全球下游加工市場規模、佔有率、成長分析、按產品、按技術 - 產業預測，2024-2031 年

Global Downstream Processing Market Size, Share, Growth Analysis, By Product(Chromatography Systems, Filters), By Technique(Cell Disruption, Solid-Liquid Separation) - Industry Forecast 2024-2031

出版日期: 2024年03月27日 | 出版商:

SkyQuest | 英文 219 Pages | 商品交期: 3-5個工作天內

價格

簡介目錄

2022年全球下游加工市場規模為309.8億美元，從2023年的356.9億美元成長到2031年的1107.9億美元，預測期間（2024-2031年）複合年成長率為15.21%。

在下游加工中，從發酵液、植物組織和動物組織等天然來源中提取和精製生物合成產品，特別是藥物。這個過程不僅可以安全地處理廢棄物，還可以回收可重複使用的組件。它是激素、疫苗（如胰島素和人體生長荷爾蒙）、抗體（如Infliximab和阿昔單抗）和抗生素等藥品生產中極為重要的製程。例如，2022年4月，默克與無錫國家高新技術產業開發區簽署合作協議，默克在中國江蘇省無錫市的製造工廠擴建。下游加工包括加工產品的各個步驟，例如使用化學、物理和生物技術的細胞分離、過濾、產品回收、萃取和精製。其結果是生物和醫藥產品，如疫苗、重組蛋白和酵素、抗生素、抗體、荷爾蒙、診斷和工業酵素以及天然香料和風味化合物。有幾個因素正在推動全球對生物製藥的需求，包括生物加工能力的擴大、生物加工中一次性技術的接受度提高、製藥公司的研發支出增加以及生物製藥市場的需求不斷成長。儘管前景樂觀，但全球下游加工市場面臨著可能阻礙成長的挑戰，例如下游加工設備和消耗品的高成本。對於中小型生技公司和新興企業來說，此類初始資本投資可能令人望而卻步，並限制了市場擴張。然而，層析法和過濾技術的進步正在使下游處理變得更加高效、擴充性且具有成本效益。此外，生物製造中一次性和拋棄式技術的趨勢正在推動市場成長，因為它簡化了下游、降低了交叉污染的風險並加速了生產。

市場概況
北美洲
- 美國
- 加拿大
歐洲
- 德國
- 西班牙
- 法國
- 英國
- 歐洲其他地區
亞太地區
- 中國
- 印度
- 日本
- 韓國
- 其他亞太地區
拉丁美洲
- 巴西
- 其他拉丁美洲
中東和非洲 (MEA)
- 海灣合作理事會國家
- 南非
- 其他中東/非洲

競爭格局

前5名企業對比
主要企業市場定位（2021年）
主要市場參與者所採取的策略
關鍵成功策略
近期市集活動
主要企業市場佔有率（2021年）

主要企業簡介

Thermo Fisher Scientific Inc.（United States）
GE Healthcare（United States）
Merck KGaA（Germany）
Sartorius AG（Germany）
Danaher Corporation（United States）
3M Company（United States）
MilliporeSigma（United States）
Novasep Holding SAS（France）
Lonza Group Ltd.（Switzerland）
Eppendorf AG（Germany）
Repligen Corporation（United States）
Charles River Laboratories International, Inc.（United States）
Boehringer Ingelheim International GmbH（Germany）
Avantor, Inc.（United States）
Corning Incorporated（United States）
Pall Corporation（United States）
Shimadzu Corporation（Japan）
Agilent Technologies, Inc.（United States）
ABEC, Inc.（United States）
Nova Biomedical（United States）
JSR Corporation（Japan）
NIZO（Netherlands）

簡介目錄

Product Code: SQMIG35H2109

Global downstream processing market size was valued at USD 30.98 billion in 2022 and is poised to grow from USD 35.69 billion in 2023 to USD 110.79 billion by 2031, at a CAGR of 15.21% during the forecast period (2024-2031).

In downstream processing, biosynthetic products, particularly pharmaceuticals, are extracted and refined from natural sources such as fermentation broth, plant tissues, and animal tissues. This process involves not only the safe disposal of waste but also the recycling of reusable components. It serves as a crucial step in the production of drugs like hormones, vaccines (such as insulin and human growth hormone), antibodies (like infliximab and abciximab), and antibiotics. For example, in April 2022, Merck and Wuxi National High-tech Industrial Development Zone entered into a collaboration agreement, leading to the expansion of Merck's manufacturing plant in Wuxi, Jiangsu Province, China. Downstream processing encompasses various procedures to treat the product, including cell separation, filtration, product recovery, extraction, and purification, utilizing chemical, physical, and biological techniques. It results in the creation of biological and pharmaceutical products such as vaccines, recombinant proteins and enzymes, antibiotics, antibodies, hormones, diagnostic enzymes, industrial enzymes, as well as natural fragrance and flavor compounds. Several factors are driving the global demand for biopharmaceuticals, including expanding bioprocessing capacity, increasing acceptance of single-use technology in bioprocessing, rising R&D spending in pharmaceutical companies, and growing demand in the biopharmaceutical market. Despite the promising outlook, the Global Downstream Processing Market encounters challenges that could impede its growth, including the high cost of downstream processing equipment and consumables. This initial capital investment might be prohibitive for smaller biotech firms and startups, potentially limiting market expansion. Nevertheless, advancements in chromatography and filtration techniques are improving the efficiency and scalability of downstream processing, making it more cost-effective. Additionally, the trend towards single-use and disposable technologies in biomanufacturing is simplifying downstream processes, reducing the risk of cross-contamination, and accelerating production, thus driving market growth.

Top-down and bottom-up approaches were used to estimate and validate the size of the global downstream processing market and to estimate the size of various other dependent submarkets. The research methodology used to estimate the market size includes the following details: The key players in the market were identified through secondary research, and their market shares in the respective regions were determined through primary and secondary research. This entire procedure includes the study of the annual and financial reports of the top market players and extensive interviews for key insights from industry leaders such as CEOs, VPs, directors, and marketing executives. All percentage shares split, and breakdowns were determined using secondary sources and verified through Primary sources. All possible parameters that affect the markets covered in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data.

Global Downstream Processing Market Segmental Analysis

The global downstream processing market is segmented based on product, technique, application and region. By product, the market is segmented into chromatography systems, filters, evaporators, centrifuges, and dryers. By technique, market is segmented into cell disruption, solid-liquid separation, concentration, purification by chromatography, and formulation. By application, the market is segmented into antibiotic production, hormone production, antibodies production, enzyme production, and vaccine production. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.

Drivers of the Global Downstream Processing Market

The demand for biopharmaceuticals, including monoclonal antibodies, vaccines, and recombinant proteins, has been consistently increasing. Downstream processing is essential for purifying and isolating these intricate biological products, guaranteeing their safety and effectiveness. With the continuous expansion of the biopharmaceutical industry, there is a growing need for downstream processing technologies and equipment.

Restraints in the Global Downstream Processing Market

Every biopharmaceutical product possesses distinct characteristics, including size, charge, solubility, and stability, which can pose challenges during downstream processing. Certain products may have low yields, undergo challenging purification, or be prone to degradation throughout purification stages. Creating customized downstream processes for individual products and tackling product-specific obstacles can be intricate and demand substantial expertise and optimization endeavors.

Market Trends of the Global Downstream Processing Market

Process intensification entails enhancing downstream processing operations to attain higher productivity, enhanced yield, and decreased processing durations. Continuous manufacturing methods, such as continuous chromatography and continuous centrifugation, are becoming increasingly popular due to their ability to facilitate real-time monitoring, process control, and heightened process efficiency. These trends aim to simplify and abbreviate the entire downstream processing timeline, resulting in amplified productivity and cost reductions.

Executive Summary

Market Overview
Wheel of Fortune

Research Methodology

Information Procurement
Secondary & Primary Data Sources
Market Size Estimation
Market Assumptions & Limitations

Parent Market Analysis

Market Overview
Market Size
Market Dynamics
- Drivers
- Opportunities
- Restraints
- Challenges

Key Market Insights

Technology Analysis
Pricing Analysis
Supply Chain Analysis
Value Chain Analysis
Ecosystem of the Market
IP Analysis
Trade Analysis
Startup Analysis
Raw Material Analysis
Innovation Matrix
Pipeline Product Analysis
Macroeconomic Indicators
Top Investment Analysis
Key Success Factor
Degree of Competition

Market Dynamics & Outlook

Market Dynamics
- Drivers
- Opportunities
- Restraints
- Challenges
Regulatory Landscape
Porters Analysis
- Competitive rivalry
- Threat of Substitute Products
- Bargaining Power of Buyers
- Threat of New Entrants
- Bargaining Power of Suppliers
Skyquest Special Insights on Future Disruptions
- Political Impact
- Economic Impact
- Social Impact
- Technical Impact
- Environmental Impact
- Legal Impact

Global Downstream Processing Market by Product

Market Overview
Chromatography Systems
Filters
Evaporators
Centrifuges
Dryers

Global Downstream Processing Market by Technique

Market Overview
Cell Disruption
Solid-Liquid Separation
Concentration
Purification by Chromatography
Formulation

Global Downstream Processing Market Size by Region

Market Overview
North America
- USA
- Canada
Europe
- Germany
- Spain
- France
- UK
- Rest of Europe
Asia Pacific
- China
- India
- Japan
- South Korea
- Rest of Asia-Pacific
Latin America
- Brazil
- Rest of Latin America
Middle East & Africa (MEA)
- GCC Countries
- South Africa
- Rest of MEA

Competitive Landscape

Top 5 Player Comparison
Market Positioning of Key Players, 2021
Strategies Adopted by Key Market Players
Top Winning Strategies
- By Development
- By Company
- By Year
Recent Activities in the Market
Key Companies Market Share (%), 2021

Key Company Profiles

Thermo Fisher Scientific Inc. (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
GE Healthcare (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Merck KGaA (Germany)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Sartorius AG (Germany)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Danaher Corporation (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
3M Company (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
MilliporeSigma (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Novasep Holding S.A.S. (France)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Lonza Group Ltd. (Switzerland)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Eppendorf AG (Germany)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Repligen Corporation (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Charles River Laboratories International, Inc. (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Boehringer Ingelheim International GmbH (Germany)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Avantor, Inc. (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Corning Incorporated (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Pall Corporation (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Shimadzu Corporation (Japan)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Agilent Technologies, Inc. (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
ABEC, Inc. (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
Nova Biomedical (United States)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
JSR Corporation (Japan)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments
NIZO (Netherlands)
- Company Overview
- Business Segment Overview
- Financial Updates
- Key Developments