市場調查報告書
商品編碼
1574655
全球癌症抗體藥物複合物市場:市場規模、藥物批准、價格、銷售和臨床試驗的見解(2030)Global Cancer Antibody Drug Conjugates Market Size, Drugs Approval, Price, Sales & Clinical Trials Insight 2030 |
抗體藥物複合物(ADC)已成為癌症治療中的創新治療劑,它將單株抗體的特異性與細胞毒性藥物的功效相結合。這種創新療法由透過穩定連接體與細胞毒性藥物結合的抗體組成,可針對癌細胞,同時最大限度地減少對周圍健康組織的損害。抗體藥物複合物的快速發展反映了它們在臨床和商業上的成功,目前有16個產品在各個市場獲得批准,銷售額預計將在2023年達到100億美元,並在2024年首次達到6個月內超過70億美元。這種成長凸顯了抗體藥物複合物是更廣泛的癌症藥物市場中商業上可行的部分,並推動了研究和開發工作,以創造更有效和安全的候選化合物。
截至2024年 10月,全球監管機構已批准 16 種抗體藥物複合物,其中 13 種目前可用於臨床用於治療各種癌症類型。其中,代表性的有Padceb、Kadcyla、Enherz等,2023年將佔抗體藥物複合物總銷售額的60%左右。 Enhertu 適用於治療多種 HER2 陽性實體腫瘤,而 Padcev 和 Kadcyla 僅分別被批准用於治療膀胱癌和乳癌。這些產品類型顯示市場對 ADC 的治療潛力以及治療各種癌症類型的有效性越來越有信心。
全球癌症抗體藥物複合物市場的特點是競爭格局,針對包括實體腫瘤和血液惡性腫瘤在內的多種癌症的積極發展。然而,其中肺癌目前的開發活動最為廣泛,有超過60個候選藥物處於臨床試驗中,包括CAB-AXL-ADC、TQB2102和MYTX-011,其中一個Enhertu已經獲得批准。這反映出肺癌治療的策略轉變,肺癌仍然是全球癌症死亡的主要原因之一,並且有很高的未滿足的醫療需求。抗體-藥物複合物有可能提供更有效、毒性更小的治療選擇,並且在該治療領域特別有吸引力。
功能 | 詳細資料 |
---|---|
關鍵片段 | 應用:癌症類型、區域、技術平台 |
涵蓋的適應症 | 目標疾病:肺癌、乳癌、子宮頸癌、胰臟癌、食道癌等 |
主要目標國 | 美國、中國、韓國、加拿大、印度等 |
目標藥 | Enhertu、Adcetris、Polivy、Kadcyla 等 |
報告範圍 | 作用模式、ADC生成、管道和批准的藥物見解、銷售見解、當前趨勢、未來機會、市場驅動因素和挑戰 |
目標公司 | Biocytogen、Merck、AstraZeneca、Pfizer、Daiichi Sankyo、ADC Therapeutics等 |
本報告調查了全球癌症抗體藥物複合物市場,並提供了市場概況以及藥物趨勢、臨床試驗趨勢、區域趨勢以及進入市場的公司的競爭格局。
"Global Cancer Antibody Drug Conjugates Market Size, Drugs Approval, Price, Sales & Clinical Trials Insight 2030" Report Finding and Inclusions:
Features | Details |
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Key Segments: | Application by Cancer Type, By Region, Technology Platforms |
Indications Covered: | Lung Cancer, Breast Cancer, Cervical Cancer, Pancreatic Cancer, Pancreatic Cancer, Esophageal Cancer, among others |
Key Countries Covered: | US, China, South Korea, Canada, India, among others |
Drugs Covered: | Enhertu, Adcetris, Polivy, Kadcyla, among others |
Report Coverage: | Mechanism of Action, ADC Generations, Pipeline & Approved Drugs Insight, Sales Insight, Current Trends, Future Opportunities, Market Drivers & Challenges |
Companies Covered: | Biocytogen, Merck, AstraZeneca, Pfizer, Daiichi Sankyo, ADC Therapeutics, among others |
Antibody drug conjugates (ADCs) have emerged as a transformative class of therapeutics in the cancer treatment landscape, integrating the specificity of monoclonal antibodies with the potency of cytotoxic drugs. These innovative therapies consist of an antibody linked to a cytotoxic agent through a stable linker, allowing targeted delivery to cancer cells while minimizing damage to surrounding healthy tissues. The rapid evolution of antibody drug conjugates reflects their clinical and commercial success, with 16 products currently approved across various markets and sales surpassing US$ 10 Billion in 2023 and US$ 7 Billion in the first 6 months of 2024. This growth highlights antibody drug conjugates as a commercially viable segment of the broader cancer therapeutics market, prompting increased research and development efforts to create more effective and safer candidates.
As of October 2024, regulatory authorities around the world have approved 16 antibody drug conjugates, with 13 currently available for clinical use for different cancer types. Among these, prominent examples include Padcev, Kadcyla, and Enhertu, which collectively accounted for approximately 60% of the total antibody drug conjugates sales in 2023. While Enhertu is indicated for the treatment of several HER2-positive solid cancers, Padcev and Kadcyla are solely approved for the treatment of bladder cancer and breast cancer, respectively. The commercialization of these products demonstrates not only their therapeutic potential but also the market's growing confidence in the effectiveness of ADCs in managing various cancer types.
Global cancer antibody drug conjugates market is characterized by a competitive landscape, with substantial development efforts targeting multiple cancers, including both solid tumors and hematological malignancies. However, out of all these, lung cancer is currently witnessing the most extensive development activity, with over 60 candidates in clinical trials, including CAB-AXL-ADC, TQB2102, and MYTX-011, and one Enhertu, approved for use in clinical setting. This reflects a strategic shift towards addressing the high-unmet medical need in lung cancer, which remains one of the leading causes of cancer mortality worldwide. The potential for antibody drug conjugates to provide more effective and less toxic treatment options makes them particularly attractive in this therapeutic area.
In contrast, however, breast cancer has experienced the highest number of antibody drug conjugates approvals to date, with four approved candidates, contributing significantly to the market's commercial success. Two key players in this domain are the aforementioned Kadcyla and Enhertu, both of which have demonstrated remarkable efficacy and have achieved significant sales milestones. The promising pipeline also includes AstraZeneca and Daiichi Sankyo's Datopotamab Deruxtecan, a TROP2-directed antibody drug conjugate that is currently under review for its use in breast cancer treatment. This continued investment in research and development underscores the critical role antibody drug conjugates play in advancing cancer care.
Regionally, the cancer antibody drug conjugates market is primarily led by the US and China, two of the largest and most dynamic pharmaceutical markets globally. In the US, robust healthcare infrastructure, high R&D expenditure, and a favorable regulatory environment foster innovation and accelerate the approval process for new therapies. Additionally, the presence of major pharmaceutical companies, such as Regeneron, Gilead, Merck and Pfizer, bolsters the competitive landscape, enabling rapid development and commercialization of antibody drug conjugates.
In China, the growing demand for advanced cancer treatments, coupled with increasing government support for biotechnology and pharmaceutical research, has catalyzed significant growth in the antibody drug conjugates sector. Local players like Mabwell, Miracogen, Chia Tai Tianqing Pharmaceutical, Hansoh BioMedical, Sichuan Baili Pharmaceuticals, Biocytogen and Affinity Biopharma are emerging as significant contributors to the market, developing novel Antibody drug conjugates tailored to the specific needs of the Chinese patient population, and out licensing promising candidates to their international counterparts through license agreements.
The global market for cancer antibody drug conjugates represents a dynamic and rapidly evolving segment of the cancer therapeutics landscape. With ongoing clinical trials, innovative research, and increasing regulatory support, antibody drug conjugates are poised to play an increasingly pivotal role in cancer treatment. As efforts continue to address existing challenges and expand the range of approved indications, the future of antibody drug conjugates appears promising, offering hope to patients worldwide in the fight against cancer. The collaborative efforts among pharmaceutical companies, regulatory bodies, and research institutions will be crucial in shaping the next wave of advancements in this exciting therapeutic field.