間的知識共享。此外,美國國立衛生研究院 (NIH) 計畫的歐洲對應計畫(稱為 EU-open-screen)為所有從事化學生物學的歐洲公司提供開放存取。高通量篩選(HTS)中心協會旨在提供有關藥物或標靶或整個過程的有用資訊。因此,開放取用為知識共享提供了更好的平台,有助於加速藥物開發進程,這可能會在未來幾年推動高通量篩選市場佔有率。
新型分子的不斷發展
各種傳染病患者病率的上升正在推動新型分子和疫苗的開發,這反過來又為高通量篩檢市場創造了積極的前景。此外,在藥物製造過程中對各種藥物和分子的精確和快速篩選的需求不斷增加,導致擴大採用自動化高通量篩選技術。此外,由於高通量篩選方法具有高靈敏度、自動化、樣品最小化以及檢測低背景訊號的能力等各種優勢,各種製藥和生物製品公司擴大採用高通量篩選方法,這支撐了高通量篩選方法的發展。根據美國國會預算辦公室公佈的資料,2021年,全球製藥業在研發上的支出接近2,000億美元,而2019年為8,300萬美元。為17.42 億美元,而2020 年為13.48 億美元。 此外,Bio-Rad Laboratories Inc. 2021 年的投資為8.796 億美元,而2020 年為8.003 億美元。量篩選分析中採用創新技術的能力,因而促進了市場成長。
技術進步
近年來,在機器人技術、自動化、資料分析和小型化不斷創新的推動下,高通量篩選(HTS)技術取得了顯著進展。此外,自動化和機器人技術的進步極大地提高了 HTS 工作流程的速度和效率。自動化液體處理系統、讀板機和機器人平台現在可以高精度和高通量地執行重複性任務,從而減少了手動干預的需要。此外,各種領先的生物技術公司也在投資研發活動,以引入改進的高溫超導方法,預計這將推動高通量篩選市場的收入。例如,2024 年2 月,生命科學分析技術領域的全球領導者SCIEX 在SLAS 2024 上推出了Echo MS+ 系統。相結合: SCIEX ZenoTOF 7600 或 Triple Quad 6500+ 系統透過強大的高通量篩選工作流程的擴展面板提供精確的定性和定量結果。
IMARC Group提供了全球高通量篩選市場報告每個細分市場的主要趨勢分析,以及 2024 年至 2032 年全球、區域和國家層面的預測。我們的報告根據技術、產品和服務、應用程式以及最終用戶對市場進行了分類。
超高通量篩選
基於細胞的檢測
晶片實驗室
無標籤技術
該報告基於該技術對市場進行了詳細的細分和分析。這包括超高通量篩選、基於細胞的測定、晶片實驗室和無標記技術。
高通量篩選市場概況表明,各種製藥和生物技術公司擴大使用基於細胞的檢測方法。高通量篩選中基於細胞的測定利用活細胞作為化合物測試的生物讀數,能夠以高通量方式評估候選藥物對細胞功能、活力和表現型的影響,通常用於藥物發現和毒性篩選。螢光成像讀板儀測定已成為最常用的基於細胞的測定,因為其結果可見並且能夠以最小的體積進行測試。除此之外,超高通量篩選是最新技術,用於在更短的時間內提高產量。大多數公司正處於從 2D 細胞培養到 3D 細胞培養的過渡階段,因為 3D 細胞在自然環境和其他細胞相關操作中進行測試時顯示出更逼真的特性,有助於藥物設計和發現。
儀器
試劑和試劑盒
服務
高通量篩選市場報告根據產品和服務對市場進行了詳細的細分和分析。這包括儀器、試劑和套件以及服務。
高通量篩選依賴專用儀器,例如自動液體處理機、讀板器和機器人平台。這些儀器能夠快速處理、分配和分析微孔板形式的樣品,從而提高篩選實驗的效率和通量。而用於高通量篩選的試劑和試劑盒包括化合物庫、生化分析以及檢測試劑,例如螢光探針或酵素底物。這些經過最佳化,可與自動化系統和小型化測定格式相容,從而可以根據特定的生物標靶或途徑篩選大型化合物庫。
目標識別和驗證
初級和次級篩選
毒理學評估
其他
該報告根據應用程式提供了詳細的市場細分和分析。這包括目標識別和驗證、初步和二次篩選、毒理學評估等。
目標識別和驗證涉及識別和驗證與疾病或生物過程有關的分子目標(例如蛋白質、基因或細胞途徑)。透過基因組學、蛋白質組學和生物資訊學等各種方法,識別並驗證潛在目標,以確保其相關性和可拖曳性以進行進一步研究。而在初級和二級篩選中,針對特定標靶或生物測定對大型化合物庫進行測試,以識別顯示活性或調節的初始命中。該方法涉及對命中化合物進行更詳細的表徵,以確認其活性、選擇性和效力。初級和次級篩選通常包括劑量反應研究、反篩選和次級測定,以驗證命中並優先考慮先導化合物最佳化和臨床前開發。
製藥和生物技術公司
學術和政府機構
合約研究組織
其他
該報告提供了基於最終用戶的詳細市場細分和分析。這包括製藥和生物技術公司、學術和政府機構、合約研究組織等。
根據IMARC的高通量篩選市場統計數據,製藥公司和政府組織的研發支出最近一直在增加,預計這將在預測期內推動市場成長。例如,全球領先的生命科學和診斷創新企業丹納赫公司(Danaher Corporation) 2021 年的研發投資為17.42 億美元,而2020 年為13.48 億美元。美元。
北美洲
美國
加拿大
亞太
中國
日本
印度
韓國
澳洲
印尼
其他
歐洲
德國
法國
英國
義大利
西班牙
俄羅斯
其他
拉丁美洲
巴西
墨西哥
其他
中東和非洲
市場研究報告還對所有主要區域市場進行了全面分析,其中包括北美(美國和加拿大);歐洲(德國、法國、英國、義大利、西班牙、俄羅斯等);亞太地區(中國、日本、印度、韓國、澳洲、印尼等);拉丁美洲(巴西、墨西哥等);以及中東和非洲。
由於高通量篩選的日益採用、研發支出的增加以及組合化學和基因組學領域的不斷進步等多種因素,預計北美將在高通量篩選市場中佔據重要的市場佔有率。除此之外,該地區知名市場參與者的存在也對高通量篩選市場前景產生正面影響。例如,2021 年8 月,Becton、Dickinson 和Company 推出了一種新型全自動高通量診斷系統,使用機器人技術和樣本管理軟體演算法,為核心實驗室和其他集中實驗室的傳染病分子檢測自動化設定了新標準在美國。此次發布使得 BD Onclarity HPV Assay 具有針對 BD COR 系統的擴展基因分型,可供高通量實驗室處理美國大多數持續感染人類乳突病毒 (HPV) 的子宮頸癌篩檢標本。
The global high-throughput screening market size reached US$ 25.2 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 49.0 Billion by 2032, exhibiting a growth rate (CAGR) of 7.5% during 2024-2032. The increased adoption of 3D cell culture models, growing demand for personalized medicine screening assays, and rising application of CRISPR-based screening techniques are some of the key factors driving high-throughput screening market growth.
Major Market Drivers: The increasing utilization of HTS for minimizing the time required for manufacturing a drug is primarily driving the growth of the market. Furthermore, the development of new medicines for treating various life-threatening diseases is also catalyzing the demand for HTS techniques.
Key Market Trends: Integration of advanced technologies, such as artificial intelligence (AI) and machine learning (ML) with high-throughput screening to facilitate automation and fast data processing is one of the significant trends, augmenting the growth of the market.
Geographical Landscape: The high-throughput screening market forecast report has provided a detailed breakup and analysis of the market based on the region. This includes North America, Asia Pacific, Europe, Latin America, and Middle East and Africa. North America is expected to hold a significant market share in the high-throughput screening market owing to factors such as the increasing adoption of high-throughput screening, rising research and development expenditure, and the growing advances in combinatorial chemistry and the field of genomics.
Competitive Landscape: Some of the leading high-throughput screening market companies include Agilent Technologies Inc., Aurora Biomed Inc., Axxam S.p.A, Beckman Coulter Inc. (Danaher Corporation), Bio-RAD Laboratories Inc., Charles River Laboratories International Inc. Corning Incorporated, Luminex Corporation (DiaSorin), Perkinelmer Inc., Sygnature Discovery, Tecan Group Ltd., and Thermo Fisher Scientific, among many others.
Challenges and Opportunities: Challenges in the high-throughput screening market include data management complexities and the need for more physiologically relevant assay models, while opportunities lie in advancing technologies like automation, artificial intelligence, and organ-on-a-chip systems for more efficient and predictive screening processes.
Increasing Number of HTS Facilities
The development of new medicines for treating various life-threatening diseases is primarily driving the growth of the market. Furthermore, the rise in the utilization of HTS for minimizing the time required for manufacturing a drug is also contributing to the market growth. In addition to this, the escalating number of high-throughput screening (HTS) facilities is also catalyzing the high-throughput screening market's recent prices. One of the significant advantages of these centers is knowledge sharing among investigators, scientists, researchers, etc. For instance, the Columbia Genome Center offers high-quality molecular screening services for investigators throughout the Columbia University research community. Also, the European counterpart of the National Institutes of Health (NIH) program, known as EU-open-screen, provides open access to all European companies engaged in chemical biology. The association of high-throughput screening (HTS) centers is intended to provide useful information about the drug or target or the entire process. Thus, open access provides a better platform for knowledge sharing and can help accelerate the drug development process, which may drive the high-throughput screening market share in the coming years.
Rising Development of Novel Molecules
The rising prevalence of various infectious diseases is prompting the development of novel molecules and vaccines, which in turn is creating a positive outlook for the high-throughput screening market. Moreover, the escalating need for precise and quick screening of various drugs and molecules during the manufacturing of a drug is resulting in an increased adoption of automated high-throughput screening techniques. Furthermore, various pharmaceutical and biologic firms are increasingly adopting high-throughput screening methods on account of their various advantages, such as high sensitivity, automation, minimization of the sample, and the ability to detect low background signals, which is bolstering the high-throughput screening market demand. According to the data published by the Congressional Budget Office, in 2021, it was observed that pharmaceutical industries spent nearly US$ 200 Billion on research and development in 2020 globally, compared to US$ 83 Million in 2019. Similarly, Danaher Corporation invested US$ 1,742 Million in its research and development in 2021, as compared to US$ 1,348 Million in 2020. In addition, Bio-Rad Laboratories Inc. invested US$ 879.6 Million in 2021 as compared to US$ 800.3 Million in 2020. Thus, the increasing investment in research and development by the companies further increases their capabilities to adopt innovative technologies in high throughput screening assays, thereby increasing the market growth.
Technological Advancements
High-throughput screening (HTS) techniques have seen significant advancements in recent years, driven by the continuous innovations in robotics, automation, data analysis, and miniaturization. Moreover, advances in automation and robotics are extensively increasing the speed and efficiency of HTS workflows. Automated liquid handling systems, plate readers, and robotic platforms can now perform repetitive tasks with high precision and throughput, reducing the need for manual intervention. Additionally, various leading biotech companies are also investing in research and development activities to introduce improved HTS methods which are anticipated to propel the high-throughput screening market revenue. For instance, in February 2024, SCIEX, a global leader in life science analytical technologies, launched the Echo MS+ system at SLAS 2024. The system couples proprietary Acoustic Ejection Mass Spectrometry technology and Open Port Interface (OPI) sampling with the capabilities of either the SCIEX ZenoTOF 7600 or Triple Quad 6500+ system to deliver precise qualitative and quantitative results through an expanded panel of robust high-throughput screening workflows.
IMARC Group provides an analysis of the key trends in each sub-segment of the global high-throughput screening market report, along with forecasts at the global, regional, and country levels from 2024-2032. Our report has categorized the market based on technology, products and services, applications, and end user.
Ultra-High-Throughput Screening
Cell-Based Assays
Lab-on-a-Chip
Label-Free Technology
The report has provided a detailed breakup and analysis of the market based on the technology. This includes ultra-high throughput screening, cell-based assays, lab-on-a-chip, and label-free technology.
The high-throughput screening market overview indicates that cell-based assays are increasingly being used by various pharmaceutical and biotech companies. Cell-based assays in high-throughput screening utilize live cells as the biological readout for compound testing, enabling the evaluation of drug candidates' effects on cellular function, viability, and phenotype in a high-throughput manner, often employed in drug discovery and toxicity screening. Fluorometric imaging plate reader assays have become the most used cell-based assays owing to visible results and their ability to test with the smallest of volumes. Besides this, ultra-high-throughput screening is the latest technology and is used for increased output in less time. A majority of companies are in a transition phase from 2D-cell cultures to 3D-cell cultures as 3D cells show more lifelike properties while testing in the natural environment and other cell-related manipulations, aided for drug design and discovery.
Instruments
Reagents and Kits
Services
The high-throughput screening market report has provided a detailed breakup and analysis of the market based on the products and services. This includes instruments, reagents and kits, and services.
High-throughput screening relies on specialized instruments, such as automated liquid handlers, plate readers, and robotic platforms. These instruments enable the rapid handling, dispensing, and analysis of samples in microplate formats, thereby increasing the efficiency and throughput of screening experiments. Whereas reagents and kits that are used in high-throughput screening include compound libraries, biochemical assays, and detection reagents such as fluorescent probes or enzyme substrates. These are optimized for compatibility with automated systems and miniaturized assay formats, allowing for the screening of large compound libraries against specific biological targets or pathways.
Target Identification and Validation
Primary and Secondary Screening
Toxicology Assessment
Others
The report has provided a detailed breakup and analysis of the market based on the application. This includes target identification and validation, primary and secondary screening, toxicology assessment and others.
Target identification and validation involves identifying and validating molecular targets (such as proteins, genes, or cellular pathways) that are implicated in a disease or biological process. Through various methods, including genomics, proteomics, and bioinformatics, potential targets are identified and then validated to ensure their relevance and draggability for further investigation. Whereas in primary and secondary screening large libraries of compounds are tested against a specific target or biological assay to identify initial hits that show activity or modulation. This method involves a more detailed characterization of hit compounds to confirm their activity, selectivity, and potency. Primary and secondary screening typically includes dose-response studies, counter-screens, and secondary assays to validate hits and prioritize them for lead optimization and preclinical development.
Pharmaceutical and Biotechnology Firms
Academic and Government Institutes
Contract Research Organizations
Others
The report has provided a detailed breakup and analysis of the market based on the end user. This includes pharmaceutical and biotechnology firms, academic and government institutes, contract research organizations, and others.
According to high-throughput screening market statistics by IMARC, the spending on research and development (R&D) by both pharmaceutical companies and government organizations has been increasing recently, which is anticipated to drive market growth over the forecast period. For instance, Danaher Corporation, a leading global life sciences and diagnostics innovator, invested US$ 1,742 Million in its research and development in 2021, as compared to US$ 1,348 Million in 2020. In addition, Bio-Rad Laboratories Inc. invested US$ 879.6 Million in 2021 as compared to US$ 800.3 Million in 2020. Thus, the huge investment by pharmaceuticals, biotech firms, and government institutions will continue to drive the market growth.
North America
United States
Canada
Asia-Pacific
China
Japan
India
South Korea
Australia
Indonesia
Others
Europe
Germany
France
United Kingdom
Italy
Spain
Russia
Others
Latin America
Brazil
Mexico
Others
Middle East and Africa
The market research report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa.
North America is expected to hold a significant market share in the high-throughput screening market owing to various factors such as the increasing adoption of high-throughput screening, rising research and development expenditure, and the growing advances in combinatorial chemistry and the field of genomics. In addition to this, the presence of prominent market players in the region is also positively impacting the high-throughput screening market outlook. For instance, in August 2021, Becton, Dickinson, and Company launched a new, fully automated high-throughput diagnostic system using robotics and sample management software algorithms to set a new standard in automation for infectious disease molecular testing in core laboratories and other centralized laboratories in the United States. This launch made BD Onclarity HPV Assay with extended genotyping for the BD COR System available to the high-throughput labs for processing most cervical cancer screening specimens in the United States with persistent infection with human papillomavirus (HPV).
Agilent Technologies Inc.
Aurora Biomed Inc.
Axxam S.p.A
Beckman Coulter Inc. (Danaher Corporation)
Bio-RAD Laboratories Inc.
Charles River Laboratories International Inc.
Corning Incorporated
Luminex Corporation (DiaSorin)
Perkinelmer Inc.
Sygnature Discovery
Tecan Group Ltd
Thermo Fisher Scientific
(Please note that this is only a partial list of the key players, and the complete list is provided in the report.)
April 2024: Gordian Biotechnology introduced a high-throughput in vivo screening platform to discover therapies and better predict human outcomes for age-related diseases.
April 2024: Metrion Biosciences Limited and Enamine Ltd., announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine's compound libraries.
February 2024: SCIEX, a global leader in life science analytical technologies, launched the Echo MS+ system at SLAS 2024. The system couples proprietary Acoustic Ejection Mass Spectrometry technology and Open Port Interface (OPI) sampling with the capabilities of either the SCIEX ZenoTOF 7600 or Triple Quad 6500+ system to deliver precise qualitative and quantitative results, through an expanded panel of robust high-throughput screening workflows.