SDi 空間生物學市場分析（2023）：市場機會分析

SDi Spatial Biology 2023 Market Opportunity Report

出版日期: 2023年11月22日 | 出版商:

Strategic Directions International, Inc. | 英文 201 Pages | 商品交期: 最快1-2個工作天內

價格

簡介目錄

空間生物市場分析與展望

太空生物學一詞是指科學家在 3D 環境中收集細胞資訊的一組技術。傳統上，研究重點是分離的細胞和組織並檢查它們的分子組成。然而，這種方法通常缺乏感興趣的細胞和組織的空間背景。例如，批量 RNA 定序會失去細胞異質性，而單細胞 RNA 定序提供的有關組織周圍環境的資訊很少，因此很難全面了解細胞環境。然而，先進空間生物學的進步使科學家更接近透過識別和定位目標組織內的不同細胞群來填補拼圖中缺少的部分。一旦獲得空間背景，就可以得出有關各種生理和病理過程的更詳細的結論。

為了保存組織內的空間訊息，必須在保護其環境的同時分離 RNA。條碼（例如寡核甘酸）通常用於單獨標記組織內的 RNA 並保護其周圍環境。然後研究人員可以檢查細胞間相互作用、組織組成和細胞內異質性。然而，分辨率和特異性的限制仍然是挑戰，各種方法正在不斷改進和開發以擴展當前的分辨率限制和適用性。在工作流程方面，供應商正在尋求改進目前的方法並使某些部分自動化。

空間組學設備包括在定序前對轉錄本中的位置資訊進行編碼的下一代定序鹼基，以及原位定序（ISS）或螢光原位雜交（FISH）。它可以大致分為採用成像鹼基然而，隨著技術的發展，沒有任何一種技術可以通用，空間組學設備通常會結合這兩個類別的元素。

基於成像的方法通常使用顯微鏡。 Nanostring 的 GeoMX 和 10x Genomics Visium 等新儀器是空間分析儀，可對組織中的蛋白質和 mRNA 進行高複數（10-10,000）數位量化。

空間研究的另一種技術是 MALDI-TOF 質譜法。利用質譜分析，研究人員可以了解蛋白質的代謝功能，包括 ATP 和脂質等代謝物的形成。與 IHC 和 FISH 不同，空間 MS 是無標記的。與 MALDI 和 DESI 結合，可以直接同時對數百至數千個分子進行成像。最後，使用 NGS 和 RNA 執行基於定序的方法來捕獲空間訊息，然後進行定序。

無論採用哪種方法，太空生物學設備的創新都在加速，公司正在響應對突破性技術的需求，這些技術將使科學家能夠加強他們的研究並開發新的治療方法。這就是我的意思。

本報告透過對北美和歐洲製藥/生物技術/CRO、臨床和公共部門的空間生物學專業人員的調查，提供了最終用戶的觀點。我們也正在考慮工作流程中使用的太空生物學技術、設備和消耗品當前/未來的使用，以及可能的改進。此外，我們還會為您提供空間生物學的使用目的、各種技術和設備的使用頻率、特定技術和設備的使用頻率、當前供應商、未來的採購計劃和預算預測等資訊。

本報告著眼於影響該行業的動態和眾多市場趨勢，並分析其對空間組學成像設備銷售成長的影響。作為分析儀器市場研究的領先供應商，SDi 創建了這份報告來評估和解釋目前推動這一重要市場的因素。本報告中的分析設備市場包括太空生物學技術中使用的染色設備、耗材、空間組學成像設備、顯微鏡、核磁共振、紅外線設備等。這些設備分為五種不同的技術，構成了整個市場。

分析概述

本報告按技術、地區、領域和功能對市場需求進行分類，並提供即將到來的市場趨勢的預測（截至 2027 年）。市場估算以 2022 年為基準年，並對以下技術進行估算：
- 顯微鏡
- 其他影像設備
- 空間組學影像設備
- MALDI-TOF
- 樣品製備
按地區劃分的最新市場趨勢和詳細趨勢：美國/加拿大、歐洲、中國、日本、印度/亞太其他地區、拉丁美洲和世界其他地區 (RoW)。
市場進入供應商的供應商份額：依技術類別。市場上的一些頂級供應商是（按字母順序排列）：

10x Genomics
Abcam PLC
Agilent
Akoya Biosciences
Biocare Medical LLC
bioMérieux
Bio-Techne
Bruker
CellSignaling Technologies
Fortis Life Sciences

Histo-Line Laboratories
Jenoptik
JEOL
Miltenyi Biotech
Motic
NanoString Technologies
Nikon
Thermo
Waters
ZEISS

The term Spatial Biology is used to describe a series of techniques with which scientists collect cellular information in the context of their 3D environment. Traditionally, studies have focused on isolated cells or tissues and looking at their molecular composition. However, these approaches often lacked the spatial context of the cells or tissues of interest. For instance, in bulk RNA sequencing, cellular heterogeneity is lost, while single-cell RNA sequencing generates minimal information regarding the tissues' surroundings; therefore developing a whole picture of a cell's environment proved difficult. However, with developments in advanced spatial biology, scientists are closer to filling the missing piece of the puzzle by identifying and localizing different cell populations within a tissue of interest. With the spatial context in hand, more in-depth conclusions can be drawn regarding various physiological and pathological processes.

For spatial information to be preserved in tissue, the RNA needs to be isolated while protecting its environment. Often, barcodes such as oligonucleotides are used to individually label the RNA in the tissue and hence preserve the surrounding environment. Researchers can then look at the cell-to-cell interactions, tissue composition and intracellular heterogeneity. However, limitations to resolution and specificity are still an issue, with various methods constantly being improved or developed to expand current resolution limits and applicability. In terms of workflow, vendors are looking to improve current methods and automate certain parts.

Spatial omics instruments can be broadly classified as next generation sequencing-based, which encode positional information onto transcripts before sequencing takes place, or imaging- based, which employ either in situ sequencing (ISS) or fluorescence in situ hybridization (FISH). However, as technology evolves, no one technique is clear-cut, and often spatial omics instruments incorporate elements of both categories.

Imaging-based methods are typically carried out using a microscope. Newer instrumentation such as Nanostring's GeoMX and 10x Genomics Visium are spatial profilers enabling high plex (10s-10,000s) digital quantitation of proteins and mRNA in tissues

An alternative technology in spatial studies is MALDI-TOF Mass Spectrometry. Utilizing mass spectrometry allows researchers to understand the metabolic functions of proteins, such as the formation of metabolites like ATP and lipids. Unlike IHC or FISH, spatial MS is label-free. Emerging methods using metal-isotope tagged tissue are also entering the market that, when coupled with MALDI or DESI, enable the direct and simultaneous imaging of hundreds to thousands of molecules. Lastly, sequencing-based methods are performed using NGS and RNA with spatial information captured and subsequently sequenced.

Regardless of the technique, innovation in spatial biology instrumentation is accelerating and companies are looking to meet the demand for breakthrough technologies to enable scientists to enhance research and develop novel therapies.

This report includes End User Perspectives derived from a survey of spatial biology experts from North America and Europe in the pharma/biotech/CRO, clinical, and public sectors. They offer insights into the current and future use of spatial biology techniques, instruments and consumables used in workflows, as well as improvements that can be made. End users share their applications utilizing spatial biology, how often they use various techniques and instruments, how often they use a particular technique or instrument, which vendors they currently purchase from, future purchase plans, and budget projections.

SDi's “2023 Spatial Biology Market” report observes the dynamics and numerous market trends influencing the industry and analyzes their effect on sales growth for spatial-omics imaging instrumentation. As the leading provider of market research on analytical instrumentation, SDi has crafted this report to evaluate and explain what is currently driving this important market. The analytical instrument market in this report includes staining equipment, consumables, spatial-omics imaging instruments, microscopes, NMR, and IR instruments utilized in spatial biology techniques. These instruments are categorized into five different technologies which build the overall market.

Report Overview:

Market demand segmented by technique, region, sector, and function, along with yearly market forecasts through 2027. The market estimates include 2022 as the base year and estimates are provided for the following techniques:
- Microscopy
- Other Imaging Systems
- Spatial Omics Imaging Instruments
- MALDI-TOF
- Sample Preparation

Recent developments and regional trends for the Unites States & Canada, Europe, China, Japan, India & Other Asia-Pacific, Latin America & the Rest of the World.

Vendor share of participating suppliers in each technology category. Some of the top vendors in the overall market are presented below, in alphabetical order: